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Conserved domains on  [gi|528470113|ref|XP_005163716|]
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Niemann-Pick C1 protein isoform X2 [Danio rerio]

Protein Classification

Niemann-Pick C type protein family( domain architecture ID 1003172)

Niemann-Pick C (NPC) type protein family is essential for sterol homeostasis that drive sterol integration into the lysosomal membrane before redistribution to other cellular membranes

Gene Ontology:  GO:0015485|GO:0030301

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
2A060601 super family cl36767
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 28-1251 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00917:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1499.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113    28 CIWYGECGNSPNvpEKKLNCNYTGPAVPLPNEGQELLQELCPRLV--YADNrVCCDTQQLNTLKSNIQIPLQYLSRCPAC 105
Cdd:TIGR00917    1 CAMYDICGARSD--GKVLNCPYNIPSVKPPDLLSSLIQSLCQYSHptISGN-VCCTETQFDTLRSNVQQAIPFIVRCPAC 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   106 FFNFMTLFCELTCSPRQSQFISVKDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDASVCTP 185
Cdd:TIGR00917   78 LRNFLNLFCELTCSPDQSLFINVTSTTKVKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKNFKEW 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   186 QIWIQYMFSISNGQVPFGIEPIFTDVPV-QGMTPMNNRTFNCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIILGL 264
Cdd:TIGR00917  158 FNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSIKLGV 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   265 DAMSFIMWCSYIAFLLIFFGVVL--GAWCYRRSVVTSEYGPIlDSNQPHSLNSDGTDlidEASCCETVGERFENSLRLVF 342
Cdd:TIGR00917  238 KCVDFILAILYIVLVSVFLGGGLlhPVRGKKKTSQMGTLSEA-DGEINSVNQQKDQN---TPQRNWGQLSTVQGHLARFF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   343 SRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSAPSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGg 422
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   423 fstitgdiIPFSPILNLSLLHQVLDLQLEIENLIAEYKGENVTLKDICVSPLSPYNdnCTILSVLNYFQNSHEVLDHEFQ 502
Cdd:TIGR00917  393 --------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPENY 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   503 DEFFLYnDYHTHLLYCASSPtslddtsrlhDPCMGTFGGPVFPWLVLGGYEDSAYNNATALVITFPVTNYLNDTEKLGKA 582
Cdd:TIGR00917  463 DDYGGV-DYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEKA 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   583 LAWEKEFIRFMKNYENPNL--TVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGI 660
Cdd:TIGR00917  532 VAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGL 611

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   661 AGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQRDERM---------PEEELHQQIGRILG 731
Cdd:TIGR00917  612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFyrqvgvdneQELTLERRLSRALM 691

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   732 DVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDGQE- 810
Cdd:TIGR00917  692 EVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSIs 771

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   811 ------EKSEGWLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLH 884
Cdd:TIGR00917  772 aekgsgQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLE 851

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   885 TGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQiytaslMSNYTRISNVPSSWLDDYFDWVKPQSTCCRYYNSTG 964
Cdd:TIGR00917  852 VGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTNG 925

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   965 AFCNasVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKGGHAAYGTAVDLKDNNTDVGATYFMSYHTIL 1044
Cdd:TIGR00917  926 TFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTPL 1003

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1045 KNSSDFINAMKMARELTDNITQTLSthdksYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAV 1124
Cdd:TIGR00917 1004 NTQVDFINAMRAAQEFAAKVSRSSK-----MEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVV 1078

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1125 LVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSVFSGITLT 1204
Cdd:TIGR00917 1079 NLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLT 1158

