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Conserved domains on  [gi|530410586|ref|XP_005256827|]
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galectin-9C isoform X3 [Homo sapiens]

Protein Classification

galectin family protein( domain architecture ID 10049251)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 200-322 3.89e-52

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


:

Pssm-ID: 214904  Cd Length: 122  Bit Score: 167.77  E-value: 3.89e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586   200 PGGLYPSKSIILSGTVLPSAQRFHINLCSG--SHIAFHMNPRFDENAVVRNTQINNSWGSEERSlpRKMPFVRGQSFSVW 277
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEGTIVRNSKQNGKWGKEERS--GGFPFQPGQPFELE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 530410586   278 ILCEAHCLKVAVDGQHVFEYYHRLrNLPTINKLEVGGDIQLTHVQ 322
Cdd:smart00908  79 ILVEEDEFKVAVNGQHFLEFPHRL-PLESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 16-146 1.30e-50

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 163.96  E-value: 1.30e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586  16 PFSGTIQGGLQDGFQITVNGAVLScSGTRFAVDFQTGfsGNDIAFHFNPRFeDGGYVVCNTRQKGTWGPEERKMHMPFQK 95
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLP-NAKRFSINLGTG--SSDIALHFNPRF-DENVIVRNSFLNGNWGPEERSGGFPFQP 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530410586  96 GMPFDLCFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYIS 146
Cdd:cd00070   77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
 
Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 200-322 3.89e-52

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 167.77  E-value: 3.89e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586   200 PGGLYPSKSIILSGTVLPSAQRFHINLCSG--SHIAFHMNPRFDENAVVRNTQINNSWGSEERSlpRKMPFVRGQSFSVW 277
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEGTIVRNSKQNGKWGKEERS--GGFPFQPGQPFELE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 530410586   278 ILCEAHCLKVAVDGQHVFEYYHRLrNLPTINKLEVGGDIQLTHVQ 322
Cdd:smart00908  79 ILVEEDEFKVAVNGQHFLEFPHRL-PLESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 16-146 1.30e-50

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 163.96  E-value: 1.30e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586  16 PFSGTIQGGLQDGFQITVNGAVLScSGTRFAVDFQTGfsGNDIAFHFNPRFeDGGYVVCNTRQKGTWGPEERKMHMPFQK 95
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLP-NAKRFSINLGTG--SSDIALHFNPRF-DENVIVRNSFLNGNWGPEERSGGFPFQP 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530410586  96 GMPFDLCFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYIS 146
Cdd:cd00070   77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 194-322 3.18e-50

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 163.19  E-value: 3.18e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586 194 PFITTIPGGLYPSKSIILSGTVLPSAQRFHINL-CSGSHIAFHMNPRFDENAVVRNTQINNSWGSEERSlpRKMPFVRGQ 272
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLgTGSSDIALHFNPRFDENVIVRNSFLNGNWGPEERS--GGFPFQPGQ 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 530410586 273 SFSVWILCEAHCLKVAVDGQHVFEYYHRLRnLPTINKLEVGGDIQLTHVQ 322
Cdd:cd00070   79 PFELTILVEEDKFQIFVNGQHFFSFPHRLP-LESIDYLSINGDVSLTSVE 127
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 22-146 5.94e-49

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 159.68  E-value: 5.94e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586    22 QGGLQDGFQITVNGAVLScSGTRFAVDFQTGfSGNDIAFHFNPRFeDGGYVVCNTRQKGTWGPEERKMHMPFQKGMPFDL 101
Cdd:smart00908   1 PGGLSPGSSITIRGIVLP-DAKRFSINLQCG-PNADIALHFNPRF-DEGTIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 530410586   102 CFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYIS 146
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 200-322 2.47e-46

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 152.79  E-value: 2.47e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586  200 PGGLYPSKSIILSGTVLPSAQRFHINLCSG----SHIAFHMNPRFDENAVVRNTQINNSWGSEERSLprKMPFVRGQSFS 275
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgpsDDIALHFNPRFDENVIVRNSRQNGQWGQEEREG--GFPFQPGQPFE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 530410586  276 VWILCEAHCLKVAVDGQHVFEYYHRLRNlPTINKLEVGGDIQLTHVQ 322
Cdd:pfam00337  79 LTILVGDDHFKIYVNGQHFTTFKHRLPP-EDIDALQVRGDVKLTSVL 124
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 22-146 1.51e-45

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 150.87  E-value: 1.51e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586   22 QGGLQDGFQITVNGAVLScSGTRFAVDFQTG-FSGNDIAFHFNPRFeDGGYVVCNTRQKGTWGPEERKMHMPFQKGMPFD 100
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLP-DAQRFSINLQTGvGPSDDIALHFNPRF-DENVIVRNSRQNGQWGQEEREGGFPFQPGQPFE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 530410586  101 LCFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYIS 146
Cdd:pfam00337  79 LTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
 
Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 200-322 3.89e-52

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 167.77  E-value: 3.89e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586   200 PGGLYPSKSIILSGTVLPSAQRFHINLCSG--SHIAFHMNPRFDENAVVRNTQINNSWGSEERSlpRKMPFVRGQSFSVW 277
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEGTIVRNSKQNGKWGKEERS--GGFPFQPGQPFELE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 530410586   278 ILCEAHCLKVAVDGQHVFEYYHRLrNLPTINKLEVGGDIQLTHVQ 322
Cdd:smart00908  79 ILVEEDEFKVAVNGQHFLEFPHRL-PLESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 16-146 1.30e-50

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 163.96  E-value: 1.30e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586  16 PFSGTIQGGLQDGFQITVNGAVLScSGTRFAVDFQTGfsGNDIAFHFNPRFeDGGYVVCNTRQKGTWGPEERKMHMPFQK 95
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLP-NAKRFSINLGTG--SSDIALHFNPRF-DENVIVRNSFLNGNWGPEERSGGFPFQP 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530410586  96 GMPFDLCFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYIS 146
Cdd:cd00070   77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 194-322 3.18e-50

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 163.19  E-value: 3.18e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586 194 PFITTIPGGLYPSKSIILSGTVLPSAQRFHINL-CSGSHIAFHMNPRFDENAVVRNTQINNSWGSEERSlpRKMPFVRGQ 272
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLgTGSSDIALHFNPRFDENVIVRNSFLNGNWGPEERS--GGFPFQPGQ 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 530410586 273 SFSVWILCEAHCLKVAVDGQHVFEYYHRLRnLPTINKLEVGGDIQLTHVQ 322
Cdd:cd00070   79 PFELTILVEEDKFQIFVNGQHFFSFPHRLP-LESIDYLSINGDVSLTSVE 127
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 22-146 5.94e-49

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 159.68  E-value: 5.94e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586    22 QGGLQDGFQITVNGAVLScSGTRFAVDFQTGfSGNDIAFHFNPRFeDGGYVVCNTRQKGTWGPEERKMHMPFQKGMPFDL 101
Cdd:smart00908   1 PGGLSPGSSITIRGIVLP-DAKRFSINLQCG-PNADIALHFNPRF-DEGTIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 530410586   102 CFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYIS 146
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 17-147 1.06e-46

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 153.92  E-value: 1.06e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586    17 FSGTIQGGLQDGFQITVNGAVLScSGTRFAVDFQTGfsGNDIAFHFNPRFEDGgYVVCNTRQKGTWGPEERKMHMPFQKG 96
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLP-DAKRFSINLLTG--GDDIALHFNPRFNEN-KIVCNSKLNGSWGSEEREGGFPFQPG 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 530410586    97 MPFDLCFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYISF 147
Cdd:smart00276  77 QPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 200-322 2.47e-46

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 152.79  E-value: 2.47e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586  200 PGGLYPSKSIILSGTVLPSAQRFHINLCSG----SHIAFHMNPRFDENAVVRNTQINNSWGSEERSLprKMPFVRGQSFS 275
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgpsDDIALHFNPRFDENVIVRNSRQNGQWGQEEREG--GFPFQPGQPFE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 530410586  276 VWILCEAHCLKVAVDGQHVFEYYHRLRNlPTINKLEVGGDIQLTHVQ 322
Cdd:pfam00337  79 LTILVGDDHFKIYVNGQHFTTFKHRLPP-EDIDALQVRGDVKLTSVL 124
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 195-322 8.20e-46

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 151.61  E-value: 8.20e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586   195 FITTIPGGLYPSKSIILSGTVLPSAQRFHINL-CSGSHIAFHMNPRFDENAVVRNTQINNSWGSEERSlpRKMPFVRGQS 273
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLlTGGDDIALHFNPRFNENKIVCNSKLNGSWGSEERE--GGFPFQPGQP 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 530410586   274 FSVWILCEAHCLKVAVDGQHVFEYYHRLrNLPTINKLEVGGDIQLTHVQ 322
Cdd:smart00276  79 FDLTIIVQPDHFQIFVNGVHITTFPHRL-PLESIDYLSINGDVQLTSVS 126
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 22-146 1.51e-45

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 150.87  E-value: 1.51e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410586   22 QGGLQDGFQITVNGAVLScSGTRFAVDFQTG-FSGNDIAFHFNPRFeDGGYVVCNTRQKGTWGPEERKMHMPFQKGMPFD 100
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLP-DAQRFSINLQTGvGPSDDIALHFNPRF-DENVIVRNSRQNGQWGQEEREGGFPFQPGQPFE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 530410586  101 LCFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYIS 146
Cdd:pfam00337  79 LTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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