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Conserved domains on  [gi|528503049|ref|XP_005157916|]
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inhibitor of Bruton tyrosine kinase [Danio rerio]

Protein Classification

inhibitor of Bruton tyrosine kinase( domain architecture ID 13793853)

inhibitor of Bruton tyrosine kinase (IBtk) acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development; contains two BTB/POZ domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 768-880 5.35e-61

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 203.75  E-value: 5.35e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  768 KGSHLCDVTLRSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVNME 847
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 528503049  848 FVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 539-645 1.25e-44

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 156.29  E-value: 1.25e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  539 FSQHLQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREgdgevrrgEDAVGCDLLVLEKIPPE 618
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTS--------EDAVGCDVVHIEKVPPE 72

                          90       100
                  ....*....|....*....|....*..
gi 528503049  619 LLEQALNFIYTDSCDMLVDGACPIIPR 645
Cdd:cd18301    73 IFEQLLQFIYTDTCDLLTDGYKPKLQR 99
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-363 1.20e-30

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 124.70  E-value: 1.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  144 EVYTWGNNTNFSLGHGNQESRQHPEIVDLFSRSgiyVKQVVLCKFHSVFLSQKGQVYTCGHGQGGRLGHGDENTYLVPRM 223
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  224 VEGLlsHHCSQIAAARDHTVVLTEEGYVYTFGLNTHHQLGLGpPPTSSSVPKQVTSkslkGRSVIGVAAGRFHTVLWTRD 303
Cdd:COG5184   195 VGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDG-TTTDRATPVQVAG----LTGVVAIAAGGSHTCALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  304 -AVYTVGLNG-GQLGYllepNGEKCVTVPRQVSALlhkdVTISMVAASNGATVCVTDKGDVY 363
Cdd:COG5184   268 gTVWCWGDNSyGQLGD----GTTTDRSTPVKVPGL----SGVVAVAAGSSHTCALLTDGTVW 321
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 878-934 9.31e-24

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


:

Pssm-ID: 350575  Cd Length: 60  Bit Score: 95.27  E-value: 9.31e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049  878 LKNAAELLEFSTIYNAEQLKLSCLQFIVLNMAALLESKALEILSDDVLVDVAAAYRR 934
Cdd:cd18500     3 LRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYRE 59
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-126 2.91e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 2.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049   47 LRDEFGRTALHLAASMGKRELLQWLLDcKHADLLAKDKEsGWTALHRSAFYGQIHCLITLIKRGGSLSMQDKEGLSVLDL 126
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 768-880 5.35e-61

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 203.75  E-value: 5.35e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  768 KGSHLCDVTLRSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVNME 847
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 528503049  848 FVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 539-645 1.25e-44

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 156.29  E-value: 1.25e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  539 FSQHLQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREgdgevrrgEDAVGCDLLVLEKIPPE 618
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTS--------EDAVGCDVVHIEKVPPE 72

                          90       100
                  ....*....|....*....|....*..
gi 528503049  619 LLEQALNFIYTDSCDMLVDGACPIIPR 645
Cdd:cd18301    73 IFEQLLQFIYTDTCDLLTDGYKPKLQR 99
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-363 1.20e-30

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 124.70  E-value: 1.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  144 EVYTWGNNTNFSLGHGNQESRQHPEIVDLFSRSgiyVKQVVLCKFHSVFLSQKGQVYTCGHGQGGRLGHGDENTYLVPRM 223
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  224 VEGLlsHHCSQIAAARDHTVVLTEEGYVYTFGLNTHHQLGLGpPPTSSSVPKQVTSkslkGRSVIGVAAGRFHTVLWTRD 303
Cdd:COG5184   195 VGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDG-TTTDRATPVQVAG----LTGVVAIAAGGSHTCALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  304 -AVYTVGLNG-GQLGYllepNGEKCVTVPRQVSALlhkdVTISMVAASNGATVCVTDKGDVY 363
Cdd:COG5184   268 gTVWCWGDNSyGQLGD----GTTTDRSTPVKVPGL----SGVVAVAAGSSHTCALLTDGTVW 321
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 878-934 9.31e-24

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 95.27  E-value: 9.31e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049  878 LKNAAELLEFSTIYNAEQLKLSCLQFIVLNMAALLESKALEILSDDVLVDVAAAYRR 934
Cdd:cd18500     3 LRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYRE 59
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 766-876 5.35e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 80.76  E-value: 5.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049   766 LKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDEshtvrdAVN 845
Cdd:pfam00651    4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK------LIS 76

                           90       100       110
                   ....*....|....*....|....*....|.
gi 528503049   846 MEFVCNVLVVADQLLITRLKEICEVVIAEKL 876
Cdd:pfam00651   77 EENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 774-869 6.87e-16

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 74.26  E-value: 6.87e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049    774 DVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHtvrdaVNMEFVCNVL 853
Cdd:smart00225    1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLD-----LPEENVEELL 74

                            90
                    ....*....|....*.
gi 528503049    854 VVADQLLITRLKEICE 869
Cdd:smart00225   75 ELADYLQIPGLVELCE 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-126 2.91e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 2.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049   47 LRDEFGRTALHLAASMGKRELLQWLLDcKHADLLAKDKEsGWTALHRSAFYGQIHCLITLIKRGGSLSMQDKEGLSVLDL 126
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-117 4.18e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 4.18e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049    27 SGSEACLRAFLSvhCHNSATLRDEFGRTALHLAASMGKRELLQWLLDCKHADllakDKESGWTALHRSAFYGQIHCLITL 106
Cdd:pfam12796    7 NGNLELVKLLLE--NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN----LKDNGRTALHYAARSGHLEIVKLL 80

                           90
                   ....*....|.
gi 528503049   107 IKRGGSLSMQD 117
Cdd:pfam12796   81 LEKGADINVKD 91
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
196-245 5.28e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 5.28e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 528503049   196 KGQVYTCGHGQGGRLGHGDENTYLVPRMVEGLLSHHCSQIAAARDHTVVL 245
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 557-630 4.78e-11

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 60.73  E-value: 4.78e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528503049   557 HDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPPELLEQALNFIYTD 630
Cdd:pfam00651   11 CDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEIT------------LDDVSPEDFEALLEFMYTG 72
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 558-634 2.18e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 55.77  E-value: 2.18e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049    558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPPELLEQALNFIYTDSCDM 634
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIY------------LDDVSPEDFRALLNFLYTGKLDL 65
PHA02713 PHA02713
hypothetical protein; Provisional
 772-874 6.92e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 43.84  E-value: 6.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPI-SSEVLQVILEYIYTdeshtvRDAVNMEfVC 850
Cdd:PHA02713   25 LCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMfDKDAVKNIVQYLYN------RHISSMN-VI 97

                          90       100
                  ....*....|....*....|....
gi 528503049  851 NVLVVADQLLITRLKEICEVVIAE 874
Cdd:PHA02713   98 DVLKCADYLLIDDLVTDCESYIKD 121
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 768-880 5.35e-61

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 203.75  E-value: 5.35e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  768 KGSHLCDVTLRSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVNME 847
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 528503049  848 FVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 539-645 1.25e-44

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 156.29  E-value: 1.25e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  539 FSQHLQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREgdgevrrgEDAVGCDLLVLEKIPPE 618
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTS--------EDAVGCDVVHIEKVPPE 72

                          90       100
                  ....*....|....*....|....*..
gi 528503049  619 LLEQALNFIYTDSCDMLVDGACPIIPR 645
Cdd:cd18301    73 IFEQLLQFIYTDTCDLLTDGYKPKLQR 99
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-363 1.20e-30

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 124.70  E-value: 1.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  144 EVYTWGNNTNFSLGHGNQESRQHPEIVDLFSRSgiyVKQVVLCKFHSVFLSQKGQVYTCGHGQGGRLGHGDENTYLVPRM 223
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  224 VEGLlsHHCSQIAAARDHTVVLTEEGYVYTFGLNTHHQLGLGpPPTSSSVPKQVTSkslkGRSVIGVAAGRFHTVLWTRD 303
Cdd:COG5184   195 VGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDG-TTTDRATPVQVAG----LTGVVAIAAGGSHTCALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  304 -AVYTVGLNG-GQLGYllepNGEKCVTVPRQVSALlhkdVTISMVAASNGATVCVTDKGDVY 363
Cdd:COG5184   268 gTVWCWGDNSyGQLGD----GTTTDRSTPVKVPGL----SGVVAVAAGSSHTCALLTDGTVW 321
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 145-363 8.61e-29

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 119.31  E-value: 8.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  145 VYTWGNNTNFSLGHGNQESRQHPEIVDLFSRsgiyVKQVVLCKFHSVFLSQKGQVYTCGHGQGGRLGHGDENTYLVPRMV 224
Cdd:COG5184    19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN----VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  225 EGLlsHHCSQIAAARDHTVVLTEEGYVYTFGLNTHHQLGLGpPPTSSSVPKQVtskSLKGRSVIGVAAGRFHTVLWTRD- 303
Cdd:COG5184    95 PGL--TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQV---DAGLSGVVAIAAGGYHTCALKSDg 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528503049  304 AVYTVGLNG-GQLGYLLEPNgekcVTVPRQVSALLhkdvTISMVAASNGATVCVTDKGDVY 363
Cdd:COG5184   169 TVWCWGANSyGQLGDGTTTD----RPTPVQVGGLS----GVVAVAAGGDHSCALKSDGTVW 221
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-363 7.49e-27

