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Conserved domains on  [gi|530412233|ref|XP_005257426|]
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microtubule-associated protein tau isoform X11 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 341-370 7.54e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 7.54e-14
                          10        20        30
                  ....*....|....*....|....*....|
gi 530412233  341 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 370
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 372-401 3.54e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 54.72  E-value: 3.54e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 530412233  372 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 401
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 403-433 2.50e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 2.50e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530412233  403 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 433
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 318-339 5.70e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.86  E-value: 5.70e-07
                          10        20
                  ....*....|....*....|..
gi 530412233  318 DLKNVKSKIGSTENLKHQPGGG 339
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 83-328 7.09e-06

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 7.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   83 GAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPK 162
Cdd:PHA03307   25 PATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  163 HPTPGSSDPLIQPSSPAVCPEP-PSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKT 241
Cdd:PHA03307  105 SPTPPGPSSPDPPPPTPPPASPpPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETAR 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  242 PPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKN 321
Cdd:PHA03307  185 APSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264


                  ....*..
gi 530412233  322 VKSKIGS 328
Cdd:PHA03307  265 LPTRIWE 271
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 341-370 7.54e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 7.54e-14
                          10        20        30
                  ....*....|....*....|....*....|
gi 530412233  341 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 370
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 372-401 3.54e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 54.72  E-value: 3.54e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 530412233  372 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 401
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 403-433 2.50e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 2.50e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530412233  403 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 433
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 318-339 5.70e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.86  E-value: 5.70e-07
                          10        20
                  ....*....|....*....|..
gi 530412233  318 DLKNVKSKIGSTENLKHQPGGG 339
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 83-328 7.09e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 7.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   83 GAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPK 162
Cdd:PHA03307   25 PATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  163 HPTPGSSDPLIQPSSPAVCPEP-PSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKT 241
Cdd:PHA03307  105 SPTPPGPSSPDPPPPTPPPASPpPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETAR 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  242 PPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKN 321
Cdd:PHA03307  185 APSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264


                  ....*..
gi 530412233  322 VKSKIGS 328
Cdd:PHA03307  265 LPTRIWE 271
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 48-315 3.08e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   48 LQTPTEDGSEEPGSETS--DAKSTPTAeDVTAPLVDEGAPgkQAAAQPHTEipeGTTAEEAGIGDTPSledEAAGHVTQA 125
Cdd:pfam05109 562 VTTPTPNATIPTLGKTSptSAVTTPTP-NATSPTVGETSP--QANTTNHTL---GGTSSTPVVTSPPK---NATSAVTTG 632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  126 RMVSKSKDGTGSDDKKAKTSTRSSAKTLKNR----PCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSS 201
Cdd:pfam05109 633 QHNITSSSTSSMSLRPSSISETLSPSTSDNStshmPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGP 712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  202 GAKEMKLK-GADGKTKIATPRGA----APPGQKGQA-NATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSR 275
Cdd:pfam05109 713 GNSSTSTKpGEVNVTKGTPPKNAtspqAPSGQKTAVpTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRTR 792

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 530412233  276 -SRTPSLPTPPTREPKKVAVVRTPPKSPSSAksrlqTAPVP 315
Cdd:pfam05109 793 yNATTYLPPSTSSKLRPRWTFTSPPVTTAQA-----TVPVP 828
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 341-370 7.54e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 7.54e-14
                          10        20        30
                  ....*....|....*....|....*....|
gi 530412233  341 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 370
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 372-401 3.54e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 54.72  E-value: 3.54e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 530412233  372 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 401
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 403-433 2.50e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 2.50e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530412233  403 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 433
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 318-339 5.70e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.86  E-value: 5.70e-07
                          10        20
                  ....*....|....*....|..
gi 530412233  318 DLKNVKSKIGSTENLKHQPGGG 339
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 83-328 7.09e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 7.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   83 GAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPK 162
Cdd:PHA03307   25 PATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  163 HPTPGSSDPLIQPSSPAVCPEP-PSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKT 241
Cdd:PHA03307  105 SPTPPGPSSPDPPPPTPPPASPpPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETAR 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  242 PPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKN 321
Cdd:PHA03307  185 APSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264


                  ....*..
gi 530412233  322 VKSKIGS 328
Cdd:PHA03307  265 LPTRIWE 271
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 27-337 8.11e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 8.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   27 GGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEA 106
Cdd:PHA03307   74 GPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPP 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  107 GIGDTPSLEDEAAGHVTQARMVSKSkdgtGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSdplIQPSSPAVCPEPPS 186
Cdd:PHA03307  154 AAGASPAAVASDAASSRQAALPLSS----PEETARAPSSPPAEPPPSTPPAAASPRPPRRSSP---ISASASSPAPAPGR 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  187 SPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQA----NATRIPAKTPPAPKTPPSSGEPPKSGDRSG 262
Cdd:PHA03307  227 SAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAsgwnGPSSRPGPASSSSSPRERSPSPSPSSPGSG 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  263 YSSPGSP------------------------GTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPD 318
Cdd:PHA03307  307 PAPSSPRasssssssressssstssssessrGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPT 386

