BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  38 GNKYVQLNVGGNLYYSTLQVLTRQDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSIMELL 117
Cdd:cd18401    1 GNKYVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQEIKELM 80

                         90       100
                 ....*....|....*....|....
gi 528501534 118 AEAKYYQIQGLIDLCQKELQDNKE 141
Cdd:cd18401   81 AEAKYYLIQGLVDMCQAALQDKKD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  38 GNKYVQLNVGGNLYYSTLQVLTRQDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSIMELL 117
Cdd:cd18401    1 GNKYVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQEIKELM 80

                         90       100
                 ....*....|....*....|....
gi 528501534 118 AEAKYYQIQGLIDLCQKELQDNKE 141
Cdd:cd18401   81 AEAKYYLIQGLVDMCQAALQDKKD 104

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534    41 YVQLNVGGNLYYSTLQVLTRQDTLLRSMFSGKMEvLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPksRQSIMELLAEA 120
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFK-ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP--EENVEELLELA 77

                           90
                   ....*....|....*....
gi 528501534   121 KYYQIQGLIDLCQKELQDN 139
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  38 GNKYVQLNVGGNLYYSTLQVLTRQDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSIMELL 117
Cdd:cd18401    1 GNKYVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQEIKELM 80

                         90       100
                 ....*....|....*....|....
gi 528501534 118 AEAKYYQIQGLIDLCQKELQDNKE 141
Cdd:cd18401   81 AEAKYYLIQGLVDMCQAALQDKKD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13); KCTD13, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BACURD1), or TNFAIP1-like protein, is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD13 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  39 NKYVQLNVGGNLYYSTLQVLTRQDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSIMELLA 118
Cdd:cd18400    1 SKYVKLNVGGSLHYTTVQTLTKQDTMLKAMFSGRVEVLTDSEGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELEELLG 80

                         90       100
                 ....*....|....*....|...
gi 528501534 119 EAKYYQIQGLIDLCQKELQDNKE 141
Cdd:cd18400   81 EARYYLVQGLVEDCQLALQQKRD 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLT-RQDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSI-MELLAE 119
Cdd:cd18376    1 VKLNVGGQKFTTTLDTLTkDPDSMLAAMFSGRHSLKKDEDGSYFIDRDGTHFRHILNYLRDGEVKIPTEDRSVlKELLEE 80

                 ....*....
gi 528501534 120 AKYYQIQGL 128
Cdd:cd18376   81 AEYYQLRGL 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTR-QDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSIMELLAEA 120
Cdd:cd18365    3 VNLNVGGVHYTTTLATLTRfPDSMLGAMFSGSMPTTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYDLLLREA 82

                         90
                 ....*....|
gi 528501534 121 KYYQIQGLID 130
Cdd:cd18365   83 DFYQIEPLIE 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTR-QDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGfvNLPKSRQSIMeLLAEA 120
Cdd:cd18366    6 VPLNVGGMHFTTRLSTLRKyEDSMLAAMFSGRHHIPKDSEGRYFIDRDGSYFGYILNFLRDG--DLPPRERARA-VYKEA 82

                         90
                 ....*....|
gi 528501534 121 KYYQIQGLID 130
Cdd:cd18366   83 QYYGIGPLIE 92

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534    41 YVQLNVGGNLYYSTLQVLTRQDTLLRSMFSGKMEvLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPksRQSIMELLAEA 120
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFK-ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP--EENVEELLELA 77

                           90
                   ....*....|....*....
gi 528501534   121 KYYQIQGLIDLCQKELQDN 139
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTRQ-DTLLRSMFSGKM--EVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSIMELLA 118
Cdd:cd18367    5 VELNVGGQVYTTSLSTLIKDpDSLLGRMFSGKNrqELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERERLKR 84

                         90
                 ....*....|.
gi 528501534 119 EAKYYQIQGLI 129
Cdd:cd18367   85 EAEYFQLPELV 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTR-QDTLLRSMFSGKMEVL----TDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSIMEL 116
Cdd:cd18370    1 VTLNVGGTLYSTTLETLTRfPDSMLGAMFRAGTPIPpnlnMQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALL 80

                 ....*...
gi 528501534 117 LAEAKYYQ 124
Cdd:cd18370   81 RAEADFYQ 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTR-QDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGfvNLPKsrQSIMELLAEA 120
Cdd:cd18371    4 VSLNVGGHIYTTTLSTLRKfPGSKLAELFNGQPKLRTDSEGRYFIDRDGTYFRYILEYLRTN--QVPT--QHIQEVYKEA 79

