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Conserved domains on  [gi|530410953|ref|XP_005257998|]
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AP-2 complex subunit beta isoform X6 [Homo sapiens]

Protein Classification

adaptin domain-containing protein( domain architecture ID 12024537)

adaptin domain-containing protein is a component of an adaptor protein (AP) complex; similar to Saccharomyces cerevisiae AP-3 complex subunit delta

CATH:  1.25.10.10
Gene Ontology:  GO:0015031|GO:0016192
PubMed:  14745134|23424177
SCOP:  4001978

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 11-534 0e+00

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 549.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   11 KKGEIFELKAELN--NEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAV 88
Cdd:pfam01602   2 EKRIQQELARILNsfRDDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   89 NSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDqgFLDSLRDL 168
Cdd:pfam01602  82 NSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRD--FVPELKEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  169 IADSNPMVVANAVAALSEIseSHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRL 248
Cdd:pfam01602 160 LSDKDPGVQSAAVALLYEI--CKNDRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLPKELLEDLLNLL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  249 SHANSAVVLSAVKVLMKFLEllpkdsdyYNMLLKKLAPPLVTLLSGEPE-VQYVALRNINLIVQKRP-EILKQEIKVFFV 326
Cdd:pfam01602 238 QNSNNAVLYETANTIVHLAP--------APELIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEPkAVQHLDLIIFCL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSY 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  406 VVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDN---ADELLESFLEGFHDESTQVQL 482
Cdd:pfam01602 390 VVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNgssPPDLLRSILEVFVLESAKVRA 469

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530410953  483 TLLTAIVKLFLKKPSET--QELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDP 534
Cdd:pfam01602 470 AALTALAKLGLTSPEETtqNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLAD 523
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 11-534 0e+00

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 549.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   11 KKGEIFELKAELN--NEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAV 88
Cdd:pfam01602   2 EKRIQQELARILNsfRDDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   89 NSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDqgFLDSLRDL 168
Cdd:pfam01602  82 NSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRD--FVPELKEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  169 IADSNPMVVANAVAALSEIseSHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRL 248
Cdd:pfam01602 160 LSDKDPGVQSAAVALLYEI--CKNDRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLPKELLEDLLNLL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  249 SHANSAVVLSAVKVLMKFLEllpkdsdyYNMLLKKLAPPLVTLLSGEPE-VQYVALRNINLIVQKRP-EILKQEIKVFFV 326
Cdd:pfam01602 238 QNSNNAVLYETANTIVHLAP--------APELIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEPkAVQHLDLIIFCL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSY 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  406 VVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDN---ADELLESFLEGFHDESTQVQL 482
Cdd:pfam01602 390 VVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNgssPPDLLRSILEVFVLESAKVRA 469

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530410953  483 TLLTAIVKLFLKKPSET--QELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDP 534
Cdd:pfam01602 470 AALTALAKLGLTSPEETtqNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLAD 523
PTZ00429 PTZ00429
beta-adaptin; Provisional
 2-582 3.24e-160

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 481.35  E-value: 3.24e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   2 TDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81
Cdd:PTZ00429  21 TGSKYFAQTRRGEGAELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQP 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  82 DMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGF 161
Cdd:PTZ00429 101 EKALLAVNTFLQDTTNSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHDDMQLFYQQDF 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 162 LDSLRDLIADSNPMVVANAVAALSEISESHPNSnlLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSIC 241
Cdd:PTZ00429 181 KKDLVELLNDNNPVVASNAAAIVCEVNDYGSEK--IESSNEWVNRLVYHLPECNEWGQLYILELLAAQRPSDKESAETLL 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 242 ERVTPRLSHANSAVVLSAVKVLMKfleLLPK-DSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQE 320
Cdd:PTZ00429 259 TRVLPRMSHQNPAVVMGAIKVVAN---LASRcSQELIERCTVRVNTALLTLSRRDAETQYIVCKNIHALLVIFPNLLRTN 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 321 IKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
Cdd:PTZ00429 336 LDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVEVVRAIASLAIKVDSVAPDCANLLLQIVD 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 401 TKVNYVVQeAIVVIRDIFRKYPNKYesIIATLCEN--LDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDEST 478
Cdd:PTZ00429 416 RRPELLPQ-VVTAAKDIVRKYPELL--MLDTLVTDygADEVVEEEAKVSLLWMLGEYCDFIENGKDIIQRFIDTIMEHEQ 492