                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*..
gi 528470113  1205 KFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAG 1251
Cdd:TIGR00917 1159 KLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 28-1251 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1499.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113    28 CIWYGECGNSPNvpEKKLNCNYTGPAVPLPNEGQELLQELCPRLV--YADNrVCCDTQQLNTLKSNIQIPLQYLSRCPAC 105
Cdd:TIGR00917    1 CAMYDICGARSD--GKVLNCPYNIPSVKPPDLLSSLIQSLCQYSHptISGN-VCCTETQFDTLRSNVQQAIPFIVRCPAC 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   106 FFNFMTLFCELTCSPRQSQFISVKDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDASVCTP 185
Cdd:TIGR00917   78 LRNFLNLFCELTCSPDQSLFINVTSTTKVKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKNFKEW 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   186 QIWIQYMFSISNGQVPFGIEPIFTDVPV-QGMTPMNNRTFNCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIILGL 264
Cdd:TIGR00917  158 FNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSIKLGV 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   265 DAMSFIMWCSYIAFLLIFFGVVL--GAWCYRRSVVTSEYGPIlDSNQPHSLNSDGTDlidEASCCETVGERFENSLRLVF 342
Cdd:TIGR00917  238 KCVDFILAILYIVLVSVFLGGGLlhPVRGKKKTSQMGTLSEA-DGEINSVNQQKDQN---TPQRNWGQLSTVQGHLARFF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   343 SRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSAPSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGg 422
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   423 fstitgdiIPFSPILNLSLLHQVLDLQLEIENLIAEYKGENVTLKDICVSPLSPYNdnCTILSVLNYFQNSHEVLDHEFQ 502
Cdd:TIGR00917  393 --------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPENY 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   503 DEFFLYnDYHTHLLYCASSPtslddtsrlhDPCMGTFGGPVFPWLVLGGYEDSAYNNATALVITFPVTNYLNDTEKLGKA 582
Cdd:TIGR00917  463 DDYGGV-DYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEKA 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   583 LAWEKEFIRFMKNYENPNL--TVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGI 660
Cdd:TIGR00917  532 VAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGL 611

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   661 AGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQRDERM---------PEEELHQQIGRILG 731
Cdd:TIGR00917  612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFyrqvgvdneQELTLERRLSRALM 691

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   732 DVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDGQE- 810
Cdd:TIGR00917  692 EVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSIs 771

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   811 ------EKSEGWLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLH 884
Cdd:TIGR00917  772 aekgsgQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLE 851

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   885 TGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQiytaslMSNYTRISNVPSSWLDDYFDWVKPQSTCCRYYNSTG 964
Cdd:TIGR00917  852 VGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTNG 925

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   965 AFCNasVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKGGHAAYGTAVDLKDNNTDVGATYFMSYHTIL 1044
Cdd:TIGR00917  926 TFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTPL 1003

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1045 KNSSDFINAMKMARELTDNITQTLSthdksYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAV 1124
Cdd:TIGR00917 1004 NTQVDFINAMRAAQEFAAKVSRSSK-----MEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVV 1078

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1125 LVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSVFSGITLT 1204
Cdd:TIGR00917 1079 NLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLT 1158

                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*..
gi 528470113  1205 KFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAG 1251
Cdd:TIGR00917 1159 KLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 26-246 9.87e-92

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 295.28  E-value: 9.87e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113    26 QHCIWYGECGNSPnVPEKKLNCNYTGPAVPLPNEGQELLQELCPRLVYADNRVCCDTQQLNTLKSNIQIPLQYLSRCPAC 105
Cdd:pfam16414    1 GRCAWYGECGKKS-LFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPAC 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   106 FFNFMTLFCELTCSPRQSQFISV-KDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDasvCT 184
Cdd:pfam16414   80 KKNFANLFCEFTCSPNQSTFLNVtKTKKSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGGA---CN 156

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528470113   185 PQIWIQYMFSISNGQVPFGIEPIF-TDVPVQGMTPMNNRTFNCSQSLDDgSEPCSCQDCSEVC 246
Cdd:pfam16414  157 YTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSC 218
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
341-1258 1.77e-30

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 129.98  E-value: 1.77e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  341 VFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVElWSAPSSRARQEKNYFDQHFGPffrTEQLIITtpwtee 420
Cdd:COG1033     3 LMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVVA------ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  421 ggfstitgdIIPFSPILNLSLLHQVLDLQLEIENLiaeykgENVTlkdicvsplspyndncTILSVLNYFQNshEVLDHE 500
Cdd:COG1033    73 ---------VEGKDDIFTPETLEALRELTEELEEI------PGVD----------------SVTSLTNVRAT--EGTEDG 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  501 FQDEFFLYNDYhthllycASSPTSLDDTSRLHDPCMGTFGGPVfpwlvlggyedSAYNNATALVITF--PVTNYLNDTEK 578
Cdd:COG1033   120 LTVEPLIPDEL-------PASPEELAELREKVLSSPLYVGRLV-----------SPDGKATLIVVTLdpDPLSSDLDRKE 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  579 LGKALawekefIRFMKNYENPNLTVSFSSERSIEDEIDRESNSDVSTIV-ISYIIMFVYISVALGRInscrtllvdskiS 657
Cdd:COG1033   182 VVAEI------RAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRSL------------R 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  658 LGIAGILIVLSSVACSLGIFSYIGIPLTLIVIeVIPFLVLAVGVDN-IFIIVqTYqRDERMPEEELHQQIGRILGDVAPS 736
Cdd:COG1033   244 GVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYgIHLLN-RY-REERRKGLDKREALREALRKLGPP 320