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 113.53  E-value: 7.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  144 EVYTWGNNTNFSLGHGNQESRQHPEIVDLFSRsgiyVKQVVLCKFHSVFLSQKGQVYTCGHGQGGRLGHGDENTYLVPRM 223
Cdd:COG5184    68 TVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG----VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQ 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  224 VEGLLShHCSQIAAARDHTVVLTEEGYVYTFGLNTHHQLGLGpPPTSSSVPKQVTSKSlkgrSVIGVAAGRFHTVLWTRD 303
Cdd:COG5184   144 VDAGLS-GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDG-TTTDRPTPVQVGGLS----GVVAVAAGGDHSCALKSD 217

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  304 -AVYTVGLNG-GQLGYLLEPNgekcVTVPRQVSALlhkdVTISMVAASNGATVCVTDKGDVY 363
Cdd:COG5184   218 gTVWCWGSNSsGQLGDGTTTD----RATPVQVAGL----TGVVAIAAGGSHTCALKSDGTVW 271
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 878-934 9.31e-24

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 95.27  E-value: 9.31e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049  878 LKNAAELLEFSTIYNAEQLKLSCLQFIVLNMAALLESKALEILSDDVLVDVAAAYRR 934
Cdd:cd18500     3 LRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYRE 59
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 188-363 1.32e-23

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 103.90  E-value: 1.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  188 FHSVFLSQKGQVYTCGHGQGGRLGHGDENTYLVPRMVEGLlsHHCSQIAAARDHTVVLTEEGYVYTFGLNTHHQLGLGpP 267
Cdd:COG5184     8 SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDG-T 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  268 PTSSSVPKQVTSKSlkgrSVIGVAAGRFHTVLWTRD-AVYTVGLNG-GQLGYLLEPNgekcVTVPRQVSALLhkdVTISM 345
Cdd:COG5184    85 TTDRTTPVKVPGLT----GVVAVAAGYYHSCALKSDgTVWCWGDNSsGQLGDGTTTN----RLTPVQVDAGL---SGVVA 153

                         170
                  ....*....|....*...
gi 528503049  346 VAASNGATVCVTDKGDVY 363
Cdd:COG5184   154 IAAGGYHTCALKSDGTVW 171
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-859 2.36e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 89.54  E-value: 2.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATScSALSLP-ISSEVLQVILEYIYTDEshtvrDAVNMEFVC 850
Cdd:cd18186     1 LCDVTLV-VGGREFPAHRAVLAARSPYFRAMFSSGMKESSS-SEIELDdVSPEAFEALLDYIYTGE-----LELSEENVE 73


                  ....*....
gi 528503049  851 NVLVVADQL 859
Cdd:cd18186    74 ELLAAADKL 82
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-274 6.95e-21

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 95.81  E-value: 6.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  144 EVYTWGNNTNFSLGHGNQESRQHPEIVDLFSRsgiyVKQVVLCKFHSVFLSQKGQVYTCGHGQGGRLGHGDENTYLVPRM 223
Cdd:COG5184   219 TVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVK 294

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 528503049  224 VEGLlsHHCSQIAAARDHTVVLTEEGYVYTFGLNTHHQLGLGpPPTSSSVP 274
Cdd:COG5184   295 VPGL--SGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDG-TTTDRSTP 342
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 774-876 6.04e-19

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 83.88  E-value: 6.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLRsVDGKEFSCHKCILCARLEYFNSML----GSSWMEATSCSALSLP-ISSEVLQVILEYIYTDESHtvrdaVNMEF 848
Cdd:cd18296    19 DVCFQ-VEGHRFPCHKAFFCGRSDYFKALLrdhfAESEENNGSIPVVTLHdVSPEVFAIVLYYIYTDDTD-----LPPEN 92

                          90       100
                  ....*....|....*....|....*...
gi 528503049  849 VCNVLVVADQLLITRLKEICEVVIAEKL 876
Cdd:cd18296    93 AYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 766-876 5.35e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 80.76  E-value: 5.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049   766 LKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDEshtvrdAVN 845
Cdd:pfam00651    4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK------LIS 76

                           90       100       110
                   ....*....|....*....|....*....|.
gi 528503049   846 MEFVCNVLVVADQLLITRLKEICEVVIAEKL 876
Cdd:pfam00651   77 EENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 774-872 2.22e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 76.53  E-value: 2.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATScSALSLP-ISSEVLQVILEYIYTDESHtVRDAVNMefvCNV 852
Cdd:cd18286    19 DITIK-VDGKTFKAHRCILCARSSYFAAMLSGSWAESNS-SEITLTgVSHAAVSFVLLFIYGGVLD-LPDDVNL---GEL 92

                          90       100
                  ....*....|....*....|
gi 528503049  853 LVVADQLLITRLKEICEVVI 872
Cdd:cd18286    93 LSLADMYGLDGLKDVVAYTL 112
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-642 5.23e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 74.13  E-value: 5.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVrrgedavgcdllVLEKIPPELLEQALNFIYTDSCDMLVD 637
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEI------------ELDDVSPEAFEALLDYIYTGELELSEE 70


                  ....*
gi 528503049  638 GACPI 642
Cdd:cd18186    71 NVEEL 75
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 774-869 6.87e-16

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 74.26  E-value: 6.87e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049    774 DVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHtvrdaVNMEFVCNVL 853
Cdd:smart00225    1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLD-----LPEENVEELL 74

                            90
                    ....*....|....*.
gi 528503049    854 VVADQLLITRLKEICE 869
Cdd:smart00225   75 ELADYLQIPGLVELCE 90
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-880 9.18e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 74.67  E-value: 9.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEaTSCSALSLP-ISSEVLQVILEYIYTDESHtvrdaV 844
Cdd:cd18240    11 LRLEGKLCDVVIR-VNGVEFPAHRNILCACSPYFRALFTNGWNE-TEKKVYKIPgVSPEMMELIIEYAYTRTVP-----I 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 528503049  845 NMEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18240    84 TAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 233-421 2.88e-15

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 78.87  E-value: 2.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  233 SQIAAARDHTVVLTEEGYVYTFGLNTHHQLGLGpPPTSSSVPKQVTSkslkGRSVIGVAAGRFHTVLWTRD-AVYTVGLN 311
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVRVPG----LSNVVAVAAGGDHTCALKADgTVWCWGNN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  312 G-GQLGyllepNGEK-CVTVPRQVSALlhkdVTISMVAASNGATVCVTDKGDVYllvdyqC-KKLASKQLNLkkilvsgG 388
Cdd:COG5184    76 SyGQLG-----DGTTtDRTTPVKVPGL----TGVVAVAAGYYHSCALKSDGTVW------CwGDNSSGQLGD-------G 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 528503049  389 SLDHRTDPQLLHDGGGEklVI---------LALDETGRVFSW 421
Cdd:COG5184   134 TTTNRLTPVQVDAGLSG--VVaiaaggyhtCALKSDGTVWCW 173
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-868 1.75e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 68.24  E-value: 1.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDeshTVRdaV 844
Cdd:cd18242    14 SLRKSNTLCDVTLR-VEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTE---TVH--V 87

                          90       100
                  ....*....|....*....|....
gi 528503049  845 NMEFVCNVLVVADQLLITRLKEIC 868
Cdd:cd18242    88 TVENVQELLPAACLLQLKGVKQAC 111
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-126 2.91e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 2.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049   47 LRDEFGRTALHLAASMGKRELLQWLLDcKHADLLAKDKEsGWTALHRSAFYGQIHCLITLIKRGGSLSMQDKEGLSVLDL 126
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-117 4.18e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 4.18e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049    27 SGSEACLRAFLSvhCHNSATLRDEFGRTALHLAASMGKRELLQWLLDCKHADllakDKESGWTALHRSAFYGQIHCLITL 106
Cdd:pfam12796    7 NGNLELVKLLLE--NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN----LKDNGRTALHYAARSGHLEIVKLL 80

                           90
                   ....*....|.
gi 528503049   107 IKRGGSLSMQD 117
Cdd:pfam12796   81 LEKGADINVKD 91
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-868 1.36e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 65.44  E-value: 1.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSW-MEATSCSALSLP-ISSEVLQVILEYIYTDE----SHT 839
Cdd:cd18245     8 FREEPHLCDATL-VVGGEEIPVQKNVLAAASPYFRAKLNYNPpKDDGSTYKIELEgISVEVMEEILDYIYTGQiklsEDN 86

