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Conserved domains on  [gi|528498106|ref|XP_005156935|]
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unhealthy ribosome biogenesis protein 2 homolog isoform X2 [Danio rerio]

Protein Classification

Urb2 domain-containing protein( domain architecture ID 10564512)

Urb2 domain-containing protein similar to Saccharomyces cerevisiae nucleolar pre-ribosomal-associated protein 2 (Npa2), also called unhealthy ribosome biogenesis protein 2 (Urb2), that is required for 27S pre-rRNA processing, and has an early role during 60S ribosomal subunit assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Urb2 pfam10441
Urb2/Npa2 family; This family includes the Urb2 protein from yeast that are involved in ...
 1291-1484 6.16e-25

Urb2/Npa2 family; This family includes the Urb2 protein from yeast that are involved in ribosome biogenesis.


:

Pssm-ID: 431289  Cd Length: 213  Bit Score: 104.26  E-value: 6.16e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528498106  1291 LEALTVLLRQgKAQISNPHQVIVVLGALQ--FVPLDSHCMEDYHSAFEAVHEALFAIIHCYPQVMLKASPTFLNCFYRLV 1368
Cdd:pfam10441    4 LEVLDTLLSS-KPWLFSQYDIEQLLSLVStlLSPLLSLESSSADEIFIALCSLLSTILRHHRDKLSGRFHLLLSVLQALL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528498106  1369 SSVMHegkqrsDTDRASEKDRESLLKCARLVERMYTH-----------------VASAAEDFTVLSSFMVAQYVSELQRV 1431
Cdd:pfam10441   83 RCLFT------WLDTGTSKPLPLSAKHAKALSRLLTNlceptvssvskssltsaTKSAKKSLGKHAPYLLAAYIKLQLGS 156

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528498106  1432 TLQPEIKAHLTEGIYCILDHCVEQDIKFLNTTLQMGVKEVFNELYSSYTHYHK 1484
Cdd:pfam10441  157 GLPPEVREALTPGLYAIFDVLSQEELQLLNAALDASGRAVFKTLYKDYKKFGK 209
 
Name Accession Description Interval E-value
Urb2 pfam10441
Urb2/Npa2 family; This family includes the Urb2 protein from yeast that are involved in ...
 1291-1484 6.16e-25

Urb2/Npa2 family; This family includes the Urb2 protein from yeast that are involved in ribosome biogenesis.


Pssm-ID: 431289  Cd Length: 213  Bit Score: 104.26  E-value: 6.16e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528498106  1291 LEALTVLLRQgKAQISNPHQVIVVLGALQ--FVPLDSHCMEDYHSAFEAVHEALFAIIHCYPQVMLKASPTFLNCFYRLV 1368
Cdd:pfam10441    4 LEVLDTLLSS-KPWLFSQYDIEQLLSLVStlLSPLLSLESSSADEIFIALCSLLSTILRHHRDKLSGRFHLLLSVLQALL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528498106  1369 SSVMHegkqrsDTDRASEKDRESLLKCARLVERMYTH-----------------VASAAEDFTVLSSFMVAQYVSELQRV 1431
Cdd:pfam10441   83 RCLFT------WLDTGTSKPLPLSAKHAKALSRLLTNlceptvssvskssltsaTKSAKKSLGKHAPYLLAAYIKLQLGS 156

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528498106  1432 TLQPEIKAHLTEGIYCILDHCVEQDIKFLNTTLQMGVKEVFNELYSSYTHYHK 1484
Cdd:pfam10441  157 GLPPEVREALTPGLYAIFDVLSQEELQLLNAALDASGRAVFKTLYKDYKKFGK 209
 
Name Accession Description Interval E-value
Urb2 pfam10441
Urb2/Npa2 family; This family includes the Urb2 protein from yeast that are involved in ...
 1291-1484 6.16e-25

Urb2/Npa2 family; This family includes the Urb2 protein from yeast that are involved in ribosome biogenesis.


Pssm-ID: 431289  Cd Length: 213  Bit Score: 104.26  E-value: 6.16e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528498106  1291 LEALTVLLRQgKAQISNPHQVIVVLGALQ--FVPLDSHCMEDYHSAFEAVHEALFAIIHCYPQVMLKASPTFLNCFYRLV 1368
Cdd:pfam10441    4 LEVLDTLLSS-KPWLFSQYDIEQLLSLVStlLSPLLSLESSSADEIFIALCSLLSTILRHHRDKLSGRFHLLLSVLQALL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528498106  1369 SSVMHegkqrsDTDRASEKDRESLLKCARLVERMYTH-----------------VASAAEDFTVLSSFMVAQYVSELQRV 1431
Cdd:pfam10441   83 RCLFT------WLDTGTSKPLPLSAKHAKALSRLLTNlceptvssvskssltsaTKSAKKSLGKHAPYLLAAYIKLQLGS 156

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528498106  1432 TLQPEIKAHLTEGIYCILDHCVEQDIKFLNTTLQMGVKEVFNELYSSYTHYHK 1484
Cdd:pfam10441  157 GLPPEVREALTPGLYAIFDVLSQEELQLLNAALDASGRAVFKTLYKDYKKFGK 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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