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  737 MFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLL-GLDIKRQEANRmdilccvklsdgqeEKSEG 815
Cdd:COG1033   321 VLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLsLLPRPKPKTRR--------------LKKPP 386

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  816 WLFRFFKKIyAPFILKdwVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDS-------YVLNYFGNLSkylhtgpP 888
Cdd:COG1033   387 ELGRLLAKL-ARFVLR--RPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpirqdldFIEENFGGSD-------P 456

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  889 VYFVVEDGHDYktfegqnavcggvGCNNDSLVQQIYTAS-LMSNYTRISNVPSswLDDYFDWVkpqstccryynstgafc 967
Cdd:COG1033   457 LEVVVDTGEPD-------------GLKDPEVLKEIDRLQdYLESLPEVGKVLS--LADLVKEL----------------- 504

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  968 NASVVDKScvhcrpmtSSGKQRPNGTEFMHFLPMFLSDNPnikcgkgghaaygtaVDLKDN--NTDVGATYFMSYHTILK 1045
Cdd:COG1033   505 NQALNEGD--------PKYYALPESRELLAQLLLLLSSPP---------------GDDLSRfvDEDYSAARVTVRLKDLD 561

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1046 NSSdfinamkmARELTDNITQTLSTH--DKSYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGfELWSA 1123
Cdd:COG1033   562 SEE--------IKALVEEVRAFLAENfpPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRLG 632

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1124 VLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFS--ISTRSSRVERAEEALAHMGSSV-FSG 1200
Cdd:COG1033   633 LISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAIlFTS 712

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 528470113 1201 ITLtkFGGILILALSKSQIfqIFYFRMYLAIVLLGAAHG-LIFLPVLLSYAGPSVNKAK 1258
Cdd:COG1033   713 LTL--AAGFGVLLFSSFPP--LADFGLLLALGLLVALLAaLLLLPALLLLLDPRIAKKR 767
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
1046-1165 6.14e-03

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 41.16  E-value: 6.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1046 NSSDFINAMKMARELTDNITQTLSthdKSYKVfpysvfYVFYEQYLTI---VDDTALNLGVSLSAIFIVTAVLLGfELWS 1122
Cdd:NF033617  287 PGANPIEVADEIRALLPELQETLP---KNIKV------NVLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLRA 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 528470113 1123 AVLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVE 1165
Cdd:NF033617  357 TLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 28-1251 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1499.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113    28 CIWYGECGNSPNvpEKKLNCNYTGPAVPLPNEGQELLQELCPRLV--YADNrVCCDTQQLNTLKSNIQIPLQYLSRCPAC 105
Cdd:TIGR00917    1 CAMYDICGARSD--GKVLNCPYNIPSVKPPDLLSSLIQSLCQYSHptISGN-VCCTETQFDTLRSNVQQAIPFIVRCPAC 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   106 FFNFMTLFCELTCSPRQSQFISVKDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDASVCTP 185
Cdd:TIGR00917   78 LRNFLNLFCELTCSPDQSLFINVTSTTKVKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKNFKEW 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   186 QIWIQYMFSISNGQVPFGIEPIFTDVPV-QGMTPMNNRTFNCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIILGL 264
Cdd:TIGR00917  158 FNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSIKLGV 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   265 DAMSFIMWCSYIAFLLIFFGVVL--GAWCYRRSVVTSEYGPIlDSNQPHSLNSDGTDlidEASCCETVGERFENSLRLVF 342
Cdd:TIGR00917  238 KCVDFILAILYIVLVSVFLGGGLlhPVRGKKKTSQMGTLSEA-DGEINSVNQQKDQN---TPQRNWGQLSTVQGHLARFF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   343 SRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSAPSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGg 422
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   423 fstitgdiIPFSPILNLSLLHQVLDLQLEIENLIAEYKGENVTLKDICVSPLSPYNdnCTILSVLNYFQNSHEVLDHEFQ 502
Cdd:TIGR00917  393 --------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPENY 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   503 DEFFLYnDYHTHLLYCASSPtslddtsrlhDPCMGTFGGPVFPWLVLGGYEDSAYNNATALVITFPVTNYLNDTEKLGKA 582
Cdd:TIGR00917  463 DDYGGV-DYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEKA 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   583 LAWEKEFIRFMKNYENPNL--TVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGI 660
Cdd:TIGR00917  532 VAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGL 611