                          90       100
                  ....*....|....*....|....*....
gi 528503049  840 VRDavnmefvcnVLVVADQLLITRLKEIC 868
Cdd:cd18245    87 IQD---------IVQAADLLLMTDLKDLC 106
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 771-869 4.85e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 63.80  E-value: 4.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  771 HLCDVT-LRSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLP-ISSEVLQVILEYIYTD----ESHTVRDav 844
Cdd:cd18294    13 EFSDVKfLVGPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSdIEPEVFRAVLEFIYTNcvtlSNHTVIE-- 90

                          90       100
                  ....*....|....*....|....*
gi 528503049  845 nmefvcnVLVVADQLLITRLKEICE 869
Cdd:cd18294    91 -------VLAAAVEYGLDELRKLCE 108
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
196-245 5.28e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 5.28e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 528503049   196 KGQVYTCGHGQGGRLGHGDENTYLVPRMVEGLLSHHCSQIAAARDHTVVL 245
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
248-300 1.30e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 1.30e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528503049   248 EGYVYTFGLNTHHQLGLGpPPTSSSVPKQVtsKSLKGRSVIGVAAGRFHTVLW 300
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLG-TTENVLVPQKV--EGLSGNKVVQVACGGDHTVAL 50
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-876 3.11e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 61.49  E-value: 3.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  763 RFTLKKGShLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATScSALSLP-ISSEVLQVILEYIYTDE--SHT 839
Cdd:cd18300     1 KLFLNKGL-FSDVTFI-VEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-KEVELPgVSKETFLALLEYLYTDQapILE 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 528503049  840 VRDAVnmefvcNVLVVADQLLITRLKEICEVVIAEKL 876
Cdd:cd18300    78 DGDCV------GLIVLANRLCLPRLVALCEQYIVKEL 108
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 557-630 4.78e-11

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 60.73  E-value: 4.78e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528503049   557 HDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPPELLEQALNFIYTD 630
Cdd:pfam00651   11 CDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEIT------------LDDVSPEDFEALLEFMYTG 72
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-834 5.31e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 61.10  E-value: 5.31e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  766 LKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSML--GsswMEATSCSALSLP-ISSEVLQVILEYIYT 834
Cdd:cd18287    16 LFLNEEYSDVTF-VVEEKRFPAHRVILAARSEYFRALLygG---MRESQQSEIELKdTNAEAFKALLKYIYT 83
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-876 9.60e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 60.56  E-value: 9.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYtDESHTVRDavnmEFVCN 851
Cdd:cd18265    23 FTDVVLL-VDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY-GGGLRIQE----DNVES 96

                          90       100
                  ....*....|....*....|....*
gi 528503049  852 VLVVADQLLITRLKEICEVVIAEKL 876
Cdd:cd18265    97 VLEASDLLQVSKLREACVRFLEGQL 121
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-880 1.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 60.18  E-value: 1.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHtvrdaVN 845
Cdd:cd18268    17 LRQERILTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEIL-----IT 90

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 528503049  846 MEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18268    91 RDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPEN 125
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-880 1.88e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 59.81  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYtdeshTVRDAVN 845
Cdd:cd18237    15 MRKQKTLCDVIL-IVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAY-----TARISVN 88

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 528503049  846 MEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18237    89 SNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASN 123
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-124 5.45e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 5.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049   43 NSATLRDEFGRTALHLAASMGKRELLQWLLDcKHADLLAKDKEsGWTALHRSAFYGQIHCLITLIKRGGSLSMQDKEGLS 122
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKD-GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155


                  ..
gi 528503049  123 VL 124
Cdd:COG0666   156 PL 157
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-881 6.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 58.32  E-value: 6.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  770 SHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDEshtvrdAVNMEFV 849
Cdd:cd18345    16 SAFSDVTL-CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK------APNLDKM 88

                          90       100       110
                  ....*....|....*....|....*....|...
gi 528503049  850 CN-VLVVADQLLITRLKEICEVVIAEKLMLKNA 881
Cdd:cd18345    89 ADdLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-868 7.46e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 58.18  E-value: 7.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHtvrdaVN 845
Cdd:cd18256    14 LRGQHEFCDVQLQ-VGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVE-----VT 87

                          90       100
                  ....*....|....*....|...
gi 528503049  846 MEFVCNVLVVADQLLITRLKEIC 868
Cdd:cd18256    88 VSNVQELLVAADMLQLTEVVEIC 110
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-880 9.37e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 57.94  E-value: 9.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  767 KKGSHLCDVTL--RSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSE------VLQVILEYIYTDEsh 838
Cdd:cd18241    18 RKQGLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEpgpdpdTVEAVIQYMYTGR-- 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 528503049  839 tVRdaVNMEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18241    96 -IR--VSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-884 1.18e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 57.27  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLgSSWMEATSCSALSLP-ISSEVLQVILEYIYTDeshtvRDA 843
Cdd:cd18306    11 ALRKNRQFCDVIL-QVGGHEIPAHRAVLACASPYLFELF-SSDSDGESILTVKLDgLDPDAVEVLVNYAYTS-----RLE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 528503049  844 VNMEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKNAAEL 884
Cdd:cd18306    84 VPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-872 1.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 56.88  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDE-SHTVRDAVNMefvcnv 852
Cdd:cd18298    14 DLKFR-VDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQvDLPPEDAIGL------ 86

                          90       100
                  ....*....|....*....|
gi 528503049  853 LVVADQLLITRLKEICEVVI 872
Cdd:cd18298    87 LDLANSYCEERLKKLCEDII 106
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-136 1.54e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049   47 LRDEFGRTALHLAASMGKRELLQWLLDcKHADLLAKDKEsGWTALHRSAFYGQIHCLITLIKRGGSLSMQDKEGLSVLDL 126
Cdd:COG0666   181 ARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDND-GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                          90
                  ....*....|
gi 528503049  127 TMKDRPAHVV 136
Cdd:COG0666   259 AAAAGAALIV 268
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-869 2.05e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 56.53  E-value: 2.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  770 SHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSL---PISSEVLQVILEYIYTDESHtvrdaVNM 846
Cdd:cd18292    15 EELSDIVLR-VGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELvedPECAAVFEKFLRYLYTGQIS-----VNL 88

                          90       100
                  ....*....|....*....|...
gi 528503049  847 EFVCNVLVVADQLLITRLKEICE 869
Cdd:cd18292    89 ETALPLLMLADKYNVTDLKQLCV 111
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 558-634 2.18e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 55.77  E-value: 2.18e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049    558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPPELLEQALNFIYTDSCDM 634
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIY------------LDDVSPEDFRALLNFLYTGKLDL 65
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-880 2.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 56.38  E-value: 2.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDEshtvrdAVNME-FVCNV 852
Cdd:cd18279    20 DCCL-CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK------APNLDkMADDL 92

                          90       100
                  ....*....|....*....|....*...
gi 528503049  853 LVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18279    93 LAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-880 3.37e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 56.37  E-value: 3.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLRSVDGKEFSCHKCILCARLEYFNSMLGSSwMEATSCSALSLP-ISSEVLQVILEYIYTDESHTVRDAVNmefvcNV 852
Cdd:cd18252    23 DITLQCASGQIFHCHKAALAACSSYFKVMFTAD-MKEKSNNVIKLSgIDHDILEALVNYVYTSQICITERNVQ-----SL 96

                          90       100
                  ....*....|....*....|....*...
gi 528503049  853 LVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18252    97 LEAADLLQFISVKKACEQFLVRHLDIDN 124
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-872 3.73e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 55.80  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  769 GSHL---------CDVTLrSVDGKEFSCHKCILCARLEYFNSML-GSSWMEATSCSALSlPISSEVLQVILEYIYTDE-- 836
Cdd:cd18280     2 GQHFgalleseegADVTF-NVDGEKFRAHKLVLAARSPVFRSMLfGPMREENEGEIVIE-DVEPPVFKALLHFIYKDElp 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 528503049  837 -----SHTVRDAVNMEFVCNVLVVADQLLITRLKEICEVVI 872
Cdd:cd18280    80 ddvepAGSDSSSLDTTMAQHLLAAADRYALERLRLLCESRL 120
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 541-631 5.29e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 55.41  E-value: 5.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  541 QHLQRLLAEADETDnihdITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVrrgedavgcdllVLEKIPPELL 620
Cdd:cd18280     3 QHFGALLESEEGAD----VTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEI------------VIEDVEPPVF 66

                          90
                  ....*....|.
gi 528503049  621 EQALNFIYTDS 631
Cdd:cd18280    67 KALLHFIYKDE 77
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-874 6.67e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 55.36  E-value: 6.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  767 KKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSL-PISSEVLQVILEYIYTDeshtvRDAVN 845
Cdd:cd18207    22 KSGGRFCDVLLR-VGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMhTISSKVFGDILDFAYTS-----RIVVR 95

                          90       100
                  ....*....|....*....|....*....
gi 528503049  846 MEFVCNVLVVADQLLITRLKEICEVVIAE 874
Cdd:cd18207    96 LESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 555-640 8.97e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 54.99  E-value: 8.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  555 NIHDITLQAGDRTFPAHKYILSVRSDFFRKILL-PEAEREgdgevrrgEDAVGCDLLVLEKIPPELLEQALNFIYTDSCD 633
Cdd:cd18296    16 SFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRdHFAESE--------ENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTD 87


