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Conserved domains on  [gi|528515562|ref|XP_005174000|]
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BCL-6 corepressor isoform X1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCOR pfam15808
BCL-6 co-repressor, non-ankyrin-repeat region; BCOR is a domain family found in eukaryotes, ...
 1214-1448 6.21e-72

BCL-6 co-repressor, non-ankyrin-repeat region; BCOR is a domain family found in eukaryotes, and is approximately 220 amino acids in length. This domain lies just upstream of the ankyrin-repeat region at the C-terminus of BCL-6 co-repressor proteins. The function of this region is not known.


:

Pssm-ID: 434953  Cd Length: 219  Bit Score: 239.82  E-value: 6.21e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1214 GLRLSKPRHLHNLQELWDRQGQLnhdrpqfgatnlglpptsKASIPPLQTTRREKLDPCTPEVPrvahgvpAVDRKVKtN 1293
Cdd:pfam15808    1 GLRLKKQRHLQHLRELWEQQVSP------------------AEPSKPGRQSRKEKAEAVQPEVT-------ARDRKVK-D 54

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1294 GIEEKGLKRKAEVE--RGWTKEQLEYAESNTAIPALSDSfcsDSIRKFSSAV------------PPHHLSDKRQRLKEHR 1359
Cdd:pfam15808   55 IAEEKPLRKRSEAKsnRSWSEESLKSSDNEQGLPAFPPS---PHMKSLSSANangkkqtqpsctPASRLSAKRQKLKESR 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1360 KSvGSSSPSPDPDCTFPGRLRRHGDPEKPKGKRQCKTKHLSQQERRMLLQSTNQECPELSPAHQHKVVKCSAQKRPALLS 1439
Cdd:pfam15808  132 KT-DPSSPDEDEDCQAASLLQKHTDSEKPKGKRQCKTKHLSLQERRRGLSLTGDSAYELENADGKVTVKRRFRKRPESSS 210


                   ....*....
gi 528515562  1440 NYESSPIKP 1448
Cdd:pfam15808  211 DYDSSPVKP 219
PUFD cd14261
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ...
 1670-1786 9.12e-69

PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


:

Pssm-ID: 271224  Cd Length: 117  Bit Score: 226.65  E-value: 9.12e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1670 EDEQRDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVTIAEAEFYKQASLSQLFSC 1749
Cdd:cd14261     1 DDAYSDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSC 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 528515562 1750 PEELEGFMPDSKELLDLVEISGELVALLGSSIECLDD 1786
Cdd:cd14261    81 PKDLEAFNPDSKELLDLVEFTNELQTLLGSSLEWLHP 117
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1503-1609 7.55e-29

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 7.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1503 NAGETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVEN 1582
Cdd:COG0666   118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196

                          90       100
                  ....*....|....*....|....*..
gi 528515562 1583 DHLDVVRLLLSYGADPTLATYSGRGLL 1609
Cdd:COG0666   197 GHLEIVKLLLEAGADVNAKDNDGKTAL 223
 
Name Accession Description Interval E-value
BCOR pfam15808
BCL-6 co-repressor, non-ankyrin-repeat region; BCOR is a domain family found in eukaryotes, ...
 1214-1448 6.21e-72

BCL-6 co-repressor, non-ankyrin-repeat region; BCOR is a domain family found in eukaryotes, and is approximately 220 amino acids in length. This domain lies just upstream of the ankyrin-repeat region at the C-terminus of BCL-6 co-repressor proteins. The function of this region is not known.


Pssm-ID: 434953  Cd Length: 219  Bit Score: 239.82  E-value: 6.21e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1214 GLRLSKPRHLHNLQELWDRQGQLnhdrpqfgatnlglpptsKASIPPLQTTRREKLDPCTPEVPrvahgvpAVDRKVKtN 1293
Cdd:pfam15808    1 GLRLKKQRHLQHLRELWEQQVSP------------------AEPSKPGRQSRKEKAEAVQPEVT-------ARDRKVK-D 54

