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Conserved domains on  [gi|530386033|ref|XP_005250464|]
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serrate RNA effector molecule homolog isoform X3 [Homo sapiens]

Protein Classification

RDD family protein( domain architecture ID 10572505)

RDD family protein that may contain an N-terminal arsenite-resistance protein 2-like domain; the RDD domain contains three highly conserved amino acids (one arginine and two aspartates) and two predicted transmembrane regions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 653-854 3.20e-108

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


:

Pssm-ID: 461498  Cd Length: 195  Bit Score: 331.08  E-value: 3.20e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  653 RGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGP 732
Cdd:pfam04959   1 RGPGPSGRITSAEVVEWQKGFEERLEPLLSEKETLSEEEAMKMGKKDPEQEVEKFVRKNTQELAKDKWLCPLSGKKFKGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  733 EFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPA-QSLTPGLPYPHQTPQGLMPYGQPRPPILGY 811
Cdd:pfam04959  81 EFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPELKPKPPPRPAnRRERPGRAFPSQRPQGQMSDGHPRPPMDGP 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 530386033  812 GagavrpavptGGPPYPHAPYGAGRGNYDAFRGQ--GGYPGKPRN 854
Cdd:pfam04959 161 G----------GGPPFPPNQYGGGRGNYDNFRGQggGGYPPKPRD 195
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 160-269 4.29e-51

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


:

Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 174.35  E-value: 4.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  160 KEFLLSLDDSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGW 239
Cdd:pfam12066   1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 530386033  240 FDNLLLDIDKADAIVKMLDAAVIKMEGGTE 269
Cdd:pfam12066  81 FDEVSLDMGIYKSESKLLDGVVIKEEGGTD 110
 
Name Accession Description Interval E-value
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 653-854 3.20e-108

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 331.08  E-value: 3.20e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  653 RGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGP 732
Cdd:pfam04959   1 RGPGPSGRITSAEVVEWQKGFEERLEPLLSEKETLSEEEAMKMGKKDPEQEVEKFVRKNTQELAKDKWLCPLSGKKFKGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  733 EFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPA-QSLTPGLPYPHQTPQGLMPYGQPRPPILGY 811
Cdd:pfam04959  81 EFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPELKPKPPPRPAnRRERPGRAFPSQRPQGQMSDGHPRPPMDGP 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 530386033  812 GagavrpavptGGPPYPHAPYGAGRGNYDAFRGQ--GGYPGKPRN 854
Cdd:pfam04959 161 G----------GGPPFPPNQYGGGRGNYDNFRGQggGGYPPKPRD 195
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 160-269 4.29e-51

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 174.35  E-value: 4.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  160 KEFLLSLDDSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGW 239
Cdd:pfam12066   1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 530386033  240 FDNLLLDIDKADAIVKMLDAAVIKMEGGTE 269
Cdd:pfam12066  81 FDEVSLDMGIYKSESKLLDGVVIKEEGGTD 110
 
Name Accession Description Interval E-value
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 653-854 3.20e-108

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 331.08  E-value: 3.20e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  653 RGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGP 732
Cdd:pfam04959   1 RGPGPSGRITSAEVVEWQKGFEERLEPLLSEKETLSEEEAMKMGKKDPEQEVEKFVRKNTQELAKDKWLCPLSGKKFKGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  733 EFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPA-QSLTPGLPYPHQTPQGLMPYGQPRPPILGY 811
Cdd:pfam04959  81 EFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPELKPKPPPRPAnRRERPGRAFPSQRPQGQMSDGHPRPPMDGP 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 530386033  812 GagavrpavptGGPPYPHAPYGAGRGNYDAFRGQ--GGYPGKPRN 854
Cdd:pfam04959 161 G----------GGPPFPPNQYGGGRGNYDNFRGQggGGYPPKPRD 195
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 160-269 4.29e-51

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 174.35  E-value: 4.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386033  160 KEFLLSLDDSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGW 239
Cdd:pfam12066   1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 530386033  240 FDNLLLDIDKADAIVKMLDAAVIKMEGGTE 269
Cdd:pfam12066  81 FDEVSLDMGIYKSESKLLDGVVIKEEGGTD 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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