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Conserved domains on  [gi|530416047|ref|XP_005258734|]
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zinc finger CCCH domain-containing protein 4 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 353-374 1.49e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


:

Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.49e-07
                           10        20
                   ....*....|....*....|..
gi 530416047   353 VICKYFVEGRCTWGDHCNFSHD 374
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
ZnF_C3H1 smart00356
zinc finger;
380-404 1.08e-05

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.08e-05
                            10        20
                    ....*....|....*....|....*
gi 530416047    380 KRELCKFYITGFCARAENCPYMHGD 404
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
1005-1244 3.13e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1005 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTdprlqkptdSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRV 1084
Cdd:PRK07003  352 LLRMLAFEPAVTGGGAPGGGVPARVAGAVPAPG---------ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATR 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1085 LAAGGLGqgggggqssvlsgislydPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPfvrksaleQPETGKAG 1164
Cdd:PRK07003  423 AEAPPAA------------------PAPPATADRGDDAADGDAPVPAKANARASADSRCDERDA--------QPPADSGS 476

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1165 ADGGTPTDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPtlfgTVKQTPKTGSGSPFAGNSPAREGEQDAA 1244
Cdd:PRK07003  477 ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA----AAPPAPEARPPTPAAAAPAARAGGAAAA 552
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 856-1082 2.59e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  856 PTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVN---IPLDPLPGHPLRDPRSQLQQFSHIKKDVtlSKPSF 932
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspAANEPDPHPPPTVPPPERPRDDPAPGRV--SRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  933 ARTVLWNPEDLIPLPIPKQDAVPPVPAALQSM-------PTLDPRLHRAATAGP-PNARQRPGASTDSSTQGANLPDFEL 1004
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadpppppPTPEPAPHALVSATPlPPGPAAARQASPALPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1005 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTAS-SRAAKPGPAEAPSPTASPSGDAS--PPATAPYD 1081
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPAAVLAPAAalPPAASPAG 2826


                  .
gi 530416047 1082 P 1082
Cdd:PHA03247 2827 P 2827
 
Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 353-374 1.49e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.49e-07
                           10        20
                   ....*....|....*....|..
gi 530416047   353 VICKYFVEGRCTWGDHCNFSHD 374
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
ZnF_C3H1 smart00356
zinc finger;
380-404 1.08e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.08e-05
                            10        20
                    ....*....|....*....|....*
gi 530416047    380 KRELCKFYITGFCARAENCPYMHGD 404
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 344-426 2.99e-05

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 47.56  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  344 HQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKREL-CKFY-ITGFCARAENCPYMHGDfP------CKLY--HTT 413
Cdd:COG5084    96 HVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSSQGPpCRSFsLKGSCSSGPSCGYSHID-PdsfagnCDQYsgATY 174

                          90
                  ....*....|...
gi 530416047  414 GNCINGDDCMFSH 426
Cdd:COG5084   175 GFCPLGASCKFSH 187
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1005-1244 3.13e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1005 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTdprlqkptdSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRV 1084
Cdd:PRK07003  352 LLRMLAFEPAVTGGGAPGGGVPARVAGAVPAPG---------ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATR 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1085 LAAGGLGqgggggqssvlsgislydPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPfvrksaleQPETGKAG 1164
Cdd:PRK07003  423 AEAPPAA------------------PAPPATADRGDDAADGDAPVPAKANARASADSRCDERDA--------QPPADSGS 476

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1165 ADGGTPTDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPtlfgTVKQTPKTGSGSPFAGNSPAREGEQDAA 1244
Cdd:PRK07003  477 ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA----AAPPAPEARPPTPAAAAPAARAGGAAAA 552
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 384-402 1.75e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 1.75e-04
                           10
                   ....*....|....*....
gi 530416047   384 CKFYITGFCARAENCPYMH 402
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
PHA03247 PHA03247
large tegument protein UL36; Provisional
 856-1082 2.59e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  856 PTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVN---IPLDPLPGHPLRDPRSQLQQFSHIKKDVtlSKPSF 932
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspAANEPDPHPPPTVPPPERPRDDPAPGRV--SRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  933 ARTVLWNPEDLIPLPIPKQDAVPPVPAALQSM-------PTLDPRLHRAATAGP-PNARQRPGASTDSSTQGANLPDFEL 1004
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadpppppPTPEPAPHALVSATPlPPGPAAARQASPALPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1005 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTAS-SRAAKPGPAEAPSPTASPSGDAS--PPATAPYD 1081
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPAAVLAPAAalPPAASPAG 2826


