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Conserved domains on  [gi|528499599|ref|XP_005157248|]
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MICOS complex subunit MIC60 isoform X1 [Danio rerio]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 39-712 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 546.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   39 GSSAGKIVAASLLTVGGGLGGTILYAKWDPKFRSSIEKSVPYSDQLFDMVLGAPPSPpvpiQKKPETVKPLQISSLSEAT 118
Cdd:pfam09731   1 KSGFGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPL----APKPKTFRPLQPSVVSAVT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  119 KDSKQPKAKAKKSDPAPPPSVEEAPApapalqsleaeecckecTEPEPAVKERPAEEvtarlAQQDKAELDALAALTAGL 198
Cdd:pfam09731  77 GESKEPKEEKKQVKIPRQSGVSSEVA-----------------EEEKEATKDAAEAK-----AQLPKSEQEKEKALEEVL 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  199 EETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERAravddagealfkakgelEKLRS 278
Cdd:pfam09731 135 KEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA-----------------EKLKE 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  279 VIDKAKQSKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKIVSQYSELVNEAKAQFQQELANITPEIQANWKGL 358
Cdd:pfam09731 198 VINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  359 SgKLSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKLEdQKAQERAVISALEHSRE----DMRLEQEKKV 434
Cdd:pfam09731 278 N-LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQKEE-LDKLAEELSARLEEVRAadeaQLRLEFERER 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  435 QEVREVMEAEMRTQLRRQAAAHTDHLRDVLKVQEQELREEAQEILNSKMMEQEthyrrltqeqlDTFTLDMNAAYARLKG 514
Cdd:pfam09731 356 EEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKG 424

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  515 IEEAIDSHVIAEEEARKAHQLWLSVEALNYTLKSAGADSPTEPLEGAVRAIKESCAENEFAQALAIAIPEESLNRGIYSE 594
Cdd:pfam09731 425 LEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTE 504

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  595 ASLRARFYDIRRLARRVALIDETRNSLYQYFLSYLQSVLLFERDQeappAKLAPEDLDTFKLLAYATYSIERGDLELAAK 674
Cdd:pfam09731 505 AALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAR 580

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 528499599  675 FVNQLRGESQRVAQDWLKEARLTLETKQVISLLSAYAN 712
Cdd:pfam09731 581 EMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 39-712 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 546.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   39 GSSAGKIVAASLLTVGGGLGGTILYAKWDPKFRSSIEKSVPYSDQLFDMVLGAPPSPpvpiQKKPETVKPLQISSLSEAT 118
Cdd:pfam09731   1 KSGFGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPL----APKPKTFRPLQPSVVSAVT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  119 KDSKQPKAKAKKSDPAPPPSVEEAPApapalqsleaeecckecTEPEPAVKERPAEEvtarlAQQDKAELDALAALTAGL 198
Cdd:pfam09731  77 GESKEPKEEKKQVKIPRQSGVSSEVA-----------------EEEKEATKDAAEAK-----AQLPKSEQEKEKALEEVL 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  199 EETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERAravddagealfkakgelEKLRS 278
Cdd:pfam09731 135 KEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA-----------------EKLKE 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  279 VIDKAKQSKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKIVSQYSELVNEAKAQFQQELANITPEIQANWKGL 358
Cdd:pfam09731 198 VINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  359 SgKLSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKLEdQKAQERAVISALEHSRE----DMRLEQEKKV 434
Cdd:pfam09731 278 N-LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQKEE-LDKLAEELSARLEEVRAadeaQLRLEFERER 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  435 QEVREVMEAEMRTQLRRQAAAHTDHLRDVLKVQEQELREEAQEILNSKMMEQEthyrrltqeqlDTFTLDMNAAYARLKG 514
Cdd:pfam09731 356 EEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKG 424

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  515 IEEAIDSHVIAEEEARKAHQLWLSVEALNYTLKSAGADSPTEPLEGAVRAIKESCAENEFAQALAIAIPEESLNRGIYSE 594
Cdd:pfam09731 425 LEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTE 504

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  595 ASLRARFYDIRRLARRVALIDETRNSLYQYFLSYLQSVLLFERDQeappAKLAPEDLDTFKLLAYATYSIERGDLELAAK 674
Cdd:pfam09731 505 AALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAR 580

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 528499599  675 FVNQLRGESQRVAQDWLKEARLTLETKQVISLLSAYAN 712
Cdd:pfam09731 581 EMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 246-535 1.37e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.33  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 246 QALNEALNERARAVDDAGEALFKAKGELEKLRSVIDKAKQsKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKI 325
Cdd:COG1196  242 EELEAELEELEAELEELEAELAELEAELEELRLELEELEL-ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 326 VSQYSELVNEAKAQFQQELANITPEIQAnwkglsgklSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKL 405
Cdd:COG1196  321 LEEELAELEEELEELEEELEELEEELEE---------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEA 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 406 EDQKAQERAVISALEHSREDMRLEQEKKVQEVREVMEAEMRTQLRRQAAAhtdhlRDVLKVQEQELREEAQEILNSKMME 485
Cdd:COG1196  392 LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE-----EALEEAAEEEAELEEEEEALLELLA 466