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   661 AGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQRDERM---------PEEELHQQIGRILG 731
Cdd:TIGR00917  612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFyrqvgvdneQELTLERRLSRALM 691

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   732 DVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDGQE- 810
Cdd:TIGR00917  692 EVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSIs 771

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   811 ------EKSEGWLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLH 884
Cdd:TIGR00917  772 aekgsgQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLE 851

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   885 TGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQiytaslMSNYTRISNVPSSWLDDYFDWVKPQSTCCRYYNSTG 964
Cdd:TIGR00917  852 VGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTNG 925

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   965 AFCNasVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKGGHAAYGTAVDLKDNNTDVGATYFMSYHTIL 1044
Cdd:TIGR00917  926 TFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTPL 1003

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1045 KNSSDFINAMKMARELTDNITQTLSthdksYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAV 1124
Cdd:TIGR00917 1004 NTQVDFINAMRAAQEFAAKVSRSSK-----MEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVV 1078

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1125 LVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSVFSGITLT 1204
Cdd:TIGR00917 1079 NLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLT 1158

                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*..
gi 528470113  1205 KFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAG 1251
Cdd:TIGR00917 1159 KLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 26-246 9.87e-92

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 295.28  E-value: 9.87e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113    26 QHCIWYGECGNSPnVPEKKLNCNYTGPAVPLPNEGQELLQELCPRLVYADNRVCCDTQQLNTLKSNIQIPLQYLSRCPAC 105
Cdd:pfam16414    1 GRCAWYGECGKKS-LFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPAC 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   106 FFNFMTLFCELTCSPRQSQFISV-KDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDasvCT 184
Cdd:pfam16414   80 KKNFANLFCEFTCSPNQSTFLNVtKTKKSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGGA---CN 156

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528470113   185 PQIWIQYMFSISNGQVPFGIEPIF-TDVPVQGMTPMNNRTFNCSQSLDDgSEPCSCQDCSEVC 246
Cdd:pfam16414  157 YTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSC 218
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 434-1248 3.41e-77

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 272.69  E-value: 3.41e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   434 SPILNLSLLHQVLDLQLEI-ENLIAEYKGENVTLKDICvsplSPYND-NCTilsvLNYFQNSHevldhefqdeffLYNDY 511
Cdd:pfam02460   56 SNILDISYLNDIYQLNDYIsTNVEIQVDGIIISFKDLC----SRYCDlNCP----VNKHYNGM------------LLSRR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   512 HTHllycassptslddTSRLHDPCMGTFGGPVFPWLVLGG---YEDSAYNNATALVITFpvtnYLNDTEKLGKALA--WE 586
Cdd:pfam02460  116 HNT-------------RIDITYPIMPVLGTPIYLGPHFGGvdfEPPGNISYAKAIVLWY----FLKFDEEEVEEDSkeWE 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   587 KEFIRFMKN-YENPNLTVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGIAGILI 665
Cdd:pfam02460  179 DELSQLLHNkYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLS 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   666 VLSSVACSLGIFSYIGIPLTLIVIeVIPFLVLAVGVDNIFIIVQTYQRDERmpEEELHQQIGRILGDVAPSMFLSSFSET 745
Cdd:pfam02460  259 PVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTA--TLSVKKRMGEALSEAGVSITITSLTDV 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   746 VAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDGQ----------EEKSEG 815
Cdd:pfam02460  336 LSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSSPQRidsegsepdkSHNIEQ 415

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   816 WLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYL-HTGPPVYFVVE 894
Cdd:pfam02460  416 LKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVN 495

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   895 DGHDYKTFEGQNAVcggvgcnnDSLVQQIYTASlmsnYTRISNVPSSWLDDYFDWvkpqstccrYYNSTGAfcnasvvdk 974
Cdd:pfam02460  496 NPPNLTIPESRDRM--------NEMVDEFENTP----YSLGPNSTLFWLREYENF---------LSTLNME--------- 545

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   975 scvhcrpMTSSGKQRPNGTEFMHFLpmflsdnpniKCGKGGHAAYGTAVDlkDNNTDVGATYFMsyhTILKNSSDFIN-- 1052
Cdd:pfam02460  546 -------EEEDEEKEWSYGNLPSFL----------KAPGNSHWAGDLVWD--DNTTMVTKFRFT---LAGKGLSTWNDrt 603

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1053 -AMKMARELTDnitqtlsthdkSYKVFPYSVF---YVFYEQYLTIVDDTALNLGVSLSAIFIVtAVLLGFELWSAVLVCF 1128
Cdd:pfam02460  604 rALQEWRSIAD-----------QYPEFNVTVFdedAPFADQYLTILPSTIQNIVITLICMFIV-CFLFIPNPPCVFVITL 671

