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Conserved domains on  [gi|578804326|ref|XP_005264000|]
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AF4/FMR2 family member 3 isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
20-473 1.35e-131

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 412.60  E-value: 1.35e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326    20 YEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQsHLVGVPKPG 99
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQ-HLVGIPKNS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   100 VPQTPVNKIDEHFVADSRAQNQPSSICSTTTST---PAAVPV-------QQSKRGTMGWQKAGHPPSDGQ---------- 159
Cdd:pfam05110   80 VPQTPQEKPDQPFFPDKTSGLPPSFHTSSHSQPmgpPSSSSPsvsssqsQKKSQARTEPAHGGHSSSGSQssqrsqgqsr 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   160 ---------------------------------------------------QRATQQGSLRTL-LGDGVGRQQPRAKQVC 187
Cdd:pfam05110  160 skggqeshssshhkrqerredlfscaslshsleelspllsslsspvkplspSHSRQHTGSKAQnSSDHHGKEYSHSKSPR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   188 NVEVGLQTQERPPAMAAKHSSsGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSEtSVHCTSYRGV 267
Cdd:pfam05110  240 DSEAGSHGPESPSTSLLASSS-QLSSQTFPPSLPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPE-DYHGQSYGKL 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   268 PASKPEparAKAKLSKFSIPKQ-GEESRSGEtNSCVEEIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHN 344
Cdd:pfam05110  318 SDLKAN---AKAKLSKLKIPSQpLEQSLSND-VHCVEEILKEMThsWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQ 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   345 NPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSS 424
Cdd:pfam05110  394 NQKQYDAPSKTLPTSQQGTSMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGS 465
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 578804326   425 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 473
Cdd:pfam05110  466 SSDSESSSESDSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
965-1225 1.64e-128

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 465894  Cd Length: 262  Bit Score: 394.81  E-value: 1.64e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   965 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 1044
Cdd:pfam18876    5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326  1045 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGAsgKSTGTPSPMSPNP 1124
Cdd:pfam18876   85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVA--KSTGTPSPLSPMP 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326  1125 SPASSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSS 1204
Cdd:pfam18876  163 SPASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSS 240
                          250       260
                   ....*....|....*....|.
gi 578804326  1205 MEHLVQYSQQGLHWLRNSAHL 1225
Cdd:pfam18876  241 MTELVRYTRQGLHWLRLDAKL 261
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
766-779 1.62e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


:

Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.62e-03
                           10
                   ....*....|....
gi 578804326   766 LWVKIDLTLLSRIP 779
Cdd:pfam18875    1 LVVKIDLSLLSRVP 14
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
20-473 1.35e-131

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 412.60  E-value: 1.35e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326    20 YEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQsHLVGVPKPG 99
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQ-HLVGIPKNS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   100 VPQTPVNKIDEHFVADSRAQNQPSSICSTTTST---PAAVPV-------QQSKRGTMGWQKAGHPPSDGQ---------- 159
Cdd:pfam05110   80 VPQTPQEKPDQPFFPDKTSGLPPSFHTSSHSQPmgpPSSSSPsvsssqsQKKSQARTEPAHGGHSSSGSQssqrsqgqsr 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   160 ---------------------------------------------------QRATQQGSLRTL-LGDGVGRQQPRAKQVC 187
Cdd:pfam05110  160 skggqeshssshhkrqerredlfscaslshsleelspllsslsspvkplspSHSRQHTGSKAQnSSDHHGKEYSHSKSPR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   188 NVEVGLQTQERPPAMAAKHSSsGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSEtSVHCTSYRGV 267
Cdd:pfam05110  240 DSEAGSHGPESPSTSLLASSS-QLSSQTFPPSLPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPE-DYHGQSYGKL 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   268 PASKPEparAKAKLSKFSIPKQ-GEESRSGEtNSCVEEIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHN 344
Cdd:pfam05110  318 SDLKAN---AKAKLSKLKIPSQpLEQSLSND-VHCVEEILKEMThsWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQ 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   345 NPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSS 424
Cdd:pfam05110  394 NQKQYDAPSKTLPTSQQGTSMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGS 465
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 578804326   425 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 473
Cdd:pfam05110  466 SSDSESSSESDSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
965-1225 1.64e-128

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 394.81  E-value: 1.64e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   965 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 1044
Cdd:pfam18876    5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326  1045 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGAsgKSTGTPSPMSPNP 1124
Cdd:pfam18876   85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVA--KSTGTPSPLSPMP 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326  1125 SPASSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSS 1204
Cdd:pfam18876  163 SPASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSS 240
                          250       260
                   ....*....|....*....|.
gi 578804326  1205 MEHLVQYSQQGLHWLRNSAHL 1225
Cdd:pfam18876  241 MTELVRYTRQGLHWLRLDAKL 261
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
766-779 1.62e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.62e-03
                           10
                   ....*....|....
gi 578804326   766 LWVKIDLTLLSRIP 779
Cdd:pfam18875    1 LVVKIDLSLLSRVP 14
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
20-473 1.35e-131

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 412.60  E-value: 1.35e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326    20 YEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQsHLVGVPKPG 99
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQ-HLVGIPKNS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   100 VPQTPVNKIDEHFVADSRAQNQPSSICSTTTST---PAAVPV-------QQSKRGTMGWQKAGHPPSDGQ---------- 159
Cdd:pfam05110   80 VPQTPQEKPDQPFFPDKTSGLPPSFHTSSHSQPmgpPSSSSPsvsssqsQKKSQARTEPAHGGHSSSGSQssqrsqgqsr 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   160 ---------------------------------------------------QRATQQGSLRTL-LGDGVGRQQPRAKQVC 187
Cdd:pfam05110  160 skggqeshssshhkrqerredlfscaslshsleelspllsslsspvkplspSHSRQHTGSKAQnSSDHHGKEYSHSKSPR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   188 NVEVGLQTQERPPAMAAKHSSsGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSEtSVHCTSYRGV 267
Cdd:pfam05110  240 DSEAGSHGPESPSTSLLASSS-QLSSQTFPPSLPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPE-DYHGQSYGKL 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   268 PASKPEparAKAKLSKFSIPKQ-GEESRSGEtNSCVEEIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHN 344
Cdd:pfam05110  318 SDLKAN---AKAKLSKLKIPSQpLEQSLSND-VHCVEEILKEMThsWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQ 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   345 NPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSS 424
Cdd:pfam05110  394 NQKQYDAPSKTLPTSQQGTSMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGS 465
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 578804326   425 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 473
Cdd:pfam05110  466 SSDSESSSESDSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
965-1225 1.64e-128

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 394.81  E-value: 1.64e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326   965 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 1044
Cdd:pfam18876    5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326  1045 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGAsgKSTGTPSPMSPNP 1124
Cdd:pfam18876   85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVA--KSTGTPSPLSPMP 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804326  1125 SPASSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSS 1204
Cdd:pfam18876  163 SPASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSS 240
                          250       260
                   ....*....|....*....|.
gi 578804326  1205 MEHLVQYSQQGLHWLRNSAHL 1225
Cdd:pfam18876  241 MTELVRYTRQGLHWLRLDAKL 261
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
766-779 1.62e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.62e-03
                           10
                   ....*....|....
gi 578804326   766 LWVKIDLTLLSRIP 779
Cdd:pfam18875    1 LVVKIDLSLLSRVP 14
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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