                  ....*..
gi 528503049  634 MLVDGAC 640
Cdd:cd18296    88 LPPENAY 94
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-880 1.00e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 54.59  E-value: 1.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEAtSCSALSLP-ISSEVLQVILEYIYTD--ESHTVRDAVNMEf 848
Cdd:cd18297    12 MSDVTFL-VEGRPFYAHKIVLVTASDRFKSMLSSGSTEA-QTPVIEIPdIRYDIFQLMMQYLYTGgvESLDVAQDDALE- 88

                          90       100       110
                  ....*....|....*....|....*....|..
gi 528503049  849 vcnVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18297    89 ---LLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 543-634 1.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 54.72  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  543 LQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVrrgedavgcdllVLEKIPPELLEQ 622
Cdd:cd18269    14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEV------------VLEDVDPDVMGM 81

                          90
                  ....*....|..
gi 528503049  623 ALNFIYTDSCDM 634
Cdd:cd18269    82 ILKYLYTSEIDL 93
Ank_4 pfam13637
Ankyrin repeats (many copies);
52-107 1.27e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 1.27e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 528503049    52 GRTALHLAASMGKRELLQWLLDcKHADLLAKDkESGWTALHRSAFYGQIHCLITLI 107
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLE-KGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-868 1.61e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 53.82  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDeshtvRDAVNMEFVCN 851
Cdd:cd18247    19 LCDVTLK-VGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSG-----RIAIDTSNVQS 92

                          90
                  ....*....|....*..
gi 528503049  852 VLVVADQLLITRLKEIC 868
Cdd:cd18247    93 LLVGASFLQLQSVKDAC 109
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 540-638 1.70e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 54.47  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  540 SQHLQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVrrgedavgcdllVLEKIPPEL 619
Cdd:cd18341    11 STLLQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEV------------VLDNVDPNI 78

                          90
                  ....*....|....*....
gi 528503049  620 LEQALNFIYTDSCDmLVDG 638
Cdd:cd18341    79 MDMILKYLYSAEID-LNDG 96
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 766-874 1.82e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 53.79  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHlCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWmEATSCSALSLP-ISSEVLQVILEYIYTDeshtvRDAV 844
Cdd:cd18295    14 LEQGSY-SDVTFN-VHGESFPAHRCILSARSPYFAEMFETKW-KDKREINLKHPlVNPDAFRALLQYLYTG-----RLEI 85

                          90       100       110
                  ....*....|....*....|....*....|....
gi 528503049  845 NMEFVCNVLVVADQ----LLITRLKEICEVVIAE 874
Cdd:cd18295    86 HVDDVEDCKRLAKQcrleELIEELEAKCKKVREF 119
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-880 1.84e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 54.24  E-value: 1.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVN 845
Cdd:cd18343    15 LWENSRFTDCSL-FVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMAD 93

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 528503049  846 mefvcNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18343    94 -----NLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 536-642 2.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 53.44  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  536 ASSFSQHLQRLLAEAdetdNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGD-GEVRRGEDAVGCDllvlek 614
Cdd:cd18292     1 SREFLQDIAQLYNNE----ELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKqSEIELVEDPECAA------ 70

                          90       100
                  ....*....|....*....|....*...
gi 528503049  615 ippeLLEQALNFIYTDSCDMLVDGACPI 642
Cdd:cd18292    71 ----VFEKFLRYLYTGQISVNLETALPL 94
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-881 4.33e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 52.85  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDeshtvRDAVN 845
Cdd:cd18250    15 LRAERKFFDVTL-CAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTG-----RVTVT 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 528503049  846 MEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKNA 881
Cdd:cd18250    89 QDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 770-880 4.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 52.87  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  770 SHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATScSALSLP-ISSEVLQVILEYIYTDESHTVRDAVNmef 848
Cdd:cd18352    11 ATLSDVTF-LVEGRRFYAHRIALLASSDAFRAMFDGGYREKEA-RDIEIPnIRWEVFELMMRFIYTGSVDITNDIAK--- 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 528503049  849 vcNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18352    86 --DLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 744-880 6.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 52.54  E-value: 6.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  744 KFENGKISVGLQKKRGNkprftLKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSE 823
Cdd:cd18236     1 KFDDTGLSLVLQNGLEN-----LRLENSLTDVIL-CVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAE 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049  824 VLQVILEYIYTDESHTVRDAVNmefvcNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18236    75 TMQILLDYTYTSKVLITKQNVQ-----RVLEAASLFQFLRMVDACASFLTEALHPEN 126
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-869 9.72e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 52.01  E-value: 9.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLgSSWMEATSCSALSLP-ISSEVLQVILEYIYTDEShtvrdA 843
Cdd:cd18255    11 ALRAKGQLLDVTL-IADGQRFQAHKVVLASCSDYFRAMF-TGGMRESSQDEIELKgVSAKGLKHILDFAYTSEL-----T 83

                          90       100
                  ....*....|....*....|....*.
gi 528503049  844 VNMEFVCNVLVVADQLLITRLKEICE 869
Cdd:cd18255    84 LDLDCIQDVLGAAVHLQMLPVVELCE 109
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 772-876 1.29e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 51.39  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVNMefvcN 851
Cdd:cd18360    10 LADVVFK-IQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASILQAM----A 84

                          90       100
                  ....*....|....*....|....*
gi 528503049  852 VLVVADQLLITRLKEICEVVIAEKL 876
Cdd:cd18360    85 LLICAEMYQVSRLQHICELYIITQL 109
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 757-869 1.33e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 51.50  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  757 KRGNKPRFTLKKGShLCDVTLRSVDGKeFSCHKCILCARLEYFNSMLGSSWMEATScSALSLP-ISSEVLQVILEYIYTD 835
Cdd:cd18358     6 RKANRIKECLSKGT-FSDVTFKLDDGT-INAHKPLLICSCEWMAAMFGGSFIESAN-SEVVLPnISKVSMQAVLDYLYTK 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 528503049  836 ESHTVRDAVNMEFVcnvlVVADQLLITRLKEICE 869
Cdd:cd18358    83 QLSPTADLDPLELI----ALANRFCLPHLVALTE 112
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 558-634 1.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 50.42  E-value: 1.52e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEregDGEVRRgedavgcdlLVLEKIPPELLEQALNFIYTDSCDM 634
Cdd:cd18314     8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMI---ESNLKE---------VTLEDVEPEIFETVLKYMYTGQVTL 72
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-869 1.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 51.05  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  767 KKGSHlCDVTLRSVDGKEFSCHKCILCARLEYFNSMLGSswmEATSCSALSLP--ISSEVLQVILEYIYTDESHTVRDAV 844
Cdd:cd18311    10 NKTEY-CDLTLQFRDNEQLKVHRLVLSACTDYFNVLEQT---CEIVDDTLIMPneLQADAVVPVINFMYTGQLEFEEKSY 85

                          90       100
                  ....*....|....*....|....*
gi 528503049  845 NmefvcNVLVVADQLLITRLKEICE 869
Cdd:cd18311    86 G-----KLLRTAKELNMTVLLKLLE 105
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 772-836 2.71e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 49.47  E-value: 2.71e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528503049  772 LCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSswMEATSCSALSLP-ISSEVLQVILEYIYTDE 836
Cdd:cd18315     1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALLKE--TPPDEHPVIILPdVPYSELKALLDFIYTGE 63
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 771-834 3.24e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 50.76  E-value: 3.24e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528503049  771 HLCDVTLRSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYT 834
Cdd:cd18274    21 QLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYT 84
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 543-629 3.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 50.60  E-value: 3.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  543 LQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVrrgedavgcdllVLEKIPPELLEQ 622
Cdd:cd18340    14 LQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREI------------VLEDVDPDVMGK 81


                  ....*..
gi 528503049  623 ALNFIYT 629
Cdd:cd18340    82 ILHYIYT 88
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-868 3.57e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 50.46  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLR---SVDGKEFSCHKCILCARLEYFNSMLGSSWMEatsCSALSLPISS---EVLQVILEYIYTDESH 838
Cdd:cd18248    14 ELRLSQQLCDVTLKvkyQDPKEEFMAHKVVLASSSPYFKAMFTSGLRE---CGMEVVPIEGvhpCVMSRLIEFAYTASIS 90

                          90       100       110
                  ....*....|....*....|....*....|
gi 528503049  839 tvrdaVNMEFVCNVLVVADQLLITRLKEIC 868
Cdd:cd18248    91 -----VGEKCVLHVLPGAVMYQMDSVVKAC 115
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-883 3.60e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 50.37  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDeshtvRDAVNMEFVCN 851
Cdd:cd18238    15 LCDVTLK-VGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTG-----KLTLTVDNVQS 88

