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Conserved domains on  [gi|530425705|ref|XP_005260765|]
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signal-regulatory protein beta-2 isoform X2 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 161-264 2.22e-30

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16097:

Pssm-ID: 472250  Cd Length: 111  Bit Score: 111.88  E-value: 2.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 161 IIQPQELVLGTTGDTVFLNCTVLGDGPPGPIRWFQGAGLSREAIYNFGGISHPKETAV----QASNNDFSILLQNVSSED 236
Cdd:cd16097    2 VIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVsdltKRNNMDFSIRISNITPAD 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 530425705 237 AGTYYCVKFQR--KPNRQYLSGQGTSLKVK 264
Cdd:cd16097   82 AGTYYCVKFRKgsPDDVEFKSGAGTELSVR 111
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 40-150 6.47e-22

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16097:

Pssm-ID: 472250  Cd Length: 111  Bit Score: 89.15  E-value: 6.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  40 QVLQPEGPMLVAEGETLLLRCMVVGSCTDGMIKWVKVSTQDQQEIYNFKRGSFPGVMPMIQRTSEPlNCDYSIYIHNVTR 119
Cdd:cd16097    1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRN-NMDFSIRISNITP 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530425705 120 EHTGTYHCVRF-DGLSEHSEMKSDEGTSVLVK 150
Cdd:cd16097   80 ADAGTYYCVKFrKGSPDDVEFKSGAGTELSVR 111
 
Name Accession Description Interval E-value
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 161-264 2.22e-30

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 111.88  E-value: 2.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 161 IIQPQELVLGTTGDTVFLNCTVLGDGPPGPIRWFQGAGLSREAIYNFGGISHPKETAV----QASNNDFSILLQNVSSED 236
Cdd:cd16097    2 VIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVsdltKRNNMDFSIRISNITPAD 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 530425705 237 AGTYYCVKFQR--KPNRQYLSGQGTSLKVK 264
Cdd:cd16097   82 AGTYYCVKFRKgsPDDVEFKSGAGTELSVR 111
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 40-150 6.47e-22

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 89.15  E-value: 6.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  40 QVLQPEGPMLVAEGETLLLRCMVVGSCTDGMIKWVKVSTQDQQEIYNFKRGSFPGVMPMIQRTSEPlNCDYSIYIHNVTR 119
Cdd:cd16097    1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRN-NMDFSIRISNITP 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530425705 120 EHTGTYHCVRF-DGLSEHSEMKSDEGTSVLVK 150
Cdd:cd16097   80 ADAGTYYCVKFrKGSPDDVEFKSGAGTELSVR 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 43-149 8.72e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.54  E-value: 8.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705   43 QPEGPMLVAEGETLLLRCMVVGSCTDG--MIKWVKVST--QDQQEIYNFKRGSFPGVMPmiQRTS---EPLNCDYSIYIH 115
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEAstSVYWYRQPPgkGPTFLIAYYSNGSEEGVKK--GRFSgrgDPSNGDGSLTIQ 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 530425705  116 NVTREHTGTYHCVRFDglseHSEMKSDEGTSVLV 149
Cdd:pfam07686  79 NLTLSDSGTYTCAVIP----SGEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 163-263 4.01e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.62  E-value: 4.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  163 QPQELVLGTTGDTVFLNCTVLG--DGPPGPIRWFQG--AGLSREAIYNFGGISHPKET--AVQA----SNNDFSILLQNV 232
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmSEASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKkgRFSGrgdpSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 530425705  233 SSEDAGTYYCVKFQRKPNRqylSGQGTSLKV 263
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGV---FGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 168-243 6.59e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.51  E-value: 6.59e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530425705   168 VLGTTGDTVFLNCTVLGDGPPGpIRWFQGAGLSreaiynfggISHPKETAVQASNNDFSILLQNVSSEDAGTYYCV 243
Cdd:smart00410   4 VTVKEGESVTLSCEASGSPPPE-VTWYKQGGKL---------LAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCA 69
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 46-149 5.24e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.11  E-value: 5.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705    46 GPMLVAEGETLLLRCMVVGScTDGMIKWVKvstQDQQEIYNFKRgsfpgvmpmIQRTSEPLNcdYSIYIHNVTREHTGTY 125
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGS-PPPEVTWYK---QGGKLLAESGR---------FSVSRSGST--STLTISNVTPEDSGTY 66