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528499599 486 QETHYRRLTQEQLDTFTLDMNAAYARLKGIEEAIDSHVIAEEEARKAHQL 535
Cdd:COG1196  467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
PTZ00121 PTZ00121
MAEBL; Provisional
 100-487 9.47e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 9.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  100 QKKPETVKPLQISSLSEATKDSKQPKAKAKKSDPApppsvEEAPAPAPalQSLEAEECCKECTEPEPAVK-ERPAEEVTA 178
Cdd:PTZ00121 1425 KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKA-----EEAKKKAE--EAKKADEAKKKAEEAKKADEaKKKAEEAKK 1497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  179 RLAQQDKAELDALAA--LTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERA 256
Cdd:PTZ00121 1498 KADEAKKAAEAKKKAdeAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKN 1577

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  257 RAVDDAGEALFKAKGELEKLRSVIDKAKQSKIDSARPqilAAEENLHSmivdldkvvTKVQTAQSEAKIVSQYSELVNEA 336
Cdd:PTZ00121 1578 MALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKK---AEEAKIKA---------EELKKAEEEKKKVEQLKKKEAEE 1645

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  337 KAQFQQ----ELANITPEIQANWKGLSGKLSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKLED-QKAQ 411
Cdd:PTZ00121 1646 KKKAEElkkaEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEElKKAE 1725

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528499599  412 ERAVISALEHSREDMrlEQEKKVQEVRevMEAEMRTQLRRQAAAHTDHLRDVLKVQEQELREEAQEILNSKMMEQE 487
Cdd:PTZ00121 1726 EENKIKAEEAKKEAE--EDKKKAEEAK--KDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 169-366 1.03e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 49.06  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  169 KERpAEEVTARLAQQDKAELDALAALTAGLEET----LGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKS 244
Cdd:NF012221 1564 KER-AEADRQRLEQEKQQQLAAISGSQSQLESTdqnaLETNGQAQRDAILEESRAVTKELTTLAQGLDALDSQATYAGES 1642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  245 TQALNEALNER-----ARAVDDAGEalfKAKGELEKLRSVIdKAKQSKIDSARPQ----ILAAEENLHSMIVDLDKVVTK 315
Cdd:NF012221 1643 GDQWRNPFAGGlldrvQEQLDDAKK---ISGKQLADAKQRH-VDNQQKVKDAVAKseagVAQGEQNQANAEQDIDDAKAD 1718

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528499599  316 VQTAQSEA--------KIVSQYSELVNEAKAQFQQELA---NITPEIQANWKGLsgKLSADD 366
Cdd:NF012221 1719 AEKRKDDAlakqneaqQAESDANAAANDAQSRGEQDASaaeNKANQAQADAKGA--KQDESD 1778
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 181-446 1.07e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   181 AQQDKAEldALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERARAVD 260
Cdd:TIGR02168  207 RQAEKAE--RYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIE 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   261 DAGEALFKAKGELEKLRSVIDKAKQSKIDSARPQILAAE--ENLHSMIVDLDKVVTKVQTAQSEAKIVSQYSELVNEAKA 338
Cdd:TIGR02168  285 ELQKELYALANEISRLEQQKQILRERLANLERQLEELEAqlEELESKLDELAEELAELEEKLEELKEELESLEAELEELE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   339 QFQQELANITPEIQANWKGLSGKLSA-------------------DDLNSLIAHAHRRIDQLNRELAEQRVREqIHIEVA 399
Cdd:TIGR02168  365 AELEELESRLEELEEQLETLRSKVAQlelqiaslnneierlearlERLEDRRERLQQEIEELLKKLEEAELKE-LQAELE 443

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 528499599   400 LEQQKLEDQKAQERAVISALEHSREDMRLEQEKKVQEVREVMEAEMR 446
Cdd:TIGR02168  444 ELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQAR 490
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 383-487 6.19e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.10  E-value: 6.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 383 RELAEQRVREQIhieVALEQQKLEDQKAQeravisaLEHSREDMRLEQEKKVQEVREVMEAEMRTQLRRQAAAhtdhLRD 462
Cdd:cd16269  198 KEIEAERAKAEA---AEQERKLLEEQQRE-------LEQKLEDQERSYEEHLRQLKEKMEEERENLLKEQERA----LES 263

