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Conserved domains on  [gi|530396980|ref|XP_005274150|]
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lysosomal Pro-X carboxypeptidase isoform X1 [Homo sapiens]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
1-372 1.19e-87

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member pfam05577:

Pssm-ID: 473884  Cd Length: 434  Bit Score: 271.94  E-value: 1.19e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980    1 MWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNfltSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLA 80
Cdd:pfam05577  51 WLDLAKEFGALVFSLEHRFYGQSRPIGDLSTENLRYLS---SLQALADLASFIKAMNQKFNGLSSSKWITFGGSYSGSLA 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980   81 AWFRMKYPHMVVGALAASAPIWQFEDLVPcgvFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCS 160
Cdd:pfam05577 128 AWFRKKYPHLVVGAVASSAPLLAKVDFKE---YNMVVETSLRQTGGECADAIEQGFAEVEQLLLTKEGRQALSSELQLCP 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  161 PL---TSQDIQHLKDWISETWvnLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYN-YSGQV 236
Cdd:pfam05577 205 PLdqtTDLDQLNFFSNIYSNF--QGVVQYTYDGQGNSTLNGYTIPDMCKIMLNATTTDLILRVEVLIQLFNYLNqKSGNN 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  237 KCLNIS----------ETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFE---PhswnLKELSDDCFQQWG-------VR 296
Cdd:pfam05577 283 STADISyqlanadygdSSYGSYADDRQWTWQTCTEFGFYQTTDSGNQPFGspfP----VTLYIDMCMDVFGasynstkIS 358
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530396980  297 PRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLE 372
Cdd:pfam05577 359 LRVLATNYYYGGADNPNATNVVFVNGDLDPWHALGLGDSTDSSVVPYLIPGAAHCADMYPARPSDSPELKAARALI 434
 
Name Accession Description Interval E-value
Peptidase_S28 pfam05577
Serine carboxypeptidase S28; These serine proteases include several eukaryotic enzymes such as ...
1-372 1.19e-87

Serine carboxypeptidase S28; These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase.


Pssm-ID: 310284  Cd Length: 434  Bit Score: 271.94  E-value: 1.19e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980    1 MWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNfltSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLA 80
Cdd:pfam05577  51 WLDLAKEFGALVFSLEHRFYGQSRPIGDLSTENLRYLS---SLQALADLASFIKAMNQKFNGLSSSKWITFGGSYSGSLA 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980   81 AWFRMKYPHMVVGALAASAPIWQFEDLVPcgvFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCS 160
Cdd:pfam05577 128 AWFRKKYPHLVVGAVASSAPLLAKVDFKE---YNMVVETSLRQTGGECADAIEQGFAEVEQLLLTKEGRQALSSELQLCP 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  161 PL---TSQDIQHLKDWISETWvnLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYN-YSGQV 236
Cdd:pfam05577 205 PLdqtTDLDQLNFFSNIYSNF--QGVVQYTYDGQGNSTLNGYTIPDMCKIMLNATTTDLILRVEVLIQLFNYLNqKSGNN 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  237 KCLNIS----------ETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFE---PhswnLKELSDDCFQQWG-------VR 296
Cdd:pfam05577 283 STADISyqlanadygdSSYGSYADDRQWTWQTCTEFGFYQTTDSGNQPFGspfP----VTLYIDMCMDVFGasynstkIS 358
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530396980  297 PRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLE 372
Cdd:pfam05577 359 LRVLATNYYYGGADNPNATNVVFVNGDLDPWHALGLGDSTDSSVVPYLIPGAAHCADMYPARPSDSPELKAARALI 434
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
13-110 2.69e-05

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 44.99  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  13 VFA-EHRYYGESlpfgdnsfkDSRHLNFLTSEQALADFAELIKHLKRtipgAENQPVIAIGGSYGGMLAAWFRMKYPHMv 91
Cdd:COG2267   58 VLAfDLRGHGRS---------DGPRGHVDSFDDYVDDLRAALDALRA----RPGLPVVLLGHSMGGLIALLYAARYPDR- 123
                         90
                 ....*....|....*....
gi 530396980  92 VGALAASAPIWQFEDLVPC 110
Cdd:COG2267  124 VAGLVLLAPAYRADPLLGP 142
 
Name Accession Description Interval E-value
Peptidase_S28 pfam05577
Serine carboxypeptidase S28; These serine proteases include several eukaryotic enzymes such as ...
1-372 1.19e-87

Serine carboxypeptidase S28; These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase.


