|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
48-340 |
1.60e-91 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 274.98 E-value: 1.60e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 48 RRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 128 TREgnvrVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDmRTFVSGAC-D 205
Cdd:cd00200 82 TGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSqD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 206 ASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICgitSVAFSKSGRL 284
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVN---SVAFSPDGYL 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 530375105 285 LLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:cd00200 234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
46-340 |
1.82e-66 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 214.39 E-value: 1.82e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 46 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 126 LKTRegnvRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319 191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 205 DASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQelLLYSHDNIICGITSVAFSKSGRL 284
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKT 344
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 530375105 285 LLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
34-193 |
8.93e-09 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 57.02 E-value: 8.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 34 TSNMDSVGRIQMRTRRTL----RGHLAKIYAMHWGY-DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSwvMTCAYAPS 108
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLvtemKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPS 627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 109 --GNYVACGGLDNICSIYNLKtregnvrvSRELP-----GHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTT--- 178
Cdd:PLN00181 628 esGRSLAFGSADHKVYYYDLR--------NPKLPlctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGInet 699
|
170 180
....*....|....*....|
gi 530375105 179 ---TFTGHSG--DVMSLSLS 193
Cdd:PLN00181 700 plhSFMGHTNvkNFVGLSVS 719
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
215-254 |
1.71e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 44.23 E-value: 1.71e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 530375105 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFD 254
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
216-254 |
9.68e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 9.68e-06
10 20 30
....*....|....*....|....*....|....*....
gi 530375105 216 GMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFD 254
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
48-340 |
1.60e-91 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 274.98 E-value: 1.60e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 48 RRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 128 TREgnvrVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDmRTFVSGAC-D 205
Cdd:cd00200 82 TGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSqD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 206 ASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICgitSVAFSKSGRL 284
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVN---SVAFSPDGYL 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 530375105 285 LLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:cd00200 234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
46-340 |
1.82e-66 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 214.39 E-value: 1.82e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 46 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 126 LKTRegnvRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319 191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 205 DASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQelLLYSHDNIICGITSVAFSKSGRL 284
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKT 344
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 530375105 285 LLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
46-340 |
7.96e-65 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 210.15 E-value: 7.96e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 46 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319 69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 126 LKTRegnvRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319 149 LATG----KLLRTLTGHSGAVTSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 205 DASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNiiCGITSVAFSKSGRL 284
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDGKL 302
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 530375105 285 LLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
46-299 |
1.35e-56 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 188.97 E-value: 1.35e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 46 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 126 LKTREgnvrVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319 233 LATGK----LLRTLTGHSGSVRSVAFSPDGRlLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 205 DASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNiicGITSVAFSKSGR 283
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRtLTGHTG---AVTSVAFSPDGR 385
|
250
....*....|....*.
gi 530375105 284 LLLAGYDDFNCNVWDT 299
Cdd:COG2319 386 TLASGSADGTVRLWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
46-256 |
5.51e-46 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 161.23 E-value: 5.51e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 46 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 126 LKTREgnvrVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319 275 LATGE----LLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 530375105 205 DASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLR 256
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
126-340 |
1.49e-38 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 141.20 E-value: 1.49e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 126 LKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACD 205
Cdd:COG2319 20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 206 ASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNiicGITSVAFSKSGRL 284
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRtLTGHSG---AVTSVAFSPDGKL 176
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 530375105 285 LLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319 177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
46-215 |
5.34e-34 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 128.88 E-value: 5.34e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 46 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 126 LKTRegnvRVSRELPGHTGYLSCCRFL-DDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC 204
Cdd:COG2319 317 LATG----KLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
|
170
....*....|.
gi 530375105 205 DASSKLWDIRD 215
Cdd:COG2319 393 DGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
150-340 |
3.18e-26 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 107.69 E-value: 3.18e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 150 RFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDI 229
Cdd:COG2319 2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 230 NAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNiicGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVL 308
Cdd:COG2319 82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLrTLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158
|
170 180 190
....*....|....*....|....*....|..