                  .
gi 530416047 1082 P 1082
Cdd:PHA03247 2827 P 2827
ZnF_C3H1 smart00356
zinc finger;
353-374 1.20e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 1.20e-03
                            10        20
                    ....*....|....*....|..
gi 530416047    353 VICKYFVEGRCTWGDHCNFSHD 374
Cdd:smart00356    5 ELCKFFKRGYCPRGDRCKFAHP 26
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 950-1170 4.49e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 41.01  E-value: 4.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047   950 KQDAVPPVPAalqsmPTLDPRLHRAATagppnarqrPGASTDSSTQGANLPDF---------ELLSRILKTVNAtGSSAA 1020
Cdd:TIGR01348   86 KKEAAPAPTA-----GAPAPAAQAQAA---------PAAGQSSGVQEVTVPDIgdiekvtviEVLVKVGDTVSA-DQSLI 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  1021 PGSSDK-------PSDPRVRKAPTDPRLQKPTDST-------ASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLA 1086
Cdd:TIGR01348  151 TLESDKasmevpaPASGVVKSVKVKVGDSVPTGDLiltlsvaGSTPATAPAPASAQPAAQSPAATQPEPAAAPAAAKAQA 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  1087 AGGLGQGGGGGqssvlsgiSLYDPRTPNAGGKATEPAADTgAQPKGAEGNGKSSASKAKEppFVrKSALEQPETGKAGAD 1166
Cdd:TIGR01348  231 PAPQQAGTQNP--------AKVDHAAPAVRRLAREFGVDL-SAVKGTGIKGRILREDVQR--FV-KEPSVRAQAAAASAA 298


                   ....
gi 530416047  1167 GGTP 1170
Cdd:TIGR01348  299 GGAP 302
 
Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 353-374 1.49e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.49e-07
                           10        20
                   ....*....|....*....|..
gi 530416047   353 VICKYFVEGRCTWGDHCNFSHD 374
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 355-373 4.37e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 44.33  E-value: 4.37e-06
                           10
                   ....*....|....*....
gi 530416047   355 CKYFVEGRCTWGDHCNFSH 373
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
380-404 1.08e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.08e-05
                            10        20
                    ....*....|....*....|....*
gi 530416047    380 KRELCKFYITGFCARAENCPYMHGD 404
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 344-426 2.99e-05

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 47.56  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  344 HQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKREL-CKFY-ITGFCARAENCPYMHGDfP------CKLY--HTT 413
Cdd:COG5084    96 HVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSSQGPpCRSFsLKGSCSSGPSCGYSHID-PdsfagnCDQYsgATY 174

                          90
                  ....*....|...
gi 530416047  414 GNCINGDDCMFSH 426
Cdd:COG5084   175 GFCPLGASCKFSH 187
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1005-1244 3.13e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1005 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTdprlqkptdSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRV 1084
Cdd:PRK07003  352 LLRMLAFEPAVTGGGAPGGGVPARVAGAVPAPG---------ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATR 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1085 LAAGGLGqgggggqssvlsgislydPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPfvrksaleQPETGKAG 1164
Cdd:PRK07003  423 AEAPPAA------------------PAPPATADRGDDAADGDAPVPAKANARASADSRCDERDA--------QPPADSGS 476

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1165 ADGGTPTDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPtlfgTVKQTPKTGSGSPFAGNSPAREGEQDAA 1244
Cdd:PRK07003  477 ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA----AAPPAPEARPPTPAAAAPAARAGGAAAA 552
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
953-1133 4.43e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.92  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  953 AVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPdfellsrilktvnaTGSSAAPGSSDKPSDPRV 1032
Cdd:PRK07003  379 AVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAP--------------PAAPAPPATADRGDDAAD 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1033 RKAPTDPRLQKPTDSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLAAGGLGQGGGGgqssvlsgislyDPRT 1112
Cdd:PRK07003  445 GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVP------------DARA 512