                           90       100
                   ....*....|....*....|....
gi 530425705   126 HCVRFDGLSEHSemksdEGTSVLV 149
Cdd:smart00410  67 TCAATNSSGSAS-----SGTTLTV 85
 
Name Accession Description Interval E-value
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 161-264 2.22e-30

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 111.88  E-value: 2.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 161 IIQPQELVLGTTGDTVFLNCTVLGDGPPGPIRWFQGAGLSREAIYNFGGISHPKETAV----QASNNDFSILLQNVSSED 236
Cdd:cd16097    2 VIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVsdltKRNNMDFSIRISNITPAD 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 530425705 237 AGTYYCVKFQR--KPNRQYLSGQGTSLKVK 264
Cdd:cd16097   82 AGTYYCVKFRKgsPDDVEFKSGAGTELSVR 111
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 40-150 6.47e-22

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 89.15  E-value: 6.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  40 QVLQPEGPMLVAEGETLLLRCMVVGSCTDGMIKWVKVSTQDQQEIYNFKRGSFPGVMPMIQRTSEPlNCDYSIYIHNVTR 119
Cdd:cd16097    1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRN-NMDFSIRISNITP 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530425705 120 EHTGTYHCVRF-DGLSEHSEMKSDEGTSVLVK 150
Cdd:cd16097   80 ADAGTYYCVKFrKGSPDDVEFKSGAGTELSVR 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 161-263 1.76e-15

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 71.60  E-value: 1.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 161 IIQPQELVLGTTGDTVFLNCTVLGDGPPGPIRWFQGA-GLSREAIYNFGGISHP-------KETAVQASNNDFSILLQNV 232
Cdd:cd00099    1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKpGQGPEFLIYLSSSKGKtkggvpgRFSGSRDGTSSFSLTISNL 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 530425705 233 SSEDAGTYYCVKFQRKPNRQYLSGQGTSLKV 263
Cdd:cd00099   81 QPEDSGTYYCAVSESGGTDKLTFGSGTRLTV 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 43-149 8.72e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.54  E-value: 8.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705   43 QPEGPMLVAEGETLLLRCMVVGSCTDG--MIKWVKVST--QDQQEIYNFKRGSFPGVMPmiQRTS---EPLNCDYSIYIH 115
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEAstSVYWYRQPPgkGPTFLIAYYSNGSEEGVKK--GRFSgrgDPSNGDGSLTIQ 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 530425705  116 NVTREHTGTYHCVRFDglseHSEMKSDEGTSVLV 149
Cdd:pfam07686  79 NLTLSDSGTYTCAVIP----SGEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 163-263 4.01e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.62  E-value: 4.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  163 QPQELVLGTTGDTVFLNCTVLG--DGPPGPIRWFQG--AGLSREAIYNFGGISHPKET--AVQA----SNNDFSILLQNV 232
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmSEASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKkgRFSGrgdpSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 530425705  233 SSEDAGTYYCVKFQRKPNRqylSGQGTSLKV 263
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGV---FGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 168-243 6.59e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.51  E-value: 6.59e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530425705   168 VLGTTGDTVFLNCTVLGDGPPGpIRWFQGAGLSreaiynfggISHPKETAVQASNNDFSILLQNVSSEDAGTYYCV 243
Cdd:smart00410   4 VTVKEGESVTLSCEASGSPPPE-VTWYKQGGKL---------LAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCA 69
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 41-149 5.09e-07