                          90       100       110
                  ....*....|....*....|....*....|..
gi 528503049  852 VLVVADQLLITRLKEICEVVIAEKLMLKNAAE 883
Cdd:cd18238    89 LLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-880 5.04e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 50.18  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATScSALSLP-ISSEVLQVILEYIYTDEShtvrdA 843
Cdd:cd18264    21 SLRAEGFLCDVVLE-AEGNEFPAHRSLLACSSDYFRALFKDYTQESKA-RVIHLPvVSAAGLQRVLDFIYTSWL-----S 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 528503049  844 VNMEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18264    94 LSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 753-868 7.18e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 49.83  E-value: 7.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  753 GLQKKRGNkPRFTlkkgshlcDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYI 832
Cdd:cd18259    22 GLQTLRSN-PKLS--------DVTL-LVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFA 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 528503049  833 YTDeshtvRDAVNMEFVCNVLVVADQLLITRLKEIC 868
Cdd:cd18259    92 YTG-----KLTINQGNVEALIRTSNRLQFPTVRKVC 122
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 537-629 7.76e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 49.16  E-value: 7.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  537 SSFSQHLQRLLaeadETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLpeaeregdGEVRRGEdavgCDLLVLEKIP 616
Cdd:cd18287     7 HFLSEDIGALF----LNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLY--------GGMRESQ----QSEIELKDTN 70

                          90
                  ....*....|...
gi 528503049  617 PELLEQALNFIYT 629
Cdd:cd18287    71 AEAFKALLKYIYT 83
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-632 9.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 48.78  E-value: 9.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049  558 DITLQAGDRTFP--AHKYILSVRSDFFRKILLPEAEREGDGEVrrgedavgcdlLVLEKIPPELLEQALNFIYTDSC 632
Cdd:cd18294    16 DVKFLVGPERQEifAHKCILAARCEVFRAMFLTGPQKESTQSP-----------LVLSDIEPEVFRAVLEFIYTNCV 81
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-885 1.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 49.51  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDeshTVRdaVNMEFVCNVL 853
Cdd:cd18272    34 DVTI-SVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHG---TVK--LRVEELQETY 107

                          90       100       110
                  ....*....|....*....|....*....|..
gi 528503049  854 VVADQLLITRLKEICEVVIAEKLMLKNAAELL 885
Cdd:cd18272   108 EVADMYQLTALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 780-881 1.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 48.80  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  780 VDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRdavNMEFVCNVLVVADQL 859
Cdd:cd18344    30 VAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHLH---SHSMACDVLAAADKY 106

                          90       100
                  ....*....|....*....|..
gi 528503049  860 LITRLKEICEVVIAEKLMLKNA 881
Cdd:cd18344   107 GLEGLKVLCEDALCRNLSVENA 128
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 538-637 1.50e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 48.40  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  538 SFSQHLQRLLaeadETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILlpeaeregdgEVR-RGEDAVGcdlLVLEKIP 616
Cdd:cd18295     5 YYDEFLRRLL----EQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMF----------ETKwKDKREIN---LKHPLVN 67

                          90       100
                  ....*....|....*....|.
gi 528503049  617 PELLEQALNFIYTDSCDMLVD 637
Cdd:cd18295    68 PDAFRALLQYLYTGRLEIHVD 88
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-876 2.63e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 47.91  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDEShtvrdAVNMEFVCN 851
Cdd:cd18253    18 FTDVII-CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKV-----KITTENVQY 91

                          90       100
                  ....*....|....*....|....*
gi 528503049  852 VLVVADQLLITRLKEICEVVIAEKL 876
Cdd:cd18253    92 LFETSSLFQISPLRDACAKFLEEQL 116
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-885 2.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 48.28  E-value: 2.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRSV-------DGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDeshtvRDAV 844
Cdd:cd18273    26 LTDVTIEVNgpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTG-----RVTL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 528503049  845 NMEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKNAAELL 885
Cdd:cd18273   101 SEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-633 3.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 47.32  E-value: 3.26e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAeregdgevrrgedavgcDLLVLEKIPPELLEQALNFIYTDSCD 633
Cdd:cd18303    20 DITIKLADKSIPAHKFVLAARSEKWSNENLAST-----------------NELDLSDISYEVVLALLRWLYTDELD 78
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 780-844 3.37e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 46.12  E-value: 3.37e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528503049  780 VDGKEFSCHKCILCARLEYFNSMLGSSwMEATSCSALSLP-ISSEVLQVILEYIYTDESHTVRDAV 844
Cdd:cd01165     5 VEGEKFHVNKELLAQSSEYFRALFRGG-FRESGQAEINLRdISPEDFRALLEFLYGGKRDLDASNL 69
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 541-637 6.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 47.01  E-value: 6.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  541 QHLQRLLAEADETDNIH---DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPP 617
Cdd:cd18256     2 KHASLILAQLNKLRGQHefcDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQ------------IHGVEP 69

                          90       100
                  ....*....|....*....|
gi 528503049  618 ELLEQALNFIYTDSCDMLVD 637
Cdd:cd18256    70 DIFHILLDFIYTGVVEVTVS 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
56-108 6.21e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 6.21e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528503049    56 LHLAASMGKRELLQWLLDCkHADLLAKDKEsGWTALHRSAFYGQIHCLITLIK 108
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLEN-GADANLQDKN-GRTALHLAAKNGHLEIVKLLLE 51
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-880 6.64e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 47.14  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSwMEATSCSALSLP-ISSEVLQVILEYIYTDEShtvrdAVNMEFVCNV 852
Cdd:cd18340    29 DCVLK-IKEKEFPCHRLVLAACSPYFRAMFLSD-LEESKKREIVLEdVDPDVMGKILHYIYTSEI-----EITEQNVQDI 101

                          90       100
                  ....*....|....*....|....*...
gi 528503049  853 LVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18340   102 FAAANMFQIPSIFTVCVSFLQKRLCLSN 129
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 779-872 6.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 46.48  E-value: 6.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  779 SVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTdeshtvrDAVNM--EFVCNVLVVA 856
Cdd:cd18353    26 RVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYT-------DSVDLppEDAIGLLDLA 98

                          90
                  ....*....|....*.
gi 528503049  857 DQLLITRLKEICEVVI 872
Cdd:cd18353    99 TSYCENRLKKLCQHII 114
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-844 9.94e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 46.34  E-value: 9.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528503049  766 LKKGSHLCDVTLRSvDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAV 844
Cdd:cd18276    15 MKELAELTDVVLVA-EGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNV 92
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 540-629 1.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 46.36  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  540 SQHLQRLLAEADE---TDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLpeaerEGDGEVRRgedavgcdLLVLEKIP 616
Cdd:cd18224     7 SDHPNNLLKELNKcrlSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFL-----STELDVAR--------TYVVDFIT 73

                          90
                  ....*....|...
gi 528503049  617 PELLEQALNFIYT 629
Cdd:cd18224    74 PANFEKVLSFIYT 86
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
144-193 1.12e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 43.66  E-value: 1.12e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 528503049   144 EVYTWGNNTNFSLGHGNQESRQHPEIVDLFsrSGIYVKQVVLCKFHSVFL 193
Cdd:pfam00415    3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGL--SGNKVVQVACGGDHTVAL 50
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 780-874 1.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 45.70  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  780 VDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPisseVLQVILEYIYTDE-SHTVRDAVNMefvcnvLVVADQ 858
Cdd:cd18354    27 VDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYP----VYRAFLEYLYTDSiSLSPEDAIGL------LDLATF 96

                          90
                  ....*....|....*.
gi 528503049  859 LLITRLKEICEVVIAE 874
Cdd:cd18354    97 YRENRLKKLCQQTIKQ 112
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
234-261 1.40e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.80  E-value: 1.40e-05
                           10        20
                   ....*....|....*....|....*...
gi 528503049   234 QIAAARDHTVVLTEEGYVYTFGLNTHHQ 261
Cdd:pfam13540    3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 542-643 1.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 45.91  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  542 HLQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILlpeaeregDGEVRRGEdavgCDLLVLEKIPPELLE 621
Cdd:cd18250     7 HLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMF--------AGELRESR----ADRVVLHGVSAEILG 74

                          90       100
                  ....*....|....*....|..
gi 528503049  622 QALNFIYTDSCDMLVDGACPII 643
Cdd:cd18250    75 LLLDFSYTGRVTVTQDNVEALL 96
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-640 1.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 45.43  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKIL---LPEAEREgdgEVRrgedavgcdllvLEKIPPELLEQALNFIYT----- 629
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFtndVREATEE---EIK------------LKDVDPDALWTLVQYCYTgrlel 67

