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Conserved domains on  [gi|528471724|ref|XP_005171431|]
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protein tilB homolog isoform X1 [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-166 4.96e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 93.70  E-value: 4.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  22 SLEELSLHQQDIQRIEHIHKwCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEVIENLEGCESLQ---------- 91
Cdd:cd21340   25 NLKVLYLYDNKITKIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlp 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  92 ------------------------------------------KLDLTVNFVGRLSSV-ETLKHNLHLKELYLVGNPCAEY 128
Cdd:cd21340  104 pgekltfdprslaalsnslrvlnisgnnidsleplaplrnleQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKK 183

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 528471724 129 HGYRQYVVATVPQLQSLDGKEISRAERiQALQELDAVR 166
Cdd:cd21340  184 PKYRDKIILASKSLEVLDGKEITDTER-QFLKRLKARK 220
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-166 4.96e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 93.70  E-value: 4.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  22 SLEELSLHQQDIQRIEHIHKwCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEVIENLEGCESLQ---------- 91
Cdd:cd21340   25 NLKVLYLYDNKITKIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlp 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  92 ------------------------------------------KLDLTVNFVGRLSSV-ETLKHNLHLKELYLVGNPCAEY 128
Cdd:cd21340  104 pgekltfdprslaalsnslrvlnisgnnidsleplaplrnleQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKK 183

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 528471724 129 HGYRQYVVATVPQLQSLDGKEISRAERiQALQELDAVR 166
Cdd:cd21340  184 PKYRDKIILASKSLEVLDGKEITDTER-QFLKRLKARK 220
LRR_9 pfam14580
Leucine-rich repeat;
1-173 2.12e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.39  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724    1 MVRISEDLIRRRAEHNNGeiFSLEELSLHQQDIQRIEHIHKWCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEV 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNP--VRERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724   81 I-ENL-EGCESLQKLDLTVNFVGRLSSVETLKHNLHLKELYLVGNPCAEYHGYRQYVVATVPQLQSLDGKEISRAERIQA 158
Cdd:pfam14580  79 IgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158

                         170
                  ....*....|....*
gi 528471724  159 LQELDAVRTRVLQQE 173
Cdd:pfam14580 159 EKMFRSKQGKQLAKE 173
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-123 1.10e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  16 NNGEIF---SLEELSLHQQDIQRIEHIHKWCRDLKILYLQNNLIPKI-ENVGRLKKLEYLNLALNNIEVI-ENLEGCESL 90
Cdd:COG4886  105 GNEELSnltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNL 184

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528471724  91 QKLDLTVNFVGRLSsvETLKHNLHLKELYLVGN 123
Cdd:COG4886  185 KELDLSNNQITDLP--EPLGNLTNLEELDLSGN 215
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-166 4.96e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 93.70  E-value: 4.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  22 SLEELSLHQQDIQRIEHIHKwCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEVIENLEGCESLQ---------- 91
Cdd:cd21340   25 NLKVLYLYDNKITKIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlp 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  92 ------------------------------------------KLDLTVNFVGRLSSV-ETLKHNLHLKELYLVGNPCAEY 128
Cdd:cd21340  104 pgekltfdprslaalsnslrvlnisgnnidsleplaplrnleQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKK 183

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 528471724 129 HGYRQYVVATVPQLQSLDGKEISRAERiQALQELDAVR 166
Cdd:cd21340  184 PKYRDKIILASKSLEVLDGKEITDTER-QFLKRLKARK 220
LRR_9 pfam14580
Leucine-rich repeat;
1-173 2.12e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.39  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724    1 MVRISEDLIRRRAEHNNGeiFSLEELSLHQQDIQRIEHIHKWCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEV 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNP--VRERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724   81 I-ENL-EGCESLQKLDLTVNFVGRLSSVETLKHNLHLKELYLVGNPCAEYHGYRQYVVATVPQLQSLDGKEISRAERIQA 158
Cdd:pfam14580  79 IgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158

                         170
                  ....*....|....*
gi 528471724  159 LQELDAVRTRVLQQE 173
Cdd:pfam14580 159 EKMFRSKQGKQLAKE 173
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-123 1.10e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  16 NNGEIF---SLEELSLHQQDIQRIEHIHKWCRDLKILYLQNNLIPKI-ENVGRLKKLEYLNLALNNIEVI-ENLEGCESL 90
Cdd:COG4886  105 GNEELSnltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNL 184

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528471724  91 QKLDLTVNFVGRLSsvETLKHNLHLKELYLVGN 123
Cdd:COG4886  185 KELDLSNNQITDLP--EPLGNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-104 2.66e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 2.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528471724  22 SLEELSLHQQDIQRIEHIHKWCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEVIENLEGCESLQKLDLTVNFVG 101
Cdd:COG4886  206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285


                 ...
gi 528471724 102 RLS 104
Cdd:COG4886  286 DLK 288
LRR_8 pfam13855
Leucine rich repeat;
46-98 7.65e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 7.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 528471724   46 LKILYLQNNLIPKIENV--GRLKKLEYLNLALNNIEVIEN--LEGCESLQKLDLTVN 98
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-111 2.02e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 2.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 528471724   66 KKLEYLNLALNNIEVIENLEGCESLQKLDLTVNFvgRLSSVETLKH 111
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN--KITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 46-86 1.34e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 528471724   46 LKILYLQNNLIPKIENVGRLKKLEYLNLALNNIevIENLEG 86
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-123 5.07e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 5.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528471724  65 LKKLEYLNLALNNIEVIENLEGCESLQKLDLTVNfvgRLSSVETLKHNLHLKELYLVGN 123
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDN---KITKIENLEFLTNLTHLYLQNN 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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