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Conserved domains on  [gi|530417050|ref|XP_005259216|]
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zinc finger protein 574 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
495-848 7.78e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 7.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 495 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 572
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 573 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFllrrllevhqlvvhagrqphrcPSCGAAFPSSL 649
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS----------------------VNTPQSNSLHP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 650 RLREHRCAAAAAQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPGEVLAKEPPAPRAPRATRAPVASPAALGSTATASP 729
Cdd:COG5048  170 PLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 730 AAPARRRGLECSECKKLFSTETSLQV-------HRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC-- 796
Cdd:COG5048  250 SSDSSSSASESPRSSLPTASSQSSSPnesdsssEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpy 326

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530417050 797 EVCGKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 848
Cdd:COG5048  327 SLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
495-848 7.78e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 7.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 495 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 572
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 573 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFllrrllevhqlvvhagrqphrcPSCGAAFPSSL 649
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS----------------------VNTPQSNSLHP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 650 RLREHRCAAAAAQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPGEVLAKEPPAPRAPRATRAPVASPAALGSTATASP 729
Cdd:COG5048  170 PLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 730 AAPARRRGLECSECKKLFSTETSLQV-------HRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC-- 796
Cdd:COG5048  250 SSDSSSSASESPRSSLPTASSQSSSPnesdsssEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpy 326

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530417050 797 EVCGKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 848
Cdd:COG5048  327 SLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
752-777 3.56e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.56e-05
                          10        20
                  ....*....|....*....|....*.
gi 530417050  752 SLQVHRRIHTGERPYPCPDCGKAFRQ 777
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
495-848 7.78e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 7.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 495 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 572
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 573 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFllrrllevhqlvvhagrqphrcPSCGAAFPSSL 649
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS----------------------VNTPQSNSLHP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 650 RLREHRCAAAAAQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPGEVLAKEPPAPRAPRATRAPVASPAALGSTATASP 729
Cdd:COG5048  170 PLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 730 AAPARRRGLECSECKKLFSTETSLQV-------HRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC-- 796
Cdd:COG5048  250 SSDSSSSASESPRSSLPTASSQSSSPnesdsssEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpy 326

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530417050 797 EVCGKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 848
Cdd:COG5048  327 SLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
752-777 3.56e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.56e-05
                          10        20
                  ....*....|....*....|....*.
gi 530417050  752 SLQVHRRIHTGERPYPCPDCGKAFRQ 777
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 757-842 5.22e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 5.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 757 RRIHT-GERPYPCP--DCGKAFRQSTHLKDHRrLHTGERPFACEVCGKAfaismrlaEHRRIHTGERPYSCPDCGKSYRS 833
Cdd:COG5189  340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKN 410


                 ....*....
gi 530417050 834 FSNLWKHRK 842
Cdd:COG5189  411 LNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
764-836 6.06e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 6.06e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530417050 764 RPYPCPDCGKAFRQSTHLKDHRRLHTGERPFACEVCGKAFAISMRLA--EHRRIHTGERPYSCPDCGKSYRSFSN 836
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLPLSNSKAS 106
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
466-585 1.61e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 466 YRCLLCSREFGKALQLTRHQRFV-HRLE--RRHKC--SICGKMFKKKSHVRNHLRTHTGERPFPC--------------- 525
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRSVnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspllnn 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 526 ----------------------PDCSKPFNSPANLARHRLTHTGERP--YRCGDCGKAFTQSSTLRQHRLVHAQHFPYRC 581
Cdd:COG5048  370 eppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449


                 ....
gi 530417050 582 QECG 585
Cdd:COG5048  450 SILK 453
zf-H2C2_2 pfam13465
Zinc-finger double domain;
537-562 1.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.81e-04
                          10        20
                  ....*....|....*....|....*.
gi 530417050  537 NLARHRLTHTGERPYRCGDCGKAFTQ 562
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
780-804 2.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|....*
gi 530417050  780 HLKDHRRLHTGERPFACEVCGKAFA 804
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 519-602 3.79e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 519 GERPFPCP--DCSKPFNSPANLARHRLThtgerpyrcGDCGKAFTQSSTLRQHRLVHAQHFPYRCQECGVRFHRPYRLLM 596
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 530417050 597 HRYHHT 602
Cdd:COG5189  417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
808-833 6.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.43e-04
                          10        20
                  ....*....|....*....|....*.
gi 530417050  808 RLAEHRRIHTGERPYSCPDCGKSYRS 833
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 495-517 6.93e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 6.93e-04
                          10        20
                  ....*....|....*....|...
gi 530417050  495 HKCSICGKMFKKKSHVRNHLRTH 517
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 822-844 8.35e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.35e-04
                          10        20
                  ....*....|....*....|...
gi 530417050  822 YSCPDCGKSYRSFSNLWKHRKTH 844
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 766-788 1.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|...
gi 530417050  766 YPCPDCGKAFRQSTHLKDHRRLH 788
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 530417050  509 HVRNHLRTHTGERPFPCPDCSKPFNS 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 551-573 2.74e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.74e-03
                          10        20
                  ....*....|....*....|...
gi 530417050  551 YRCGDCGKAFTQSSTLRQHRLVH 573
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
792-849 6.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 6.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417050 792 RPFACEVCGKAFAISMRLAEHRRIHTGERPYSCPD--CGKSYRSFSNLWKHRKTHQQQHQ 849
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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