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1129 TIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSVFSGITLTkFGG 1208
Cdd:pfam02460  672 AIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLST-ILG 750

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|
gi 528470113  1209 ILILALSKSQIFQIFYFRMYLaIVLLGAAHGLIFLPVLLS 1248
Cdd:pfam02460  751 VLVLLFVPSYMVVVFFKTVFL-VVAIGLLHGLFILPIILS 789
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
570-1252 7.96e-65

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 240.94  E-value: 7.96e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   570 TNYLNDTEKLGKAL--AWEKEFIRFMKNY--ENPNLTVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYisvalgrin 645
Cdd:TIGR00918  342 VHHIGWNEEKAAAVleAWQRNFSEEVQQSlpKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAY--------- 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   646 SCRTLL----VDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQrdERMPEEE 721
Cdd:TIGR00918  413 ACLTMLrwdcAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFS--ETGQNIP 490

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   722 LHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILC 801
Cdd:TIGR00918  491 FEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFC 570

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   802 C----------------------------------------------------------VKLSD---------------- 807
Cdd:TIGR00918  571 CffspcsarviqiepqayadgsappvysshmqstvqlrteydpgtqhyyttneprshlsVQPSDplscqspdiagstrdl 650

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   808 -GQEEKSEG---------W-LFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYF 876
Cdd:TIGR00918  651 lSQFEDSKAaclslpcarWtLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFL 730

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   877 GNLSKYLhTGPPVYFVVEDGHDYKTFEgqnavcggvgcnndslvQQIYtaSLMSNYTRISNV--------PSSWLDDYFD 948
Cdd:TIGR00918  731 DAQFRYF-SFYNMYAVTQGNFDYPTQQ-----------------QLLY--DLHQSFSSVKYVlkedngqlPRMWLHYFRD 790

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   949 WV--------------KPQSTCCRYYNSTGAFC---------NASVVDKSCVHCRPMTSS-GKQRPNGteFMHFLPMFLS 1004
Cdd:TIGR00918  791 WLqglqkafdedwrdgRITKENYRNGSDDAVLAykllvqtghRDKPVDKEQLTTQRLVNAdGIINPNA--FYIYLSAWVS 868

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1005 DNPnikcgkgghAAYGTAVD---------LKDNNTDVGATY------------FMSYHTILKNSSDFINAMKMARELTDN 1063
Cdd:TIGR00918  869 NDP---------VAYAASQAniyphppewLHDKNDYDPENLripaaepleyaqFPFYLNGLRETSQFVEAIEHVRAICNN 939

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1064 ITQtLSTHDksykvFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLgFELWSAVLVCFTIAMILINMFGVMWL 1143
Cdd:TIGR00918  940 YEG-FGLPS-----YPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGL 1012

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1144 WSISLNAVSLVNLVMSCGISVEFCSHIVRAFsISTRSSRVERAEEALAHMGSSVFSGiTLTKFGGILILALSKSQiFQIF 1223
Cdd:TIGR00918 1013 LGIKLSAIPVVILIASVGIGVEFTVHIALGF-LTAIGDRNRRAVLALEHMFAPVLDG-ALSTLLGVLMLAGSEFD-FIVR 1089

                          810       820       830
                   ....*....|....*....|....*....|
gi 528470113  1224 YFRMYLAIV-LLGAAHGLIFLPVLLSYAGP 1252
Cdd:TIGR00918 1090 YFFAVLAVLtCLGVLNGLVLLPVLLSMFGP 1119
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 651-805 1.32e-63

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 212.83  E-value: 1.32e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   651 LVDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQRDERMPEEElhQQIGRIL 730
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVS--ERIAEAL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528470113   731 GDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKL 805
Cdd:pfam12349   79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
341-1258 1.77e-30

