NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|564362517|ref|XP_006242651|]
View 

KN motif and ankyrin repeat domain-containing protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
646-821 4.74e-33

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.30  E-value: 4.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 646 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVcQVDKLNRAGYSPIMLTALAtlktqDDIDTILQLFRLG 725
Cdd:COG0666   70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 726 -NVNAKASQaGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPScDISLTDRDGST 804
Cdd:COG0666  144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                        170
                 ....*....|....*..
gi 564362517 805 ALMVALDAGQSEIASML 821
Cdd:COG0666  222 ALDLAAENGNLEIVKLL 238
KN_motif super family cl13504
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-59 1.99e-14

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


The actual alignment was detected with superfamily member pfam12075:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 67.76  E-value: 1.99e-14
                          10        20
                  ....*....|....*....|....*....
gi 564362517   31 PYSVETPYGYRLDLDFLKYVDDIEKGHTL 59
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTI 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
646-821 4.74e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.30  E-value: 4.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 646 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVcQVDKLNRAGYSPIMLTALAtlktqDDIDTILQLFRLG 725
Cdd:COG0666   70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 726 -NVNAKASQaGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPScDISLTDRDGST 804
Cdd:COG0666  144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                        170
                 ....*....|....*..
gi 564362517 805 ALMVALDAGQSEIASML 821
Cdd:COG0666  222 ALDLAAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
739-824 8.04e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.78  E-value: 8.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517  739 LMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLtdrDGSTALMVALDAGQSEIA 818
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIV 77


                  ....*.
gi 564362517  819 SMLYSR 824
Cdd:pfam12796  78 KLLLEK 83
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-59 1.99e-14

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 67.76  E-value: 1.99e-14
                          10        20
                  ....*....|....*....|....*....
gi 564362517   31 PYSVETPYGYRLDLDFLKYVDDIEKGHTL 59
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTI 29
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 651-788 9.16e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 9.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 651 LLDYV--VNIADSNGNTALHYSVS--HANFPVVRQLLDSGVcQVDKLNRAGYspimltalaTLKTQDDIDTIlqlfrlgN 726
Cdd:PHA03100 127 LLDNGanVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV-DINAKNRVNY---------LLSYGVPINIK-------D 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564362517 727 VNakasqaGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLL 788
Cdd:PHA03100 190 VY------GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 735-763 2.54e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.54e-04
                           10        20
                   ....*....|....*....|....*....
gi 564362517   735 GQTALMLAVSHGRVDVVKALLACEVDVNM 763
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
646-821 4.74e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.30  E-value: 4.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 646 AMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVcQVDKLNRAGYSPIMLTALAtlktqDDIDTILQLFRLG 725
Cdd:COG0666   70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 726 -NVNAKASQaGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPScDISLTDRDGST 804
Cdd:COG0666  144 aDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKT 221

                        170
                 ....*....|....*..
gi 564362517 805 ALMVALDAGQSEIASML 821
Cdd:COG0666  222 ALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
624-821 3.41e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.44  E-value: 3.41e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 624 LRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVcQVDKLNRAGYSPIML 703
Cdd:COG0666   15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-DINAKDDGGNTLLHA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 704 TAlatlkTQDDIDTILQLFRLG-NVNAKASQaGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKE 782
Cdd:COG0666   94 AA-----RNGDLEIVKLLLEAGaDVNARDKD-GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLE 167

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 564362517 783 ITGLLLAVPsCDISLTDRDGSTALMVALDAGQSEIASML 821
Cdd:COG0666  168 IVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
624-818 6.39e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 6.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 624 LRLACRSDaHPELVRRhlvtframsarLLDY--VVNIADSNGNTALHYSVSHANFPVVRQLLDSGVcQVDKLNRAGYSPI 701
Cdd:COG0666   91 LHAAARNG-DLEIVKL-----------LLEAgaDVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPL 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 702 MLTALatlktQDDIDTILQLFRLG-NVNAKaSQAGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGH 780
Cdd:COG0666  158 HLAAA-----NGNLEIVKLLLEAGaDVNAR-DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 564362517 781 KEITGLLLAVPScDISLTDRDGSTALMVALDAGQSEIA 818
Cdd:COG0666  232 LEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIV 268
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
649-821 1.51e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.79  E-value: 1.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 649 ARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCQVDKLNRAGYSPIMLTALATLKTQDDIDTILQLFRLGNVN 728
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 729 AKASQAGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLL---AvpscDISLTDRDGSTA 805
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLeagA----DVNAQDNDGNTP 156