                         90       100
                 ....*....|....*....|....*
gi 528499599 463 VLKVQEQELREEAQEIlnSKMMEQE 487
Cdd:cd16269  264 KLKEQEALLEEGFKEQ--AELLQEE 286
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 39-712 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 546.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   39 GSSAGKIVAASLLTVGGGLGGTILYAKWDPKFRSSIEKSVPYSDQLFDMVLGAPPSPpvpiQKKPETVKPLQISSLSEAT 118
Cdd:pfam09731   1 KSGFGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPL----APKPKTFRPLQPSVVSAVT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  119 KDSKQPKAKAKKSDPAPPPSVEEAPApapalqsleaeecckecTEPEPAVKERPAEEvtarlAQQDKAELDALAALTAGL 198
Cdd:pfam09731  77 GESKEPKEEKKQVKIPRQSGVSSEVA-----------------EEEKEATKDAAEAK-----AQLPKSEQEKEKALEEVL 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  199 EETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERAravddagealfkakgelEKLRS 278
Cdd:pfam09731 135 KEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA-----------------EKLKE 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  279 VIDKAKQSKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKIVSQYSELVNEAKAQFQQELANITPEIQANWKGL 358
Cdd:pfam09731 198 VINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  359 SgKLSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKLEdQKAQERAVISALEHSRE----DMRLEQEKKV 434
Cdd:pfam09731 278 N-LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQKEE-LDKLAEELSARLEEVRAadeaQLRLEFERER 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  435 QEVREVMEAEMRTQLRRQAAAHTDHLRDVLKVQEQELREEAQEILNSKMMEQEthyrrltqeqlDTFTLDMNAAYARLKG 514
Cdd:pfam09731 356 EEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKG 424

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  515 IEEAIDSHVIAEEEARKAHQLWLSVEALNYTLKSAGADSPTEPLEGAVRAIKESCAENEFAQALAIAIPEESLNRGIYSE 594
Cdd:pfam09731 425 LEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTE 504

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  595 ASLRARFYDIRRLARRVALIDETRNSLYQYFLSYLQSVLLFERDQeappAKLAPEDLDTFKLLAYATYSIERGDLELAAK 674
Cdd:pfam09731 505 AALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAR 580

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 528499599  675 FVNQLRGESQRVAQDWLKEARLTLETKQVISLLSAYAN 712
Cdd:pfam09731 581 EMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 246-535 1.37e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.33  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 246 QALNEALNERARAVDDAGEALFKAKGELEKLRSVIDKAKQsKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKI 325
Cdd:COG1196  242 EELEAELEELEAELEELEAELAELEAELEELRLELEELEL-ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 326 VSQYSELVNEAKAQFQQELANITPEIQAnwkglsgklSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKL 405
Cdd:COG1196  321 LEEELAELEEELEELEEELEELEEELEE---------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEA 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 406 EDQKAQERAVISALEHSREDMRLEQEKKVQEVREVMEAEMRTQLRRQAAAhtdhlRDVLKVQEQELREEAQEILNSKMME 485
Cdd:COG1196  392 LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE-----EALEEAAEEEAELEEEEEALLELLA 466

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528499599 486 QETHYRRLTQEQLDTFTLDMNAAYARLKGIEEAIDSHVIAEEEARKAHQL 535
Cdd:COG1196  467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
PTZ00121 PTZ00121
MAEBL; Provisional
 100-487 9.47e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 9.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  100 QKKPETVKPLQISSLSEATKDSKQPKAKAKKSDPApppsvEEAPAPAPalQSLEAEECCKECTEPEPAVK-ERPAEEVTA 178
Cdd:PTZ00121 1425 KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKA-----EEAKKKAE--EAKKADEAKKKAEEAKKADEaKKKAEEAKK 1497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  179 RLAQQDKAELDALAA--LTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERA 256
Cdd:PTZ00121 1498 KADEAKKAAEAKKKAdeAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKN 1577

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  257 RAVDDAGEALFKAKGELEKLRSVIDKAKQSKIDSARPqilAAEENLHSmivdldkvvTKVQTAQSEAKIVSQYSELVNEA 336
Cdd:PTZ00121 1578 MALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKK---AEEAKIKA---------EELKKAEEEKKKVEQLKKKEAEE 1645

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  337 KAQFQQ----ELANITPEIQANWKGLSGKLSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKLED-QKAQ 411
Cdd:PTZ00121 1646 KKKAEElkkaEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEElKKAE 1725

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528499599  412 ERAVISALEHSREDMrlEQEKKVQEVRevMEAEMRTQLRRQAAAHTDHLRDVLKVQEQELREEAQEILNSKMMEQE 487
Cdd:PTZ00121 1726 EENKIKAEEAKKEAE--EDKKKAEEAK--KDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797
PTZ00121 PTZ00121
MAEBL; Provisional
 99-498 4.83e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 4.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   99 IQKKPETVKPLQisslsEATKDSKQPKAKAKKSDPApppsvEEAPAPAPALQSlEAEECCKECTEPEPAVKERPAEEVTA 178
Cdd:PTZ00121 1383 AKKKAEEKKKAD-----EAKKKAEEDKKKADELKKA-----AAAKKKADEAKK-KAEEKKKADEAKKKAEEAKKADEAKK 1451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  179 RLAQQDKAELDALAALTAGLEETLGSSAKVTLQAIGAQEAALTAiAAHTDKLREAMDSETPPDEkstqaLNEAlnERARA 258
Cdd:PTZ00121 1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEA-KKKADEAKKAAEAKKKADE-----AKKA--EEAKK 1523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  259 VDDAGEALFKAKGEleKLRSVIDKAKQSKIDSARpQILAAEENlhsmivdldKVVTKVQTAQSEAKIVSQYSELVNEAKA 338
Cdd:PTZ00121 1524 ADEAKKAEEAKKAD--EAKKAEEKKKADELKKAE-ELKKAEEK---------KKAEEAKKAEEDKNMALRKAEEAKKAEE 1591