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 129.98  E-value: 1.77e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  341 VFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVElWSAPSSRARQEKNYFDQHFGPffrTEQLIITtpwtee 420
Cdd:COG1033     3 LMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVVA------ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  421 ggfstitgdIIPFSPILNLSLLHQVLDLQLEIENLiaeykgENVTlkdicvsplspyndncTILSVLNYFQNshEVLDHE 500
Cdd:COG1033    73 ---------VEGKDDIFTPETLEALRELTEELEEI------PGVD----------------SVTSLTNVRAT--EGTEDG 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  501 FQDEFFLYNDYhthllycASSPTSLDDTSRLHDPCMGTFGGPVfpwlvlggyedSAYNNATALVITF--PVTNYLNDTEK 578
Cdd:COG1033   120 LTVEPLIPDEL-------PASPEELAELREKVLSSPLYVGRLV-----------SPDGKATLIVVTLdpDPLSSDLDRKE 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  579 LGKALawekefIRFMKNYENPNLTVSFSSERSIEDEIDRESNSDVSTIV-ISYIIMFVYISVALGRInscrtllvdskiS 657
Cdd:COG1033   182 VVAEI------RAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRSL------------R 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  658 LGIAGILIVLSSVACSLGIFSYIGIPLTLIVIeVIPFLVLAVGVDN-IFIIVqTYqRDERMPEEELHQQIGRILGDVAPS 736
Cdd:COG1033   244 GVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYgIHLLN-RY-REERRKGLDKREALREALRKLGPP 320

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  737 MFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLL-GLDIKRQEANRmdilccvklsdgqeEKSEG 815
Cdd:COG1033   321 VLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLsLLPRPKPKTRR--------------LKKPP 386

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  816 WLFRFFKKIyAPFILKdwVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDS-------YVLNYFGNLSkylhtgpP 888
Cdd:COG1033   387 ELGRLLAKL-ARFVLR--RPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpirqdldFIEENFGGSD-------P 456

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  889 VYFVVEDGHDYktfegqnavcggvGCNNDSLVQQIYTAS-LMSNYTRISNVPSswLDDYFDWVkpqstccryynstgafc 967
Cdd:COG1033   457 LEVVVDTGEPD-------------GLKDPEVLKEIDRLQdYLESLPEVGKVLS--LADLVKEL----------------- 504

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  968 NASVVDKScvhcrpmtSSGKQRPNGTEFMHFLPMFLSDNPnikcgkgghaaygtaVDLKDN--NTDVGATYFMSYHTILK 1045
Cdd:COG1033   505 NQALNEGD--------PKYYALPESRELLAQLLLLLSSPP---------------GDDLSRfvDEDYSAARVTVRLKDLD 561

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1046 NSSdfinamkmARELTDNITQTLSTH--DKSYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGfELWSA 1123
Cdd:COG1033   562 SEE--------IKALVEEVRAFLAENfpPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRLG 632

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1124 VLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFS--ISTRSSRVERAEEALAHMGSSV-FSG 1200
Cdd:COG1033   633 LISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAIlFTS 712

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 528470113 1201 ITLtkFGGILILALSKSQIfqIFYFRMYLAIVLLGAAHG-LIFLPVLLSYAGPSVNKAK 1258
Cdd:COG1033   713 LTL--AAGFGVLLFSSFPP--LADFGLLLALGLLVALLAaLLLLPALLLLLDPRIAKKR 767
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
329-775 3.60e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 84.14  E-value: 3.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  329 TVGERFENSLRLVFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVElWSAPSSRARQEKNYFDQHFGpffRT 408
Cdd:COG1033   379 TRRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFG---GS 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  409 EQLIITTPWTEEGGfstitgdiipfspILNLSLLHQVLDLQLEIENLiaeykgENVTlkdicvsplspyndncTILSVLN 488
Cdd:COG1033   455 DPLEVVVDTGEPDG-------------LKDPEVLKEIDRLQDYLESL------PEVG----------------KVLSLAD 499

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  489 YFQNSHEVLDHEFQDEFFLyndyhthllycassPTSLDDTSRLHDPCMGTFGGpvfpwlVLGGYEDSAYNNAtalVITFP 568
Cdd:COG1033   500 LVKELNQALNEGDPKYYAL--------------PESRELLAQLLLLLSSPPGD------DLSRFVDEDYSAA---RVTVR 556

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  569 VTNylNDTEKLGKALAWEKEFIRfmKNYENPNLTVSFSSERSIEDEI-DRESNSDVSTIVISYIIMFVYISVALGRInsc 647
Cdd:COG1033   557 LKD--LDSEEIKALVEEVRAFLA--ENFPPDGVEVTLTGSAVLFAAInESVIESQIRSLLLALLLIFLLLLLAFRSL--- 629

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  648 rtllvdskiSLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPfLVLAVGVDNIFIIVQTYqRDERMPEEELHQQIG 727
Cdd:COG1033   630 ---------RLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYTIHFLSRY-REERRKGGDLEEAIR 698

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 528470113  728 RILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFL 775
Cdd:COG1033   699 RALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALL 746
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1049-1266 1.84e-10