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 47.71  E-value: 5.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  41 VLQPEGPMLVAEGETLLLRCMVVGSCTDGMIKWVKvstQDQQE-------IYNFKRGSFPGVMPMIQRTSEPLNcDYSIY 113
Cdd:cd00099    1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWYR---QKPGQgpefliyLSSSKGKTKGGVPGRFSGSRDGTS-SFSLT 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530425705 114 IHNVTREHTGTYHCVRFDGLSeHSEMKSDEGTSVLV 149
Cdd:cd00099   77 ISNLQPEDSGTYYCAVSESGG-TDKLTFGSGTRLTV 111
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 46-149 5.24e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.11  E-value: 5.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705    46 GPMLVAEGETLLLRCMVVGScTDGMIKWVKvstQDQQEIYNFKRgsfpgvmpmIQRTSEPLNcdYSIYIHNVTREHTGTY 125
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGS-PPPEVTWYK---QGGKLLAESGR---------FSVSRSGST--STLTISNVTPEDSGTY 66

                           90       100
                   ....*....|....*....|....
gi 530425705   126 HCVRFDGLSEHSemksdEGTSVLV 149
Cdd:smart00410  67 TCAATNSSGSAS-----SGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 161-243 1.20e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 45.63  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  161 IIQPQELVLGTTGDTVFLNCTVLGDGPPGpIRWFqgaglsreaiYNFGGISHPKETAVQASNNDFSILLQNVSSEDAGTY 240
Cdd:pfam13927   4 ITVSPSSVTVREGETVTLTCEATGSPPPT-ITWY----------KNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTY 72


                  ...
gi 530425705  241 YCV 243
Cdd:pfam13927  73 TCV 75
I-set pfam07679
Immunoglobulin I-set domain;
161-243 1.58e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.01  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  161 IIQPQELVLgTTGDTVFLNCTVLGDGPPgPIRWF-QGAGLSREAIYNfggishpketaVQASNNDFSILLQNVSSEDAGT 239
Cdd:pfam07679   4 TQKPKDVEV-QEGESARFTCTVTGTPDP-EVSWFkDGQPLRSSDRFK-----------VTYEGGTYTLTISNVQPDDSGK 70


                  ....
gi 530425705  240 YYCV 243
Cdd:pfam07679  71 YTCV 74
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 50-127 1.06e-04

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 40.98  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  50 VAEGETLLLRCMVVGSCTDGMIKWVKVstQDQQEIYNFK----RGSFPGVMPMIqrtseplncDYSIYIHNVTREHTGTY 125
Cdd:cd20946   11 VVENQEVILSCKTPKKTSSPRVEWKKL--QRDVTFVVFQnnkiQGDYKGRAEIL---------GTNITIKNVTRSDSGKY 79


                 ..
gi 530425705 126 HC 127
Cdd:cd20946   80 RC 81
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 163-243 1.24e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 40.26  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  163 QPQELVLGTTGDTVFLNCTVLGDGPPGPIRWFQGAGlsreaiynfggiSHPKETAVQASNND---FSILLQNVSSEDAGT 239
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGG------------TLIESLKVKHDNGRttqSSLLISNVTKEDAGT 68


                  ....
gi 530425705  240 YYCV 243
Cdd:pfam00047  69 YTCV 72
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 172-264 1.33e-04

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 41.10  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 172 TGDTVFLNCTVLGDGPPGPIRWFQGAGLSREAIYNFGGiSHPKETAVQASNNDF---SILLQNVSSEDAGTYYCvKFQRK 248
Cdd:cd20940   14 VGDSVELHCEAVGSPIPEIQWWFEGQEPNEICSQLWDG-ARLDRVHINATYHQHatsTISIDNLTEEDTGTYEC-RASND 91