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  339 QFQQELANITPEIQanwkglsgKLSADDLNSLiAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKLED-QKAQERAVIS 417
Cdd:PTZ00121 1592 ARIEEVMKLYEEEK--------KMKAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElKKAEEENKIK 1662

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  418 ALEHSREDMrlEQEKKVQEVREVMEAEmrtqlrRQAAAHTDHLRDVLKVQEQELREEAQEILNSKMMEQETHYRRLTQEQ 497
Cdd:PTZ00121 1663 AAEEAKKAE--EDKKKAEEAKKAEEDE------KKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEE 1734


                  .
gi 528499599  498 L 498
Cdd:PTZ00121 1735 A 1735
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 169-366 1.03e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 49.06  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  169 KERpAEEVTARLAQQDKAELDALAALTAGLEET----LGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKS 244
Cdd:NF012221 1564 KER-AEADRQRLEQEKQQQLAAISGSQSQLESTdqnaLETNGQAQRDAILEESRAVTKELTTLAQGLDALDSQATYAGES 1642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  245 TQALNEALNER-----ARAVDDAGEalfKAKGELEKLRSVIdKAKQSKIDSARPQ----ILAAEENLHSMIVDLDKVVTK 315
Cdd:NF012221 1643 GDQWRNPFAGGlldrvQEQLDDAKK---ISGKQLADAKQRH-VDNQQKVKDAVAKseagVAQGEQNQANAEQDIDDAKAD 1718

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528499599  316 VQTAQSEA--------KIVSQYSELVNEAKAQFQQELA---NITPEIQANWKGLsgKLSADD 366
Cdd:NF012221 1719 AEKRKDDAlakqneaqQAESDANAAANDAQSRGEQDASaaeNKANQAQADAKGA--KQDESD 1778
PTZ00121 PTZ00121
MAEBL; Provisional
 97-542 3.46e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.44  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   97 VPIQKKPETVKPLQISSLSEATKDSKQPKaKAKKSDPAPPPSVEEAPAPAPALQSLEAEECCKECTEPEPAVKE---RPA 173
Cdd:PTZ00121 1154 VEIARKAEDARKAEEARKAEDAKKAEAAR-KAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAeavKKA 1232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  174 EEVTARLAQQDKAELDALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALn 253
Cdd:PTZ00121 1233 EEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKA- 1311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  254 ERARAVDDAGEALFKAKGELEKLRSVI------DKAKQSKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKIVS 327
Cdd:PTZ00121 1312 EEAKKADEAKKKAEEAKKKADAAKKKAeeakkaAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK 1391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  328 QYSELVNEA-----KAQFQQELANITPEIQANWKGLSGKLSADDLNSLiAHAHRRIDQLNRELAEQRVREQIHiEVALEQ 402
Cdd:PTZ00121 1392 KADEAKKKAeedkkKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK-AEEAKKADEAKKKAEEAKKAEEAK-KKAEEA 1469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  403 QKLED--QKAQERAVISALEHSREDMR---------LEQEKKVQEVREVMEAEMRTQLRR-QAAAHTDHLRDVLKVQEQE 470
Cdd:PTZ00121 1470 KKADEakKKAEEAKKADEAKKKAEEAKkkadeakkaAEAKKKADEAKKAEEAKKADEAKKaEEAKKADEAKKAEEKKKAD 1549

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528499599  471 LREEAQEILNSKMMEQETHYRRLTQEQLDTFTLDMNAAYARLKGIEEAI----DSHVIAEEEARKAHQLWLSVEAL 542
Cdd:PTZ00121 1550 ELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMklyeEEKKMKAEEAKKAEEAKIKAEEL 1625
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
167-466 8.55e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 8.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  167 AVKERPAEEVTARLAQQDK--AELDALAALTAGLEETLGSSAKVTLQAIGAQEAAlTAIAAHTDKLREAmdsETPPDEks 244
Cdd:COG4913   613 AALEAELAELEEELAEAEErlEALEAELDALQERREALQRLAEYSWDEIDVASAE-REIAELEAELERL---DASSDD-- 686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  245 TQALNEALNERARAVDDAGEALFKAKGELEKLRSVIDKAKQsKIDSARPQILAAEENLHS-MIVDLDKVVTKVQTAQSEA 323
Cdd:COG4913   687 LAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEE-ELDELQDRLEAAEDLARLeLRALLEERFAAALGDAVER 765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  324 KIVSQYSELVNEAKAQF---QQELANITPEIQANWKGLSGKLSAD----------------------------------- 365
Cdd:COG4913   766 ELRENLEERIDALRARLnraEEELERAMRAFNREWPAETADLDADleslpeylalldrleedglpeyeerfkellnensi 845

