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Conserved domains on  [gi|530399038|ref|XP_005253377|]
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electron transfer flavoprotein regulatory factor 1 isoform X1 [Homo sapiens]

Protein Classification

LYR motif-containing protein( domain architecture ID 14448812)

LYR motif-containing protein similar to human electron transfer flavoprotein regulatory factor 1 (ETFRF1) that acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 22-81 2.49e-27

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380760  Cd Length: 74  Bit Score: 94.57  E-value: 2.49e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399038 22 GRDYPKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKELEALYFLRKYRAMKQR 81
Cdd:cd20265  15 GRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
 
Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 22-81 2.49e-27

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380760  Cd Length: 74  Bit Score: 94.57  E-value: 2.49e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399038 22 GRDYPKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKELEALYFLRKYRAMKQR 81
Cdd:cd20265  15 GRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 30-65 3.35e-04

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 35.25  E-value: 3.35e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 530399038  30 DYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKE 65
Cdd:pfam05347 24 EYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
 
Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 22-81 2.49e-27

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380760  Cd Length: 74  Bit Score: 94.57  E-value: 2.49e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399038 22 GRDYPKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKELEALYFLRKYRAMKQR 81
Cdd:cd20265  15 GRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
 33-74 2.42e-05

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380762  Cd Length: 72  Bit Score: 38.70  E-value: 2.42e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 530399038 33 KKRLKNIFLKNKDVKNPEKIKELIAQGEfvmkelEALYFLRK 74
Cdd:cd20267  27 RQKIREEFEKNRNETDPEKIAELLKEAR------EAAEFLRK 62
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 25-65 6.39e-05

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 37.14  E-value: 6.39e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 530399038 25 YPKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKE 65
Cdd:cd20251  17 PSRKRDALRQRIREEFRKNKNETDPEKIEELLAEARRGLKN 57
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 30-65 3.35e-04

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 35.25  E-value: 3.35e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 530399038  30 DYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKE 65
Cdd:pfam05347 24 EYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 26-81 1.38e-03

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 34.24  E-value: 1.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530399038  26 PKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKELEA---LYFLRKYRAMKQR 81
Cdd:pfam13233 17 PNGRSYGRQYLRAEFRRHKHLTDPEEIAEFLKSWREYKELLERynpMTEEERVRLTARR 75
Complex1_LYR_LYRM4 cd20264
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ...
 31-69 1.94e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380759  Cd Length: 69  Bit Score: 33.65  E-value: 1.94e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 530399038 31 YFKKRLKNIFLKNKDVKNPEKIKELIAQGEfvmKELEAL 69
Cdd:cd20264  24 YFLRRIRDAFRENKNLKDPEEIKKLYEEGE---EQLEVL 59
Nckap1 pfam09735
Nck-associated protein 1; Nck-associated protein 1 is part of lamellipodial complex that ...
 29-83 2.40e-03

Nck-associated protein 1; Nck-associated protein 1 is part of lamellipodial complex that controls Rac-dependent actin remodeling. It associates preferentially with the first SH3 domain of Nck and is a component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. It is also a component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease.


Pssm-ID: 462866  Cd Length: 1114  Bit Score: 35.31  E-value: 2.40e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 530399038    29 ADYFKKRLKNIFLKNKDVKNPeKIKELIaqgeFVMKELEALyfLRKYRAMKQRYY 83
Cdd:pfam09735  376 ADNVPKKSKKKYNKQEDLVDR-QIAELL----FYMEELRSL--VRKYSQVIQRYY 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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