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1294 GIEEKGLKRKAEVE--RGWTKEQLEYAESNTAIPALSDSfcsDSIRKFSSAV------------PPHHLSDKRQRLKEHR 1359
Cdd:pfam15808   55 IAEEKPLRKRSEAKsnRSWSEESLKSSDNEQGLPAFPPS---PHMKSLSSANangkkqtqpsctPASRLSAKRQKLKESR 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1360 KSvGSSSPSPDPDCTFPGRLRRHGDPEKPKGKRQCKTKHLSQQERRMLLQSTNQECPELSPAHQHKVVKCSAQKRPALLS 1439
Cdd:pfam15808  132 KT-DPSSPDEDEDCQAASLLQKHTDSEKPKGKRQCKTKHLSLQERRRGLSLTGDSAYELENADGKVTVKRRFRKRPESSS 210


                   ....*....
gi 528515562  1440 NYESSPIKP 1448
Cdd:pfam15808  211 DYDSSPVKP 219
PUFD cd14261
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ...
 1670-1786 9.12e-69

PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271224  Cd Length: 117  Bit Score: 226.65  E-value: 9.12e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1670 EDEQRDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVTIAEAEFYKQASLSQLFSC 1749
Cdd:cd14261     1 DDAYSDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSC 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 528515562 1750 PEELEGFMPDSKELLDLVEISGELVALLGSSIECLDD 1786
Cdd:cd14261    81 PKDLEAFNPDSKELLDLVEFTNELQTLLGSSLEWLHP 117
PUFD pfam16553
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ...
 1674-1787 1.74e-66

BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.


Pssm-ID: 465171  Cd Length: 114  Bit Score: 219.95  E-value: 1.74e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1674 RDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVTIAEAEFYKQASLSQLFSCPEEL 1753
Cdd:pfam16553    1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 528515562  1754 EGFMPDSKELLDLVEISGELVALLGSSIECLDDR 1787
Cdd:pfam16553   81 EAFNPDSKELVELVEFTPELQTLLGSSVEFLHPS 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1503-1609 7.55e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 7.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1503 NAGETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVEN 1582
Cdd:COG0666   118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196

                          90       100
                  ....*....|....*....|....*..
gi 528515562 1583 DHLDVVRLLLSYGADPTLATYSGRGLL 1609
Cdd:COG0666   197 GHLEIVKLLLEAGADVNAKDNDGKTAL 223
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1509-1600 7.06e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.94  E-value: 7.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1509 LQRAARLGYEEVVLYCLENKvCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHgADINCSAQDGTrPLHDAVENDHLDVV 1588
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 528515562  1589 RLLLSYGADPTL 1600
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1506-1597 2.08e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.99  E-value: 2.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1506 ETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHL 1585
Cdd:PHA03100  160 KLLIDKGVDINAKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238

                          90
                  ....*....|..
gi 528515562 1586 DVVRLLLSYGAD 1597
Cdd:PHA03100  239 EIFKLLLNNGPS 250
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1498-1597 4.55e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1498 LIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGAD-----INCSAQDG 1572
Cdd:cd22192    10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQG 89

                          90       100
                  ....*....|....*....|....*
gi 528515562 1573 TRPLHDAVENDHLDVVRLLLSYGAD 1597
Cdd:cd22192    90 ETALHIAVVNQNLNLVRELIARGAD 114
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1575-1600 9.70e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.03  E-value: 9.70e-05
                            10        20
                    ....*....|....*....|....*.
gi 528515562   1575 PLHDAVENDHLDVVRLLLSYGADPTL 1600
Cdd:smart00248    5 PLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
BCOR pfam15808
BCL-6 co-repressor, non-ankyrin-repeat region; BCOR is a domain family found in eukaryotes, ...
 1214-1448 6.21e-72

BCL-6 co-repressor, non-ankyrin-repeat region; BCOR is a domain family found in eukaryotes, and is approximately 220 amino acids in length. This domain lies just upstream of the ankyrin-repeat region at the C-terminus of BCL-6 co-repressor proteins. The function of this region is not known.