                          90
                  ....*....|...
gi 528503049  630 --DSCDMLVDGAC 640
Cdd:cd18234    68 keDNVESLLATAC 80
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-629 1.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 45.65  E-value: 1.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRRGEDAVGCD-LLVLEKIPPELLEQALNFIYT 629
Cdd:cd18195    20 DVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQSPErVLELPGVKAGVFSDVLNFIYS 92
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-868 2.25e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 45.24  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSML--GSSWMEATSCSALSLPISSEVLQV-----ILEYIYTDES 837
Cdd:cd18228    12 SLRNEGHFCDVTIR-VQDKIFRAHKVVLAACSDFFRSKLvgQASPRLVLVSPAGKCVLDLHHVTVtgfapLLEYAYTSTL 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 528503049  838 htvrdAVNMEFVCNVLVVADQLLITRLKEIC 868
Cdd:cd18228    91 -----SINTENIIDVLAAASYMQMFNVANTC 116
Ank_5 pfam13857
Ankyrin repeats (many copies);
71-126 2.36e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 2.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 528503049    71 LLDCKHADLLAKDKEsGWTALHRSAFYGQIHCLITLIKRGGSLSMQDKEGLSVLDL 126
Cdd:pfam13857    1 LLEHGPIDLNRLDGE-GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-881 2.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 45.09  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVN 845
Cdd:cd18342    16 LWENSRFTDCCL-CVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMAD 94

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 528503049  846 mefvcNVLVVADQLLITRLKEICEVVIAEKLMLKNA 881
Cdd:cd18342    95 -----DLLAAADKYALERLKVMCEDALCSNLSVENA 125
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 554-632 2.64e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 44.66  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  554 DNIHDITLQAGD-RTFPAHKYILSVRSDFFRKILlpeaereGDGEVrrgeDAVGCDLLVLEkIPPELLEQALNFIYTDSC 632
Cdd:cd18302     3 SDLYDVTIVSEDgKEFPCHKCVLVARLEYFHSML-------SSSWI----EASSCSALTMP-IPSDILEIILDYLYTDEA 70
Ank_5 pfam13857
Ankyrin repeats (many copies);
40-92 3.29e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 3.29e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528503049    40 HCHNSATLRDEFGRTALHLAASMGKRELLQWLLDcKHADLLAKDKEsGWTALH 92
Cdd:pfam13857    4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEE-GLTALD 54
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 543-629 3.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 44.25  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  543 LQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKiLLPEAEREGDGEVRRgedavgcdlLVLEKIPPELLEQ 622
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRA-KLNYNPPKDDGSTYK---------IELEGISVEVMEE 70


                  ....*..
gi 528503049  623 ALNFIYT 629
Cdd:cd18245    71 ILDYIYT 77
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-644 3.57e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 44.74  E-value: 3.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVrrgedavgcdllVLEKIPPELLEQALNFIYTDSCDMLVD 637
Cdd:cd18242    23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEV------------ELQGLTASTMEILLDFVYTETVHVTVE 90


                  ....*..
gi 528503049  638 GACPIIP 644
Cdd:cd18242    91 NVQELLP 97
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-874 3.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 44.46  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  767 KKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSML----GSSWMEATS-----CSALSLPissevlqvILEYIYTdeS 837
Cdd:cd18202    14 RLNNQFCDVTLL-IEGEEYKAHKSVLAANSEYFRELFiekgAVSSHEAVVdlsgfCKSSFLP--------LLEFAYT--S 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 528503049  838 HTVRDAVNMEfvcNVLVVADQLLITRLKEICEVVIAE 874
Cdd:cd18202    83 ELTFDFCSMA---EVAMLARHLFMNEVLEICESVHKQ 116
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 757-877 3.77e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 44.61  E-value: 3.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  757 KRGNKPRFTLKKGShLCDVTLRSVDGKeFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDE 836
Cdd:cd18359     6 RRTNRVKECLAKGT-FSDVTFMLDDGT-ISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQ 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 528503049  837 SHTVRDAVNMEFVcnvlVVADQLLITRLKEICEVVIAEKLM 877
Cdd:cd18359    84 FSSSPDLDDMKLI----ILANRLCLPHLVALTEQYTVTVLM 120
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 773-868 4.73e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 43.64  E-value: 4.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  773 CDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATscSALSLPI-----SSEVLQVILEYIYTDEshTVRDAVNME 847
Cdd:cd18307     2 CDVVI-SVDNHSFAAHRNVLAAVSPFVKSLISSNDMKAT--DELSITIdcdylSPETVEQLLDYFYTGK--IVISEKNVE 76

                          90       100
                  ....*....|....*....|.
gi 528503049  848 fvcNVLVVADQLLITRLKEIC 868
Cdd:cd18307    77 ---DLLKGAKYFNIPRLKDHC 94
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 783-868 4.98e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 43.49  E-value: 4.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  783 KEFSCHKCILCARLEYFNSMLGSSWMEatsCSALSLP---ISSEVLQVILEYIYTDEshtVRdaVNMEFVCNVLVVADQL 859
Cdd:cd18314    16 RKFFAHRIVLCARSPVFRSMLTGSMIE---SNLKEVTledVEPEIFETVLKYMYTGQ---VT--LSEENVLDLLMLASKY 87


                  ....*....
gi 528503049  860 LITRLKEIC 868
Cdd:cd18314    88 QVPDLEKLC 96
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 773-880 5.55e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 44.26  E-value: 5.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  773 CDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSlpissevLQVILEYIYTDEShtvrdAVNMEFVCNV 852
Cdd:cd18243    33 CDVTL-TAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIG-------LRLVLEYLYTANV-----TLSLDTVEEV 99

                          90       100
                  ....*....|....*....|....*...
gi 528503049  853 LVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18243   100 LSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 540-644 6.74e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 43.67  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  540 SQHLQRLLaeadETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPPEL 619
Cdd:cd18279     6 AEDLGNLW----ENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVE------------INDVDPEV 69

                          90       100
                  ....*....|....*....|....*
gi 528503049  620 LEQALNFIYTDSCDMLVDGACPIIP 644
Cdd:cd18279    70 FKEMMRFIYTGKAPNLDKMADDLLA 94
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-869 8.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 43.30  E-value: 8.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVN 845
Cdd:cd18257    12 LRQHHELCDVVLR-VGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVE 90

                          90       100
                  ....*....|....*....|....*
gi 528503049  846 MefvcnVLVVADQLLITR-LKEICE 869
Cdd:cd18257    91 S-----LLPAANLLQIKLvLKECCD 110
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-869 8.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 43.47  E-value: 8.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLRsVDGKEFSCHKCILCARleyfnsmlGSSWMEATSCSALSLPISS---EVLQVILEYIYTDESHTVRDAvnmEFVC 850
Cdd:cd18303    20 DITIK-LADKSIPAHKFVLAAR--------SEKWSNENLASTNELDLSDisyEVVLALLRWLYTDELDLTLDD---EFLL 87

                          90
                  ....*....|....*....
gi 528503049  851 NVLVVADQLLITRLKEICE 869
Cdd:cd18303    88 ELMKAAKRFQLTDLVERCE 106
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-629 9.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 43.80  E-value: 9.12e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKIL-LPEAEREGDGEVRRGEDAVGcdllvlekippelLEQALNFIYT 629
Cdd:cd18261    30 DITLVAEEQKFHAHKAVLAACSDYFRAMFsLCMVESEADEVNLHGVTSLG-------------LKQALDFAYT 89
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-639 1.03e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 42.99  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILlpeaerEGDGEVRRGEdavgcdlLVLEKIPPELLEQALNFIYTDScdMLVD 637
Cdd:cd18231    18 DIVLVRQRSTFPAHKGVLAAYSQFFHSLF------TQNKQLQRVE-------LSLEALTSQGLQQILNFIYTSK--LLVN 82


                  ..
gi 528503049  638 GA 639
Cdd:cd18231    83 SC 84
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 557-628 1.17e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 43.02  E-value: 1.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  557 HDITLQAGDRTFPAHKYILSVRSDFFRKILlpeaeREGDGEVRRGEdavgcdlLVLEKIPPELLEQALNFIY 628
Cdd:cd18286    18 SDITIKVDGKTFKAHRCILCARSSYFAAML-----SGSWAESNSSE-------ITLTGVSHAAVSFVLLFIY 77
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 558-629 1.31e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 41.77  E-value: 1.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILlpeaeregdGEVRRGEDAVgcdlLVLEKIPPELLEQALNFIYT 629
Cdd:cd18315     3 DVTLACEGGSLKAHKLVLAAASPYFAALL---------KETPPDEHPV----IILPDVPYSELKALLDFIYT 61
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-885 1.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 43.07  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDEShtvrdAVNMEFVCN 851
Cdd:cd18270    26 LTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNL-----AINDSTVEQ 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 528503049  852 VLVVADQLLITRLKEICEVVIAEKLMLKNAAELL 885
Cdd:cd18270   100 LYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 878-928 1.62e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 40.72  E-value: 1.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 528503049  878 LKNAAELLEFSTIYNAEQLKLSCLQFIVLNMAALLESKALEILSDDVLVDV 928
Cdd:cd14733     2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLEL 52
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 773-834 1.89e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 42.49  E-value: 1.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528503049  773 CDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATScSALSLP-ISSEVLQVILEYIYT 834
Cdd:cd18263    14 CDVQL-EADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQ-SVVQLPtIPAKDLRLLISFAYS 74
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 539-629 2.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 42.52  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  539 FSQHLQRLLAEADETDN---IHDITLQAGDRTFPAHKYILSVRSDFFRKILlpeaeREGDGEVRRGEDAVGCDLLVLEKI 615
Cdd:cd18327     5 FPEHSSELLSCLNEQRRaglLCDLTIKTRGLEYRTHRAVLAACSLYFRKLF-----TGGGGGSGDLGAGGGQDVCELDFV 79