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 65.27  E-value: 1.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1049 DFINAMKMARELTDNITQTLSTH-DKSYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGfELWSAVLVC 1127
Cdd:COG1033   171 DPLSSDLDRKEVVAEIRAIIAKYeDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFR-SLRGVLLPL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1128 FTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAF--SISTRSSRVERAEEALAHMGSSVFSGiTLTK 1205
Cdd:COG1033   250 LVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYreERRKGLDKREALREALRKLGPPVLLT-SLTT 328

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528470113 1206 FGGILILALSKSQIFQIFYFRMYLAIVLLGAAHgLIFLPVLLSYAGPSVNKAKVLAAHNRF 1266
Cdd:COG1033   329 AIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS-LTLLPALLSLLPRPKPKTRRLKKPPEL 388
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 623-787 1.17e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 55.38  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   623 VSTIVISYIIMF-VYISValgrinscrtllvdskislgIAGILIVLS---SVACSLG---IFSYI-GIPLTLIVIEVIPF 694
Cdd:pfam03176  149 AVTLVVIFIILLiVYRSV--------------------VAALLPLLTvglSLGAAQGlvaILAHIlGIGLSTFALNLLVV 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   695 LVLAVGVD-NIFIIvqTYQRDERMPEEELHQQIGRILGDVAPSMFLSSFseTVAFFLGAL--STMPAVRTFSLFAGLAIF 771
Cdd:pfam03176  209 LLIAVGTDyALFLV--SRYREELRAGEDREEAVIRAVRGTGKVVTAAGL--TVAIAMLALsfARLPVFAQVGPTIAIGVL 284

                          170
                   ....*....|....*.
gi 528470113   772 IDFLLQISCFVSLLGL 787
Cdd:pfam03176  285 VDVLAALTLLPALLAL 300
COG4258 COG4258
Predicted exporter [General function prediction only];
626-776 1.24e-07

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 56.40  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  626 IVISYIIMFVYISVALGRINscRTLLVdskislgiagILIVLSSVACSLGIFSYIGIPLTLIVIeVIPFLVLAVGVD-NI 704
Cdd:COG4258   645 LLLALLLILLLLLLRLRSLR--RALRV----------LLPPLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyAL 711

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528470113  705 FIivqtyqrDErmpeeelHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLL 776
Cdd:COG4258   712 FF-------TE-------GLLDKGELARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLL 769
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 610-813 2.98e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 54.84  E-value: 2.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   610 SIEDEIDRE-SNSDVSTIVISYIIMFVYIsvalgrinscrtLLVDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIV 688
Cdd:TIGR00921  182 AINYDIEREfGKDMGTTMAISGILVVLVL------------LLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATT 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   689 IEVIPfLVLAVGVDnifIIVQTYQRdermPEEELHqqIGRILGD--------VAPSMFLSSFSETVAFFLGALSTMPAVR 760
Cdd:TIGR00921  250 LLAVP-MLIGVGID---YGIQTLNR----YEEERD--IGRAKGEaivtavrrTGRAVLIALLTTSAGFAALALSEFPMVS 319

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 528470113   761 TFSLFAGLAIFIDFLLQISCFVSLLGL-DIKRQEANRMDILCCVKLSDGQEEKS 813
Cdd:TIGR00921  320 EFGLGLVAGLITAYLLTLLVLPALLQSiDIGREKVKKEIIAIGGKSSEIEEELS 373
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 588-787 4.84e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 54.07  E-value: 4.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   588 EFIRFMKNYEN--------PNLTVSFSSERSIEDEIDRESNSDVSTI-VISYIIMFVYISVALGRInscrtllvdskiSL 658
Cdd:TIGR00921  526 EPKVQGRKILRdvqhehppPGVKVGVTGLPVAFAEMHELVNEGMRRMtIAGAILVLMILLAVFRNP------------IK 593

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   659 GIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPfLVLAVGVDNIFIIVQTY--QRDERMPEEELHQQIGRilgdVAPS 736
Cdd:TIGR00921  594 AVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTIS-IILGLGMDYSIHLAERYfeERKEHGPKEAITHTMER----TGPG 668

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528470113   737 MFLSSFseTVAFFLGAL--STMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGL 787
Cdd:TIGR00921  669 ILFSGL--TTAGGFLSLllSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1091-1266 2.95e-05

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 48.56  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1091 LTIVDDTALNLGVSLS--------AIFIVTAVLLGF--ELWSAVLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSC 1160
Cdd:COG0841   316 LTIVYDQSEFIRASIEevvktlleAILLVVLVVFLFlrSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAI 395