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 479 QVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTA--KEVVLSEKPLISEETDLIE 556
Cdd:PTZ00429 493 RVQLAILSAAVKMFLRDPQGMEPQLNRVLETVTTHSDDPDVRDRAFAYWRLLSKGITVAqmKKVVHGQMVPVNVDSTFSD 572

                        570       580
                 ....*....|....*....|....*.
gi 530410953 557 PTLLDELICHIGSLASVYHKPPNAFV 582
Cdd:PTZ00429 573 AMTMADLKKSLNTAAIVFARPYQSFL 598
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 21-585 2.30e-149

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 453.80  E-value: 2.30e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  21 ELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNP 100
Cdd:COG5096   27 RLESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 101 LIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
Cdd:COG5096  107 EIRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLIDILKELVADSDPIVIANA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 181 VAALSEISE------SHPNSNLLDlnpqniNKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSA 254
Cdd:COG5096  187 LASLAEIDPelahgySLEVILRIP------QLDLLSLSVSTEWLLLIILEVLTERVPTTPDSAEDFEERLSPPLQHNNAE 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 255 VVLSAVKVLMKFLELLPkdsdyYNMLLKKLAPPLVTLLS-GEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIY 333
Cdd:COG5096  261 VLLIAVKVILRLLVFLP-----SNNLFLISSPPLVTLLAkPESLIQYVLRRNIQIDLEVCSKLLDKVKKLFLIEYNDDIY 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 334 VKLEKLDIMIRLASQANIAQVLAELKEYATE--VDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL---IQTKVNYVVQ 408
Cdd:COG5096  336 IKLEKLDQLTRLADDQNLSQILLELIYYIAEnhIDAEMVSEAIKALGDLASKAESSVNDCISELLELlegVWIRGSYIVQ 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 409 EA-----IVVIR---DIFRKYPNKYESIIAT-LCENLDSLD----EPDARAAM-----IWIVGEYAERI-DNADELLESF 469
Cdd:COG5096  416 EVrivdcISVIRisvLVLRILPNEYPKILLRgLYALEETLElqsrEPRAKSVTdkylgAWLLGEFSDIIpRLEPELLRIA 495

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 470 LEGFHDESTQVQLTLLTAIVKLFLKKPSETQ----ELVQQVLSLATQDSDNPDLRDRGYIYWRLLST-DPVTAKEVVLSE 544
Cdd:COG5096  496 ISNFVDETLEVQYTILMSSVKLIANSIRKAKqcnsELDQDVLRRCFDYVLVPDLRDRARMYSRLLSTpLPEFSDPILCEA 575

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 530410953 545 KPLIS-----EETDLIE--PTLLDELICHI--GSLASVYHKPPNAFVEGS 585
Cdd:COG5096  576 KKSNSqfeiiLSALLTNqtPELLENLRLDFtlGTLSTIPLKPIFNLRKGA 625
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 152-188 2.70e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.87  E-value: 2.70e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530410953   152 NAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEIS 188
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 11-534 0e+00