Pssm-ID: 434953  Cd Length: 219  Bit Score: 239.82  E-value: 6.21e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1214 GLRLSKPRHLHNLQELWDRQGQLnhdrpqfgatnlglpptsKASIPPLQTTRREKLDPCTPEVPrvahgvpAVDRKVKtN 1293
Cdd:pfam15808    1 GLRLKKQRHLQHLRELWEQQVSP------------------AEPSKPGRQSRKEKAEAVQPEVT-------ARDRKVK-D 54

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1294 GIEEKGLKRKAEVE--RGWTKEQLEYAESNTAIPALSDSfcsDSIRKFSSAV------------PPHHLSDKRQRLKEHR 1359
Cdd:pfam15808   55 IAEEKPLRKRSEAKsnRSWSEESLKSSDNEQGLPAFPPS---PHMKSLSSANangkkqtqpsctPASRLSAKRQKLKESR 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1360 KSvGSSSPSPDPDCTFPGRLRRHGDPEKPKGKRQCKTKHLSQQERRMLLQSTNQECPELSPAHQHKVVKCSAQKRPALLS 1439
Cdd:pfam15808  132 KT-DPSSPDEDEDCQAASLLQKHTDSEKPKGKRQCKTKHLSLQERRRGLSLTGDSAYELENADGKVTVKRRFRKRPESSS 210


                   ....*....
gi 528515562  1440 NYESSPIKP 1448
Cdd:pfam15808  211 DYDSSPVKP 219
PUFD cd14261
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ...
 1670-1786 9.12e-69

PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271224  Cd Length: 117  Bit Score: 226.65  E-value: 9.12e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1670 EDEQRDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVTIAEAEFYKQASLSQLFSC 1749
Cdd:cd14261     1 DDAYSDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSC 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 528515562 1750 PEELEGFMPDSKELLDLVEISGELVALLGSSIECLDD 1786
Cdd:cd14261    81 PKDLEAFNPDSKELLDLVEFTNELQTLLGSSLEWLHP 117
PUFD pfam16553
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ...
 1674-1787 1.74e-66

BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.


Pssm-ID: 465171  Cd Length: 114  Bit Score: 219.95  E-value: 1.74e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1674 RDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVTIAEAEFYKQASLSQLFSCPEEL 1753
Cdd:pfam16553    1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 528515562  1754 EGFMPDSKELLDLVEISGELVALLGSSIECLDDR 1787
Cdd:pfam16553   81 EAFNPDSKELVELVEFTPELQTLLGSSVEFLHPS 114
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
 1672-1782 6.22e-38

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


Pssm-ID: 271223  Cd Length: 115  Bit Score: 138.44  E-value: 6.22e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1672 EQRDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVTIAEAEFYKQASLSQLFSCPE 1751
Cdd:cd14260     1 TEEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 528515562 1752 ELEGFM----PDSKELLDLVEISGELVALLGSSIE 1782
Cdd:cd14260    81 RPGGLDdrspQGSSETVELVRYEPELLRLLGSAVE 115
PUFD_like cd14259
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ...
 1675-1782 4.88e-34

PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271222  Cd Length: 106  Bit Score: 126.66  E-value: 4.88e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1675 DVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVTIAEAEFYKQASLSQLFSCPEELE 1754
Cdd:cd14259     1 DDFEFEFSDEPLPPLYNLRISPNDGPRNWHLLSDVLTRLKLKSRDFLLKQICLELTSIPIEDFLEQASCLQLLCAGEKLT 80

                          90       100
                  ....*....|....*....|....*...
gi 528515562 1755 GfmPDSKELLDLVEISGELVALLGSSIE 1782
Cdd:cd14259    81 N--NVSSSKVELVEYNDSLRSLLGIEVE 106
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1503-1609 7.55e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 7.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1503 NAGETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVEN 1582
Cdd:COG0666   118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196

                          90       100
                  ....*....|....*....|....*..
gi 528515562 1583 DHLDVVRLLLSYGADPTLATYSGRGLL 1609
Cdd:COG0666   197 GHLEIVKLLLEAGADVNAKDNDGKTAL 223
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1498-1609 2.38e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.90  E-value: 2.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1498 LIVNKNAGETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLH 1577
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                          90       100       110
                  ....*....|....*....|....*....|..
gi 528515562 1578 DAVENDHLDVVRLLLSYGADPTLATYSGRGLL 1609
Cdd:COG0666   159 LAAANGNLEIVKLLLEAGADVNARDNDGETPL 190
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1493-1610 2.39e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 2.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1493 PEARRLIVNKNA--------GETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGAD 1564
Cdd:COG0666   133 LEIVKLLLEAGAdvnaqdndGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 528515562 1565 INCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLATYSGRGLLK 1610
Cdd:COG0666   212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1509-1600 7.06e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.94  E-value: 7.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562  1509 LQRAARLGYEEVVLYCLENKvCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHgADINCSAQDGTrPLHDAVENDHLDVV 1588
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 528515562  1589 RLLLSYGADPTL 1600
Cdd:pfam12796   78 KLLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1498-1635 2.15e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.70  E-value: 2.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1498 LIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLH 1577
Cdd:COG0666    46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528515562 1578 DAVENDHLDVVRLLLSYGADPTLATYSGRGLLKMT----HSDIMEcFLSDYFADLQGRVDDD 1635
Cdd:COG0666   126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAaangNLEIVK-LLLEAGADVNARDNDG 186
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1503-1597 2.54e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.60  E-value: 2.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1503 NAGETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVEN 1582
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262