                         170       180
                  ....*....|....*....|.
gi 530416047 1113 PNAGGKATEPAADTGAQPKGA 1133
Cdd:PRK07003  513 PAAASREDAPAAAAPPAPEAR 533
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 947-1148 6.61e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 6.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  947 PIPKQDAVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDfellsrilktVNATGSSAAPGSSDK 1026
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPG----------VAAPEHHPKHVAVPD 661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1027 PSDPRVRKAPTDPRLQKPTDSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGIS 1106
Cdd:PRK07764  662 ASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 530416047 1107 LYDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPP 1148
Cdd:PRK07764  742 PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
947-1148 1.39e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  947 PIPKQDAVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDFELLSRILKTVNATGSSAAPGSSDK 1026
Cdd:PRK12323  375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1027 PSDP--RVRKAPTDPRLQKPTDSTASSRAAkPGPAEAPSPTASPSGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSG 1104
Cdd:PRK12323  455 AAAPaaAARPAAAGPRPVAAAAAAAPARAA-PAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATAD 533

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 530416047 1105 ISlyDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPP 1148
Cdd:PRK12323  534 PD--DAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 856-1182 1.60e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  856 PTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVNIPLDPLPGHP--LRDPRSQLQQFSHIKKDVTLSKPSFA 933
Cdd:PHA03307   84 SRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSemLRPVGSPGPPPAASPPAAGASPAAVA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  934 RTVLWNPEDLIPLPIPKQDAVPPVPAAlqsmPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDFELLSRILKTVN 1013
Cdd:PHA03307  164 SDAASSRQAALPLSSPEETARAPSSPP----AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1014 ATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTASSRAAKPGPAEAPSPTASPSGDASPPAtapydPRVLAAGGLGQG 1093
Cdd:PHA03307  240 SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSS-----PGSGPAPSSPRA 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1094 GGGGQSSVLSGISLYDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSAS--KAKEPPFVRKSA-------LEQPETGKAG 1164
Cdd:PHA03307  315 SSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSspRKRPRPSRAPSSpaasagrPTRRRARAAV 394

                         330
                  ....*....|....*...
gi 530416047 1165 ADGGTPTDRYNSYNRPRP 1182
Cdd:PHA03307  395 AGRARRRDATGRFPAGRP 412
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 384-402 1.75e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 1.75e-04
                           10
                   ....*....|....*....
gi 530416047   384 CKFYITGFCARAENCPYMH 402
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
PHA03247 PHA03247
large tegument protein UL36; Provisional
 856-1082 2.59e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  856 PTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVN---IPLDPLPGHPLRDPRSQLQQFSHIKKDVtlSKPSF 932
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspAANEPDPHPPPTVPPPERPRDDPAPGRV--SRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  933 ARTVLWNPEDLIPLPIPKQDAVPPVPAALQSM-------PTLDPRLHRAATAGP-PNARQRPGASTDSSTQGANLPDFEL 1004
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadpppppPTPEPAPHALVSATPlPPGPAAARQASPALPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1005 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTAS-SRAAKPGPAEAPSPTASPSGDAS--PPATAPYD 1081
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPAAVLAPAAalPPAASPAG 2826


                  .
gi 530416047 1082 P 1082
Cdd:PHA03247 2827 P 2827
PHA03247 PHA03247
large tegument protein UL36; Provisional
 945-1237 2.89e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  945 PLPIPKQDAVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDFELLSRILKTVNATGSSAA---- 1020
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepd 2639

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1021 -PGSSDKPSDPRVRKAPTDPRLQKPTDSTASSRAAKP-GPAEAPSPTASP--------SGDASPPATAPYDPRVLAAGGL 1090
Cdd:PHA03247 2640 pHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAsSPPQRPRRRAARptvgsltsLADPPPPPPTPEPAPHALVSAT 2719

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1091 GQGGGGGQSSVLSGISLYDPRTPNAGGKATEPAADTgAQPKGAEGNGKSSASKAKEPPFVRKSALEQPETGKAGADGGTP 1170
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530416047 1171 TDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPTLFGTVKQTPKTGS----GSPFAGNSPAR 1237
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvapGGDVRRRPPSR 2869
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
379-404 3.41e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.10  E-value: 3.41e-04
                           10        20
                   ....*....|....*....|....*..
gi 530416047   379 KKRELCKFY-ITGFCARAENCPYMHGD 404
Cdd:pfam00642    1 YKTELCRFFlRTGYCKYGDRCKFAHGQ 27
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 986-1136 8.80e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 8.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  986 PGASTDsstQGANLPDFELLSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRlqkPTDSTASSRAAKPGPAEAPSPT 1065
Cdd:PRK07764  365 PSASDD---ERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAA---PAAAAAPAPAAAPQPAPAPAPA 438