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 549.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   11 KKGEIFELKAELN--NEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAV 88
Cdd:pfam01602   2 EKRIQQELARILNsfRDDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   89 NSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDqgFLDSLRDL 168
Cdd:pfam01602  82 NSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRD--FVPELKEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  169 IADSNPMVVANAVAALSEIseSHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRL 248
Cdd:pfam01602 160 LSDKDPGVQSAAVALLYEI--CKNDRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLPKELLEDLLNLL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  249 SHANSAVVLSAVKVLMKFLEllpkdsdyYNMLLKKLAPPLVTLLSGEPE-VQYVALRNINLIVQKRP-EILKQEIKVFFV 326
Cdd:pfam01602 238 QNSNNAVLYETANTIVHLAP--------APELIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEPkAVQHLDLIIFCL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSY 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  406 VVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDN---ADELLESFLEGFHDESTQVQL 482
Cdd:pfam01602 390 VVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNgssPPDLLRSILEVFVLESAKVRA 469

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530410953  483 TLLTAIVKLFLKKPSET--QELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDP 534
Cdd:pfam01602 470 AALTALAKLGLTSPEETtqNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLAD 523
PTZ00429 PTZ00429
beta-adaptin; Provisional
 2-582 3.24e-160

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 481.35  E-value: 3.24e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   2 TDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81
Cdd:PTZ00429  21 TGSKYFAQTRRGEGAELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQP 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  82 DMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGF 161
Cdd:PTZ00429 101 EKALLAVNTFLQDTTNSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHDDMQLFYQQDF 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 162 LDSLRDLIADSNPMVVANAVAALSEISESHPNSnlLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSIC 241
Cdd:PTZ00429 181 KKDLVELLNDNNPVVASNAAAIVCEVNDYGSEK--IESSNEWVNRLVYHLPECNEWGQLYILELLAAQRPSDKESAETLL 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 242 ERVTPRLSHANSAVVLSAVKVLMKfleLLPK-DSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQE 320
Cdd:PTZ00429 259 TRVLPRMSHQNPAVVMGAIKVVAN---LASRcSQELIERCTVRVNTALLTLSRRDAETQYIVCKNIHALLVIFPNLLRTN 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 321 IKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
Cdd:PTZ00429 336 LDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVEVVRAIASLAIKVDSVAPDCANLLLQIVD 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 401 TKVNYVVQeAIVVIRDIFRKYPNKYesIIATLCEN--LDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDEST 478
Cdd:PTZ00429 416 RRPELLPQ-VVTAAKDIVRKYPELL--MLDTLVTDygADEVVEEEAKVSLLWMLGEYCDFIENGKDIIQRFIDTIMEHEQ 492

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 479 QVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTA--KEVVLSEKPLISEETDLIE 556
Cdd:PTZ00429 493 RVQLAILSAAVKMFLRDPQGMEPQLNRVLETVTTHSDDPDVRDRAFAYWRLLSKGITVAqmKKVVHGQMVPVNVDSTFSD 572

                        570       580
                 ....*....|....*....|....*.
gi 530410953 557 PTLLDELICHIGSLASVYHKPPNAFV 582
Cdd:PTZ00429 573 AMTMADLKKSLNTAAIVFARPYQSFL 598
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 21-585 2.30e-149

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 453.80  E-value: 2.30e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  21 ELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNP 100
Cdd:COG5096   27 RLESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 101 LIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
Cdd:COG5096  107 EIRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLIDILKELVADSDPIVIANA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 181 VAALSEISE------SHPNSNLLDlnpqniNKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSA 254
Cdd:COG5096  187 LASLAEIDPelahgySLEVILRIP------QLDLLSLSVSTEWLLLIILEVLTERVPTTPDSAEDFEERLSPPLQHNNAE 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 255 VVLSAVKVLMKFLELLPkdsdyYNMLLKKLAPPLVTLLS-GEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIY 333
Cdd:COG5096  261 VLLIAVKVILRLLVFLP-----SNNLFLISSPPLVTLLAkPESLIQYVLRRNIQIDLEVCSKLLDKVKKLFLIEYNDDIY 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 334 VKLEKLDIMIRLASQANIAQVLAELKEYATE--VDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL---IQTKVNYVVQ 408
Cdd:COG5096  336 IKLEKLDQLTRLADDQNLSQILLELIYYIAEnhIDAEMVSEAIKALGDLASKAESSVNDCISELLELlegVWIRGSYIVQ 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 409 EA-----IVVIR---DIFRKYPNKYESIIAT-LCENLDSLD----EPDARAAM-----IWIVGEYAERI-DNADELLESF 469
Cdd:COG5096  416 EVrivdcISVIRisvLVLRILPNEYPKILLRgLYALEETLElqsrEPRAKSVTdkylgAWLLGEFSDIIpRLEPELLRIA 495