                          90
                  ....*....|....*
gi 528515562 1583 DHLDVVRLLLSYGAD 1597
Cdd:COG0666   263 GAALIVKLLLLALLL 277
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1500-1566 2.03e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 2.03e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528515562  1500 VNKNAGETLLQRAARLGYEEVVLYCLENkvCDVNHRDNaGYCALHEACSRGWLSIVQHLLEHGADIN 1566
Cdd:pfam12796   25 LQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADIN 88
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1506-1597 2.08e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.99  E-value: 2.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1506 ETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHL 1585
Cdd:PHA03100  160 KLLIDKGVDINAKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238

                          90
                  ....*....|..
gi 528515562 1586 DVVRLLLSYGAD 1597
Cdd:PHA03100  239 EIFKLLLNNGPS 250
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1493-1605 2.56e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 2.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1493 PEARRLIVNKNA--------GETLLQRAA--RLGYEEVVLYcLENKVCDVNHRDNAGYCALHEA--CSRGWLSIVQHLLE 1560
Cdd:PHA03100   86 KEIVKLLLEYGAnvnapdnnGITPLLYAIskKSNSYSIVEY-LLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLID 164

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528515562 1561 HGADINcsAQD------------------GTRPLHDAVENDHLDVVRLLLSYGADPTLATYSG 1605
Cdd:PHA03100  165 KGVDIN--AKNrvnyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG 225
Ank_4 pfam13637
Ankyrin repeats (many copies);
1542-1592 8.49e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 8.49e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 528515562  1542 ALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLL 1592
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1494-1622 1.56e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 1.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1494 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGT 1573
Cdd:COG0666     9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528515562 1574 RPLHDAVENDHLDVVRLLLSYGADPTLATYSGRGLLKMT----HSDIMECFLS 1622
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAayngNLEIVKLLLE 141
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1531-1594 3.59e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 3.59e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528515562 1531 DVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSY 1594
Cdd:PTZ00322  107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1558-1600 1.82e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.06  E-value: 1.82e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 528515562 1558 LLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTL 1600
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTL 143
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1505-1597 3.62e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.26  E-value: 3.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1505 GETLLQRAARLGYEEVVLYCLENkVCDVNHRDNAGYCALHEACS-------------------------------RGWLS 1553
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKH-ACNVHIRDANGNTALWNAISakhhkifrilyhfasisdphaagdllctaakRNDLT 636

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 528515562 1554 IVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGAD 1597
Cdd:PLN03192  637 AMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
Ank_5 pfam13857
Ankyrin repeats (many copies);
1558-1611 1.58e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 1.58e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 528515562  1558 LLEHG-ADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLATYSGRGLLKM 1611
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1531-1597 2.40e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.33  E-value: 2.40e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528515562 1531 DVNHRDNAGYCALHEACSRGW---LSIVQHLLEHGADINCSAQDGTRPLHDAVENDH-LDVVRLLLSYGAD 1597
Cdd:PHA03095   39 DVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1531-1605 2.63e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 2.63e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528515562 1531 DVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLATYSG 1605
Cdd:PHA02874  116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNG 190
Ank_4 pfam13637
Ankyrin repeats (many copies);
1507-1559 3.32e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 3.32e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528515562  1507 TLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLL 1559
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1509-1598 5.90e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.03  E-value: 5.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1509 LQRAARLGYEEVVLYCLENKvCDVNHRDNAGYCALHEACSRGW-LSIVQHLLEHGADINC-SAQDGTRPLHDAVENDhlD 1586
Cdd:PHA02878  205 LHHAVKHYNKPIVHILLENG-ASTDARDKCGNTPLHISVGYCKdYDILKLLLEHGVDVNAkSYILGLTALHSSIKSE--R 281

