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Conserved domains on  [gi|530396998|ref|XP_005274159|]
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integral membrane protein GPR137 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPR137A cd21474
Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G ...
16-325 0e+00

Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137A, also called GPR137 or transmembrane 7 superfamily member 1-like 1 protein (TM7SF1L1), is an orphan G protein-coupled receptor (GPCR) expressed in the central nervous system (CNS), endocrine gland, thymus, and lung. It is associated with different cancers including gastric cancer, pancreatic cancer, colon cancer, and malignant glioma. It is highly expressed in ovarian cancer and plays a pro-oncogenic role in the disease, promoting cell proliferation and metastasis through regulation of the PI3K/AKT pathway. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 410551  Cd Length: 310  Bit Score: 538.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  16 PALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPF 95
Cdd:cd21474    1 PAVPPAVKLGLTALYTTLYALLFLSVYAQLWLVLLYRHKRLSYQTVFLFLCLLWAALRTTLFSFYFRDTLKANHLGPFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  96 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVR 175
Cdd:cd21474   81 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKAKFRPEMSKGLLAVRGACLGASLLFLLVNVACAVLVRMRRAEPWALVLVR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 176 VLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALAPQSRLDTFDYDW 255
Cdd:cd21474  161 VLINDSLFVLCAVSLAACLCLVARRSPSTSIYLEAKGTTVCQTAAMGGAVILLYASRACYNLAALALSPRTRLDAFDYDW 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 256 YNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRA 325
Cdd:cd21474  241 YNVSDQADLITDLGDKGYLVFGLILFVWELLPTALLVGFFRVRRPPQDLSASRIINGQSFGSRSYFFDNP 310
 
Name Accession Description Interval E-value
7tm_GPR137A cd21474
Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G ...
16-325 0e+00

Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137A, also called GPR137 or transmembrane 7 superfamily member 1-like 1 protein (TM7SF1L1), is an orphan G protein-coupled receptor (GPCR) expressed in the central nervous system (CNS), endocrine gland, thymus, and lung. It is associated with different cancers including gastric cancer, pancreatic cancer, colon cancer, and malignant glioma. It is highly expressed in ovarian cancer and plays a pro-oncogenic role in the disease, promoting cell proliferation and metastasis through regulation of the PI3K/AKT pathway. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410551  Cd Length: 310  Bit Score: 538.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  16 PALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPF 95
Cdd:cd21474    1 PAVPPAVKLGLTALYTTLYALLFLSVYAQLWLVLLYRHKRLSYQTVFLFLCLLWAALRTTLFSFYFRDTLKANHLGPFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  96 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVR 175
Cdd:cd21474   81 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKAKFRPEMSKGLLAVRGACLGASLLFLLVNVACAVLVRMRRAEPWALVLVR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 176 VLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALAPQSRLDTFDYDW 255
Cdd:cd21474  161 VLINDSLFVLCAVSLAACLCLVARRSPSTSIYLEAKGTTVCQTAAMGGAVILLYASRACYNLAALALSPRTRLDAFDYDW 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 256 YNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRA 325
Cdd:cd21474  241 YNVSDQADLITDLGDKGYLVFGLILFVWELLPTALLVGFFRVRRPPQDLSASRIINGQSFGSRSYFFDNP 310
 
Name Accession Description Interval E-value
7tm_GPR137A cd21474
Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G ...
16-325 0e+00

Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137A, also called GPR137 or transmembrane 7 superfamily member 1-like 1 protein (TM7SF1L1), is an orphan G protein-coupled receptor (GPCR) expressed in the central nervous system (CNS), endocrine gland, thymus, and lung. It is associated with different cancers including gastric cancer, pancreatic cancer, colon cancer, and malignant glioma. It is highly expressed in ovarian cancer and plays a pro-oncogenic role in the disease, promoting cell proliferation and metastasis through regulation of the PI3K/AKT pathway. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410551  Cd Length: 310  Bit Score: 538.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  16 PALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPF 95
Cdd:cd21474    1 PAVPPAVKLGLTALYTTLYALLFLSVYAQLWLVLLYRHKRLSYQTVFLFLCLLWAALRTTLFSFYFRDTLKANHLGPFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  96 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVR 175
Cdd:cd21474   81 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKAKFRPEMSKGLLAVRGACLGASLLFLLVNVACAVLVRMRRAEPWALVLVR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 176 VLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALAPQSRLDTFDYDW 255
Cdd:cd21474  161 VLINDSLFVLCAVSLAACLCLVARRSPSTSIYLEAKGTTVCQTAAMGGAVILLYASRACYNLAALALSPRTRLDAFDYDW 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 256 YNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRA 325
Cdd:cd21474  241 YNVSDQADLITDLGDKGYLVFGLILFVWELLPTALLVGFFRVRRPPQDLSASRIINGQSFGSRSYFFDNP 310
7tm_GPR137 cd21464
GPR137 family belonging to the seven-transmembrane G protein-coupled receptor superfamily; The ...
16-323 1.16e-146