                         90
                 ....*....|....*...
gi 528501534 121 KYYQIQGLIdlcqKELQD 138
Cdd:cd18371   80 LFYDIEPLV----KLLEE 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  40 KYVQLNVGGNLYYSTLQVLTRQ-DTLLRSMFSGKMEVLTDKE--GWILIDRCGKHFGSILSYLRDG--FVNLPKSRQSIM 114
Cdd:cd18389    1 KWVRLNVGGTYFVSTKQTLCRDpKSFLYRLCQEDPDLDSDKDetGAYLIDRDPTYFGPILNYLRHGklIINKELAEEGVL 80

                         90       100
                 ....*....|....*....|....*...
gi 528501534 115 EllaEAKYYQIQGLIDLCQKELQDNKEK 142
Cdd:cd18389   81 E---EAEFYNIASLVRLVKERIRDNENR 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  40 KYVQLNVGGNLYYSTLQVLTRQDT--LLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPK--SRQSIME 115
Cdd:cd18391    1 KWVRLNVGGTVFLTTRQTLCREQKsfLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKdmAEEGVLE 80

                         90       100
                 ....*....|....*....|...
gi 528501534 116 llaEAKYYQIQGLIDLCQKELQD 138
Cdd:cd18391   81 ---EAEFYNIGPLIRIIKDRMEE 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTR-QDTLLRSMFSGKMEVLTD----KEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSIMEL 116
Cdd:cd18398    5 VELNVGGQVYFTRHATLVSiPHSLLWKMFSPKRDTANDlakdSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRL 84

                         90
                 ....*....|....*
gi 528501534 117 LAEAKYYQIQGLIDL 131
Cdd:cd18398   85 KREAEYFQLPDLVKL 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTR-QDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSrqSIMELLAEA 120
Cdd:cd18363    4 INLNVGGKRFSTSRQTLTWiPDSFFTSLLSGRISSLKDETGAIFIDRDPKLFSIILNYLRTKEIDLRNV--DISSLRHEA 81

                 ....*
gi 528501534 121 KYYQI 125
Cdd:cd18363   82 EFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLT-RQDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLPKSRQSImeLLAEA 120
Cdd:cd18393    4 IHLNVGGKRFSTSRQTLTwIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGIHVSL--LLHEA 81

                         90
                 ....*....|...
gi 528501534 121 KYYQIQGLIDLCQ 133
Cdd:cd18393   82 QFYGITPLVRRLQ 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTR-QDTLLRSMFsGKMEVLTDKE--GWILIDRCGKHFGSILSYLRDGFVNLPKSrQSIMELLA 118
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLTRhPDTLLGRMF-KPGREFTFPNetGEYFIDRDPTVFRTILNYYRTGKLNCPDG-ISIPDLRE 78

                 ....*
gi 528501534 119 EAKYY 123
Cdd:cd18187   79 ECDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  42 VQLNVGGNLYYSTLQVLTR-QDTLLRSMFSGKMEVLTDKEGWILIDRCGKHFGSILSYLRDGFVNLpkSRQSIMELLAEA 120
Cdd:cd18392    4 IQLNVGGTRFSTSRQTLMWiPDSFFSSLLSGRISSLKDETGAIFIDRDPTAFVPILNFLRTKELDL--RGVNINVLRHEA 81

                 ....*
gi 528501534 121 KYYQI 125
Cdd:cd18392   82 EFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528501534  41 YVQLNVGGNLYYSTLQVLTR-QDTLLRSMFSGKMEVLTDKE--GWILIDRCGKHFGSILSYLRDGFVNLPKSrQSIMELL 117
Cdd:cd18362    1 WVKLNVGGTYFLTTRTTLCRdPKSFLCRLCQEDPDLPSDKDetGAYLIDRDPTYFGPILNYLRHGKLIIDKD-LAEEGVL 79

                 ....*.
gi 528501534 118 AEAKYY 123
Cdd:cd18362   80 EEAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 528501534  92 FGSILSYLRDGFVN--LPKSRQSIMELLAEAKYYQIQGLIDLCQKELQDN 139
Cdd:cd18333   69 FRLILDYIYTGRLSegDPGSEQNLGAVLAAASYLQIPDLVALCKKKLKRN 118