                          90
                  ....*....|....
gi 528503049  616 PPELLEQALNFIYT 629
Cdd:cd18327    80 GPEALGALLEFAYT 93
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 552-629 2.24e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 42.14  E-value: 2.24e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528503049  552 ETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPPELLEQALNFIYT 629
Cdd:cd18345    14 ERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVE------------ITDVDHEVMREMLRFIYT 79
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 774-835 2.26e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 41.50  E-value: 2.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528503049  774 DVTLRsVDGKEFSCHKCILCARLEYFNSMLGSS---WMEATSCSALSLP-ISSEVLQVILEYIYTD 835
Cdd:cd18301    20 DVVFQ-VGGKTFPAHKFILASRSDYFRKLFLSSlltSEDAVGCDVVHIEkVPPEIFEQLLQFIYTD 84
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 771-883 2.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 42.15  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  771 HLCDVTLRSV---DGKEFSCHKCILCARLEYFNSMLgsswmeatscsalslpISSEVLQVILEYIYTDESHTVRDAVNME 847
Cdd:cd18211    24 HLCDVTVQVEhqgSKEEFSAHKAVLAASSKYFKEVF----------------LNEKISDGKNTNVMLNEIYTADFASFLE 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 528503049  848 FVCNVLVVADQLLITRLKEicevvIAEKLMLKNAAE 883
Cdd:cd18211    88 FVYTAKVEVEEDRVQRMLE-----IAEKLKCLDLSE 118
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 540-629 3.67e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 41.87  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  540 SQH----LQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILlpEAEREGDGEVRRgedavgcdlLVLEKI 615
Cdd:cd18207     7 SQHsadmLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVF--SAQEGDGGTPRE---------LEMHTI 75

                          90
                  ....*....|....
gi 528503049  616 PPELLEQALNFIYT 629
Cdd:cd18207    76 SSKVFGDILDFAYT 89
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-629 3.73e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 41.92  E-value: 3.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllVLEKIPPELLEQALNFIYT 629
Cdd:cd18254    24 DVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVN-----------FHDSLHPEVLELLLDFAYS 84
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-874 3.92e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 41.60  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLRSVDgKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVn 845
Cdd:cd18338    15 LRSQNLLCDVTIVAED-VEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENV- 92

                          90       100       110
                  ....*....|....*....|....*....|...
gi 528503049  846 mefvcNVLVVADQLLitRLKEI----CEVVIAE 874
Cdd:cd18338    93 -----QVLLPAAGLL--QLQDVkktcCEFLESQ 118
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 564-642 3.98e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 41.94  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  564 GDRTFPAHKYILSVRSDFFRKILLpeaEREGDGEVRRgedAVGCDLLVLEK--IPPELLEQALNFIYTDSCD--MLVDGA 639
Cdd:cd18284    26 PDFELRCHKAILSARSPFFRNLLQ---RRIRTGEDRT---LSTPTRIVLDEsiIPRRYARVLLHAMYTDSVDlsLILRSS 99


                  ...
gi 528503049  640 CPI 642
Cdd:cd18284   100 PSE 102
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-880 4.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 41.71  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLRSVDGKE-FSCHKCILCARLEYFNSMLgSSWMEATSCSALSLPISSEV-LQVILEYIYTDeshtvRD 842
Cdd:cd18239    16 QLRGEGLLCDVTLVPGDGDEtFPVHRAMMASASDYFKAMF-TGGMKEQELMCIKLHGVSKIgLKNIIDFIYTA-----KL 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 528503049  843 AVNMEFVCNVLVVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18239    90 SLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 780-848 4.56e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 41.74  E-value: 4.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528503049  780 VDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVNMEF 848
Cdd:cd18271    31 VKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFF 99
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-868 4.65e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 41.34  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDEShtvrdAVN 845
Cdd:cd18251    17 LRDSGILFDVVLV-VEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSEL-----ELS 90

                          90       100
                  ....*....|....*....|...
gi 528503049  846 MEFVCNVLVVADQLLITRLKEIC 868
Cdd:cd18251    91 LDNVQETLTAACQLQIPEVIGFC 113
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-868 5.30e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 41.90  E-value: 5.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  766 LKKGSHLCDVTLRSvDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSA-LSLPISSEVLQVILEYIYTDeshtvRDAV 844
Cdd:cd18267    34 LRQQRLFTDVLLHA-GNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVnFHDSIHPEVLELLLDYAYSS-----RVII 107

                          90       100
                  ....*....|....*....|....
gi 528503049  845 NMEFVCNVLVVADQLLITRLKEIC 868
Cdd:cd18267   108 NEENAESLLEAGDMLEFQDIRDAC 131
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-859 5.59e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 41.15  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLRSVDgKEFSCHKCILCARLEYFNSMLGSSWMEATSCSA-LSLPISSEVLQVILEYIYTDeshtvRDA 843
Cdd:cd18254    15 TLRKQCMFTDVTLWAGN-RSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVnFHDSLHPEVLELLLDFAYSS-----RII 88

                          90
                  ....*....|....*.
gi 528503049  844 VNMEFVCNVLVVADQL 859
Cdd:cd18254    89 INEENAESLLEAGDML 104
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-836 6.15e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 40.94  E-value: 6.15e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  768 KGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGsswmEATSCSALSLP-ISSEVLQVILEYIYTDE 836
Cdd:cd18226    18 KQSSFCDLVI-TVEGKEFSAHKVVVAVGSSYFHACLS----KNPNTDAVTLDhVSYSVFQHLLEFLYTSE 82
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 540-633 6.62e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 40.51  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  540 SQHLQRLLAEADETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKIllpeAEREGDGEVrrgedavgcdLLVLEKIPPEL 619
Cdd:cd18217     2 CEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQ----YKDTEDNIV----------FLDQSQVSADG 67

                          90
                  ....*....|....*....
gi 528503049  620 LEQALNFIYT-----DSCD 633
Cdd:cd18217    68 FQKLLEFIYTgnlnlDSWN 86
PHA02713 PHA02713
hypothetical protein; Provisional
 772-874 6.92e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 43.84  E-value: 6.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPI-SSEVLQVILEYIYTdeshtvRDAVNMEfVC 850
Cdd:PHA02713   25 LCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMfDKDAVKNIVQYLYN------RHISSMN-VI 97

                          90       100
                  ....*....|....*....|....
gi 528503049  851 NVLVVADQLLITRLKEICEVVIAE 874
Cdd:PHA02713   98 DVLKCADYLLIDDLVTDCESYIKD 121
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 52-84 8.19e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 8.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 528503049    52 GRTALHLAA-SMGKRELLQWLLDcKHADLLAKDK 84
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLS-KGADVNARDK 34
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-834 8.70e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 40.55  E-value: 8.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  765 TLKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSlPISSEVLQVILEYIYT 834
Cdd:cd18212    16 EQRKKDFLCDITL-IVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLE-GMVAETFGALLEFIYT 83
BACK_AtBPM-like cd14736
BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The ...
 874-923 9.57e-04

BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins. BPM protein, also termed protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350516  Cd Length: 62  Bit Score: 38.87  E-value: 9.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 528503049  874 EKLMLKNAAELLEFSTIYNAEQLKLSCLQFIVLNMAALLESKALEILSDD 923
Cdd:cd14736     2 EGVDVNTVATTLALAEQHHASQLKAVCLKFVARNLAAVMQTDGFEYLKES 51
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 780-834 9.74e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 40.73  E-value: 9.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 528503049  780 VDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLP---ISSEVLQVILEYIYT 834
Cdd:cd18258    24 VEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTmsnINADVLELLLEFVYT 81
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-629 1.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 40.54  E-value: 1.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILlpEAEREGDGEVRRgedavgcdlLVLEKIPPELLEQALNFIYT 629
Cdd:cd18293    17 DVLLQAEGESVPAHCCVLSACSPYLTERL--SSEPPPAGQKVV---------LELQGLKAHTLLKLVDFLYT 77
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 774-869 1.03e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 39.89  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLRSVDGKEFSCHKCILCARLEYFNSMLGSswMEATScsaLSLPISSEVLQVILEYIYT---DESHTVRDavnmefvc 850
Cdd:cd18299    14 DVVFILQGGVRIFAHRIVLAAASSVFADLFLM--MTVVT---LDSDITPEAFRRVLEFLYTgvlDENEDDLK-------- 80

                          90
                  ....*....|....*....
gi 528503049  851 NVLVVADQLLITRLKEICE 869
Cdd:cd18299    81 ELKDAAELLELFDLVMMCT 99
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-640 1.06e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 40.41  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPPELLEQALNFIYT-------D 630
Cdd:cd18336    21 DVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIK------------MEGVDPDALKALVHYAYTgvlelkeD 88