                          90
                  ....*....|..
gi 528515562 1587 VVRLLLSYGADP 1598
Cdd:PHA02878  282 KLKLLLEYGADI 293
Ank_5 pfam13857
Ankyrin repeats (many copies);
1525-1577 1.04e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 1.04e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 528515562  1525 LENKVCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLH 1577
Cdd:pfam13857    2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 1519-1638 1.86e-05

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 49.53  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1519 EVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLS--IVQHLLEHGADINCSAQDGTRPLH-------------DAVEND 1583
Cdd:PHA02716  298 SVVYSFLQPGV-KLHYKDSAGRTCLHQYILRHNIStdIIKLLHEYGNDLNEPDNIGNTVLHtylsmlsvvnildPETDND 376

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528515562 1584 -HLDVVRLLLSYGADPTLATYSGRGLLK---------MTHsDIMECFLSD---------YFADLQGRVDDDPSV 1638
Cdd:PHA02716  377 iRLDVIQCLISLGADITAVNCLGYTPLTsyictaqnyMYY-DIIDCLISDkvlnmvkhrILQDLLIRVDDTPCI 449
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1519-1628 3.48e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 3.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1519 EVVLYCLENKvCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLH-----DAVENDHLDVVRLLLS 1593
Cdd:PHA03100   16 KNIKYIIMED-DLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLE 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 528515562 1594 YGADPTLATYSGRGLL------KMTHSDIMEcFLSDYFADL 1628
Cdd:PHA03100   95 YGANVNAPDNNGITPLlyaiskKSNSYSIVE-YLLDNGANV 134
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1498-1597 4.55e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1498 LIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGAD-----INCSAQDG 1572
Cdd:cd22192    10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQG 89

                          90       100
                  ....*....|....*....|....*
gi 528515562 1573 TRPLHDAVENDHLDVVRLLLSYGAD 1597
Cdd:cd22192    90 ETALHIAVVNQNLNLVRELIARGAD 114
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1494-1599 5.91e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 5.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1494 EARRLI-----VN--KNAGETLLQRAARLGYEEV--VLYCLENKVCDVNHRDNAGYCALH-EACSRGWLSIVQHLLEHGA 1563
Cdd:PHA03095   29 EVRRLLaagadVNfrGEYGKTPLHLYLHYSSEKVkdIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGA 108

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 528515562 1564 DINCSAQDGTRPLHD--AVENDHLDVVRLLLSYGADPT 1599
Cdd:PHA03095  109 DVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVN 146
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1539-1567 8.47e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 41.09  E-value: 8.47e-05
                           10        20
                   ....*....|....*....|....*....
gi 528515562  1539 GYCALHEACSRGWLSIVQHLLEHGADINC 1567
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1554-1598 8.52e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.18  E-value: 8.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 528515562 1554 IVQHLLEHGADINCSAQD-GTRPLHDAVENDHLDVVRLLLSYGADP 1598
Cdd:PHA02878  149 ITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANV 194
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1575-1600 9.70e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.03  E-value: 9.70e-05
                            10        20
                    ....*....|....*....|....*.
gi 528515562   1575 PLHDAVENDHLDVVRLLLSYGADPTL 1600
Cdd:smart00248    5 PLHLAAENGNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1530-1606 1.21e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 1.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528515562 1530 CDVNHRDNAGYCALHEAC--SRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLATYSGR 1606
Cdd:PHA03095  213 CDPAATDMLGNTPLHSMAtgSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1543-1602 1.25e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 1.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528515562 1543 LHEACSRGWLSIVQHLLEHGADIN-CSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLAT 1602
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPN 132
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1525-1602 1.73e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 1.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528515562 1525 LENKVCdVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDG-TRPLHDAVENDHLDVVRLLLSYGADPTLAT 1602
Cdd:PHA02875  155 IDHKAC-LDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCNIMF 232
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1517-1611 3.12e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1517 YEEVVLYCLENKvCDVNHRDNAGYCALH-----EACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVEN--DHLDVVR 1589
Cdd:PHA03100   47 NIDVVKILLDNG-ADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVE 125