                         90
                 ....*....|....*.
gi 530425705 249 PNRQYLSgqgTSLKVK 264
Cdd:cd20940   92 PDRNHLT---RAPKVK 104
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 176-243 1.93e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 39.23  E-value: 1.93e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530425705 176 VFLNCTVLGDgPPGPIRWFQGAGlsreaiynfgGISHPKETAVQASNNDFSILLQNVSSEDAGTYYCV 243
Cdd:cd00096    1 VTLTCSASGN-PPPTITWYKNGK----------PLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCV 57
IGv smart00406
Immunoglobulin V-Type;
221-242 2.84e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.90  E-value: 2.84e-04
                           10        20
                   ....*....|....*....|..
gi 530425705   221 SNNDFSILLQNVSSEDAGTYYC 242
Cdd:smart00406  58 SKNDVSLTISNLRVEDTGTYYC 79
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 164-243 2.89e-04

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 39.30  E-value: 2.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 164 PQELVLgTTGDTVFLNCTVLGDGPPGpIRWFQGAG---LSREAIYNfggishpketavqasnnDFSILLQNVSSEDAGTY 240
Cdd:cd05725    4 PQNQVV-LVDDSAEFQCEVGGDPVPT-VRWRKEDGelpKGRYEILD-----------------DHSLKIRKVTAGDMGSY 64


                 ...
gi 530425705 241 YCV 243
Cdd:cd05725   65 TCV 67
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 161-264 3.43e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 39.56  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 161 IIQPQELVLGTTGDTVFLNCTVLGDGPPGpIRWF-QGAGLSREAIYNFGGISHPKE-----TAVQASNNDFSILLQNVSS 234
Cdd:cd04983    1 VTQSPQSLSVQEGENVTLNCNYSTSTFYY-LFWYrQYPGQGPQFLIYISSDSGNKKkgrfsATLDKSRKSSSLHISAAQL 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 530425705 235 EDAGTYYCVKFQRKPNRQYLSGQGTSLKVK 264
Cdd:cd04983   80 SDSAVYFCALSESGGTGKLTFGKGTRLTVE 109
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 40-128 3.53e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.70  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705   40 QVLQPEGPMLVAEGETLLLRCMVVGScTDGMIKWvkvstqdqqeiynFKRGSFPGVMPMIQRTSEPLNCdySIYIHNVTR 119
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGS-PPPTITW-------------YKNGEPISSGSTRSRSLSGSNS--TLTISNVTR 66


                  ....*....
gi 530425705  120 EHTGTYHCV 128
Cdd:pfam13927  67 SDAGTYTCV 75
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 163-263 4.41e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 39.65  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 163 QPQELVLGTTGDTVFLNCTVLG-DGPPGPIRWFQ---GAGLSREAIYNF-------GGISHPKETAVQASNNDFSIL-LQ 230
Cdd:cd04982    3 QPQLSITREESKSVTISCKVSGiDFSTTYIHWYRqkpGQALERLLYVSStsavrkdSGKTKNKFEARKDVGKSTSTLtIT 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530425705 231 NVSSEDAGTYYCVKFQRKPNRQY-LSGQGTSLKV 263
Cdd:cd04982   83 NLEKEDSATYYCAYWESGSGYYIkVFGSGTKLIV 116
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 221-263 1.49e-03

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 37.76  E-value: 1.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 530425705 221 SNNDFSILLQNVSSEDAGTYYCVKFQRKPnrqYLSGQGTSLKV 263
Cdd:cd04980   67 SGTDFTLTISSVEPEDAAVYYCQQGYTFP---YTFGGGTKLEI 106
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 160-243 2.20e-03

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 36.60  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 160 WIIQPQELVLGTTGDTVFLNCTVLGDgPPGPIRWFQ-GAGLSREA-IYNFGgishpketavqasnnDFSILLQNVSSEDA 237
Cdd:cd20978    3 FIQKPEKNVVVKGGQDVTLPCQVTGV-PQPKITWLHnGKPLQGPMeRATVE---------------DGTLTIINVQPEDT 66