                         330
                  ....*....|....*....
gi 530412233  319 LKNVKSKIGSTENLKHQPG 337
Cdd:PHA03307  387 RRRARAAVAGRARRRDATG 405
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 46-318 9.63e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 9.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   46 SPLQTPTEDGSEEPGSETSDAKSTPTAEDVtAPLVDEGAPG-----------KQAAAQPHTEIPEGTTAEEAGIGDTPSL 114
Cdd:PHA03307  146 PPPAASPPAAGASPAAVASDAASSRQAALP-LSSPEETARApssppaepppsTPPAAASPRPPRRSSPISASASSPAPAP 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  115 EDEAAGHVTQARMVSKSKDGTGSD--------DKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPS 186
Cdd:PHA03307  225 GRSAADDAGASSSDSSSSESSGCGwgpenecpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPG 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  187 SPKYVSSVTSRTGSSGAKEMKLKGADGKTkiATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSP 266
Cdd:PHA03307  305 SGPAPSSPRASSSSSSSRESSSSSTSSSS--ESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASA 382

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530412233  267 GSP----------GTPGSRSRTPSLPTPPTRepkkvavvRTPPKSPSSAKSRLQTAPVPMPD 318
Cdd:PHA03307  383 GRPtrrraraavaGRARRRDATGRFPAGRPR--------PSPLDAGAASGAFYARYPLLTPS 436
PHA03247 PHA03247
large tegument protein UL36; Provisional
 49-317 1.39e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   49 QTPTEDGSEEPGSetsdAKSTPTAEDVTAPlvDEGAPGKQAAAqphTEIPEGTTAeeAGIGDTPSLEDEAAGHVTQARMV 128
Cdd:PHA03247 2599 RAPVDDRGDPRGP----APPSPLPPDTHAP--DPPPPSPSPAA---NEPDPHPPP--TVPPPERPRDDPAPGRVSRPRRA 2667

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  129 SKSKdgtgsddkkakTSTRSSAKTLKNRPCLSPkhPTPGSSDPLIQPSSPAVCPEPPSSPkYVSSVTSRTGSSGAkemkl 208
Cdd:PHA03247 2668 RRLG-----------RAAQASSPPQRPRRRAAR--PTVGSLTSLADPPPPPPTPEPAPHA-LVSATPLPPGPAAA----- 2728

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  209 kgadGKTKIATPRGAAPPGQKgQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGS--RSRTPSLPTPPT 286
Cdd:PHA03247 2729 ----RQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAslSESRESLPSPWD 2803

                         250       260       270
                  ....*....|....*....|....*....|.
gi 530412233  287 REPKKVAVvrtPPKSPSSAKSRLQTAPVPMP 317
Cdd:PHA03247 2804 PADPPAAV---LAPAAALPPAASPAGPLPPP 2831
PHA03247 PHA03247
large tegument protein UL36; Provisional
 50-317 2.91e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   50 TPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVS 129
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  130 KSKdgTGSDDKKAKTSTRSSAKTLKNRPclSPKHPTPGSSDPLIQPSSPAvcPEPPSSPkyvssvtsrTGSSGAkemklK 209
Cdd:PHA03247 2799 PSP--WDPADPPAAVLAPAAALPPAASP--AGPLPPPTSAQPTAPPPPPG--PPPPSLP---------LGGSVA-----P 2858

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  210 GADGKTKIATPRGAAPPGQKGQANATRIPaktppapktppssgEPPKSgdRSGYSSPGSPGTPgSRSRTPSLPTPPTREP 289
Cdd:PHA03247 2859 GGDVRRRPPSRSPAAKPAAPARPPVRRLA--------------RPAVS--RSTESFALPPDQP-ERPPQPQAPPPPQPQP 2921

                         250       260
                  ....*....|....*....|....*...
gi 530412233  290 KKVAVVRTPPKSPSSAKSRLQTAPVPMP 317
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 48-315 3.08e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233   48 LQTPTEDGSEEPGSETS--DAKSTPTAeDVTAPLVDEGAPgkQAAAQPHTEipeGTTAEEAGIGDTPSledEAAGHVTQA 125
Cdd:pfam05109 562 VTTPTPNATIPTLGKTSptSAVTTPTP-NATSPTVGETSP--QANTTNHTL---GGTSSTPVVTSPPK---NATSAVTTG 632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  126 RMVSKSKDGTGSDDKKAKTSTRSSAKTLKNR----PCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSS 201
Cdd:pfam05109 633 QHNITSSSTSSMSLRPSSISETLSPSTSDNStshmPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGP 712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233  202 GAKEMKLK-GADGKTKIATPRGA----APPGQKGQA-NATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSR 275
Cdd:pfam05109 713 GNSSTSTKpGEVNVTKGTPPKNAtspqAPSGQKTAVpTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRTR 792

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 530412233  276 -SRTPSLPTPPTREPKKVAVVRTPPKSPSSAksrlqTAPVP 315
Cdd:pfam05109 793 yNATTYLPPSTSSKLRPRWTFTSPPVTTAQA-----TVPVP 828
PHA03378 PHA03378
EBNA-3B; Provisional
 159-317 3.36e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.05  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233 159 LSPKHPTPGSSDPLIQPS---SPAVCPEPPSS----PKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPP-GQKG 230
Cdd:PHA03378 633 MRPLRMQPITFNVLVFPTphqPPQVEITPYKPtwtqIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPaAPPG 712

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412233 231 QANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKvAVVRTPPKSPSSAKSRLQ 310
Cdd:PHA03378 713 RAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGA-PTPQPPPQAPPAPQQRPR 791


                 ....*..
gi 530412233 311 TAPVPMP 317
Cdd:PHA03378 792 GAPTPQP 798
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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