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Conserved domains on  [gi|564356682|ref|XP_006240412|]
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latent-transforming growth factor beta-binding protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 687-730 1.92e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 66.15  E-value: 1.92e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564356682   687 GTCTLPLVQRITKQICCCSRVGKAWGSKCEHCPLPGTEAFREIC 730
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1433-1473 1.10e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 52.67  E-value: 1.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564356682  1433 CSQILGQNSTQAECCC-TQGARWGETCDPCPSEDSVEFSELC 1473
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1603-1646 2.34e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 564356682  1603 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1646
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1313-1346 3.25e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 3.25e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 564356682   1313 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 1346
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
940-970 2.78e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.78e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 564356682    940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGY 970
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1145-1175 2.84e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 2.84e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682  1145 DVDECEGPQNSC-LGGECKNTDGSYQCLCPQG 1175
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1020-1051 4.82e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.82e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682   1020 DMNECLTPGICAHG-RCINMEGSFRCSCEPGYE 1051
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1186-1227 5.75e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.75e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564356682   1186 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFasaEGGTRCQ 1227
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1228-1259 8.34e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.34e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682   1228 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1259
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 897-931 1.86e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564356682  897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYTLAT 931
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1784-1818 5.60e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564356682   1784 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 1818
Cdd:smart00179    1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
628-657 2.17e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.17e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 564356682    628 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 657
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 980-1015 3.57e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.57e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 564356682  980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYIGQS 1015
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1103-1133 5.11e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 5.11e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564356682  1103 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 1133
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1061-1102 7.73e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.73e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564356682   1061 DVDECASRASCPTG-LCLNTEGSFTCSaCQSGYwvnEDGTACE 1102
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
PHA03378 super family cl33729
EBNA-3B; Provisional
 756-854 1.89e-03

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356682  756 ASPVREQRQQSSGPPPGAAERQPLRAATATWIEAETLPDKGDSRAIQITTSAPHlPARVPGDATGRPTPSLPGQGIPE-- 833
Cdd:PHA03378  709 APPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAPPApq 787

                          90       100
                  ....*....|....*....|....*....
gi 564356682  834 -----GPA---EEQVIPSSDVLVTHGPPG 854
Cdd:PHA03378  788 qrprgAPTpqpPPQAGPTSMQLMPRAAPG 816
EGF_CA smart00179
Calcium-binding EGF-like domain;
1495-1528 2.20e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.20e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 564356682   1495 DADECILFGPalCQNG-RCLNTVPGYICLCNPGYH 1528
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-601 8.20e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 8.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564356682   567 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 601
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 687-730 1.92e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 66.15  E-value: 1.92e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564356682   687 GTCTLPLVQRITKQICCCSRVGKAWGSKCEHCPLPGTEAFREIC 730
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1433-1473 1.10e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 52.67  E-value: 1.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564356682  1433 CSQILGQNSTQAECCC-TQGARWGETCDPCPSEDSVEFSELC 1473
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1603-1646 2.34e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 564356682  1603 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1646
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1313-1346 3.25e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 3.25e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 564356682   1313 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 1346
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1313-1345 4.33e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.33e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564356682 1313 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1345
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
940-970 2.78e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.78e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 564356682    940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGY 970
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1145-1175 2.84e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 2.84e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682  1145 DVDECEGPQNSC-LGGECKNTDGSYQCLCPQG 1175
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1020-1051 4.82e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.82e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682   1020 DMNECLTPGICAHG-RCINMEGSFRCSCEPGYE 1051
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1186-1227 5.75e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.75e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564356682   1186 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFasaEGGTRCQ 1227
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 940-970 6.56e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.56e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 564356682  940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGY 970
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1228-1259 8.34e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.34e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682   1228 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1259
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1145-1185 1.71e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 564356682   1145 DVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQlaNGTVCE 1185
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 897-931 1.86e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564356682  897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYTLAT 931