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530416047 1066 ASPSGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKATEPAADTGAQPKGAEGN 1136
Cdd:PRK07764  439 PAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDA 509
PHA03247 PHA03247
large tegument protein UL36; Provisional
 851-1244 8.85e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 8.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  851 LARALPTSKPEGSLHSSPVGPSSSKgsgpppteEEEGERALREKAVNIPLDP-LPGHPLRDPRSQLQQFSHIKKDVTLSK 929
Cdd:PHA03247 2555 LPPAAPPAAPDRSVPPPRPAPRPSE--------PAVTSRARRPDAPPQSARPrAPVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  930 PSFAR----TVLWNPEDLIPLPIPKQDAVPPVPAAlqSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANL-----P 1000
Cdd:PHA03247 2627 PPPSPspaaNEPDPHPPPTVPPPERPRDDPAPGRV--SRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadpppP 2704

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1001 DFELLSRILKTVNATGSSAAPGSSDK-----PSDPRVRKAPTDPrlqkPTDSTASSRAAKPGPAEAPSPTASPSGDASPP 1075
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQaspalPAAPAPPAVPAGP----ATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1076 ATAPYDPRVLAAGGLGQGGGGGQSSvlsgislyDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPFVRKSAL 1155
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPA--------DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047 1156 E-----------QPETGKAGADGGTPTdRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPTLFGTVKQTPKT 1224
Cdd:PHA03247 2853 GgsvapggdvrrRPPSRSPAAKPAAPA-RPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                         410       420
                  ....*....|....*....|
gi 530416047 1225 GSGSPFAGNSPAREGEQDAA 1244
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAG 2951
ZnF_C3H1 smart00356
zinc finger;
353-374 1.20e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 1.20e-03
                            10        20
                    ....*....|....*....|..
gi 530416047    353 VICKYFVEGRCTWGDHCNFSHD 374
Cdd:smart00356    5 ELCKFFKRGYCPRGDRCKFAHP 26
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 962-1079 1.87e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 42.41  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  962 QSMPTLDPRLHRAAtagppnARQRPGASTDSSTQGANLPDfellsrilktvnatgsSAAPGSSDKPSDPRVRKAPTDPRL 1041
Cdd:PHA03269   22 LNTNIPIPELHTSA------ATQKPDPAPAPHQAASRAPD----------------PAVAPTSAASRKPDLAQAPTPAAS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 530416047 1042 QKPTDSTASSRAA--KPGPAEAPSPTASPSGDAS-PPATAP 1079
Cdd:PHA03269   80 EKFDPAPAPHQAAsrAPDPAVAPQLAAAPKPDAAeAFTSAA 120
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 950-1170 4.49e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 41.01  E-value: 4.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047   950 KQDAVPPVPAalqsmPTLDPRLHRAATagppnarqrPGASTDSSTQGANLPDF---------ELLSRILKTVNAtGSSAA 1020
Cdd:TIGR01348   86 KKEAAPAPTA-----GAPAPAAQAQAA---------PAAGQSSGVQEVTVPDIgdiekvtviEVLVKVGDTVSA-DQSLI 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  1021 PGSSDK-------PSDPRVRKAPTDPRLQKPTDST-------ASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLA 1086
Cdd:TIGR01348  151 TLESDKasmevpaPASGVVKSVKVKVGDSVPTGDLiltlsvaGSTPATAPAPASAQPAAQSPAATQPEPAAAPAAAKAQA 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  1087 AGGLGQGGGGGqssvlsgiSLYDPRTPNAGGKATEPAADTgAQPKGAEGNGKSSASKAKEppFVrKSALEQPETGKAGAD 1166
Cdd:TIGR01348  231 PAPQQAGTQNP--------AKVDHAAPAVRRLAREFGVDL-SAVKGTGIKGRILREDVQR--FV-KEPSVRAQAAAASAA 298


                   ....
gi 530416047  1167 GGTP 1170
Cdd:TIGR01348  299 GGAP 302
PHA03381 PHA03381
tegument protein VP22; Provisional
 977-1084 8.86e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 39.61  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416047  977 AGPPNARqRPGASTDSSTQGAnlpdfellSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTASSRAAKP 1056
Cdd:PHA03381   85 ADPRPSR-RPHAQPEASGPGP--------ARGARGPAGSRGRGRRAESPSPRDPPNPKGASAPRGRKSACADSAALLDAP 155

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 530416047 1057 GPAeAPSPTASPSG--------DASPPATAPYDPRV 1084
Cdd:PHA03381  156 APA-APKRQKTPAGlarklhfsTAPTSPTAPWTPRV 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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