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Conserved domains on  [gi|564360647|ref|XP_006241920|]
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zinc finger protein GLI4 isoform X1 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
115-337 3.22e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 115 SLEQPAGLPPGTKPCSQKRDTWHMVLLPQGAPGTEGSAKKTAEVGSSLSRDCRQPGPQGTKAHRCEVCGKSFKYKSLLLK 194
Cdd:COG5048  228 PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTR 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 195 HQR--IHTGE--KPYACHE--CGKHFgSWWGFM-QHHRIHTGEKPYEC--GHCGQAFSHSSH--FTQHLRIHNGEKPYKC 263
Cdd:COG5048  308 HLRsvNHSGEslKPFSCPYslCGKLF-SRNDALkRHILLHTSISPAKEklLNSSSKFSPLLNnePPQSLQQYKDLKNDKK 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 264 GECGH-----AFSQSSNLVRHQRLHTGEKPYVC--SQCGKAFIWSSVLIEHQRIHTGEKPYKCEDCGKaFRGRSHFFRHL 336
Cdd:COG5048  387 SETLSnscirNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 564360647 337 R 337
Cdd:COG5048  466 K 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-354 9.98e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 9.98e-04
                          10        20
                  ....*....|....*....|....
gi 564360647  331 HFFRHLRTHTGEKPFSCGSCGKAF 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
115-337 3.22e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 115 SLEQPAGLPPGTKPCSQKRDTWHMVLLPQGAPGTEGSAKKTAEVGSSLSRDCRQPGPQGTKAHRCEVCGKSFKYKSLLLK 194
Cdd:COG5048  228 PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTR 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 195 HQR--IHTGE--KPYACHE--CGKHFgSWWGFM-QHHRIHTGEKPYEC--GHCGQAFSHSSH--FTQHLRIHNGEKPYKC 263
Cdd:COG5048  308 HLRsvNHSGEslKPFSCPYslCGKLF-SRNDALkRHILLHTSISPAKEklLNSSSKFSPLLNnePPQSLQQYKDLKNDKK 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 264 GECGH-----AFSQSSNLVRHQRLHTGEKPYVC--SQCGKAFIWSSVLIEHQRIHTGEKPYKCEDCGKaFRGRSHFFRHL 336
Cdd:COG5048  387 SETLSnscirNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 564360647 337 R 337
Cdd:COG5048  466 K 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-298 1.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.53e-04
                          10        20
                  ....*....|....*....|....
gi 564360647  275 NLVRHQRLHTGEKPYVCSQCGKAF 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-354 9.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 9.98e-04
                          10        20
                  ....*....|....*....|....
gi 564360647  331 HFFRHLRTHTGEKPFSCGSCGKAF 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
115-337 3.22e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 115 SLEQPAGLPPGTKPCSQKRDTWHMVLLPQGAPGTEGSAKKTAEVGSSLSRDCRQPGPQGTKAHRCEVCGKSFKYKSLLLK 194
Cdd:COG5048  228 PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTR 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 195 HQR--IHTGE--KPYACHE--CGKHFgSWWGFM-QHHRIHTGEKPYEC--GHCGQAFSHSSH--FTQHLRIHNGEKPYKC 263
Cdd:COG5048  308 HLRsvNHSGEslKPFSCPYslCGKLF-SRNDALkRHILLHTSISPAKEklLNSSSKFSPLLNnePPQSLQQYKDLKNDKK 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564360647 264 GECGH-----AFSQSSNLVRHQRLHTGEKPYVC--SQCGKAFIWSSVLIEHQRIHTGEKPYKCEDCGKaFRGRSHFFRHL 336
Cdd:COG5048  387 SETLSnscirNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 564360647 337 R 337
Cdd:COG5048  466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-324 4.62e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 4.62e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564360647 259 KPYKCGECGHAFSQSSNLVRHQRLHTGEKPYVCSQ--CGKAFIWSSVLIEHQRIHTGEKPYKCEDCGK 324
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-298 1.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.53e-04
                          10        20
                  ....*....|....*....|....
gi 564360647  275 NLVRHQRLHTGEKPYVCSQCGKAF 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-296 1.89e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.89e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564360647 231 KPYECGHCGQAFSHSSHFTQHLRIHNGEKPYKCGECGHA--FSQSSNLVRHQRLHTGEKPYVCSQCGK 296
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-326 2.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.81e-04
                          10        20
                  ....*....|....*....|...
gi 564360647  304 LIEHQRIHTGEKPYKCEDCGKAF 326
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 317-339 9.22e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 9.22e-04
                          10        20
                  ....*....|....*....|...
gi 564360647  317 YKCEDCGKAFRGRSHFFRHLRTH 339
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-354 9.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 9.98e-04
                          10        20
                  ....*....|....*....|....
gi 564360647  331 HFFRHLRTHTGEKPFSCGSCGKAF 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-214 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|...
gi 564360647  192 LLKHQRIHTGEKPYACHECGKHF 214
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 177-199 1.52e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|...
gi 564360647  177 HRCEVCGKSFKYKSLLLKHQRIH 199
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
315-367 1.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564360647 315 KPYKCEDCGKAFRGRSHFFRHLRTHTGEKPFSCG--SCGKAFGQSSQLIQHQRVH 367
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 261-283 3.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.05e-03
                          10        20
                  ....*....|....*....|...
gi 564360647  261 YKCGECGHAFSQSSNLVRHQRLH 283
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
220-244 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*
gi 564360647  220 FMQHHRIHTGEKPYECGHCGQAFSH 244
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 3.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.44e-03
                          10        20
                  ....*....|....*....|....*.
gi 564360647  247 HFTQHLRIHNGEKPYKCGECGHAFSQ 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 233-255 4.74e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.74e-03
                          10        20
                  ....*....|....*....|...
gi 564360647  233 YECGHCGQAFSHSSHFTQHLRIH 255
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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