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  366 ----DLNSLIAHAHR----RIDQLNRELAEQRVREQIHIEVALEQQKLEDQKAQERAVISALEHSREDMRLEQEKKVQEV 437
Cdd:COG4913   846 efvaDLLSKLRRAIReikeRIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAAL 925

                         330       340       350
                  ....*....|....*....|....*....|
gi 528499599  438 REVMEaemrtQLRRQAAAHTDH-LRDVLKV 466
Cdd:COG4913   926 KRLIE-----RLRSEEEESDRRwRARVLDV 950
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 78-195 1.13e-04

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 45.06  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  78 VPYSDQLFDMVLGAPPSPPVPiqKKPETVKPLQISSLSEATKDSKQPKAKAKKSDPAP-PPSVEEAPAPAPALQSLeaee 156
Cdd:PTZ00144 109 VEVGAPLSEIDTGGAPPAAAP--AAAAAAKAEKTTPEKPKAAAPTPEPPAASKPTPPAaAKPPEPAPAAKPPPTPV---- 182

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528499599 157 cckecTEPEPAVKERPAEEVTARLAQQDKAELDALAALT 195
Cdd:PTZ00144 183 -----ARADPRETRVPMSRMRQRIAERLKASQNTCAMLT 216
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 365-643 1.30e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 365 DDLNSLIAHAHRRIDQLNRELAEQRvREQIHIEVALEQQK---------LEDQKAQERAVISALEHSREDMRLEQEKKVQ 435
Cdd:COG1196  235 RELEAELEELEAELEELEAELEELE-AELAELEAELEELRleleeleleLEEAQAEEYELLAELARLEQDIARLEERRRE 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 436 -EVREVMEAEMRTQLRRQAAAHTDHLRDVLkvQEQELREEAQEILNSKMMEQETHYRRLTQEQLDTFTLDMNAAYARLKG 514
Cdd:COG1196  314 lEERLEELEEELAELEEELEELEEELEELE--EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEA 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 515 IEEAID-----SHVIAEEEARKAHQLWLSVEALNYTLKSAGADSPTEPLEGAVRAIKESCAENEFAQALAiaipEESLNR 589
Cdd:COG1196  392 LRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEAL----LELLAE 467

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528499599 590 GIYSEASLRARFYDIRRLARRVALIDETRNSLYQYFLSYLQSVLLFERDQEAPP 643
Cdd:COG1196  468 LLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
215-472 3.34e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  215 AQEAALTAIAAHTDKLREAmdsetppdeKSTQALNEALNERARaVDDAGEALFKAKGELEKLRSVIDKAKQsKIDSARPQ 294
Cdd:COG4913   249 EQIELLEPIRELAERYAAA---------RERLAELEYLRAALR-LWFAQRRLELLEAELEELRAELARLEA-ELERLEAR 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  295 ILAAEENLHSMIVDLDKV-VTKVQTAQSEAKIVSQYSELVNEAKAQFQQELANItpeiqanwkGLSGKLSADDLNSLIAH 373
Cdd:COG4913   318 LDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAAL---------GLPLPASAEEFAALRAE 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  374 AHRRIDQLNRELAeqRVREQIHiEVALEQQKLEDQKAQERAVISALEHSREDMRLEQEkkvqevrevmeaEMRTQLRRQA 453
Cdd:COG4913   389 AAALLEALEEELE--ALEEALA-EAEAALRDLRRELRELEAEIASLERRKSNIPARLL------------ALRDALAEAL 453

                         250       260
                  ....*....|....*....|..
gi 528499599  454 AAHTDHLR---DVLKVQEQELR 472
Cdd:COG4913   454 GLDEAELPfvgELIEVRPEEER 475
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 181-446 1.07e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   181 AQQDKAEldALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERARAVD 260
Cdd:TIGR02168  207 RQAEKAE--RYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIE 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   261 DAGEALFKAKGELEKLRSVIDKAKQSKIDSARPQILAAE--ENLHSMIVDLDKVVTKVQTAQSEAKIVSQYSELVNEAKA 338
Cdd:TIGR02168  285 ELQKELYALANEISRLEQQKQILRERLANLERQLEELEAqlEELESKLDELAEELAELEEKLEELKEELESLEAELEELE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   339 QFQQELANITPEIQANWKGLSGKLSA-------------------DDLNSLIAHAHRRIDQLNRELAEQRVREqIHIEVA 399
Cdd:TIGR02168  365 AELEELESRLEELEEQLETLRSKVAQlelqiaslnneierlearlERLEDRRERLQQEIEELLKKLEEAELKE-LQAELE 443

