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Conserved domains on  [gi|564365450|ref|XP_006243824|]
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protein shisa-5 isoform X1 [Rattus norvegicus]

Protein Classification

shisa family protein( domain architecture ID 10621415)

shisa family protein is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 16-118 7.37e-27

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


:

Pssm-ID: 464036  Cd Length: 187  Bit Score: 98.75  E-value: 7.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365450   16 GATVAIGLTVFVVFIATIIVCFTCSCCCLYKMCCRPRPVVSNTTTTTVVHTAYPQPQPVAPSYPGPTYQGYHPMP--PQP 93
Cdd:pfam13908  82 GLIVAIGGSVFVAFVIVGIFCATCCCCCLYKMCRRPRPVVTTTTTTTVVETPYPQPPSAPPSYPGPSYQGYTPMPssSQP 161

                          90       100
                  ....*....|....*....|....*.
gi 564365450   94 GMPAAPYPTQYPPPYLAQ-STGPPAY 118
Cdd:pfam13908 162 GMPAAPYPTQYPPPYPAQlPMGPPPY 187
 
Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 16-118 7.37e-27

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


Pssm-ID: 464036  Cd Length: 187  Bit Score: 98.75  E-value: 7.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365450   16 GATVAIGLTVFVVFIATIIVCFTCSCCCLYKMCCRPRPVVSNTTTTTVVHTAYPQPQPVAPSYPGPTYQGYHPMP--PQP 93
Cdd:pfam13908  82 GLIVAIGGSVFVAFVIVGIFCATCCCCCLYKMCRRPRPVVTTTTTTTVVETPYPQPPSAPPSYPGPSYQGYTPMPssSQP 161

                          90       100
                  ....*....|....*....|....*.
gi 564365450   94 GMPAAPYPTQYPPPYLAQ-STGPPAY 118
Cdd:pfam13908 162 GMPAAPYPTQYPPPYPAQlPMGPPPY 187
CASIMO1 cd20246
Cancer Associated Small Integral Membrane Open reading frame 1 (CASIMO1); The ...
 15-53 4.99e-03

Cancer Associated Small Integral Membrane Open reading frame 1 (CASIMO1); The Cancer-Associated Small Integral Membrane Open reading frame 1 (CASIMO1), a small open reading frame (sORF)-encoded protein (also known as a microprotein), controls cell proliferation and interacts with squalene epoxidase (SQLE) modulating lipid droplet formation. CASIMO1 RNA is overexpressed predominantly in hormone receptor-positive breast tumors, and its knockdown has been shown to decrease proliferation in multiple breast cancer cell lines. Loss of CASIMO1 disturbs the organization of the actin cytoskeleton, leads to inhibition of cell motility, and stalls the cell cycle in the G0/G1 phase. CASIMO1 interacts with SQLE, a key enzyme in cholesterol synthesis and a known oncogene in breast cancer. This family contains two variants expressed on different chromosomes in humans, small integral membrane protein 5 (SMIM5) and small integral membrane protein 22 (SMIM22).


Pssm-ID: 380775  Cd Length: 68  Bit Score: 33.71  E-value: 4.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564365450  15 FGATVAIG-LTVFVVFIAT-----IIVCFTCSCCClykMCCRPRP 53
Cdd:cd20246   22 FASPWEIAaFAIFLLFIGTvllllLLACISCCCCC---CCSRGRK 63
 
Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 16-118 7.37e-27

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


Pssm-ID: 464036  Cd Length: 187  Bit Score: 98.75  E-value: 7.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564365450   16 GATVAIGLTVFVVFIATIIVCFTCSCCCLYKMCCRPRPVVSNTTTTTVVHTAYPQPQPVAPSYPGPTYQGYHPMP--PQP 93
Cdd:pfam13908  82 GLIVAIGGSVFVAFVIVGIFCATCCCCCLYKMCRRPRPVVTTTTTTTVVETPYPQPPSAPPSYPGPSYQGYTPMPssSQP 161

                          90       100
                  ....*....|....*....|....*.
gi 564365450   94 GMPAAPYPTQYPPPYLAQ-STGPPAY 118
Cdd:pfam13908 162 GMPAAPYPTQYPPPYPAQlPMGPPPY 187
CASIMO1 cd20246
Cancer Associated Small Integral Membrane Open reading frame 1 (CASIMO1); The ...
 15-53 4.99e-03

Cancer Associated Small Integral Membrane Open reading frame 1 (CASIMO1); The Cancer-Associated Small Integral Membrane Open reading frame 1 (CASIMO1), a small open reading frame (sORF)-encoded protein (also known as a microprotein), controls cell proliferation and interacts with squalene epoxidase (SQLE) modulating lipid droplet formation. CASIMO1 RNA is overexpressed predominantly in hormone receptor-positive breast tumors, and its knockdown has been shown to decrease proliferation in multiple breast cancer cell lines. Loss of CASIMO1 disturbs the organization of the actin cytoskeleton, leads to inhibition of cell motility, and stalls the cell cycle in the G0/G1 phase. CASIMO1 interacts with SQLE, a key enzyme in cholesterol synthesis and a known oncogene in breast cancer. This family contains two variants expressed on different chromosomes in humans, small integral membrane protein 5 (SMIM5) and small integral membrane protein 22 (SMIM22).


Pssm-ID: 380775  Cd Length: 68  Bit Score: 33.71  E-value: 4.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 564365450  15 FGATVAIG-LTVFVVFIAT-----IIVCFTCSCCClykMCCRPRP 53
Cdd:cd20246   22 FASPWEIAaFAIFLLFIGTvllllLLACISCCCCC---CCSRGRK 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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