                        170
                 ....*....|....*.
gi 564362517 806 LMVALDAGQSEIASML 821
Cdd:COG0666  157 LHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
739-824 8.04e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.78  E-value: 8.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517  739 LMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLtdrDGSTALMVALDAGQSEIA 818
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIV 77


                  ....*.
gi 564362517  819 SMLYSR 824
Cdd:pfam12796  78 KLLLEK 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
624-789 1.85e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.93  E-value: 1.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 624 LRLACRSDaHPELVRRhlvtframsarLLDY--VVNIADSNGNTALHYSVSHANFPVVRQLLDSGVcQVDKLNRAGYSPI 701
Cdd:COG0666  124 LHLAAYNG-NLEIVKL-----------LLEAgaDVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPL 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 702 MLTALatlktQDDIDTILQLFRLG-NVNAKaSQAGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGH 780
Cdd:COG0666  191 HLAAE-----NGHLEIVKLLLEAGaDVNAK-DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264


                 ....*....
gi 564362517 781 KEITGLLLA 789
Cdd:COG0666  265 ALIVKLLLL 273
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-59 1.99e-14

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 67.76  E-value: 1.99e-14
                          10        20
                  ....*....|....*....|....*....
gi 564362517   31 PYSVETPYGYRLDLDFLKYVDDIEKGHTL 59
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTI 29
Ank_2 pfam12796
Ankyrin repeats (3 copies);
667-765 1.33e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517  667 LHYSVSHANFPVVRQLLDSGvCQVDKLNRAGYSPIMLTALAtlktqDDIDTILQLFRLGNVNAKASqaGQTALMLAVSHG 746
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKN-----GHLEIVKLLLEHADVNLKDN--GRTALHYAARSG 72

                          90
                  ....*....|....*....
gi 564362517  747 RVDVVKALLACEVDVNMQD 765
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
737-788 2.40e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.51  E-value: 2.40e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 564362517  737 TALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLL 788
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
719-772 5.90e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.04  E-value: 5.90e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 564362517  719 LQLFRLGNVNAKaSQAGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTAL 772
Cdd:pfam13857   1 LLEHGPIDLNRL-DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 651-788 9.16e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 9.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 651 LLDYV--VNIADSNGNTALHYSVS--HANFPVVRQLLDSGVcQVDKLNRAGYspimltalaTLKTQDDIDTIlqlfrlgN 726
Cdd:PHA03100 127 LLDNGanVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV-DINAKNRVNY---------LLSYGVPINIK-------D 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564362517 727 VNakasqaGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLL 788
Cdd:PHA03100 190 VY------GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 656-775 1.51e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 656 VNIADSNGNTALHYSVSHANFPVVRQLLDSGvCQVDKLNRAGYSPIMLtALATLKTQDDIDTILQlfRLGNVNAKASQAG 735
Cdd:PHA02878 194 VNIPDKTNNSPLHHAVKHYNKPIVHILLENG-ASTDARDKCGNTPLHI-SVGYCKDYDILKLLLE--HGVDVNAKSYILG 269

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564362517 736 QTALMLAVSHGRvdVVKALLACEVDVNMQDEDGSTALMCA 775
Cdd:PHA02878 270 LTALHSSIKSER--KLKLLLEYGADINSLNSYKLTPLSSA 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
772-829 2.53e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 2.53e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 564362517  772 LMCACEHGHKEITGLLLAVPsCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKC 829
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL 57
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 751-823 3.48e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 3.48e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564362517 751 VKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVpSCDISLTDRDGSTALMVALDAGQSEIASMLYS 823
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEF-GADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PHA03095 PHA03095
ankyrin-like protein; Provisional
 640-756 3.51e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 640 HLVTFRAMSA---RLLDYVVNIA--DSNGNTALHYSVSHANF--PVVRQLLDSGVcQVDKLNRAGYSPIMLTALATLKTQ 712
Cdd:PHA03095 194 HLQSFKPRARivrELIRAGCDPAatDMLGNTPLHSMATGSSCkrSLVLPLLIAGI-SINARNRYGQTPLHYAAVFNNPRA 272