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 528499599   400 LEQQKLEDQKAQERAVISALEHSREDMRLEQEKKVQEVREVMEAEMR 446
Cdd:TIGR02168  444 ELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQAR 490
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 237-531 1.16e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.52  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   237 ETPPDEKSTQALNEALNERARAVDDAGEALFKAKGELEKLRSVIDKAkQSKIDSARPQILAAEENLHSMIVDLDKVVTKV 316
Cdd:pfam12128  591 DVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKA-SREETFARTALKNARLDLRRLFDEKQSEKDKK 669

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   317 QTAQSEAK---------IVSQYSELVNE---AKAQFQQELANITPEIQANWKGLSGKLSA------DDLNSLIAHAHRRI 378
Cdd:pfam12128  670 NKALAERKdsanerlnsLEAQLKQLDKKhqaWLEEQKEQKREARTEKQAYWQVVEGALDAqlallkAAIAARRSGAKAEL 749

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   379 DQLN----RELAEQRVREQIHIEVALE----QQKLEDQKAQERAVISALEHSREDMRLEQEKKVQEVREVMEA--EMRTQ 448
Cdd:pfam12128  750 KALEtwykRDLASLGVDPDVIAKLKREirtlERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAisELQQQ 829

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   449 LRRQAAahtDHLRDVLKVQEQELREEAQEILnskmMEQETHYRRLTQEQLDTFTLDMNAAYA------RLKGIEEAIDSH 522
Cdd:pfam12128  830 LARLIA---DTKLRRAKLEMERKASEKQQVR----LSENLRGLRCEMSKLATLKEDANSEQAqgsigeRLAQLEDLKLKR 902


                   ....*....
gi 528499599   523 VIAEEEARK 531
Cdd:pfam12128  903 DYLSESVKK 911
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
90-173 2.11e-03

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 40.94  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  90 GAPPSPPvpiqKKPETVKPLQISSLsEATKDSKQPKAKAKKSDPAPPPSVEEAPAPAPALQSLEAEECCKECTE--PEPA 167
Cdd:PRK12373 240 PVPPSEA----ARPKSADAETNAAL-KTPATAPKAAAKNAKAPEAQPVSGTAAAEPAPKEAAKAAAAAAKPALEdkPRPL 314


                 ....*.
gi 528499599 168 VKERPA 173
Cdd:PRK12373 315 GIARPG 320
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 169-666 2.14e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 169 KERPAEEVTARLAQQDKAELDALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSetppdEKSTQAL 248
Cdd:COG1196  289 EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEA-----EAELAEA 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 249 NEALNERARAVDDAGEALFKAKGELEklrsvidkAKQSKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKIVSQ 328
Cdd:COG1196  364 EEALLEAEAELAEAEEELEELAEELL--------EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE 435

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 329 YSELVNEAKAQFQQELANITPEIQANwkglsgKLSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEV-ALEQQKLED 407
Cdd:COG1196  436 EEEEEEEALEEAAEEEAELEEEEEAL------LELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAeADYEGFLEG 509

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 408 QKAQERAVISALEHSREDMRLEQEKKVQEVREVMEAEMRTQLRRQAAAHTDHLRDVLKvqeQELREEAQEILNSKMMEQE 487
Cdd:COG1196  510 VKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLK---AAKAGRATFLPLDKIRARA 586

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 488 THYRRLTQEQLDTFTLDMNAAYARLKGIEEAIDSHVIAEE-EARKAHQLWLSVEALNYTLKSAGADSPT-EPLEGAVRAI 565
Cdd:COG1196  587 ALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTlVAARLEAALRRAVTLAGRLREVTLEGEGgSAGGSLTGGS 666

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 566 KESCAENEFAQALAIAIPEESLNRGIYSEASLRARFYDIRRLARRVALIDETRNSLYQYFLSYLQSVLLFERDQEAPPAK 645
Cdd:COG1196  667 RRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEE 746

