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Conserved domains on  [gi|530411966|ref|XP_005257299|]
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caveolae-associated protein 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTRF_SDPR super family cl21098
PTRF/SDPR family; This family of proteins includes muscle-related coiled-coil protein (MURC), ...
 48-191 1.93e-61

PTRF/SDPR family; This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway. PRKCDBP appears to act as an immune potentiator. PTRF is involved in caveolae formation and function. SDPR is involved in the targetting of protein kinase Calpha to caveolae.


The actual alignment was detected with superfamily member pfam15237:

Pssm-ID: 464578  Cd Length: 250  Bit Score: 192.63  E-value: 1.93e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411966   48 QVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGS 127
Cdd:pfam15237   1 QVNALTVLSLLDKVAGIVDSVQENQQRMEERQAELENAVKTIQGDVLKLSKSHSSTSNTVNKLLEKTRKVSAHVKEVRAR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530411966  128 LERQAGQIKKLEVNEAELLRRRNFKVMIYQ----------PKKKPNAPSDLATPKIvpfDLPETEPFDLKPETV 191
Cdd:pfam15237  81 VEKQAVQVKKLEANQAELLKRNKFKVVIYQeeneipsslsVKKSPEPSKGSEGGSV---EGNETEEDTLQPPTV 151
 
Name Accession Description Interval E-value
PTRF_SDPR pfam15237
PTRF/SDPR family; This family of proteins includes muscle-related coiled-coil protein (MURC), ...
 48-191 1.93e-61

PTRF/SDPR family; This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway. PRKCDBP appears to act as an immune potentiator. PTRF is involved in caveolae formation and function. SDPR is involved in the targetting of protein kinase Calpha to caveolae.


Pssm-ID: 464578  Cd Length: 250  Bit Score: 192.63  E-value: 1.93e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411966   48 QVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGS 127
Cdd:pfam15237   1 QVNALTVLSLLDKVAGIVDSVQENQQRMEERQAELENAVKTIQGDVLKLSKSHSSTSNTVNKLLEKTRKVSAHVKEVRAR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530411966  128 LERQAGQIKKLEVNEAELLRRRNFKVMIYQ----------PKKKPNAPSDLATPKIvpfDLPETEPFDLKPETV 191
Cdd:pfam15237  81 VEKQAVQVKKLEANQAELLKRNKFKVVIYQeeneipsslsVKKSPEPSKGSEGGSV---EGNETEEDTLQPPTV 151
 
Name Accession Description Interval E-value
PTRF_SDPR pfam15237
PTRF/SDPR family; This family of proteins includes muscle-related coiled-coil protein (MURC), ...
 48-191 1.93e-61

PTRF/SDPR family; This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway. PRKCDBP appears to act as an immune potentiator. PTRF is involved in caveolae formation and function. SDPR is involved in the targetting of protein kinase Calpha to caveolae.


Pssm-ID: 464578  Cd Length: 250  Bit Score: 192.63  E-value: 1.93e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530411966   48 QVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGS 127
Cdd:pfam15237   1 QVNALTVLSLLDKVAGIVDSVQENQQRMEERQAELENAVKTIQGDVLKLSKSHSSTSNTVNKLLEKTRKVSAHVKEVRAR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530411966  128 LERQAGQIKKLEVNEAELLRRRNFKVMIYQ----------PKKKPNAPSDLATPKIvpfDLPETEPFDLKPETV 191
Cdd:pfam15237  81 VEKQAVQVKKLEANQAELLKRNKFKVVIYQeeneipsslsVKKSPEPSKGSEGGSV---EGNETEEDTLQPPTV 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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