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1161 GISV-------EfcsHIVRAfsISTRSSRVERAEEALAHMGSSVFSgITLTkfggiLI-----LALSKSQIFQIFYfrmY 1228
Cdd:COG0841   396 GIVVddaivvvE---NIERH--MEEGLSPLEAAIKGAREVAGAVIA-STLT-----LVavflpLAFMGGITGQLFR---Q 461

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 528470113 1229 LAIVLLGA-------AhgLIFLPVLLSY---AGPSVNKAKVLAAHNRF 1266
Cdd:COG0841   462 FALTVAIAllislfvA--LTLTPALCARllkPHPKGKKGRFFRAFNRG 507
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 1087-1267 5.98e-05

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 47.68  E-value: 5.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1087 YEQYLTIVDDTALNLGVSlsaiFIVTAVLL-----GFELWSAVLVCFTIAMILINMFGVMWLWSisLNAVSLVNLVMSCG 1161
Cdd:TIGR03480  261 DEELATVSEGATVAGLLS----FVLVLVLLwlalrSPRLVFAVLVTLIVGLILTAAFATLAVGH--LNLISVAFAVLFIG 334

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1162 ISVEFCSHivraFSISTRSSR----VERA--EEALAHMGSSvfsgitltkfggILILALSKSQIFQIFYFRMYLAIVLLG 1235
Cdd:TIGR03480  335 LGVDFAIQ----FSLRYREERfrggNHREalSVAARRMGAA------------LLLAALATAAGFFAFLPTDYKGVSELG 398

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 528470113  1236 --AAHGLI--------FLPVLLSYAGPSVNKAKVLAAHNRFV 1267
Cdd:TIGR03480  399 iiAGTGMFialfvtltVLPALLRLLRPPRRRKPPGYATLAPL 440
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 1099-1247 8.48e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.14  E-value: 8.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1099 LNLGVSLSAIFIVTAVLLGFELWSAVLVCFTIAMILINM-FGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSIS 1177
Cdd:TIGR00921  195 MGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEE 274

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528470113  1178 TRSSRV--ERAEEALAHMGSSVFsGITLTKFGGILILALSKSQIFQIFYFRMYLAIvLLGAAHGLIFLPVLL 1247
Cdd:TIGR00921  275 RDIGRAkgEAIVTAVRRTGRAVL-IALLTTSAGFAALALSEFPMVSEFGLGLVAGL-ITAYLLTLLVLPALL 344
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 1109-1247 3.72e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 41.52  E-value: 3.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1109 FIVTAVLLGFELWSAVLVCFTIAMILIN---MFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVrafsistrsSRVER 1185
Cdd:TIGR03480  722 LVAITVLLLLTLRRVRDVLLVLAPLLLAgllTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMV---------HRWRN 792

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113  1186 AEEALAHMGSS-----VFSGIT-LTKFGGI------------LILALSksqifqifyfrmyLAIVLLGAahgLIFLPVLL 1247
Cdd:TIGR03480  793 GVDSGNLLQSStaravFFSALTtATAFGSLavsshpgtasmgILLSLG-------------LGLTLLCT---LIFLPALL 856
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
 613-792 4.59e-03

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 41.38  E-value: 4.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   613 DEIDRESNSD---VSTIVISYIIMFVYIsvalgRINSCRTLlvDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVi 689
Cdd:TIGR00920   51 PKFEEEYLSSdviVMTITRCIAVLYIYY-----QFCNLRQL--GSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLN- 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113   690 EVIPFLVLAVGVDNI-----FIIVQTYQrdermpeEELHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSL 764
Cdd:TIGR00920  123 EALPFFLLLIDLSKAsalakFALSSNSQ-------DEVRDNIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCC 195

                          170       180       190
                   ....*....|....*....|....*....|.
gi 528470113   765 FAGLAIFIDFLLQISCF---VSLLgLDIKRQ 792
Cdd:TIGR00920  196 FGCMSVLANYFVFMTFFpacLSLV-LELSRS 225
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
1046-1165 6.14e-03

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 41.16  E-value: 6.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470113 1046 NSSDFINAMKMARELTDNITQTLSthdKSYKVfpysvfYVFYEQYLTI---VDDTALNLGVSLSAIFIVTAVLLGfELWS 1122
Cdd:NF033617  287 PGANPIEVADEIRALLPELQETLP---KNIKV------NVLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLRA 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 528470113 1123 AVLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVE 1165
Cdd:NF033617  357 TLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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