                 ....*.
gi 530425705 238 GTYYCV 243
Cdd:cd20978   67 GYYGCV 72
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 161-243 2.67e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 36.22  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705  161 IIQPQELVLgTTGDTVFLNCTVLGDGPPGpIRWFQGaglsreaiynfggishpkETAVQASNNDFSillQNVSSEDAGTY 240
Cdd:pfam13895   3 VLTPSPTVV-TEGEPVTLTCSAPGNPPPS-YTWYKD------------------GSAISSSPNFFT---LSVSAEDSGTY 59


                  ...
gi 530425705  241 YCV 243
Cdd:pfam13895  60 TCV 62
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 162-242 5.64e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 36.27  E-value: 5.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705 162 IQPQELVLGTTGDTVFLNCTVLgdgPPGP-----IRWFQGAGLSREAIYNFG---GISHPKE-------TAVQASNNDFS 226
Cdd:cd05718    3 VQVPTEVTGFLGGSVTLPCSLT---SPGTtkitqVTWMKIGAGSSQNVAVFHpqyGPSVPNPyaervefLAARLGLRNAT 79

                         90
                 ....*....|....*.
gi 530425705 227 ILLQNVSSEDAGTYYC 242
Cdd:cd05718   80 LRIRNLRVEDEGNYIC 95
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 49-137 5.89e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.63  E-value: 5.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530425705   49 LVAEGETLLLRCMVVGSCTDGMIKWVKvstQDQQEIYNFKrgsfpgVMPMIQRTSeplncDYSIYIHNVTREHTGTYHCV 128
Cdd:pfam00047   7 TVLEGDSATLTCSASTGSPGPDVTWSK---EGGTLIESLK------VKHDNGRTT-----QSSLLISNVTKEDAGTYTCV 72


                  ....*....
gi 530425705  129 RFDGLSEHS 137
Cdd:pfam00047  73 VNNPGGSAT 81
CD19_double_Ig cd23997
CD19 (Cluster of Differentiation 19), a unique double immunoglobulin (Ig)-fold domain; CD19, ...
 171-242 9.76e-03

CD19 (Cluster of Differentiation 19), a unique double immunoglobulin (Ig)-fold domain; CD19, also known as B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12, and CVID3, is a transmembrane receptor present on various types of B cells, including progenitor, naive, and memory B cells, as well as plasmablasts. Until recently, it was believed to comprise two extracellular immunoglobulin (Ig) structural domains arranged in tandem with C2 topology. However, recent crystal structures have shown that the CD19 extracellular domain contains a unique double Ig domain that is responsible for its binding to proteins such as CD21, CD81, and CD225, which regulate B cell activation and survival. A recent analysis of the CD19 extracellular domain sequence reveals two "Ig domains", but the structure demonstrates that these two domains are not folded independently and connected in tandem. Rather, they fold together as one intertwined domain that can be referred to as a "double Ig" domain. Each of the two regular Ig domain sequences has a noticeably short linker that forms a loop between strands C' and D, rather than allowing the formation of a C" strand. Additionally, the two Ig-domain sequences are separated by a long linker that is structured as a small insertion domain, enabling both Ig sequences to fold together as a unique double Ig-domain. The CD19 domain comprises four "protodomains": two formed by A'B-CC' strands and two by DE-FG strands that interdigitate to form a novel double Ig fold. When analyzing this double Ig domain in terms of the usual Ig-fold, A'B-CC' protodomain of the first Ig sequence combines with DE-FG protodomain of the second, and vice versa. Hence, the second combined Ig fold is inverted, with DE-FG protodomain of the first Ig sequence combining with A'B-CC' protodomain of the second Ig sequence and in that order, as if it were a circular permutation, obtained only through structural folding.


Pssm-ID: 467824  Cd Length: 89  Bit Score: 35.01  E-value: 9.76e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530425705 171 TTGDTVFLNCTV-LGDGPPGPIRWFQGAGLSREAIYNFGGishpKETAVQASNNDFSILLQNVSSEDAGTYYC 242
Cdd:cd23997    6 AEGSTLWLPCLVpPSDGPRGPLTWSRGHPKTPLLSLELGS----PGLWVLVGPLGILLLLPNVSAQMGGFYLC 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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