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Conserved domains on  [gi|530391113|ref|XP_005252044|]
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WD repeat-containing protein 38 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-272 4.57e-84

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.92  E-value: 4.57e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGSWDSTV 144
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtgkllrtltghsgsvrsvafspdgrllASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 145 HIWDlrmVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 223
Cdd:COG2319  271 RLWD---LATGELLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530391113 224 AGYSRMVKVWDCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAADQT 272
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGT 395
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-272 4.57e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.92  E-value: 4.57e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGSWDSTV 144
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtgkllrtltghsgsvrsvafspdgrllASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 145 HIWDlrmVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 223
Cdd:COG2319  271 RLWD---LATGELLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530391113 224 AGYSRMVKVWDCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAADQT 272
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-274 3.94e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 208.34  E-value: 3.94e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR 99
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGSWDSTVHIWDLRMV 152
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtgkclttlrghtdwvnsvafspdgtfvASSSQDGTIKLWDLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 153 TPAvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 231
Cdd:cd00200  168 KCV---ATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530391113 232 VWDCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAADQTRR 274
Cdd:cd00200  245 VWDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIR 286
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 13-233 4.47e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 4.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  13 RVKFFGQHGGEVNSS------AFSPDGQMLLTGSEDGCVYGWETRS--------GQLLWRLGGHTGPVKFCRFSPDGHLF 78
Cdd:PLN00181 469 RVKADLKQGDLLNSSnlvcaiGFDRDGEFFATAGVNKKIKIFECESiikdgrdiHYPVVELASRSKLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF-SPDSRQLASGGWDKRVMLWDVQ---------------------- 135
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINqgvsigtiktkaniccvqfpse 628

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 136 -----ATGSWDSTVHIWDLRmvTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS------SLLIQLKG 204
Cdd:PLN00181 629 sgrslAFGSADHKVYYYDLR--NPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMG 706

                        250       260
                 ....*....|....*....|....*....
gi 530391113 205 HVTWVKSIAFSPDELWLASAGYSRMVKVW 233
Cdd:PLN00181 707 HTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-91 4.44e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 4.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530391113    52 SGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-133 2.67e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.67e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530391113   96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-272 4.57e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.92  E-value: 4.57e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGSWDSTV 144
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtgkllrtltghsgsvrsvafspdgrllASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 145 HIWDlrmVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 223
Cdd:COG2319  271 RLWD---LATGELLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530391113 224 AGYSRMVKVWDCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAADQT 272
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
7-274 4.88e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 242.51  E-value: 4.88e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113   7 ATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCT 86
Cdd:COG2319   64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  87 VRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGS 139
Cdd:COG2319  144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtgkllrtltghtgavrsvafspdgkllASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 140 WDSTVHIWDLRmvTPAVSHQaLEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 218
Cdd:COG2319  224 ADGTVRLWDLA--TGKLLRT-LTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530391113 219 LWLASAGYSRMVKVWDCNTGKCLETLKQGVLDVaHTCAFTPDGKILVSGAADQTRR 274
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV-RSVAFSPDGKTLASGSDDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
20-237 1.45e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.95  E-value: 1.45e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR 99
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGSWDSTVHIWDLRMV 152
Cdd:COG2319  241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtgellrtltghsggvnsvafspdgkllASGSDDGTVRLWDLATG 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 153 TPAvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 231
Cdd:COG2319  321 KLL---RTLTGHTGAVRSVAFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                 ....*.
gi 530391113 232 VWDCNT 237
Cdd:COG2319  398 LWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
5-272 2.81e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 2.81e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113   5 VPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCD 84
Cdd:COG2319   20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  85 CTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------AT 137
Cdd:COG2319  100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtgkllrtltghsgavtsvafspdgkllAS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 138 GSWDSTVHIWDLRmvTPAVSHqALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 216
Cdd:COG2319  180 GSDDGTVRLWDLA--TGKLLR-TLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP 256

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530391113 217 DELWLASAGYSRMVKVWDCNTGKCLETLKqGVLDVAHTCAFTPDGKILVSGAADQT 272
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGT 311
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-274 3.94e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 208.34  E-value: 3.94e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR 99
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGSWDSTVHIWDLRMV 152
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtgkclttlrghtdwvnsvafspdgtfvASSSQDGTIKLWDLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 153 TPAvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 231
Cdd:cd00200  168 KCV---ATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530391113 232 VWDCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAADQTRR 274
Cdd:cd00200  245 VWDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIR 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-272 1.55e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 1.55e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ--- 135
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtge 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 136 ------------------------ATGSWDSTVHIWDLRmvtPAVSHQALEGHSANISCLCYS-ASGLLASGSWDKTIHI 190
Cdd:cd00200   85 cvrtltghtsyvssvafspdgrilSSSSRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVAFSpDGTFVASSSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 191 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAAD 270
Cdd:cd00200  162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDGYLLASGSED 240