gi 530375105 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
218-340 |
2.26e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 83.92 E-value: 2.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 218 CRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNiicGITSVAFSKSGRLLLAGYDDFNCNV 296
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTG---PVRDVAASADGTYLASGSSDKTIRL 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 530375105 297 WDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:cd00200 78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
34-193 |
8.93e-09 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 57.02 E-value: 8.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 34 TSNMDSVGRIQMRTRRTL----RGHLAKIYAMHWGY-DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSwvMTCAYAPS 108
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLvtemKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPS 627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 109 --GNYVACGGLDNICSIYNLKtregnvrvSRELP-----GHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTT--- 178
Cdd:PLN00181 628 esGRSLAFGSADHKVYYYDLR--------NPKLPlctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGInet 699
|
170 180
....*....|....*....|
gi 530375105 179 ---TFTGHSG--DVMSLSLS 193
Cdd:PLN00181 700 plhSFMGHTNvkNFVGLSVS 719
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
97-331 |
1.96e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 52.78 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-----REGNVRVSrELPGHTGYLSCC-RFLDDSQIVTSSGDTTCALWD 170
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 171 IETAQQTTTFTGHSGDVMSLSL-SPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHvSDINAVSfFPN--GYAFATGSDD 247
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQ-FPSesGRSLAFGSAD 639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 248 ATCRLFDLRADQELL--LYSHDNIicgITSVAFSKSGRLLLAGYDDfNCNVWDtLKGDRAGV-------LAGHDNRVSCL 318
Cdd:PLN00181 640 HKVYYYDLRNPKLPLctMIGHSKT---VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVKNFV 714
|
250
....*....|...
gi 530375105 319 GVTDDGMAVATGS 331
Cdd:PLN00181 715 GLSVSDGYIATGS 727
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
215-254 |
1.71e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 44.23 E-value: 1.71e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 530375105 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFD 254
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
216-254 |
9.68e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 9.68e-06
10 20 30
....*....|....*....|....*....|....*....
gi 530375105 216 GMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFD 254
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
49-83 |
1.23e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 1.23e-05
10 20 30
....*....|....*....|....*....|....*
gi 530375105 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWD 83
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
153-301 |
1.94e-05 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 46.04 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 153 DDSQIVTSSGDTTCALWDI--ETAQQTTT-----FTGHSGDVMSLSLSPD-MRTFVSGACDASSKLWDIRDGMCRQSFTG 224
Cdd:PTZ00421 87 DPQKLFTASEDGTIMGWGIpeEGLTQNISdpivhLQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKC 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375105 225 HVSDINAVSFFPNGYAFATGSDDATCRLFDLRadqelllysHDNIICGITSVAFSKSGRLLLAGYDD----FNCN----- 295
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR---------DGTIVSSVEAHASAKSQRCLWAKRKDliitLGCSksqqr 237
|
....*....
gi 530375105 296 ---VWDTLK 301
Cdd:PTZ00421 238 qimLWDTRK 246
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
49-83 |
2.00e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.18 E-value: 2.00e-05
10 20 30
....*....|....*....|....*....|....*
gi 530375105 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWD 83
Cdd:pfam00400 5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
173-212 |
3.45e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.37 E-value: 3.45e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 530375105 173 TAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWD 212
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
175-212 |
3.61e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 3.61e-05
10 20 30
....*....|....*....|....*....|....*...
gi 530375105 175 QQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWD 212
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
302-340 |
1.16e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.87 E-value: 1.16e-04
10 20 30
....*....|....*....|....*....|....*....
gi 530375105 302 GDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
307-340 |
2.46e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.06 E-value: 2.46e-04
10 20 30
....*....|....*....|....*....|....
gi 530375105 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Cdd:smart00320 7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
134-170 |
3.62e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 34.60 E-value: 3.62e-03
10 20 30
....*....|....*....|....*....|....*...
gi 530375105 134 RVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWD 170
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
311-339 |
3.85e-03 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 38.90 E-value: 3.85e-03
10 20
....*....|....*....|....*....
gi 530375105 311 HDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW 151
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
137-170 |
6.08e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 34.24 E-value: 6.08e-03
10 20 30
....*....|....*....|....*....|....*
gi 530375105 137 RELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWD 170
Cdd:pfam00400 5 KTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
|
|
|