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 470 LEGFHDESTQVQLTLLTAIVKLFLKKPSETQ----ELVQQVLSLATQDSDNPDLRDRGYIYWRLLST-DPVTAKEVVLSE 544
Cdd:COG5096  496 ISNFVDETLEVQYTILMSSVKLIANSIRKAKqcnsELDQDVLRRCFDYVLVPDLRDRARMYSRLLSTpLPEFSDPILCEA 575

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 530410953 545 KPLIS-----EETDLIE--PTLLDELICHI--GSLASVYHKPPNAFVEGS 585
Cdd:COG5096  576 KKSNSqfeiiLSALLTNqtPELLENLRLDFtlGTLSTIPLKPIFNLRKGA 625
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 101-265 5.01e-80

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 252.38  E-value: 5.01e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  101 LIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLhdINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
Cdd:pfam12717   1 LIRALAIRTMGCIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCVAKL--ILPDMVKVKGFISELAKLLEDPNPMVVANA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  181 VAALSEISESHPNsNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVLSAV 260
Cdd:pfam12717  79 LAALTEISEKDPN-AIYNLLPDIISKLSDALNECSEWGQIYILDFLASYIPKDKQEAESLVEKLCPRLQHANSAVVLRAI 157


                  ....*
gi 530410953  261 KVLMK 265
Cdd:pfam12717 158 KVILS 162
HEAT COG1413
HEAT repeat [General function prediction only];
96-212 5.53e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 60.80  E-value: 5.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  96 EDPNPLIRALAVRTMGCIRVDKITeylcEPLRKCLKDEDPYVRKTAAVCVAKLHDINAqmvedqgfLDSLRDLIADSNPM 175
Cdd:COG1413   26 ADEDPDVRAAAARALGRLGDPRAV----PALLEALKDPDPEVRAAAAEALGRIGDPEA--------VPALIAALKDEDPE 93

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530410953 176 VVANAVAALSEISeshpnsnlldlNPQNINKLLTALN 212
Cdd:COG1413   94 VRRAAAEALGRLG-----------DPAAVPALLEALK 119
HEAT COG1413
HEAT repeat [General function prediction only];
102-265 1.29e-10

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 59.64  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 102 IRALAVRTMGCIRVDKITEylcePLRKCLKDEDPYVRKTAAVCVAKLHDINAqmvedqgfLDSLRDLIADSNPMVVANAV 181
Cdd:COG1413    1 VRRAAARALGRLGDPAAVP----ALIAALADEDPDVRAAAARALGRLGDPRA--------VPALLEALKDPDPEVRAAAA 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 182 AALSEISeshpnsnlldlNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAqsicerVTPRLSHANSAVVLSAVK 261
Cdd:COG1413   69 EALGRIG-----------DPEAVPALIAALKDEDPEVRRAAAEALGRLGDPAAVPA------LLEALKDPDWEVRRAAAR 131


                 ....
gi 530410953 262 VLMK 265
Cdd:COG1413  132 ALGR 135
SEC21 COG5240
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion];
3-530 4.47e-10

Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion];