                        490       500
                 ....*....|....*....|.
gi 528499599 646 LAPEDLDTFKLLAYATYSIER 666
Cdd:COG1196  747 LLEEEALEELPEPPDLEELER 767
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
492-713 2.43e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 40.42  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 492 RLTQEQLDTFTLDMNAAYARLKGIEEAIDSHVIAEEEARKAHQLWLSVEALNYTLKSAGadsptePLEGAVRAIKESCAE 571
Cdd:COG4223   49 ALAAAREAVAAAAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PFAAELAALEALAPD 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 572 NEFAQALaiaipEESLNRGIYSEASLRARFYDIRRLARRVALIDETRNSLYQYFLSYLQSVL----LFERDQEAPPAkla 647
Cdd:COG4223  123 APALAAL-----AAFAATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLVtvrrVGPVEGDDPDA--- 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528499599 648 pedldtfkLLAYATYSIERGDLELAAKFVNQLRGESQRVAQDWLKEARLTLETKQVISLLSAYANA 713
Cdd:COG4223  195 --------ILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 334-497 3.14e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 3.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 334 NEAKAQFQQELANITPEIQANWKGLSG-----KLSADDLNSL---IAHAHRRIDQLNRELAEQRVR-EQIHIEVALEQQK 404
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAAlkkeeKALLKQLAALerrIAALARRIRALEQELAALEAElAELEKEIAELRAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 405 LEDQKAQERAVISAL----EHSREDMRLEQEKKVQEVREVMEAEMRTQLRRQAAAHTDHLRDVLKVQEQELREEAQEiLN 480
Cdd:COG4942   99 LEAQKEELAELLRALyrlgRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE-LE 177

                        170
                 ....*....|....*..
gi 528499599 481 SKMMEQETHYRRLTQEQ 497
Cdd:COG4942  178 ALLAELEEERAALEALK 194
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 253-530 3.35e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 40.80  E-value: 3.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   253 NERARAVDDAGEALFKAKGELEKLRSVIdKAKQSKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKIVSQYSEL 332
Cdd:TIGR00606  835 QHELDTVVSKIELNRKLIQDQQEQIQHL-KSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSP 913

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   333 VNEAKAQFQQElanitPEIQANWKGLSGKLSADDLNSLIA-----HAHRRIDQLNRELAEQRVREQIHIEVA-LEQQKLE 406
Cdd:TIGR00606  914 LETFLEKDQQE-----KEELISSKETSNKKAQDKVNDIKEkvkniHGYMKDIENKIQDGKDDYLKQKETELNtVNAQLEE 988

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   407 DQKAQERAvisalehsREDMRL-EQEKKVQEVREVMEAEMRTQLRRqaaahtdhlRDVLKVQEQELREEAQEILNSKMME 485
Cdd:TIGR00606  989 CEKHQEKI--------NEDMRLmRQDIDTQKIQERWLQDNLTLRKR---------ENELKEVEEELKQHLKEMGQMQVLQ 1051

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 528499599   486 QETHYRRLtQEQLDTFTLDMNAAYARLKGIEEAIdshVIAEEEAR 530
Cdd:TIGR00606 1052 MKQEHQKL-EENIDLIKRNHVLALGRQKGYEKEI---KHFKKELR 1092
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 213-519 3.61e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 3.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   213 IGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERARAVDDAGealfKAKGELEKLRSVIDKAKQSKidsar 292
Cdd:TIGR02169  683 LEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEE----KLKERLEELEEDLSSLEQEI----- 753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   293 pqilaaeENLHSMIVDLDKVVtkvqtAQSEAKIvSQYSELVNEAKAQFQQElanITPEIQAnwkglsgklSADDLNSLIA 372
Cdd:TIGR02169  754 -------ENVKSELKELEARI-----EELEEDL-HKLEEALNDLEARLSHS---RIPEIQA---------ELSKLEEEVS 808

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   373 HAHRRIDQLNRELAEQRVREQI---HIEVALEQQK-LEDQKAQERAVISALEHSREDMRLEQEKKVQEVREV-------- 440
Cdd:TIGR02169  809 RIEARLREIEQKLNRLTLEKEYlekEIQELQEQRIdLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLesrlgdlk 888

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   441 -----MEAEMRTQLRR--QAAAHTDHLRD---VLKVQEQELREEAQEILNSKMMEQETHYRRLTQEQLdtftldmnaaYA 510
Cdd:TIGR02169  889 kerdeLEAQLRELERKieELEAQIEKKRKrlsELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDV----------QA 958


                   ....*....
gi 528499599   511 RLKGIEEAI 519
Cdd:TIGR02169  959 ELQRVEEEI 967
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 210-479 4.28e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 4.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   210 LQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERARAVddagEALFKAKGELE-KLRSVIDKAKQSKI 288
Cdd:TIGR02169  725 IEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDL----HKLEEALNDLEaRLSHSRIPEIQAEL 800

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   289 DSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKIVSQYSELVNEAKAQFQQELANIT---PEIQANWKGLSGKLSad 365
Cdd:TIGR02169  801 SKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNgkkEELEEELEELEAALR-- 878

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599   366 DLNSLIAHAHRRIDQLNRELAE-QRVREQIHIEVALEQQKLEDQKAQ-----------ERAVISALEHSREDMRLEqekK 433
Cdd:TIGR02169  879 DLESRLGDLKKERDELEAQLRElERKIEELEAQIEKKRKRLSELKAKlealeeelseiEDPKGEDEEIPEEELSLE---D 955

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 528499599   434 VQEVREVMEAEMRT-----QLRRQAAAHTDHLRDVLKVQEQELREEAQEIL 479
Cdd:TIGR02169  956 VQAELQRVEEEIRAlepvnMLAIQEYEEVLKRLDELKEKRAKLEEERKAIL 1006
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 219-476 6.18e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 40.04  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  219 ALTAIAAHTDKLR----EAMDSETPPDEKSTQALNEALNerarAVDDAGEALFKAKgeleKLRSVID------KAKQSKI 288
Cdd:PRK10929   17 AYAATAPDEKQITqeleQAKAAKTPAQAEIVEALQSALN----WLEERKGSLERAK----QYQQVIDnfpklsAELRQQL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  289 DSARPQILAAEENLHSMivDLDKVVTKV-----------QTAQSEAKIVS--------QYSE---LVNEAKAQFQQELAN 346
Cdd:PRK10929   89 NNERDEPRSVPPNMSTD--ALEQEILQVssqlleksrqaQQEQDRAREISdslsqlpqQQTEarrQLNEIERRLQTLGTP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  347 ITPEIQANWKGLSGKLSAD-------DLNSLIAHAHRRIDQLNRELAEQRvREQIHIEVALEQQKLEDQKAQERAviSAL 419
Cdd:PRK10929  167 NTPLAQAQLTALQAESAALkalvdelELAQLSANNRQELARLRSELAKKR-SQQLDAYLQALRNQLNSQRQREAE--RAL 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528499599  420 EHSRedMRLEQE--------KKVQEVREVMEA--------EMRTQLRRQAAAHTDHLRDVLKVqeqeLREEAQ 476
Cdd:PRK10929  244 ESTE--LLAEQSgdlpksivAQFKINRELSQAlnqqaqrmDLIASQQRQAASQTLQVRQALNT----LREQSQ 310
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 383-487 6.19e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.10  E-value: 6.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 383 RELAEQRVREQIhieVALEQQKLEDQKAQeravisaLEHSREDMRLEQEKKVQEVREVMEAEMRTQLRRQAAAhtdhLRD 462
Cdd:cd16269  198 KEIEAERAKAEA---AEQERKLLEEQQRE-------LEQKLEDQERSYEEHLRQLKEKMEEERENLLKEQERA----LES 263

                         90       100
                 ....*....|....*....|....*
gi 528499599 463 VLKVQEQELREEAQEIlnSKMMEQE 487
Cdd:cd16269  264 KLKEQEALLEEGFKEQ--AELLQEE 286
PRK11633 PRK11633
cell division protein DedD; Provisional
 88-146 8.79e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 38.45  E-value: 8.79e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528499599  88 VLGAPPSPPVPIQKKPETVKPLQISSLSEATKDSKQPKAKAkKSDPAPPPSVEEAPAPA 146
Cdd:PRK11633  89 TVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPP-APKPEPKPVVEEKAAPT 146
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 173-478 8.86e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 173 AEEVTARLAQQDKAELDALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETppdekSTQALNEAL 252
Cdd:COG1196  478 ALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAA-----LAAALQNIV 552

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 253 NERARAVDDAGEAL-FKAKGELEKLR-SVIDKAKQSKIDSARPQILAAEENLHSMIVDLDKVVTKVQTAQSEAKIVSQYS 330
Cdd:COG1196  553 VEDDEVAAAAIEYLkAAKAGRATFLPlDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARL 632

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599 331 ELVNEAKAQFQQELANITPEIQ-ANWKGLSGKLSADDLNSLIAHAHRRIDQLNRELAEQRVREQIHIEVALEQQKLEDQK 409
Cdd:COG1196  633 EAALRRAVTLAGRLREVTLEGEgGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEA 712

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528499599 410 AQERAvisalEHSREDMRLEQEKKVQEVREVMEAEMRTQLRRQAAAHTDHLRDVLKVQEQELREEAQEI 478
Cdd:COG1196  713 EEERL-----EEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREI 776
PTZ00121 PTZ00121
MAEBL; Provisional
 322-535 9.17e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 9.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  322 EAKIVSQYSELVNEAKAQFQQELANITPEIQANWKGLSGKLSADDLNSL----IAHAHRRIDQLNRelAEQRVREQIHIE 397
Cdd:PTZ00121 1082 DAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAeearKAEDARKAEEARK--AEDAKRVEIARK 1159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  398 VALEQQKLEDQKAQERAVISALEHSREDMRLEQEKKVQEVREVMEAEMRTQLRRqaaahtdhLRDVLKVQEQELREEAQE 477
Cdd:PTZ00121 1160 AEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERK--------AEEARKAEDAKKAEAVKK 1231

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499599  478 ILNSKMMEQETHY--RRLTQEQLDTFTLDMNAAYARLKGIEEAidshviaeEEARKAHQL 535
Cdd:PTZ00121 1232 AEEAKKDAEEAKKaeEERNNEEIRKFEEARMAHFARRQAAIKA--------EEARKADEL 1283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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