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564362517 713 DDidtilQLFRLG-NVNAkASQAGQTALMLAVSHGRVDVVKALLA 756
Cdd:PHA03095 273 CR-----RLIALGaDINA-VSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA03095 PHA03095
ankyrin-like protein; Provisional
 656-774 8.54e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 8.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 656 VNIADSNGNTALHYSVSHANFP---VVRQLLDSGVcQVDKLNRAGYSPIMLTALAtlktQDDIDTILQLFRLG-NVNAKa 731
Cdd:PHA03095  40 VNFRGEYGKTPLHLYLHYSSEKvkdIVRLLLEAGA-DVNAPERCGFTPLHLYLYN----ATTLDVIKLLIKAGaDVNAK- 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 564362517 732 SQAGQTAL--MLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMC 774
Cdd:PHA03095 114 DKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAV 158
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 735-763 1.37e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 42.63  E-value: 1.37e-05
                          10        20
                  ....*....|....*....|....*....
gi 564362517  735 GQTALMLAVSHGRVDVVKALLACEVDVNM 763
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 657-788 1.38e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 657 NIADSNGNTALHYSVSHANFPVVRQLLDSGvCQVDKLNRAGYSPiMLTALATlkTQDDIDTILQLFrlgnvnAKAS--QA 734
Cdd:PLN03192 552 DIGDSKGRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTA-LWNAISA--KHHKIFRILYHF------ASISdpHA 621

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564362517 735 GQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLL 788
Cdd:PLN03192 622 AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
Ank_5 pfam13857
Ankyrin repeats (many copies);
754-809 2.63e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.33  E-value: 2.63e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 564362517  754 LLACE-VDVNMQDEDGSTALMCACEHGHKEITGLLLAVPsCDISLTDRDGSTALMVA 809
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 735-766 3.30e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.51  E-value: 3.30e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 564362517  735 GQTALMLAVSH-GRVDVVKALLACEVDVNMQDE 766
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 667-824 4.66e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 4.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 667 LHYSVSHANFPVVRQLLDSGVCQVDKLNRAGYSPIMLTALAtlktqDDIDTILQLFRLGNVNAKASQAGQTALMLAVSHG 746
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATIL-----KKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564362517 747 RVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAvPSCDISLTDRDGSTALM-VALDAGQSEIASMLYSR 824
Cdd:PHA02875 147 DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKR 224
Ank_4 pfam13637
Ankyrin repeats (many copies);
768-821 6.50e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 6.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 564362517  768 GSTALMCACEHGHKEITGLLLAvPSCDISLTDRDGSTALMVALDAGQSEIASML 821
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 672-810 8.20e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.17  E-value: 8.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 672 SHANFPVVRQLLDSGVcqvDKLNRAGYSPIMLTALATLKTQDDIDTILQLFRLG-NVNAKaSQAGQTALMLAVSHG-RVD 749
Cdd:PHA03095  23 SNVTVEEVRRLLAAGA---DVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAGaDVNAP-ERCGFTPLHLYLYNAtTLD 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564362517 750 VVKALLACEVDVNMQDEDGSTAL-MCAC-EHGHKEITGLLLAVpSCDISLTDRDGSTALMVAL 810
Cdd:PHA03095  99 VIKLLIKAGADVNAKDKVGRTPLhVYLSgFNINPKVIRLLLRK-GADVNALDLYGMTPLAVLL 160
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 735-821 8.20e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.40  E-value: 8.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 735 GQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPS-----------C---------- 793
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisdphaagdllCtaakrndlta 637

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564362517 794 ---------DISLTDRDGSTALMVALDAGQSEIASML 821
Cdd:PLN03192 638 mkellkqglNVDSEDHQGATALQVAMAEDHVDMVRLL 674
PHA03095 PHA03095
ankyrin-like protein; Provisional
 656-810 8.49e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.17  E-value: 8.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 656 VNIADSNGNTALH-Y-SVSHANFPVVRQLLDSGVcQVDKLNRAGYSPI----------------MLTALATLKTQDDI-D 716
Cdd:PHA03095 110 VNAKDKVGRTPLHvYlSGFNINPKVIRLLLRKGA-DVNALDLYGMTPLavllksrnanvellrlLIDAGADVYAVDDRfR 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 717 TIL---------------QLFRLGNVNAKASQAGQTAL--MLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHG 779
Cdd:PHA03095 189 SLLhhhlqsfkprarivrELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFN 268