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1020-1053 1.95e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564356682 1020 DMNECLTPGIC-AHGRCINMEGSFRCSCEPGYELT 1053
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1228-1259 3.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.12e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564356682 1228 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1259
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1186-1227 3.99e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.99e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564356682 1186 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFAsaegGTRCQ 1227
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
897-928 4.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.26e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682    897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYT 928
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1784-1818 5.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564356682   1784 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 1818
Cdd:smart00179    1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1145-1180 8.84e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 8.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564356682 1145 DVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQLAN 1180
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
628-657 2.17e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.17e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 564356682    628 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 657
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
1313-1343 2.49e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.49e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682  1313 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 1343
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1228-1257 2.54e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.54e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682  1228 DVDECAT-TEPC-LGGHCVNTEGSFNCLCETG 1257
Cdd:pfam07645    1 DVDECATgTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 980-1015 3.57e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.57e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 564356682  980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYIGQS 1015
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1103-1133 5.11e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 5.11e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564356682  1103 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 1133
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 628-661 5.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 5.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564356682  628 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 661
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1784-1818 7.61e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564356682 1784 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 1818
Cdd:cd00054     1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1061-1102 7.73e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.73e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564356682   1061 DVDECASRASCPTG-LCLNTEGSFTCSaCQSGYwvnEDGTACE 1102
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
940-969 1.30e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.30e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682   940 DVDECEQPG-VC-SGGRCSNTEGSYHCECDQG 969
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1784-1817 1.69e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 564356682  1784 DVNECEDlngPAALC-AHGHCENTEGSYRCHCSPG 1817
Cdd:pfam07645    1 DVDECAT---GTHNCpANTVCVNTIGSFECRCPDG 32
PHA03378 PHA03378
EBNA-3B; Provisional
 756-854 1.89e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356682  756 ASPVREQRQQSSGPPPGAAERQPLRAATATWIEAETLPDKGDSRAIQITTSAPHlPARVPGDATGRPTPSLPGQGIPE-- 833
Cdd:PHA03378  709 APPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAPPApq 787

                          90       100
                  ....*....|....*....|....*....
gi 564356682  834 -----GPA---EEQVIPSSDVLVTHGPPG 854
Cdd:PHA03378  788 qrprgAPTpqpPPQAGPTSMQLMPRAAPG 816
EGF_CA smart00179
Calcium-binding EGF-like domain;
1495-1528 2.20e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.20e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 564356682   1495 DADECILFGPalCQNG-RCLNTVPGYICLCNPGYH 1528
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1103-1144 2.65e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564356682   1103 DLDECAFPGVCPTG-VCTNTVGSFSCkDCDRGFRPsplGNSCE 1144
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRC-ECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
980-1011 3.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.01e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682    980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGY 1011
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGY 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 901-928 4.48e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.48e-03
                           10        20
                   ....*....|....*....|....*...
gi 564356682   901 CLRNPCEGRGRCVNSVGSYSCLCYPGYT 928
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1103-1144 6.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 564356682 1103 DLDECAFPGVC-PTGVCTNTVGSFSCkDCDRGFRpsplGNSCE 1144
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRC-SCPPGYT----GRNCE 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-601 8.20e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 8.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564356682   567 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 601
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 687-730 1.92e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 66.15  E-value: 1.92e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564356682   687 GTCTLPLVQRITKQICCCSRVGKAWGSKCEHCPLPGTEAFREIC 730
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1433-1473 1.10e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 52.67  E-value: 1.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 564356682  1433 CSQILGQNSTQAECCC-TQGARWGETCDPCPSEDSVEFSELC 1473
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1603-1646 2.34e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 564356682  1603 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1646
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1313-1346 3.25e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 3.25e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 564356682   1313 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 1346
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1313-1345 4.33e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.33e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564356682 1313 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1345
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
940-970 2.78e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.78e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 564356682    940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGY 970
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1145-1175 2.84e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 2.84e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682  1145 DVDECEGPQNSC-LGGECKNTDGSYQCLCPQG 1175
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1020-1051 4.82e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.82e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682   1020 DMNECLTPGICAHG-RCINMEGSFRCSCEPGYE 1051
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1186-1227 5.75e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.75e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 564356682   1186 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFasaEGGTRCQ 1227