                          90
                  ....*....|
gi 528503049  631 SCDMLVDGAC 640
Cdd:cd18336    89 TIESLLAAAC 98
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-880 1.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 40.47  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  774 DVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDEShtvrdAVNMEFVCNVL 853
Cdd:cd18269    29 DCVLK-IGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEI-----DLNDQNVQDIF 102

                          90       100
                  ....*....|....*....|....*..
gi 528503049  854 VVADQLLITRLKEICEVVIAEKLMLKN 880
Cdd:cd18269   103 ALASRFQIPSIFTVCVSYLQKRLSLSN 129
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-844 1.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 40.16  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRSVDGKeFSCHKCILCARLEYFNSMLGSS--WMeatSCSALSLP-ISSEVLQVILEYIYTD-----ESHTVRDA 843
Cdd:cd18223    18 LCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQeiWI---SSHVLELPdLKAEVFAEILNFIYSSkvvvkRQETVTDL 93


                  .
gi 528503049  844 V 844
Cdd:cd18223    94 V 94
Ank_4 pfam13637
Ankyrin repeats (many copies);
24-72 1.14e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 1.14e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 528503049    24 ALTSGSEACLRAFLSVHCHNSATlrDEFGRTALHLAASMGKRELLQWLL 72
Cdd:pfam13637    8 AAASGHLELLRLLLEKGADINAV--DGNGETALHFAASNGNVEVLKLLL 54
PHA03098 PHA03098
kelch-like protein; Provisional
 773-926 1.37e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 42.83  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  773 CDVT-LRSVDGKEFSCHKCILCARLEYFNSMLGSSWMEatscSALSLPISSEVLQVILEYIYTDE-SHTVRDAVNMefvc 850
Cdd:PHA03098   10 CDESiIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE----NEINLNIDYDSFNEVIKYIYTGKiNITSNNVKDI---- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  851 nvLVVADQLLITRLKEICEVVIAEKLMLKNAAELLEFSTIYNAEQLKLSCLQFIVLNMAALLESKAL---------EILS 921
Cdd:PHA03098   82 --LSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFiylskneliKILS 159


                  ....*
gi 528503049  922 DDVLV 926
Cdd:PHA03098  160 DDKLN 164
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 557-629 1.58e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 39.94  E-value: 1.58e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528503049  557 HDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRrgedavgcdllvLEKIPPELLEQALNFIYT 629
Cdd:cd18306    19 CDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVK------------LDGLDPDAVEVLVNYAYT 79
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 764-833 1.67e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 40.06  E-value: 1.67e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528503049  764 FTLKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLgSSWMEATSCSALSL----PiSSEVLQVILEYIY 833
Cdd:cd18309    12 FLESVGGDFCDITL-LLDGHPIPAHKAILAARCSYFEAMF-RSFMPEDNTVNISIgemvP-SRQAFDSLLRYIY 82
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-629 2.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 39.97  E-value: 2.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILlpeaeregDGEVRRGEDAvgcDLLVLEKIPPELLEQALNFIYT 629
Cdd:cd18267    42 DVLLHAGNRSFPCHRAVLAACSRYFEAMF--------SGGLKESQDS---EVNFHDSIHPEVLELLLDYAYS 102
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-834 2.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 38.89  E-value: 2.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528503049  772 LCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYT 834
Cdd:cd18234     1 LCDVIL-IAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYT 62
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-873 2.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 39.14  E-value: 2.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLrSVDGKEFSCHKCILCARLEYFNSMLgsswmeATSCSALSLPISSEV-LQVILEYIYtdeshTVRDAVNMEFVC 850
Cdd:cd18206    22 LCDCTF-VVDGVDFKAHKAVLAACSEYFRMLF------VDQKDVVHLDISNAAgLGQVLEFMY-----TAKLSLSPENVD 89

                          90       100
                  ....*....|....*....|...
gi 528503049  851 NVLVVADQLLITRLKEICEVVIA 873
Cdd:cd18206    90 DVLAVATFLQMQDIVTACHALKS 112
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 51-81 2.90e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 2.90e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 528503049    51 FGRTALHLAASMGKRELLQWLLDCkHADLLA 81
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLEN-GADINA 30
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 771-834 3.97e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 38.67  E-value: 3.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528503049  771 HLCDVTLRSvDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLP-------ISSEVLQVILEYIYT 834
Cdd:cd18327    24 LLCDLTIKT-RGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGGQdvceldfVGPEALGALLEFAYT 93
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 558-587 4.11e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 37.70  E-value: 4.11e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILL 587
Cdd:cd18283     4 DVDLVFQGTCFPVHRAILSARCPFFRDLLS 33
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 771-834 5.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 38.31  E-value: 5.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528503049  771 HLCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYT 834
Cdd:cd18198    24 LLCDVVIL-VQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYT 86
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 773-846 5.86e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 38.09  E-value: 5.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528503049  773 CDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSswMEATSCSALSLP-ISSEVLQVILEYIYTDESHTVRDAVNM 846
Cdd:cd18204    19 CDIAI-VVEDVKFRAHRCVLAACSTYFKKLFKK--LEVDSSSVIEIDfLRSDIFEEVLNYMYTAKISVKKEDVNL 90
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 542-629 6.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 38.24  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  542 HLQRLLAEADE---TDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEregdgevrrgedaVGCDLLVLEKIPPE 618
Cdd:cd18212     6 HKDTVLTNFEEqrkKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGE-------------VGQSIYMLEGMVAE 72

                          90
                  ....*....|.
gi 528503049  619 LLEQALNFIYT 629
Cdd:cd18212    73 TFGALLEFIYT 83
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-629 7.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 38.24  E-value: 7.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKiLLPEAEREGDGEVrrgedavgcdlLVLEKIPPELLEQALNFIYT 629
Cdd:cd18264    30 DVVLEAEGNEFPAHRSLLACSSDYFRA-LFKDYTQESKARV-----------IHLPVVSAAGLQRVLDFIYT 89
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-834 7.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 38.10  E-value: 7.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528503049  766 LKKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPissEVLQVILEYIYT 834
Cdd:cd18222    19 LRMQGRLCDIVV-NVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNP---TVFEQLLSFCYT 83
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-834 7.55e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 38.01  E-value: 7.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  767 KKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSswmEATSCSALSLP--ISSEVLQVILEYIYT 834
Cdd:cd18278    26 RKQDILCDVTL-IVEGKEFRAHRAVLAACSEYFLQALVG---QTENDLVVSLPeeVTARGFGPLLQFAYT 91
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-868 8.50e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 37.89  E-value: 8.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLRsVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLpISSEVLQVILEYIYTDESHTvrDAVNmefVCN 851
Cdd:cd18224    26 MCDVTIV-VGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDF-ITPANFEKVLSFIYTSELFT--DLIN---VGV 98

                          90
                  ....*....|....*..
gi 528503049  852 VLVVADQLLITRLKEIC 868
Cdd:cd18224    99 IYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-872 8.61e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 37.60  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  767 KKGSHLCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPI-SSEVLQVILEYIYTDeshtvRDAVN 845
Cdd:cd18330    13 RKRDFFCDCSI-IVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIvTSEAFSIILDFLYSG-----KLDLC 86

                          90       100
                  ....*....|....*....|....*..
gi 528503049  846 MEFVCNVLVVADQLLITRLKEICEVVI 872
Cdd:cd18330    87 SENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 558-634 8.69e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 37.61  E-value: 8.69e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528503049  558 DITLQAGDRTFPAHKYILSVRSDFFRKILLPEAeregdgevrRGEdavgcdLLVLEKIPPELLEQALNFIYTDSCDM 634
Cdd:cd18218    20 DTLITVGSQEFPAHSLVLAGASQQLGRQLTNPN---------PGQ------WCLGEGISPSTFKQLLDFVYGESVEV 81
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 773-841 9.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 37.12  E-value: 9.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528503049  773 CDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSswmeATSCSALSLpISSEVLQVILEYIYTDESHTVR 841
Cdd:cd18219    22 CDVTV-IVEDRKFRAHKNILSASSTYFHQLFSV----AGQVVELNF-IRADIFAEILNYIYSSKIVRVR 84
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 540-586 9.32e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 37.33  E-value: 9.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 528503049  540 SQHLQRLLAEADETDnihdITLQAGDRTFPAHKYILSVRS-DFFRKIL 586
Cdd:cd18285     3 SQDLLRLLREELHTD----VTFYVGSTLFKAHKAILLARVpEFFSHII 46
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 772-868 9.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 37.61  E-value: 9.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528503049  772 LCDVTLrSVDGKEFSCHKCILCARLEYFNSMLGSSWMEATSCSALSLPISSEVLQVILEYIYTDESHTVRDAVNmefvcN 851
Cdd:cd18326    25 LCDVVI-LVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVG-----D 98

                          90
                  ....*....|....*..
gi 528503049  852 VLVVADQLLITRLKEIC 868
Cdd:cd18326    99 ILSAARLLEIPAVSHVC 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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