GPR137 family belonging to the seven-transmembrane G protein-coupled receptor superfamily; The GPR137 family includes GPR137A, GPR137B, and GPR137C, which are all orphan G protein-coupled receptors (GPCRs). GPR137A, also called GPR137 or transmembrane 7 superfamily member 1-like 1 protein (TM7SF1L1), is expressed in the central nervous system (CNS), endocrine gland, thymus, and lung. It is associated with different cancers including gastric cancer, pancreatic cancer, colon cancer, and malignant glioma. GPR137B, also called transmembrane 7 superfamily member 1 (TM7SF1), is a lysosome integral membrane protein that is strongly expressed in the heart, liver, kidney, and brain. It is associated with M2 macrophage polarization, and has been shown to perform a regulatory function in controlling dynamic Rag and mTORC1 localization and activity, as well as lysosome morphology. GPR137C, also called transmembrane 7 superfamily member 1-like 2 protein (TM7SF1L2), may be a key player in the prognosis of small cell lung cancer. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410550  Cd Length: 310  Bit Score: 418.94  E-value: 1.16e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  16 PALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPF 95
Cdd:cd21464    1 PALSPAVHLGLTIVFTVLYALLFIFVYVQLWLILYYRHKRLSYQTVFLFLCLLWSGLRTTLFSFYFKNCILANNLSFFPY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  96 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKVKRRpEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRR----RAQPWAL 171
Cdd:cd21464   81 WLLYCFPVCLQFLTLCLLVLYFAQVVFKARAKYY-EPSRYKKPLRLLFVLANLLFLATNITCAVLVREYqatdRSVLKAL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 172 LLVRVLVSDSLFVICALSLAACLCLVARRAPStSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALaPQSRLDTF 251
Cdd:cd21464  160 VLTRVIINDLLFVLAAIVLSICIYKITKMSSA-NVLLEAKGTTVCQAIAVCIIIILLYVSRAVYNIIAVSP-SSSKLPSF 237
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530396998 252 DYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFD 323
Cdd:cd21464  238 GYGWINVSDQADLVNLLSGYAYISFGVVLFVWEFLPTFIVVLFFRVRRPQTDLLLSSDISSSSTNSRSYFFD 309
7tm_GPR137B cd21476
Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G ...
16-323 4.24e-128

Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137B, also called transmembrane 7 superfamily member 1 (TM7SF1), is a lysosome integral membrane protein that is strongly expressed in the heart, liver, kidney, and brain. It is an orphan G protein-coupled receptor (GPCR) associated with M2 macrophage polarization, and has been shown to perform a regulatory function in controlling dynamic Rag and mTORC1 localization and activity, as well as lysosome morphology. It also plays a role in bone remodeling in mouse and zebrafish, functioning as a negative regulator of osteoclast activity essential for normal resorption and patterning of the skeleton. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410553  Cd Length: 320  Bit Score: 372.22  E-value: 4.24e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  16 PALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPF 95
Cdd:cd21476    1 PAVPPYVKLGLTAVYTVFYALLFVFIYVQLWLVLRYRHKRFSYQTVFLFLCLFWASLRTVLFSFYFRDFVAANSLSPFVF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  96 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVR 175
Cdd:cd21476   81 WLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLLFLLVNLTCAVLVKTGNWERKVIVSVR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 176 VLVSDSLFVICALSLAACLCLVARRAPStSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALAPQSRLDTFDYDW 255
Cdd:cd21476  161 VAINDTLFVLCAVSLSICLYKISKMSLA-NIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQIKSVHSFDYDW 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530396998 256 YNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFD 323
Cdd:cd21476  240 YNVSDQADLKSQLGDAGYVVFGVILFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFD 307
7tm_GPR137C cd21475
Integral membrane protein GPR137C, an orphan receptor member of the seven-transmembrane G ...
16-323 4.50e-121

Integral membrane protein GPR137C, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137C, also called transmembrane 7 superfamily member 1-like 2 protein (TM7SF1L2), is an orphan G protein-coupled receptor (GPCR) of unknown function. Bioinformatics analysis identified it as a likely key player in the prognosis of small cell lung cancer. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410552  Cd Length: 319  Bit Score: 354.48  E-value: 4.50e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  16 PALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPF 95
Cdd:cd21475    1 AAVPPSVELGLTVLYTVLYSALFLFAYLQLWLLLHYRHKRLSYQSLFLFLCLLWAALRTTLFSFYFKNCVQANQLQPFPH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998  96 WLLYCCPVCLQFFTLTLMNLYFAQVVFKAKVKrrPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHR---RRAQPWAlL 172
Cdd:cd21475   81 WLLYCFPVCLQFFTLCLLNLYFAQVIFKAKCA--PELNKYKIPLRLGFLLASLLFLVVNLTCAMLVHGdvpENQLKWT-V 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396998 173 LVRVLVSDSLFVICALSLAACLCLVARRApSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTALALAPQSRLDTFD 252
Cdd:cd21475  158 LARVLINDSLFVLCAISLACCIFKIAKMS-SANVYLESKGTSVCQAVAVGSVVILLYSSRACYNLVVVAISPEDRPSPFN 236
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530396998 253 YDWYNVSDQADlVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFD 323
Cdd:cd21475  237 YGWDNVSDQAD-VEKISGEEYVVFGIVLFFWELLPTSLVVLFFRAQRLNQNLAPAGMINSHSFSSRAYFFD 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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