                 ..
gi 530391113 271 QT 272
Cdd:cd00200  241 GT 242
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-234 2.81e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 175.22  E-value: 2.81e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAK 96
Cdd:cd00200   89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  97 CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQaTGSWDSTvhiwdlrmvtpavshqaLEGHSANISCLCYSAS 176
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-TGKCLGT-----------------LRGHENGVNSVAFSPD 230

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530391113 177 G-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 234
Cdd:cd00200  231 GyLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
28-272 5.57e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.10  E-value: 5.57e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  28 AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS 107
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 108 VETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGSWDSTVHIWDLRmvTPAVSHQa 160
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLAtglllrtltghtgavrsvafspdgktlASGSADGTVRLWDLA--TGKLLRT- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 161 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 239
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 530391113 240 CLETLKqGVLDVAHTCAFTPDGKILVSGAADQT 272
Cdd:COG2319  238 LLRTLT-GHSGSVRSVAFSPDGRLLASGSADGT 269
WD40 COG2319
WD40 repeat [General function prediction only];
12-195 1.30e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 1.30e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQATGSWdstvhiwdlrmvtpavshQALEGHSANISCL 171
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL------------------RTLTGHTGAVTSV 378

                        170       180
                 ....*....|....*....|....*
gi 530391113 172 CYSASG-LLASGSWDKTIHIWKPTT 195
Cdd:COG2319  379 AFSPDGrTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-192 1.55e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.79  E-value: 1.55e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVA 93
Cdd:cd00200  128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  94 RAKCLRVLKGHQRSVETVSFSPDSRQLASggwdkrvmlwdvqatGSWDSTVHIWDLRMVTPavsHQALEGHSANISCLCY 173
Cdd:cd00200  208 TGKCLGTLRGHENGVNSVAFSPDGYLLAS---------------GSEDGTIRVWDLRTGEC---VQTLSGHTNSVTSLAW 269

                        170       180
                 ....*....|....*....|
gi 530391113 174 SASG-LLASGSWDKTIHIWK 192
Cdd:cd00200  270 SPDGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-272 4.64e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 133.23  E-value: 4.64e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  97 CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---------------------------ATGSWDSTVHIWDL 149
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLEtgellrtlkghtgpvrdvaasadgtylASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 150 RmvTPAVSHQaLEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSR 228
Cdd:cd00200   81 E--TGECVRT-LTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 530391113 229 MVKVWDCNTGKCLETLKQGVLDVaHTCAFTPDGKILVSGAADQT 272
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-133 2.13e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 2.13e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:cd00200  168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530391113  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:cd00200  248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 13-233 4.47e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 4.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  13 RVKFFGQHGGEVNSS------AFSPDGQMLLTGSEDGCVYGWETRS--------GQLLWRLGGHTGPVKFCRFSPDGHLF 78
Cdd:PLN00181 469 RVKADLKQGDLLNSSnlvcaiGFDRDGEFFATAGVNKKIKIFECESiikdgrdiHYPVVELASRSKLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF-SPDSRQLASGGWDKRVMLWDVQ---------------------- 135
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINqgvsigtiktkaniccvqfpse 628

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 136 -----ATGSWDSTVHIWDLRmvTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS------SLLIQLKG 204
Cdd:PLN00181 629 sgrslAFGSADHKVYYYDLR--NPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMG 706

                        250       260
                 ....*....|....*....|....*....
gi 530391113 205 HVTWVKSIAFSPDELWLASAGYSRMVKVW 233
Cdd:PLN00181 707 HTNVKNFVGLSVSDGYIATGSETNEVFVY 735
PTZ00420 PTZ00420
coronin; Provisional
 58-244 6.67e-11