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 940-970 6.56e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.56e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 564356682  940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGY 970
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1228-1259 8.34e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.34e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682   1228 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1259
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1145-1185 1.71e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 564356682   1145 DVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQlaNGTVCE 1185
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 897-931 1.86e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564356682  897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYTLAT 931
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1020-1053 1.95e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564356682 1020 DMNECLTPGIC-AHGRCINMEGSFRCSCEPGYELT 1053
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1228-1259 3.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.12e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564356682 1228 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1259
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1186-1227 3.99e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.99e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564356682 1186 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFAsaegGTRCQ 1227
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
897-928 4.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.26e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682    897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYT 928
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1784-1818 5.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 564356682   1784 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 1818
Cdd:smart00179    1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1145-1180 8.84e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 8.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564356682 1145 DVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQLAN 1180
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
628-657 2.17e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.17e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 564356682    628 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 657
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
1313-1343 2.49e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.49e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682  1313 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 1343
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1228-1257 2.54e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.54e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682  1228 DVDECAT-TEPC-LGGHCVNTEGSFNCLCETG 1257
Cdd:pfam07645    1 DVDECATgTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 980-1015 3.57e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.57e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 564356682  980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYIGQS 1015
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1103-1133 5.11e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 5.11e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564356682  1103 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 1133
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 628-661 5.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 5.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564356682  628 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 661
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35
EGF smart00181
Epidermal growth factor-like domain;
1023-1055 6.30e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 39.04  E-value: 6.30e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682   1023 ECLTPGICAHGRCINMEGSFRCSCEPGYELTPD 1055
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1784-1818 7.61e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 564356682 1784 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 1818
Cdd:cd00054     1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1061-1102 7.73e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.73e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564356682   1061 DVDECASRASCPTG-LCLNTEGSFTCSaCQSGYwvnEDGTACE 1102
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
940-969 1.30e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.30e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564356682   940 DVDECEQPG-VC-SGGRCSNTEGSYHCECDQG 969
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1784-1817 1.69e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 564356682  1784 DVNECEDlngPAALC-AHGHCENTEGSYRCHCSPG 1817
Cdd:pfam07645    1 DVDECAT---GTHNCpANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
943-975 1.70e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.70e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682    943 ECEQPGVCSGGRCSNTEGSYHCECDQGYVMVRR 975
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
PHA03378 PHA03378
EBNA-3B; Provisional
 756-854 1.89e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564356682  756 ASPVREQRQQSSGPPPGAAERQPLRAATATWIEAETLPDKGDSRAIQITTSAPHlPARVPGDATGRPTPSLPGQGIPE-- 833
Cdd:PHA03378  709 APPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAPPApq 787

                          90       100
                  ....*....|....*....|....*....
gi 564356682  834 -----GPA---EEQVIPSSDVLVTHGPPG 854
Cdd:PHA03378  788 qrprgAPTpqpPPQAGPTSMQLMPRAAPG 816
EGF_CA smart00179
Calcium-binding EGF-like domain;
1495-1528 2.20e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.20e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 564356682   1495 DADECILFGPalCQNG-RCLNTVPGYICLCNPGYH 1528
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1103-1144 2.65e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 564356682   1103 DLDECAFPGVCPTG-VCTNTVGSFSCkDCDRGFRPsplGNSCE 1144
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRC-ECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
980-1011 3.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.01e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 564356682    980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGY 1011
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGY 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 901-928 4.48e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.48e-03
                           10        20
                   ....*....|....*....|....*...
gi 564356682   901 CLRNPCEGRGRCVNSVGSYSCLCYPGYT 928
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1316-1345 4.78e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 4.78e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 564356682 1316 ECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1345
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1043-1064 5.42e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.85  E-value: 5.42e-03
                           10        20
                   ....*....|....*....|..
gi 564356682  1043 RCSCEPGYELTPDKKGCRDVDE 1064
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1103-1144 6.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 564356682 1103 DLDECAFPGVC-PTGVCTNTVGSFSCkDCDRGFRpsplGNSCE 1144
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRC-SCPPGYT----GRNCE 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-601 8.20e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 8.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564356682   567 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 601
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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