Pssm-ID: 310284  Cd Length: 434  Bit Score: 271.94  E-value: 1.19e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980    1 MWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNfltSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLA 80
Cdd:pfam05577  51 WLDLAKEFGALVFSLEHRFYGQSRPIGDLSTENLRYLS---SLQALADLASFIKAMNQKFNGLSSSKWITFGGSYSGSLA 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980   81 AWFRMKYPHMVVGALAASAPIWQFEDLVPcgvFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCS 160
Cdd:pfam05577 128 AWFRKKYPHLVVGAVASSAPLLAKVDFKE---YNMVVETSLRQTGGECADAIEQGFAEVEQLLLTKEGRQALSSELQLCP 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  161 PL---TSQDIQHLKDWISETWvnLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYN-YSGQV 236
Cdd:pfam05577 205 PLdqtTDLDQLNFFSNIYSNF--QGVVQYTYDGQGNSTLNGYTIPDMCKIMLNATTTDLILRVEVLIQLFNYLNqKSGNN 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  237 KCLNIS----------ETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFE---PhswnLKELSDDCFQQWG-------VR 296
Cdd:pfam05577 283 STADISyqlanadygdSSYGSYADDRQWTWQTCTEFGFYQTTDSGNQPFGspfP----VTLYIDMCMDVFGasynstkIS 358
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530396980  297 PRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLE 372
Cdd:pfam05577 359 LRVLATNYYYGGADNPNATNVVFVNGDLDPWHALGLGDSTDSSVVPYLIPGAAHCADMYPARPSDSPELKAARALI 434
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
13-110 2.69e-05

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 44.99  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  13 VFA-EHRYYGESlpfgdnsfkDSRHLNFLTSEQALADFAELIKHLKRtipgAENQPVIAIGGSYGGMLAAWFRMKYPHMv 91
Cdd:COG2267   58 VLAfDLRGHGRS---------DGPRGHVDSFDDYVDDLRAALDALRA----RPGLPVVLLGHSMGGLIALLYAARYPDR- 123
                         90
                 ....*....|....*....
gi 530396980  92 VGALAASAPIWQFEDLVPC 110
Cdd:COG2267  124 VAGLVLLAPAYRADPLLGP 142
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
43-109 4.59e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 38.35  E-value: 4.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530396980   43 EQALADFAELIKHLKRTIPGaenQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVP 109
Cdd:pfam12146  56 DDYVDDLDTFVDKIREEHPG---LPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLAP 119
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
41-93 5.80e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 38.06  E-value: 5.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530396980  41 TSEQALADFAELIKHLKRtipgaenQPVIAIGGSYGGMLAAWFRMKYPHMVVG 93
Cdd:COG0596   71 TLDDLADDLAALLDALGL-------ERVVLVGHSMGGMVALELAARHPERVAG 116
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
43-144 9.25e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 37.30  E-value: 9.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396980  43 EQALADFAELIKHLKRTiPGAENQPVIAIGGSYGGMLAAWFRMKYPHmVVGALAASAPIWQFEDLVPCGVFMkivtTDFR 122
Cdd:COG1506   71 GDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHPD-RFKAAVALAGVSDLRSYYGTTREY----TERL 144
                         90       100
                 ....*....|....*....|..
gi 530396980 123 KSGPHCSESIHRSWDAINRLSN 144
Cdd:COG1506  145 MGGPWEDPEAYAARSPLAYADK 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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