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 62.66  E-value: 6.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  58 RLGGHTGPVKFCRFSP-DGHLFASASCDCTVRLW----------DVARAKClrVLKGHQRSVETVSFSPdsrqlasggwd 126
Cdd:PTZ00420  69 KLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphndesvkEIKDPQC--ILKGHKKKISIIDWNP----------- 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 127 krvMLWDVQATGSWDSTVHIWDLRMvtpavSHQALE-GHSANISCLCYSASGLLASGSW-DKTIHIWKP----TTSSLLI 200
Cdd:PTZ00420 136 ---MNYYIMCSSGFDSFVNIWDIEN-----EKRAFQiNMPKKLSSLKWNIKGNLLSGTCvGKHMHIIDPrkqeIASSFHI 207

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530391113 201 QLKGHVT---WVKsiAFSPDELWLASAGYS----RMVKVWDC-NTGKCLETL 244
Cdd:PTZ00420 208 HDGGKNTkniWID--GLGGDDNYILSTGFSknnmREMKLWDLkNTTSALVTM 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-91 4.44e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 4.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530391113    52 SGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 18-133 5.56e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.44  E-value: 5.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113  18 GQHGgEVNSSAFSP-DGQMLLTGSEDGCVYGWETRSGQL-------LWRLGGHTGPVKFCRFSPDG-HLFASASCDCTVR 88
Cdd:PTZ00421  73 GQEG-PIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVN 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530391113  89 LWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-133 8.90e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 8.90e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530391113    96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-133 2.67e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.67e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530391113   96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
53-91 3.52e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 3.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530391113   53 GQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 179-285 8.09e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 8.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 179 LASGSWDKTIHIW-------KPTTSSLLIQLKGHVTWVKSIAFSPDEL-WLASAGYSRMVKVWDCNTGKCLETLKQgVLD 250
Cdd:PTZ00421  91 LFTASEDGTIMGWgipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKC-HSD 169

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 530391113 251 VAHTCAFTPDGKILVSGAADQTRRQIsrtskSPRD 285
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNII-----DPRD 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 195-234 1.49e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530391113   195 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 234
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-271 2.97e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.54  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 108 VETVSFSPDSRQLASGGWDKRVMLWDVQATGSWDSTVHIwdlrmvtPAVShqaLEGHSaNISCLCYSA--SGLLASGSWD 185
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHY-------PVVE---LASRS-KLSGICWNSyiKSQVASSNFE 554

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 186 KTIHIWKPTTSSLLIQLKGHVTWVKSIAF-SPDELWLASAGYSRMVKVWDCNTGKCLETLKQGvldvAHTCA--FTPD-G 261
Cdd:PLN00181 555 GVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTK----ANICCvqFPSEsG 630

                        170
                 ....*....|
gi 530391113 262 KILVSGAADQ 271
Cdd:PLN00181 631 RSLAFGSADH 640
WD40 pfam00400
WD domain, G-beta repeat;
196-234 6.57e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 6.57e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530391113  196 SSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 234
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 161-192 1.85e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.85e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530391113   161 LEGHSANISCLCYSASG-LLASGSWDKTIHIWK 192
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
161-191 2.79e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.79e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 530391113  161 LEGHSANISCLCYSASG-LLASGSWDKTIHIW 191
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-49 5.16e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 5.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530391113    12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWE 49
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
174-274 1.22e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113 174 SASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLkQGVLDVAH 253
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTAAVL 82

                         90       100
                 ....*....|....*....|.
gi 530391113 254 TCAFTPDGKILVSGAADQTRR 274
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVR 103
WD40 pfam00400
WD domain, G-beta repeat;
12-49 3.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530391113   12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWE 49
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 28-114 1.32e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113   28 AFSPDGQMLLTGSEDGCVygWETR-SGQLLW--RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH 104
Cdd:pfam12894   2 SWCPTMDLIALATEDGEL--LLHRlNWQRVWtlSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79

                          90
                  ....*....|
gi 530391113  105 QRSVETVSFS 114
Cdd:pfam12894  80 SDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 28-135 4.88e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.48  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391113   28 AFSPDGQMLLTGSEDGCVYGWETRS------------GQLLWRlgghTGPVkfcrFSPDGHLFASASCDCTVRLWDVARA 95
Cdd:COG4946   349 AWSPDGKSIAYFSDASGEYELYIAPadgsgepkqltlGDLGRV----FNPV----WSPDGKKIAFTDNRGRLWVVDLASG 420

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 530391113   96 KCLRVLKG-HQRSVETVSFSPDSRQLA----SGGWDKRVMLWDVQ 135
Cdd:COG4946   421 KVRKVDTDgYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVE 465
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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