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nuclear receptor corepressor 1 isoform X4 [Homo sapiens]
nuclear receptor corepressor 1( domain architecture ID 11239196)
nuclear receptor corepressor 1 (NCOR1) is a transcriptional coregulatory protein which assists nuclear receptors in the down regulation of gene expression
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
GPS2_interact super family | cl24372 | G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ... |
149-238 | 2.79e-27 | ||||
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways. The actual alignment was detected with superfamily member pfam15784: Pssm-ID: 464868 [Multi-domain] Cd Length: 89 Bit Score: 107.25 E-value: 2.79e-27
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
628-671 | 6.36e-12 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. : Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 62.14 E-value: 6.36e-12
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
440-482 | 1.31e-04 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. : Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 41.41 E-value: 1.31e-04
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PRK12323 super family | cl46901 | DNA polymerase III subunit gamma/tau; |
684-858 | 1.09e-03 | ||||
DNA polymerase III subunit gamma/tau; The actual alignment was detected with superfamily member PRK08691: Pssm-ID: 481241 [Multi-domain] Cd Length: 709 Bit Score: 44.31 E-value: 1.09e-03
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Name | Accession | Description | Interval | E-value | ||||
GPS2_interact | pfam15784 | G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ... |
149-238 | 2.79e-27 | ||||
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways. Pssm-ID: 464868 [Multi-domain] Cd Length: 89 Bit Score: 107.25 E-value: 2.79e-27
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
628-671 | 6.36e-12 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 62.14 E-value: 6.36e-12
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
628-671 | 1.37e-10 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 58.36 E-value: 1.37e-10
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
628-673 | 2.19e-10 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 58.00 E-value: 2.19e-10
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
440-482 | 1.31e-04 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 41.41 E-value: 1.31e-04
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
438-483 | 4.05e-04 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 40.28 E-value: 4.05e-04
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
440-479 | 5.38e-04 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 39.79 E-value: 5.38e-04
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PRK08691 | PRK08691 | DNA polymerase III subunits gamma and tau; Validated |
684-858 | 1.09e-03 | ||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236333 [Multi-domain] Cd Length: 709 Bit Score: 44.31 E-value: 1.09e-03
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MDN1 | COG5271 | Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
693-911 | 1.64e-03 | ||||
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 43.85 E-value: 1.64e-03
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Name | Accession | Description | Interval | E-value | ||||
GPS2_interact | pfam15784 | G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ... |
149-238 | 2.79e-27 | ||||
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways. Pssm-ID: 464868 [Multi-domain] Cd Length: 89 Bit Score: 107.25 E-value: 2.79e-27
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
628-671 | 6.36e-12 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 62.14 E-value: 6.36e-12
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
628-671 | 1.37e-10 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 58.36 E-value: 1.37e-10
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
628-673 | 2.19e-10 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 58.00 E-value: 2.19e-10
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
440-482 | 1.31e-04 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 41.41 E-value: 1.31e-04
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
438-483 | 4.05e-04 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 40.28 E-value: 4.05e-04
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
440-479 | 5.38e-04 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 39.79 E-value: 5.38e-04
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SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
440-483 | 9.93e-04 | ||||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 39.13 E-value: 9.93e-04
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PRK08691 | PRK08691 | DNA polymerase III subunits gamma and tau; Validated |
684-858 | 1.09e-03 | ||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236333 [Multi-domain] Cd Length: 709 Bit Score: 44.31 E-value: 1.09e-03
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MDN1 | COG5271 | Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
693-911 | 1.64e-03 | ||||
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 43.85 E-value: 1.64e-03
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MDN1 | COG5271 | Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
701-913 | 2.39e-03 | ||||
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 43.46 E-value: 2.39e-03
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Myb_DNA-bind_6 | pfam13921 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
629-676 | 3.19e-03 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 372817 [Multi-domain] Cd Length: 60 Bit Score: 38.06 E-value: 3.19e-03
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PRK13108 | PRK13108 | prolipoprotein diacylglyceryl transferase; Reviewed |
746-914 | 8.08e-03 | ||||
prolipoprotein diacylglyceryl transferase; Reviewed Pssm-ID: 237284 [Multi-domain] Cd Length: 460 Bit Score: 41.50 E-value: 8.08e-03
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Blast search parameters | ||||
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