                          90       100
                  ....*....|....*....|..
gi 528515562 1590 LLLSYGADPTLATYSGRGLLKM 1611
Cdd:PHA03100  126 YLLDNGANVNIKNSDGENLLHL 147
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1506-1595 3.49e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 3.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1506 ETLLQRAARLGYEEVVLYCLENKVcDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHL 1585
Cdd:PHA02874  125 KTFLHYAIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203

                          90
                  ....*....|
gi 528515562 1586 DVVRLLLSYG 1595
Cdd:PHA02874  204 ACIKLLIDHG 213
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1485-1597 3.72e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.44  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1485 PPVNRPMPPEARRLI-VN-KN-AGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACSRG-WLSIVQHLLE 1560
Cdd:PHA02876  284 PSLSRLVPKLLERGAdVNaKNiKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLE 363

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 528515562 1561 HGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGAD 1597
Cdd:PHA02876  364 LGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1531-1609 4.48e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1531 DVNHRDNAGYCALHeACSRGW---LSIVQHLLEHGADINCSAQDGTRPLHDAVENDH--LDVVRLLLSYGADPTLATYSG 1605
Cdd:PHA03095  109 DVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRF 187


                  ....
gi 528515562 1606 RGLL 1609
Cdd:PHA03095  188 RSLL 191
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1571-1602 4.78e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 4.78e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528515562  1571 DGTRPLHDAVE-NDHLDVVRLLLSYGADPTLAT 1602
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 1519-1611 5.01e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 44.73  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1519 EVVLYCLENKvCDVNHRdnaGY-----CAL---HEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDH---LDV 1587
Cdd:PHA02989   51 KIVKLLIDNG-ADVNYK---GYietplCAVlrnREITSNKIKKIVKLLLKFGADINLKTFNGVSPIVCFIYNSNinnCDM 126

                          90       100
                  ....*....|....*....|....*
gi 528515562 1588 VRLLLSYGAD-PTLATYSGRGLLKM 1611
Cdd:PHA02989  127 LRFLLSKGINvNDVKNSRGYNLLHM 151
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1539-1567 6.00e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 6.00e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 528515562  1539 GYCALHEACSR-GWLSIVQHLLEHGADINC 1567
Cdd:pfam00023    2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
Ank_4 pfam13637
Ankyrin repeats (many copies);
1572-1621 8.56e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 8.56e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 528515562  1572 GTRPLHDAVENDHLDVVRLLLSYGADPTLATYSGRGLL----KMTHSDIMECFL 1621
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALhfaaSNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1552-1610 2.00e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.13  E-value: 2.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 528515562 1552 LSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLATYSGRGLLK 1610
Cdd:PHA02876  158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLE 216
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1500-1609 3.56e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.87  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1500 VNKNAGETLLQRAARLGYEEVVLYCLENKvCDVNHRDNAGYCALHEACSRGwLSIVQhLLEHGADINCSAQDGTRPLHDA 1579
Cdd:PHA02874  185 VKDNNGESPLHNAAEYGDYACIKLLIDHG-NHIMNKCKNGFTPLHNAIIHN-RSAIE-LLINNASINDQDIDGSTPLHHA 261

                          90       100       110
                  ....*....|....*....|....*....|.
gi 528515562 1580 VEND-HLDVVRLLLSYGADPTLATYSGRGLL 1609
Cdd:PHA02874  262 INPPcDIDIIDILLYHKADISIKDNKGENPI 292
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1531-1593 3.76e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 3.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528515562 1531 DVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLS 1593
Cdd:PHA03095  249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1499-1603 4.14e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528515562 1499 IVNKNAGETLLQRAARLGYEEVVLYCLeNKVCDVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHD 1578
Cdd:PHA02878  162 MKDRHKGNTALHYATENKDQRLTELLL-SYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHI 240

                          90       100
                  ....*....|....*....|....*.
gi 528515562 1579 AVEN-DHLDVVRLLLSYGADPTLATY 1603
Cdd:PHA02878  241 SVGYcKDYDILKLLLEHGVDVNAKSY 266
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1531-1592 7.71e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 7.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528515562 1531 DVNHRDNAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLL 1592
Cdd:PHA02876  170 DVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAII 231
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1531-1596 9.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.63  E-value: 9.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528515562 1531 DVNHRD-NAGYCALHEACSRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGA 1596
Cdd:PHA02878  159 DINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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