Pssm-ID: 227565 [Multi-domain]  Cd Length: 898  Bit Score: 63.09  E-value: 4.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   3 DSKYFTTNKKGEIFELKAELNNEKKEKRKEAVK---KVIAAMTVGK-----DVSSLFPDVVNCMQTDNLELKKLVYLYLM 74
Cdd:COG5240   11 KTKVFTTLTERTLLQDMNESFNKSPVSTRSARKllsNLFYLLSTGElfpeaTATNLFFAILKLFQHKDLYLRQCVYSAIK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  75 NYAKSQPDmAIMAVNSFVKDCEDPNP-LIRALAVRTMGCIrVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVA-KLHDIN 152
Cdd:COG5240   91 ELSKLTED-VLMGTSSIMKDLNGGVPdDVKPMAIRSLFSV-IDGETVYDFERYLNQAFVSTSMARRSAALVVAyHLLPNN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 153 AQMVEDqgFLDSLRDLIAD--SNPMVVANavaalseiSESHPNSNllDLNPQNINKLLTALNECTEWGQIFILDCLSNYN 230
Cdd:COG5240  169 FNQTKR--WLNETQEAVLDlkQFPNQHGN--------EGYEPNGN--PISQYHALGLLYQSKRTDKMAQLKLVEHFRGNA 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 231 PKDDREAQSICERVTPRLSHANSAVVLSAVKVL---------MKFLE---LLPKDSDYY--NMLLKKLAPPLVTLLSGEP 296
Cdd:COG5240  237 SMKNQLAGVLLVRATVELLKENSQALLQLRPFLnswlsdkfeMVFLEaarAVCALSEENvgSQFVDQTVSSLRTFLKSTR 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 297 EV-QYVALRNINLIVQKRPEIL---KQEIKVFFVKYNDPIyvKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRK 372
Cdd:COG5240  317 VVlRFSAMRILNQLAMKYPQKVsvcNKEVESLISDENRTI--STYAITTLLKTGTEETIDRLVNLIPSFVHDMSDGFKII 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 373 AVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV-VIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWI 451
Cdd:COG5240  395 AIDALRSLSLLFPSKKLSYLDFLGSSLLQEGGLEFKKYMVdAISDAMENDPDSKERALEVLCTFIEDCEYHQITVRILGI 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953 452 VGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSET-QELVQQVLSLATQDSDNpDLRDRGYIYWRLL 530
Cdd:COG5240  475 LGREGPRAKTPGKYVRHIYNRLILENNIVRSAAVQALSKFALNISDVVsPQSVENALKRCLNDQDD-EVRDRASFLLRNM 553
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 96-185 1.30e-08

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 52.73  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953   96 EDPNPLIRALAVRTMGCIRVDKITEylcePLRKCLKDEDPYVRKTAAVCVAKLHDINAqmvedqgfLDSLRDLIA-DSNP 174
Cdd:pfam13646  10 RDPDPEVRAAAIRALGRIGDPEAVP----ALLELLKDEDPAVRRAAAEALGKIGDPEA--------LPALLELLRdDDDD 77

                          90
                  ....*....|.
gi 530410953  175 MVVANAVAALS 185
Cdd:pfam13646  78 VVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
96-187 3.63e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.71  E-value: 3.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530410953  96 EDPNPLIRALAVRTMGCIRVDKITEylcePLRKCLKDEDPYVRKTAAVCVAKLHDINAqmvedqgfLDSLRDLIADSNPM 175
Cdd:COG1413   57 KDPDPEVRAAAAEALGRIGDPEAVP----ALIAALKDEDPEVRRAAAEALGRLGDPAA--------VPALLEALKDPDWE 124

                         90
                 ....*....|..
gi 530410953 176 VVANAVAALSEI 187
Cdd:COG1413  125 VRRAAARALGRL 136
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 124-187 6.67e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.94  E-value: 6.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530410953  124 EPLRKCL-KDEDPYVRKTAAVCVAKLHDinaqmvedQGFLDSLRDLIADSNPMVVANAVAALSEI 187
Cdd:pfam13646   2 PALLQALlRDPDPEVRAAAIRALGRIGD--------PEAVPALLELLKDEDPAVRRAAAEALGKI 58
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 152-188 2.70e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.87  E-value: 2.70e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530410953   152 NAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEIS 188
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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