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564362517 780 HKEITGLLLAVpSCDISLTDRDGSTALMVAL 810
Cdd:PHA03095 269 NPRACRRLIAL-GADINAVSSDGNTPLSLMV 298
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 739-836 8.71e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.40  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 739 LMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAvPSCDISLTDRDGSTALMVALDAGQSEIA 818
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLK-HACNVHIRDANGNTALWNAISAKHHKIF 607

                         90
                 ....*....|....*...
gi 564362517 819 SMLYsrmnikcSFAPMSD 836
Cdd:PLN03192 608 RILY-------HFASISD 618
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 735-797 1.29e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 1.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564362517 735 GQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPSCDISL 797
Cdd:PTZ00322 115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 735-763 2.54e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.54e-04
                           10        20
                   ....*....|....*....|....*....
gi 564362517   735 GQTALMLAVSHGRVDVVKALLACEVDVNM 763
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_2 pfam12796
Ankyrin repeats (3 copies);
624-687 3.00e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 3.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564362517  624 LRLACRSDaHPELVRRhlvtframsarLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGV 687
Cdd:pfam12796  34 LHLAAKNG-HLEIVKL-----------LLEHADVNLKDNGRTALHYAARSGHLEIVKLLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 651-809 3.43e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 651 LLDY--VVNIADSNGNTALHYSVSHAN-FPVVRQLLDSGVcQVDKLNRAGYSP--IMLTALATlktqdDIDTILQLFRLG 725
Cdd:PHA03095  69 LLEAgaDVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGA-DVNAKDKVGRTPlhVYLSGFNI-----NPKVIRLLLRKG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 726 -NVNAKASQaGQTAL-MLAVSHG-RVDVVKALLACEVDVNMQDEDGSTALmcaceHGH----KEITGLL--LAVPSCDIS 796
Cdd:PHA03095 143 aDVNALDLY-GMTPLaVLLKSRNaNVELLRLLIDAGADVYAVDDRFRSLL-----HHHlqsfKPRARIVreLIRAGCDPA 216

                        170
                 ....*....|...
gi 564362517 797 LTDRDGSTALMVA 809
Cdd:PHA03095 217 ATDMLGNTPLHSM 229
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 656-810 5.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.33  E-value: 5.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 656 VNIADSN-GNTALHYSVSHANFPVVRQLLDSGVcQVDKLNRAGYSPIMltaLATLKTQDDIDTIlqLFRLG-NVNAKaSQ 733
Cdd:PHA02878 160 INMKDRHkGNTALHYATENKDQRLTELLLSYGA-NVNIPDKTNNSPLH---HAVKHYNKPIVHI--LLENGaSTDAR-DK 232

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564362517 734 AGQTALMLAVSHGR-VDVVKALLACEVDVNMQDE-DGSTALMCACEHGHKeiTGLLLAVPScDISLTDRDGSTALMVAL 810
Cdd:PHA02878 233 CGNTPLHISVGYCKdYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSERK--LKLLLEYGA-DINSLNSYKLTPLSSAV 308
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 656-772 6.50e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.32  E-value: 6.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362517 656 VNIADSNGNTALHYSVSHANFPVVRQLLdsgvcqvdKLNRAGYSPIMLTALATLKTQDDIDTILQLFRLG-NVNAKASQa 734
Cdd:PLN03192 584 VHIRDANGNTALWNAISAKHHKIFRILY--------HFASISDPHAAGDLLCTAAKRNDLTAMKELLKQGlNVDSEDHQ- 654

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564362517 735 GQTALMLAVSHGRVDVVKALLACEVDV---NMQDEDGSTAL 772
Cdd:PLN03192 655 GATALQVAMAEDHVDMVRLLIMNGADVdkaNTDDDFSPTEL 695
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 662-687 7.04e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 7.04e-03
                           10        20
                   ....*....|....*....|....*.
gi 564362517   662 NGNTALHYSVSHANFPVVRQLLDSGV 687
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 662-687 7.19e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 7.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 564362517  662 NGNTALHYSVSHANFPVVRQLLDSGV 687
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGA 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH