NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568905270|ref|XP_006495533|]
View 

kappa-type opioid receptor isoform X1 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
1-252 4.50e-167

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15091:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 282  Bit Score: 464.43  E-value: 4.50e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15091   31 MKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15091  111 RTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDDYSWWDTFMKICVFIFAFVIPVLIIIVCYTLM 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15091  191 ILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPIL 270
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15091  271 YAFLDENFKRCF 282
 
Name Accession Description Interval E-value
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
1-252 4.50e-167

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 464.43  E-value: 4.50e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15091   31 MKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15091  111 RTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDDYSWWDTFMKICVFIFAFVIPVLIIIVCYTLM 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15091  191 ILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPIL 270
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15091  271 YAFLDENFKRCF 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-241 5.33e-68

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 211.77  E-value: 5.33e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270    1 MKTATNIYIFNLALADALVT-TTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:pfam00001  15 LRTPTNIFLLNLAVADLLFSlLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYK 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   79 DFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWwdLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:pfam00001  95 RRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKP--VSYTLLISVLGFLLPLLVILVCYT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  159 LMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGST-SHSTAALSSYYFCIALGYTNSSLN 237
Cdd:pfam00001 173 LIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDcELSRLLDKALSVTLWLAYVNSCLN 252

                  ....
gi 568905270  238 PVLY 241
Cdd:pfam00001 253 PIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
2-248 1.76e-34

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 127.59  E-value: 1.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:PHA03087  71 KTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKIN 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKvrEDVDVIECSLqFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:PHA03087 151 TVKYGYIVSLVIWIISIIETTPILFVYTTK--KDHETLICCM-FYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKIL 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKsvrllsGSREKDRNLRRItKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYT------NSS 235
Cdd:PHA03087 228 ITLK------GINKSKKNKKAI-KLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAVKYIQYALHVTeiislsHCC 300
                        250
                 ....*....|...
gi 568905270 236 LNPVLYAFLDENF 248
Cdd:PHA03087 301 INPLIYAFVSEFF 313
 
Name Accession Description Interval E-value
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
1-252 4.50e-167

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 464.43  E-value: 4.50e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15091   31 MKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15091  111 RTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDDYSWWDTFMKICVFIFAFVIPVLIIIVCYTLM 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15091  191 ILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPIL 270
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15091  271 YAFLDENFKRCF 282
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
1-252 1.66e-130

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 371.98  E-value: 1.66e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15089   31 MKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIeCSLQFPDDEYsWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15089  111 RTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVV-CMLQFPSPSW-YWDTVTKICVFIFAFVVPILVITVCYGLM 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTA-ALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15089  189 ILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVDIDRRNPlVVAALHLCIALGYANSSLNPV 268
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15089  269 LYAFLDENFKRCF 281
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
1-252 1.87e-127

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 363.92  E-value: 1.87e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd14970   31 MKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTkVREDVDVIECSLQFPDDeYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd14970  111 RTPRKAKLVSLCVWALSLVLGLPVIIFART-LQEEGGTISCNLQWPDP-PDYWGRVFTIYTFVLGFAVPLLVITVCYSLI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLS--GSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd14970  189 IRRLRSSRNLStsGAREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGVFLFCIALSYANSCLNP 268
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd14970  269 ILYAFLDENFRKSF 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
1-252 2.32e-123

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 353.79  E-value: 2.32e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15092   31 MKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVdvIECSLQFPDDEySWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15092  111 RTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEE--IECLVEIPTPQ-DYWDPVFGICVFLFSFIIPVLIISVCYSLM 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15092  188 IRRLRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQPSSETAVAILRFCTALGYVNSSLNPVL 267
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15092  268 YAFLDENFKACF 279
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
1-252 4.02e-122

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 350.45  E-value: 4.02e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15090   31 MKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVdvIECSLQFPDDEYsWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15090  111 RTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGS--IDCTLTFSHPSW-YWENLLKICVFIFAFIMPVLIITVCYGLM 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15090  188 ILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVL 267
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15090  268 YAFLDENFKRCF 279
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 3.11e-74

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 228.89  E-value: 3.11e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15093   31 MKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTSIFCLTVMSVDRYLAVVHPIKSARW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDvDVIECSLQFPDDEYSWWDLFMkICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15093  111 RRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQD-GSSACNMQWPEPAAAWSAGFI-IYTFVLGFLLPLLIICLCYLLI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15093  189 VIKVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLPETPALVGVYHFVVILSYANSCANPIL 268
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15093  269 YGFLSDNFKKSF 280
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-241 5.33e-68

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 211.77  E-value: 5.33e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270    1 MKTATNIYIFNLALADALVT-TTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:pfam00001  15 LRTPTNIFLLNLAVADLLFSlLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYK 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   79 DFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWwdLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:pfam00001  95 RRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKP--VSYTLLISVLGFLLPLLVILVCYT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  159 LMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGST-SHSTAALSSYYFCIALGYTNSSLN 237
Cdd:pfam00001 173 LIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDcELSRLLDKALSVTLWLAYVNSCLN 252

                  ....
gi 568905270  238 PVLY 241
Cdd:pfam00001 253 PIIY 256
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
1-252 9.52e-67

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 209.38  E-value: 9.52e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15970   31 MKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSIDRYIAVVHPIKAARY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDViECSLQFPDDEYSWWDLFMkICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15970  111 RRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSV-ACNMQMPEPSQRWLAVFV-VYTFLMGFLLPVIAICLCYILI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyfcIALGYTNSSLNPVL 240
Cdd:cd15970  189 IVKMRVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVGQHDATVSQLS----VILGYANSCANPIL 264
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15970  265 YGFLSDNFKRSF 276
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
1-252 6.83e-66

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 207.40  E-value: 6.83e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15973   31 MKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDvDVIECSLQFPddEYSWWDLFMkICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15973  111 RRPTVAKMINICVWILSLLVISPIIIFADTATRKG-QAVACNLIWP--HPAWSAAFV-IYTFLLGFLLPVLAIGLCYILI 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAAlssyYFCIALGYTNSSLNPVL 240
Cdd:cd15973  187 IGKMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLPRLDATVN----HASLILSYANSCANPIL 262
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15973  263 YGFLSDNFRRSF 274
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
1-252 1.03e-64

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 204.59  E-value: 1.03e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPV--KAL 78
Cdd:cd15087   31 MKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLTVMSVDRYLVVLATVrsRRM 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDvDVIECSLQFPDDEYSWWDLfMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15087  111 PYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSNEL-GRKSCVLSFPSPESLWFKA-SRIYTLVLGFAIPVSTICILYT 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15087  189 MMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALTTDLPQTPLVIGISYFITSLSYANSCLNP 268
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15087  269 FLYAFLDDSFRKSF 282
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
1-252 3.07e-61

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 195.45  E-value: 3.07e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15971   31 MKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDviECSLQFPDDEYSWWDLFMkICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15971  111 RKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRS--SCTIIWPGESSAWYTGFI-IYTFILGFFVPLTIICLCYLFI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15971  188 IIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPIL 267
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15971  268 YAFLSDNFKKSF 279
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
1-252 4.69e-61

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 195.00  E-value: 4.69e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15094   31 MKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15094  111 RTPFIAKVVCATTWSISFLVMLPIILY--ASTVPDSGRYSCTIVWPDSSAVNGQKAFTLYTFLLGFAIPLLLISVFYTLV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCI--ALGYTNSSLNP 238
Cdd:cd15094  189 ILRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDMPKWEILMFLLltVLSYANSMVNP 268
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15094  269 LLYAFLSENFRKSF 282
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
1-252 7.16e-59

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 189.60  E-value: 7.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd14971   31 MRSTTNLFILNLAVADlTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYswwDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd14971  111 IRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRAH---RRAFALCTFLFGYLLPLLLICVCYAA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRL-KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd14971  188 MLRHLwRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFPLTYATYALRIWAHCLAYSNSAVNP 267
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd14971  268 VLYAFLSEHFRKAF 281
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
1-250 4.65e-57

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 184.58  E-value: 4.65e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15088   31 LRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDgQWYFGEVMCKIITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWlLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWdlFMkICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15088  111 YRTRFVAKLVNVGLW-AASFLSILPVWVYSSLIYFPDGTTFCYVSLPSPDDLYW--FT-IYHFILGFAVPLVVITVCYIL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEaLGSTSHSTAALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15088  187 ILHRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVN-LAMNRPTLAFEVAYFLSICLGYANSCLNPF 265
                        250
                 ....*....|.
gi 568905270 240 LYAFLDENFKR 250
Cdd:cd15088  266 VYILVSENFRK 276
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
1-252 4.50e-56

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 182.31  E-value: 4.50e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15974   31 MKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVieCSLQFPDDEYSWWDLFMkICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15974  111 RRPRVAKLINATVWTLSFLVVLPVIIF--SDVQPDLNT--CNISWPEPVSVWSTAFI-IYTAVLGFFGPLLVICLCYLLI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15974  186 VIKVKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVILPEEPAFVGVYFFVVVLSYANSCANPIL 265
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15974  266 YGFLSDNFKQSF 277
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
1-252 1.45e-54

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 178.63  E-value: 1.45e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVisidYYNMFTSI----FTLTMMSVDRYIAVCHPV 75
Cdd:cd15095   31 MRTVTNYYIVNLAVTDlAFLVCCVPFTAALYATPSWVFGDFMCKFV----NYMMQVTVqatcLTLTALSVDRYYAIVHPI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  76 KALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDV-DVIECSLQFPDDEyswWDLFMKICVFVFAFVIPVLIII 154
Cdd:cd15095  107 RSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYgPQTYCREVWPSKA---FQKAYMIYTVLLTYVIPLAIIA 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRL-----KSVRLLSGSREKDRNL-RRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSY-YFCI 227
Cdd:cd15095  184 VCYGLILRRLwrrsvDGNNQSEQLSERALRQkRKVTRMVIVVVVLFAICWLPNHVLNLWQRFDPNFPETYATYALkIAAL 263
                        250       260
                 ....*....|....*....|....*
gi 568905270 228 ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15095  264 CLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
2-250 2.66e-54

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 177.41  E-value: 2.66e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd14984   32 RSMTDVYLLNLALADLLFVLTLPFW-AVYAADGWVFGSFLCKLVSALYTINFYSGILFLACISIDRYLAIVHAVSALRAR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd14984  111 TLLHGKLTCLGVWALALLLSLPEFIF--SQVSEENGSSICSYDYPEDTATTWKTLLRLLQNILGFLLPLLVMLFCYSRII 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 lrlksvRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEAL---GSTSHSTAALSSYYFCI----ALGYTNS 234
Cdd:cd14984  189 ------RTLLRARNHKK--HRALRVIFAVVVVFFLCWLPYNIVLLLDTLqllGIISRSCELSKSLDYALqvteSLAFSHC 260
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd14984  261 CLNPVLYAFVGVKFRK 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
1-244 1.22e-53

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 175.94  E-value: 1.22e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd00637   29 LRTVTNYFILNLAVADLLVGLLvIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLasSVGISAIVLGGTKVREDVDVIECSLQFPDDeysWWDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd00637  109 RFTRRRAKLLIALIWLL--SLLLALPPLLGWGVYDYGGYCCCCLCWPDL---TLSKAYTIFLFVLLFLLPLLVIIVCYVR 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLK-------SVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALsSYYFCIALGYT 232
Cdd:cd00637  184 IFRKLRrhrrrirSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLPRI-LYFLALLLAYL 262
                        250
                 ....*....|..
gi 568905270 233 NSSLNPVLYAFL 244
Cdd:cd00637  263 NSAINPIIYAFF 274
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
1-252 6.31e-53

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 174.02  E-value: 6.31e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15096   31 MRSTTNILILNLAVADlLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDE-YSWWDLFMkiCVFVFAFVIPVLIIIVCYT 158
Cdd:cd15096  111 IRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYCTFLTEVgTAAQTFFT--SFFLFSYLIPLTLICVLYM 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRLLSG--SREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSL 236
Cdd:cd15096  189 LMLRRLRRQKSPGGrrSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLKYYGVLPETVLYVVIQILSNCLAYGNSCV 268
                        250
                 ....*....|....*.
gi 568905270 237 NPVLYAFLDENFKRCF 252
Cdd:cd15096  269 NPILYAFLSQNFRKAF 284
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
5-252 7.90e-53

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 173.76  E-value: 7.90e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15098   37 TNVFILNLSIADlFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLGGTKVREDVDviECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILR 163
Cdd:cd15098  117 RNALLGVLVIWVLSLAMASPVAVHQDLVHHWTAS--NQTFCWENWPEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNH 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 LKSVrLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAalsSYYFCIA---LGYTNSSLNPVL 240
Cdd:cd15098  195 LHKK-LKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGDFPLTQA---SFVLRITahcLAYANSCVNPII 270
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15098  271 YAFLSENFRKAY 282
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
1-252 8.27e-53

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 173.83  E-value: 8.27e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15972   31 SESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKvredVDVIECSLQFPDDEYSWWDLFMkICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15972  111 RKPPVAKTVNATVWALSFLVVLPVVIFSGVP----GGMGTCHIAWPEPAQVWRAGFI-IYTATLGFFCPLLVICLCYLLI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSV--RLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15972  186 VVKVRSSgrRVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEPSLFGLYFFVVVLSYANSCANP 265
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15972  266 IIYGFLSDNFKQGF 279
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
1-252 1.31e-52

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 173.55  E-value: 1.31e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd14993   31 MRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGI-----SAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLfmkICVFVFAFVIPVLIII 154
Cdd:cd14993  111 VSTKRRARIIIVAIWVIAIIIMLpllvvYELEEIISSEPGTITIYICTEDWPSPELRKAYN---VALFVVLYVLPLLIIS 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKSV-------RLLSGSREK-DRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALS---SY 223
Cdd:cd14993  188 VAYSLIGRRLWRRkppgdrgSANSTSSRRiLRSKKKVARMLIVVVVLFALSWLPYYVLSILLDFGPLSSEESDENfllIL 267
                        250       260
                 ....*....|....*....|....*....
gi 568905270 224 YFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14993  268 PFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
3-252 2.76e-51

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 169.28  E-value: 2.76e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd14967   32 TVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLM 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLqFPDDEYSwwdlfmkICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd14967  112 TKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEF-TPNKIYV-------LVSSVISFFIPLLIMIVLYARIF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKsvrllsgsREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALssYYFCIALGYTNSSLNPVLY 241
Cdd:cd14967  184 RVAR--------RE-----LKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVPPIL--YAVFFWLGYLNSALNPIIY 248
                        250
                 ....*....|.
gi 568905270 242 AFLDENFKRCF 252
Cdd:cd14967  249 ALFNRDFRRAF 259
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
2-250 3.41e-51

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 169.75  E-value: 3.41e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd14982   32 RSPTTIYMINLALADLLFVLTLPFRIYYYLNgGWWPFGDFLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIeCsLQFPDDEYSWWDLFMkICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd14982  112 RRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTT-C-FEFLSEWLASAAPIV-LIALVVGFLIPLLIILVCYSLI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSgsrEKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHST------AALSSYYFCIALGYTNS 234
Cdd:cd14982  189 IRALRRRSKQS---QKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRLSFIAdcsarnSLYKAYRITLCLASLNS 265
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd14982  266 CLDPLIYYFLSKTFRK 281
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
2-252 2.60e-49

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 164.40  E-value: 2.60e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFqSAVYLMNS--WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd14974   31 RTVNTVWFLNLALADFLFCLFLPF-LIVYIAMGhhWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWAQN 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDvdviECSLQFPDDEYSWWDLFMKICV----FVFAFVIPVLIIIV 155
Cdd:cd14974  110 HRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHN----GRSCNLTCVEDYDLRRSRHKALtvirFLCGFLLPLLIIAI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMILRLKSVRLLSGSREkdrnlrriTKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSS 235
Cdd:cd14974  186 CYSVIAVKLRRKRLAKSSKP--------LRVLLAVVVAFFLCWLPYHVFALLELVAAAGLPEVVLLGLPLATGLAYFNSC 257
                        250
                 ....*....|....*..
gi 568905270 236 LNPVLYAFLDENFKRCF 252
Cdd:cd14974  258 LNPILYVFMGQDFRKRL 274
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
2-250 3.52e-49

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 164.47  E-value: 3.52e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd14985   32 KRVADIFIANLAAADLVFVLTLPLWATYTANQyDWPFGAFLCKVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPddeYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd14985  112 RRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACIMLYP---HEAWHFGLSLELNILGFVLPLLIILTCYFHI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKsvRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYY------FCIALGYTNS 234
Cdd:cd14985  189 ARSLR--KRYERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGAIRPCFWELFldlglpIATCLAFTNS 266
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd14985  267 CLNPFIYVFVDRRFRQ 282
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
1-252 5.99e-44

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 151.27  E-value: 5.99e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15927   31 MRNVPNIFILSLALGDLLLlLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVRE---DVDVIECSlQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVC 156
Cdd:cd15927  111 SQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTltdNQTIQICY-PYPQELGPNYPKIMVLLRFLVYYLIPLLIIGVF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YTLMILRL-KSVRLL-----SGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA-- 228
Cdd:cd15927  190 YVLMARHLiRSTRNIgsgqnQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHVFMLWFHFAPNGLVDYNAFWHVLKIVgf 269
                        250       260
                 ....*....|....*....|....*
gi 568905270 229 -LGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15927  270 cLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
2-249 1.62e-43

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 149.90  E-value: 1.62e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVY-LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDf 80
Cdd:cd15191   32 KTVASIYIFNLAVADLLFLATLPLWATYYsYGYNWLFGSVMCKICGSLLTLNLFASIFFITCMSVDRYLAVVYPLRSQR- 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15191  111 RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGVNACIMAFPNEKYAQWSAGLALMKNTLGFLIPLIVIATCYFGI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ---ILRLKSVRLLSGSREKdrnlrrITKLVLVVVAVFIICWTPIHIFILVEALG------STSHSTAALSSYYFCIALGY 231
Cdd:cd15191  191 grhLLKTKGFGKNKQRRDK------VLKMVAAVVLAFLICWFPFHVLTFLDALArmgvinNCWVITVIDKALPFAICLGF 264
                        250
                 ....*....|....*...
gi 568905270 232 TNSSLNPVLYAFLDENFK 249
Cdd:cd15191  265 SNSCINPFLYCFVGNHFR 282
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
1-252 5.14e-43

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 148.91  E-value: 5.14e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkald 79
Cdd:cd15203   31 MQTVTNIFILNLAVSDLLLClVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIFVSTLTLTAIAIDRYQLIVYP----- 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLK---AKIINICIW----LLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSwwdLFMKICVFVFAFVIPVLI 152
Cdd:cd15203  106 TRPRMSkrhALLIIALIWilslLLSLPLAIFQELSDVPIEILPYCGYFCTESWPSSSSR---LIYTISVLVLQFVIPLLI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 153 IIVCYTLMILRLK--------SVRLLSGSREKD-RNLRRITKLVLVVVAVFIICWTPIHIFILVEALgstSHSTAALSSY 223
Cdd:cd15203  183 ISFCYFRISLKLRkrvkkkrgKRTLSSRRRRSElRRKRRTNRLLIAMVVVFAVCWLPLNLFNLLRDF---EPLPQIDGRH 259
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568905270 224 Y-----FCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15203  260 FyliflICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
1-252 7.97e-43

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 147.96  E-value: 7.97e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15192   31 LKTVANIFLLNLALADLCFLITLPLWAAYTAMEyHWPFGNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEySWWDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15192  111 RRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVCAFHYPSQN-STLLVGLGLMKNLLGFLIPFLIILTCYTL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKSVRLLSGSREKDRNlrrITKLVLVVVAVFIICWTPIHIFILVEAL------GSTSHSTAALSSYYFCIALGYTN 233
Cdd:cd15192  190 IGKALKKAYEIQRNKPRNDE---IFKMIMAVVLFFFFCWIPHQIFTFLDVLiqlkviQDCHIADIVDTAMPFTICIAYFN 266
                        250
                 ....*....|....*....
gi 568905270 234 SSLNPVLYAFLDENFKRCF 252
Cdd:cd15192  267 SCLNPILYGFVGKNFRKKF 285
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
1-252 1.51e-42

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 147.04  E-value: 1.51e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFqSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15178   31 SRSSTDVYLLHLAIADLLFALTLPF-WAVSVVKGWIFGTFMCKLVSLLQEANFYSGILLLACISVDRYLAIVHATRALTQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLkAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15178  110 KRHL-VKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGRTVCYENLGNESADKWRVVLRILRHTLGFLLPLVVMLFCYGFT 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRllsgSREKDRNLRRItklvLVVVAVFIICWTPIHIFILVEALGSTS----------HSTAALssyYFCIALG 230
Cdd:cd15178  189 IKTLLQTR----SFQKHRAMRVI----FAVVLAFLLCWLPYNVTVLIDTLMRTKlitetcelrnHVDVAL---YVTQILG 257
                        250       260
                 ....*....|....*....|..
gi 568905270 231 YTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15178  258 FLHSCINPVLYAFIGQKFRNNL 279
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
6-252 1.63e-42

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 147.26  E-value: 1.63e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd14976   38 NKFVFNLALTDLIFVLTLPFWAVEYALDfVWPFGTAMCKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAF 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLGGTKVrEDVDVIECSLQFPD-----DEYSWWDLFMKICVfVFAFVIPVLIIIVCYtL 159
Cdd:cd14976  118 GAFATTIAIWAAAALAAIPEAIFSTDTW-SSVNHTLCLLRFPKnssvtRWYNWLGMYQLQKV-VLGFFLPLGIITLSY-L 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKSVRLLSGSREKdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGS-----TSHSTAALSSYYFCIA--LGYT 232
Cdd:cd14976  195 LLLRFLQRKRGGSKRRK----SRVTKSVFIVVLSFFICWLPNQALSLWSALIKfddvpFSDAFFAFQTYAFPVAicLAHS 270
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd14976  271 NSCLNPVLYCLVRREFRDAL 290
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
1-252 2.71e-42

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 147.00  E-value: 2.71e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKalD 79
Cdd:cd15207   31 MRTVTNYFILNLAVSDLLVGVfCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPTE--P 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGI-SAIVLGGT--KVREDVDVIECSLQFPDDEYSwwdlfmKI---CVFVFAFVIPVLII 153
Cdd:cd15207  109 KLTNRQAFVIIVAIWVLALAIMIpQALVLEVKeyQFFRGQTVHICVEFWPSDEYR------KAyttSLFVLCYVAPLLII 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 154 IVCYTLMILRL---KSVRLLSGSREKD----RNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAA-LSSYYF 225
Cdd:cd15207  183 AVLYVRIGYRLwfkPVPGGGSASREAQaavsKKKVRVIKMLIVVVVLFALSWLPLHTVTMLDDFGNLSPNQREvLYVYIY 262
                        250       260
                 ....*....|....*....|....*....
gi 568905270 226 CIA--LGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15207  263 PIAhwLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
2-251 3.28e-41

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 144.52  E-value: 3.28e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSA-VYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15190   43 RRSADTFIANLALADLTFVVTLPLWAVyTALGYHWPFGSFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKL 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFP----DDEYSWWDLFMKICVFVFAFVIPVLIIIVC 156
Cdd:cd15190  123 RSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICDMDYSgvvsNESEWAWIAGLGLSSTVLGFLLPFLIMLTC 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YtLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG-------STSHSTAALSSYYFCIAL 229
Cdd:cd15190  203 Y-FFIGRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVKTLYALMylgilpfSCGFDLFLMNAHPYATCL 281
                        250       260
                 ....*....|....*....|...
gi 568905270 230 GYTNSSLNPVLYAFLDENF-KRC 251
Cdd:cd15190  282 AYVNSCLNPFLYAFFDPRFrQQC 304
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
2-249 4.72e-41

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 142.99  E-value: 4.72e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15115   31 RTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGhWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPddeyswwdLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15115  111 RSVLLACLLCGCIWILALLLCLPVFIY--RTTVTDGNHTRCGYDFL--------VAITITRAVFGFLLPLLIIAACYSFI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSvrllsGSREKDRNlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVL 240
Cdd:cd15115  181 AFRMQR-----GRFAKSQS--KTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLSKVLMSWDHLSIALAYANSCLNPVL 253

                 ....*....
gi 568905270 241 YAFLDENFK 249
Cdd:cd15115  254 YVFMGKDFK 262
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
2-250 1.06e-40

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 142.65  E-value: 1.06e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15339   31 KTVPDIYVCNLAVADLVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLDTCNQFACSAIMTAMSLDRYIALVHPFRLTSL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGT-KVREDVDVIECSLQFPDDEYsWWDLFMKICVFVFafviPVLIIIVCYTL 159
Cdd:cd15339  111 RTRSKTIRINLLVWAASFILVLPVWVYAKViKFRDGLESCAFNLTSPDDVL-WYTLYQTITTFFF----PLPLILICYIL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 -------MILRLKSVRLLSGSREKDRnLRRITKLVLVVVAVFIICWTPIHIFILVEaLGSTSHSTAALSSYYFCIALGYT 232
Cdd:cd15339  186 ilcytweMYRKNKKAGRYNTSIPRQR-VMRLTKMVLVLVGVFLVSAAPYHVIQLVN-LSVSQPTLAFYVSYYLSICLSYA 263
                        250
                 ....*....|....*...
gi 568905270 233 NSSLNPVLYAFLDENFKR 250
Cdd:cd15339  264 SSSINPFLYILLSGNFRK 281
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
1-252 3.90e-39

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 138.58  E-value: 3.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAld 79
Cdd:cd15390   31 MRTVTNYFLVNLAVADLLISAfNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHPLRP-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 fRTPLKAKIINIC-IWLLASSVGISAIVLGGTKVREDVDVIE---CSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIV 155
Cdd:cd15390  109 -RLSRRTTKIAIAvIWLASFLLALPQLLYSTTETYYYYTGSErtvCFIAWPDGPNSLQDFVYNIVLFVVTYFLPLIIMAV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMILRLKSVRLLSGSR----EKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA-LG 230
Cdd:cd15390  188 AYTRVGVELWGSKTIGENTprqlESVRAKRKVVKMMIVVVVIFAICWLPYHLYFILTYLYPDINSWKYIQQIYLAIYwLA 267
                        250       260
                 ....*....|....*....|..
gi 568905270 231 YTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15390  268 MSNSMYNPIIYCWMNKRFRYGF 289
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
3-250 6.85e-39

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 137.98  E-value: 6.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15189   33 TVAEIYLGNLAAADLVFVSGLPFWAMNILNQfNWPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEyswWDLFMKICVFVFAFVIPVLIIIVCyTLMI 161
Cdd:cd15189  113 RRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNITACVLLYPHEA---WHFAHIVLLNIVGFLLPLLVITFC-NYNI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLLSGSREkDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALgstsHSTAALSSYY----------FCIALGY 231
Cdd:cd15189  189 LQALRTREESTRCE-DRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFL----FDVGVLDECFwehfidiglqLAVFLAF 263
                        250
                 ....*....|....*....
gi 568905270 232 TNSSLNPVLYAFLDENFKR 250
Cdd:cd15189  264 SNSCLNPVLYVFVGRYFRR 282
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
1-252 1.15e-38

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 137.56  E-value: 1.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd14992   31 LRGATNYFIASLAISDLLMALfCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECS--LQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCY 157
Cdd:cd14992  111 RQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIfcCQIPPVDNKTYEKVYFLLIFVVIFVLPLIVMTLAY 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKSVRLLSGS-----REKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAA-LSSYYFCIALGY 231
Cdd:cd14992  191 ARISRELWFRKVPGFSikeveRKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRDFFPLIMKEKHtLQVYYFLHWIAM 270
                        250       260
                 ....*....|....*....|.
gi 568905270 232 TNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14992  271 SNSMYNPIIYVTLNNNFRKNF 291
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
3-250 1.39e-38

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 136.74  E-value: 1.39e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15180   33 SVTDTFILHLALADILLLVTLPFW-AVQAVHGWIFGTGLCKLAGAVFKINFYCGIFLLACISFDRYLSIVHAVQMYSRKK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWdLFMKICVFVFAFVIPVLIIIVCYTLMIL 162
Cdd:cd15180  112 PMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKTECVHNFPQSDTYWW-LALRLLYHIVGFLLPLAVMVYCYTSILL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 rlksvRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTA----------ALSsyyFCIALGYT 232
Cdd:cd15180  191 -----RLLRSSQGFQK--QRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRncgtesrldiALS---VTSSLGYF 260
                        250
                 ....*....|....*...
gi 568905270 233 NSSLNPVLYAFLDENFKR 250
Cdd:cd15180  261 HCCLNPLLYAFVGVKFRR 278
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
2-249 6.52e-38

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 135.25  E-value: 6.52e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSA-VYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15117   31 RTVTTVCFLNLAVADFAFCLFLPFSVVyTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTkvREDVDVIECSLQF-PDDEYSW-WDLFMKICV----------FVFAFVI 148
Cdd:cd15117  111 RTPARAALVAVGAWLLALALSGPHLVFRDT--RKENGCTHCYLNFdPWNETAEdPVLWLETVVqrlsaqvitrFVLGFLV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 149 PVLIIIVCYTLMILRLKSVRLLSGSREKdrnlrritKLVLVVVAVFIICWTPIHIFILVE---ALGSTSH------STAA 219
Cdd:cd15117  189 PLVIIGGCYGLIAARLWREGWVHSSRPF--------RVLTAVVAAFFLCWFPFHLVSLLElvvILNQKEDlnplliLLLP 260
                        250       260       270
                 ....*....|....*....|....*....|
gi 568905270 220 LSSyyfciALGYTNSSLNPVLYAFLDENFK 249
Cdd:cd15117  261 LSS-----SLACVNSCLNPLLYVFVGRDFR 285
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
3-252 1.25e-37

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 134.37  E-value: 1.25e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15168   33 NSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREdvDVIECSLQFPDDEYSWWDLFmKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15168  113 KKRHAVAISVAVWILVLLQLLPILFFATTGRKN--NRTTCYDTTSPEELNDYVIY-SMVLTGLGFLLPLLIILACYGLIV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRL-KSVRLLSGSREKDRNLRritkLVLVVVAVFIICWTPIHI----FILVEALGSTSHSTAALSSYYFCIA---LGYTN 233
Cdd:cd15168  190 RALiRKLGEGVTSALRRKSIR----LVIIVLALFAVCFLPFHVtrtiNLAARLLSGTASCATLNGIYVAYKVtrpLASLN 265
                        250
                 ....*....|....*....
gi 568905270 234 SSLNPVLYAFLDENFKRCF 252
Cdd:cd15168  266 SCLNPLLYFLAGDKFRRRL 284
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
1-250 1.95e-37

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 133.64  E-value: 1.95e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15182   31 LKTLTNIFILNLAISDLLFTFTLPFW-ASYHSSGWIFGEILCKAVTSIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRS 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLggTKVRE-DVDVIECSlqfpDDEYSWWDLFMKicVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15182  110 RKLRYASLVSVAVWVISILASLPELIL--STVMKsDEDGSLCE----YSSIKWKLGYYY--QQNLFFLIPLGIIVYCYVR 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKSVRllsgSREKDRNLrritKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSS-----YYFCIALGYTNS 234
Cdd:cd15182  182 ILQTLMRTR----TMRKHRTV----KLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIPICECSKqldyaFYICRNIAFSHC 253
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15182  254 CLNPVFYVFVGVKFRN 269
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
2-250 2.23e-37

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 133.74  E-value: 2.23e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15116   31 KTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFhWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFP---DDEYSWWDLF-------MKICVFVFAFVIPV 150
Cdd:cd15116  111 RSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICFNNFSlsgDNSSPEVNQLrnmrhqvMTITRFLLGFLIPF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLMILRLKSVRLLSGSREkdrnlrriTKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALG 230
Cdd:cd15116  191 TIIICCYAAIVLKLKRNRLAKSSKP--------FKIIAAVIVTFFLCWAPYHILNLLEMEATRSPASVFKIGLPITSSLA 262
                        250       260
                 ....*....|....*....|
gi 568905270 231 YTNSSLNPVLYAFLDENFKR 250
Cdd:cd15116  263 FINSCLNPILYVFMGQDFKK 282
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
5-252 1.29e-36

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 131.87  E-value: 1.29e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15097   36 TNLFILNLSVADlCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTP 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLasSVGISAIVLGGTKVREDVDVIECSLQFPDdeysWWDLFMKICVFVFAFVIPVLIIIVCYTLMILR 163
Cdd:cd15097  116 RNAVAAIALIWGL--SLLFAGPYLSYYDLIDYANSTVCMPGWEE----ARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 L-KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYA 242
Cdd:cd15097  190 LwTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYA 269
                        250
                 ....*....|
gi 568905270 243 FLDENFKRCF 252
Cdd:cd15097  270 LVSKHFRKGF 279
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
7-249 4.51e-36

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 130.25  E-value: 4.51e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDfRTPLKA 86
Cdd:cd14999   36 VYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  87 KIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPddeySWWDLFMKICV---FVFAFVIPVLIIIVCYTLMILR 163
Cdd:cd14999  115 KLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLP----TWSEESYKVYLtllFSTSIVIPGLVIGYLYIRLARK 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 L-KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHI-FILVEALGSTSHSTAALSSYYFCIA-LGYTNSSLNPVL 240
Cdd:cd14999  191 YwLSQAAASNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIwQLLYLYSPSLSLSPRTTTYVNYLLTcLTYSNSCINPFL 270

                 ....*....
gi 568905270 241 YAFLDENFK 249
Cdd:cd14999  271 YTLLTKNYK 279
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
1-252 7.09e-36

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 129.93  E-value: 7.09e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALd 79
Cdd:cd15202   31 MRTVTNYFIVNLAVADIMITLfNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTAIAVDRYQAIMHPLKPR- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 fRTPLKAKIINICIWLLASSVGISAIVLGGT---KVREDVDVIECSLQFPDDEYSWWDLFmKICVFVFAFVIPVLIIIVC 156
Cdd:cd15202  110 -ISKTKAKFIIAVIWTLALAFALPHAICSKLetfKYSEDIVRSLCLEDWPERADLFWKYY-DLALFILQYFLPLLVISFA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YTLMILRLKSVRLLSGSR-----EKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHsTAALSSYYFCIA-LG 230
Cdd:cd15202  188 YARVGIKLWASNMPGDATteryfALRRKKKKVIKMLMVVVVLFALCWLPFNIYVLLLSSKPDYL-IKTINAVYFAFHwLA 266
                        250       260
                 ....*....|....*....|..
gi 568905270 231 YTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15202  267 MSSTCYNPFIYCWLNERFRIEF 288
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
1-252 8.58e-36

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 129.32  E-value: 8.58e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15001   30 MRSVTNVFLASLATADLLLLVFcVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAISIERYYVILHPMKAKS 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLasSVGISAIVLGGTKVRE-----DVDVIECSLQFPDDEYSwwdLFMKICVFVFAFVIPVLIII 154
Cdd:cd15001  110 FCTIGRARKVALLIWIL--SAILASPVLFGQGLVRyesenGVTVYHCQKAWPSTLYS---RLYVVYLAIVIFFIPLIVMT 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLmilrlksvrllsgsrekdRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG--STSHSTAALSSYYFCIALGYT 232
Cdd:cd15001  185 FAYAR------------------DTRKQVIKMLISVVVLFAVCWGPLLIDNLLVSFDviSTLHTQALKYMRIAFHLLSYA 246
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd15001  247 NSCINPIIYAFMSKNFRSSF 266
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
2-250 1.33e-35

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 129.10  E-value: 1.33e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15162   32 KAPAVIYMANLAIADLLLVIWLPFKIAYHIHgNNWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15162  112 RARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTCHDVLPEQLLVGDWFYYFLSLAIVGFLIPFILTASCYVAT 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLrritKLVLVVVAVFIICWTPIHIFILVE-ALGSTSHSTAALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15162  192 IRTLAALEDENSEKKKKRAI----KLAATVLAIFIICFAPSNLLLLAHySLISSSGTGHLYFAYLLALCLSTLNSCIDPF 267
                        250
                 ....*....|.
gi 568905270 240 LYAFLDENFKR 250
Cdd:cd15162  268 IYYFVSKEFRD 278
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
1-252 2.07e-35

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 128.68  E-value: 2.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAld 79
Cdd:cd15393   31 MRTVTNIFIANLAVADIIIGLfSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLKA-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGIS-AIVLGGTKVREDVDVIE---CSLQFPDDEysWWDLFmKICVFVFAFVIPVLIIIV 155
Cdd:cd15393  109 RCSKKSAKIIILIIWILALLVALPvALALRVEELTDKTNNGVkpfCLPVGPSDD--WWKIY-NLYLVCVQYFVPLVIICY 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMILRLKSVRL---LSGSREKD--RNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA-L 229
Cdd:cd15393  186 AYTRIAVKIWGTKApgnAQDVRDDEilKNKKKVIKMLIIVVALFALCWLPLQTYNLLNEIKPEINKYKYINIIWFCSHwL 265
                        250       260
                 ....*....|....*....|...
gi 568905270 230 GYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15393  266 AMSNSCYNPFIYGLYNEKFKREF 288
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
7-249 2.69e-35

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 127.94  E-value: 2.69e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15372   36 IFLINLAVADLLLILVLPFKISYHFLgNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRF 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMIlrlk 165
Cdd:cd15372  116 ALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHDVLPLDEQDTYLFYYFACLAVLGFLLPLVVILFCYGSVL---- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 166 svRLLSGSREKDRNLRRITKLVLVvvaVFIICWTPIHIFILVEALGSTSHSTAAL-SSYYFCIALGYTNSSLNPVLYAFL 244
Cdd:cd15372  192 --HTLLRSGQRYGHAMKLTVLVLV---SFVLCFTPSNLLLLLHYSDPTLDDGGNLyIVYMVSLAISTLNSCVDPFIYYYV 266

                 ....*
gi 568905270 245 DENFK 249
Cdd:cd15372  267 SEEFR 271
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
1-250 2.71e-35

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 128.33  E-value: 2.71e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15184   31 LKSMTDIYLLNLAISDLLFLLTLPFW-AHYAANEWVFGNAMCKLLTGLYHIGFFSGIFFIILLTIDRYLAIVHAVFALKA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15184  110 RTVTFGVVTSVVTWVVAVFASLPGIIF--TKSQKEGSHYTCSPHFPPSQYQFWKNFQTLKMNILGLVLPLLVMIICYSGI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRllsgsREKDRNlrRITKLVLVVVAVFIICWTPIHIFILVE------ALGSTSHSTAALSSYYFCIALGYTNS 234
Cdd:cd15184  188 LKTLLRCR-----NEKKRH--KAVRLIFTIMIVYFLFWAPYNIVLLLNtfqeffGLNNCSSSNRLDQAMQVTETLGMTHC 260
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15184  261 CINPVIYAFVGEKFRS 276
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
2-252 3.14e-35

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 128.01  E-value: 3.14e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15338   35 QTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGvWHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKI 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLaSSVGISAIVLGGTKVREDVDVIECSLQFPDDEYS--WWDLFMkicvFVFAFVIPVLIIIVCYT 158
Cdd:cd15338  115 RTPRVAVAVICLVWIL-SLLSITPVWMYAGLMPLPDGSVGCALLLPNPETDtyWFTLYQ----FFLAFALPLVVICVVYF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEaLGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15338  190 KILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAH-LSIDRPSLAFLYAYNVAISMGYANSCINP 268
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15338  269 FLYIMLSETFKRQF 282
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
2-249 4.77e-35

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 127.55  E-value: 4.77e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15119   31 KTVNTLWFLNLAIADFVFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTkVREDVDVIECSLQFPDDEYSWWDLFMKICV---FVFAFVIPVLIIIVCY 157
Cdd:cd15119  111 RTLKSALILCGIVWLSAAAISGPALYFRDT-MELSINVTICFNNFHKHDGDLIVMRHTILVwvrFFFGFLFPLLTMVVCY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKSVRLLSGSrekdrnlrRITKLVLVVVAVFIICWTPIHIFILVE-ALGSTSHSTAAL-SSYYFCIALGYTNSS 235
Cdd:cd15119  190 SLLAIKVKRRTLLISS--------KFFWTISAVIVAFFVCWTPYHIFSILElSIHHSSYLHNVLrAGIPLATSLAFINSC 261
                        250
                 ....*....|....
gi 568905270 236 LNPVLYAFLDENFK 249
Cdd:cd15119  262 LNPILYVLIGKKFK 275
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
3-252 6.08e-35

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 127.53  E-value: 6.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDfR 81
Cdd:cd15002   34 SLIDSLILNLSAADLLLLLfSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVT-I 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSwwdLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15002  113 KQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLAHEFM---SAFVKLYPLFVFCLPLTFALFYFWRAY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLY 241
Cdd:cd15002  190 GQCQRRGTKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVAWLWLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIF 269
                        250
                 ....*....|.
gi 568905270 242 AFLDENFKRCF 252
Cdd:cd15002  270 LLMSEEFREGF 280
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
1-250 8.29e-35

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 126.87  E-value: 8.29e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15185   31 LRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKvrEDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15185  111 RTVTFGIITSIITWGLAVLAALPEFIFYETQ--ELFEEFLCSPLYPEDTEDSWKRFHALRMNIFGLALPLLIMVICYTGI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLksvrLLSGSREKDRNLRritkLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA------LGYTNS 234
Cdd:cd15185  189 IKTL----LRCPSKKKYKAIR----LIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCERSKHLDLAmqvtevIAYTHC 260
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15185  261 CINPVIYAFVGERFRK 276
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
1-250 9.26e-35

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 126.84  E-value: 9.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15187   31 LRSMTDVYLLNLAASDLLFVFSLPFQ-AYYLLDQWVFGNAMCKIVSGAYYIGFYSSMFFITLMSIDRYLAIVHAVYALKV 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPDDEYSwWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15187  110 RTASHGTILSLALWLVAILASVPLLVF--YQVASEDGRLQCIPFYPGQGNS-WKVFTNFEVNILGLLIPFSILIFCYHNI 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKsvrllsgsREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIAL------GYTNS 234
Cdd:cd15187  187 LRNLR--------RCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLHIIDGCQNSQRLTLALhltetiSFTHC 258
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15187  259 CLNPVIYAFVGEKFKK 274
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
2-248 1.39e-34

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 126.46  E-value: 1.39e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSaVYLM--NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15118   31 RTVISIWILNLALSDLLATLSLPFFT-YYLAsgHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQN 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDvDVIECSLQFP---------DDEYSWWDLFMKICVFVFAFVIPV 150
Cdd:cd15118  110 HRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKD-GRKLCYYNFAlfspspdnnHPICKQRQEGLAISKLLLAFLIPL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLMILRLKsvrllsgSREKDRNLrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAAL--SSYYFCIA 228
Cdd:cd15118  189 VIIAVSYAVVSLIIR-------HRCRRRPG-RFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQHSLRPLviQGLPFATT 260
                        250       260
                 ....*....|....*....|
gi 568905270 229 LGYTNSSLNPVLYAFLDENF 248
Cdd:cd15118  261 LAFLNSVLNPVLYVFSCPDF 280
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
2-248 1.76e-34

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 127.59  E-value: 1.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:PHA03087  71 KTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKIN 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKvrEDVDVIECSLqFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:PHA03087 151 TVKYGYIVSLVIWIISIIETTPILFVYTTK--KDHETLICCM-FYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKIL 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKsvrllsGSREKDRNLRRItKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYT------NSS 235
Cdd:PHA03087 228 ITLK------GINKSKKNKKAI-KLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAVKYIQYALHVTeiislsHCC 300
                        250
                 ....*....|...
gi 568905270 236 LNPVLYAFLDENF 248
Cdd:PHA03087 301 INPLIYAFVSEFF 313
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
1-252 2.21e-34

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 125.94  E-value: 2.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQS-AVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15392   31 MRTVTNYFIVNLALSDILMAVfCVPFSFiALLILQYWPFGEFMCPVVNYLQAVSVFVSAFTLVAISIDRYVAIMWPLRPR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 dfRTPLKAKIINICIWLLASSVGI-SAIVlggTKVREDVDVIE----CSLQFPDDEYSWwdlFMKICVFVFAFVIPVLII 153
Cdd:cd15392  111 --MTKRQALLLIAVIWIFALATALpIAIT---SRLFEDSNASCgqyiCTESWPSDTNRY---IYSLVLMILQYFVPLAVL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 154 IVCYTLMILRL---KSVRLLSGSREKD--RNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCI- 227
Cdd:cd15392  183 VFTYTRIGIVVwakRTPGEAENNRDQRmaESKRKLVKMMITVVAIFALCWLPLNILNLVGDHDESIYSWPYIPYLWLAAh 262
                        250       260
                 ....*....|....*....|....*
gi 568905270 228 ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15392  263 WLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
3-250 2.45e-34

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 126.04  E-value: 2.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQsAVYLMN--SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15381   33 TVAEIYLGNLAAADLLLVCCLPFW-AINISNgfNWPFGEFLCKSVNAVIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRM 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDeysWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15381  112 RRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLDYPSE---GWHVALNILLNVVGFLIPLSIITFCSTQI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRllSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVealgSTSHSTAALSS----------YYFCIALG 230
Cdd:cd15381  189 IQVLRNNK--MQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFL----DTLHKLGLISGcrwedildigTQIATFLA 262
                        250       260
                 ....*....|....*....|
gi 568905270 231 YTNSSLNPVLYAFLDENFKR 250
Cdd:cd15381  263 YSNSCLNPLLYVIVGKHFRK 282
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
2-252 3.59e-34

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 125.31  E-value: 3.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15921   32 QTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNShWPFGDIACRIILYVLYVNMYSSIYFLTALSVFRYLALVWPYLYLRV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLassVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWdLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15921  112 QTHSVAGIICGLIWIL---MGLASSPLLFAKSKQHDEGSTRCLELAHDAVDKL-LLINYVTLPVGFVVPFMTVIFCYIFI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALS------SYYFCIALGYTNS 234
Cdd:cd15921  188 IKNLLKPSPALGRTRPSR--RKACALIIISLGIFLVCFLPYHIVRTIHLITERQIKESCGYilrvrkAAVITLCLAASNS 265
                        250
                 ....*....|....*...
gi 568905270 235 SLNPVLYAFLDENFKRCF 252
Cdd:cd15921  266 CFDPLLYFFVGENFRSRL 283
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
2-249 7.79e-34

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 124.44  E-value: 7.79e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15161   32 GTPSNVFLMHLAVADLSYVLILPMRLVYHLSgNHWPFGEVPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLassVGIS-AIVLGGTKVREDVDVIECSLQFPDDEyswwDLFMKICVFVfAFVIPVLIIIVCYTL 159
Cdd:cd15161  112 RKPLYAHVVCGFLWVI---VTVAmAPLLVSPQTVEVNNTTVCLQLYREKA----SRGALVSLAV-AFTIPFVTTVTCYLL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKsvrllSGSREKDRNLRRITKLVLVVVAVFIICWTPIHI----FILVEALGSTSHSTA---ALSSyYFCIALGYT 232
Cdd:cd15161  184 IIRSLR-----TGKREEKPLKDKAIKMIILVLTIFLICFVPYHIsryiYILSHNGAGASCSSRrglALAN-RITSCLTCL 257
                        250
                 ....*....|....*..
gi 568905270 233 NSSLNPVLYAFLDENFK 249
Cdd:cd15161  258 NGALDPVMYFFVAEKFR 274
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
2-252 1.24e-33

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 124.12  E-value: 1.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15120   31 RTVNTLWFLHLILSNLIFTLILPFMAVHVLMdNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIeCSLQF----------PDDEYSWWDLFMKICVFVFAFVIPV 150
Cdd:cd15120  111 RTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTI-CQNNYalstnwesaeVQASRQWIHVAMFVFRFLLGFLLPF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLMILRLKSVRLLSGSREkdrnlrriTKLVLVVVAVFIICWTPIHIF----ILVEALGSTSHSTAALSSYYFC 226
Cdd:cd15120  190 LIITFCYVRMALKMKERGLARSSKP--------FKVMFTAVVSFFVCWLPYHLHsglvLTRGRPPSLTDITLLLTVGTTC 261
                        250       260
                 ....*....|....*....|....*.
gi 568905270 227 IalgytNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15120  262 F-----NTCFTPVLYLFVGENFKKVL 282
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
3-249 1.25e-33

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 124.14  E-value: 1.25e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSA-VYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15380   33 TIAEIYLANLAASDLVFVLGLPFWAEnIRNQFNWPFGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVHTMTSRRQR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYswwdLFMKICVF-VFAFVIPVLIIIVCYTLM 160
Cdd:cd15380  113 SRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNISACILLFPHEAW----HFARRVELnIVGFLLPLAAIVFFNFHI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYY------FCIALGYTNS 234
Cdd:cd15380  189 IASLRERTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVIQGCFWEEFidlglqLANFFAFANS 268
                        250
                 ....*....|....*
gi 568905270 235 SLNPVLYAFLDENFK 249
Cdd:cd15380  269 CLNPVIYVFAGKLFR 283
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
2-249 1.99e-33

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 123.28  E-value: 1.99e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15157   32 KTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGShWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEyswwdLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15157  112 TSIKYARILCAVIWIFVMAASSPLLSKGTSKYNSQTKCLDLHPSKIDKL-----LILNYIVLVVGFILPFCTLSICYILI 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 IlrlksvRLLSGSREKDRNLRRITKLVLVVVAV----FIICWTPIHIFILVEAL-GSTSHSTAAL-SSYYFCIALGYTNS 234
Cdd:cd15157  187 I------KALLKPRVPQSKLRVSHKKALLTIIItlilFLLCFLPYHILRTVHLMqWSEGQCNLRLhKAVVITLCLAAANS 260
                        250
                 ....*....|....*
gi 568905270 235 SLNPVLYAFLDENFK 249
Cdd:cd15157  261 CLDPLLYYFAGENFK 275
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
2-251 2.68e-33

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 123.32  E-value: 2.68e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15158   32 KSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGqWLFGDFLCRISSYALYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLAsSVGISAIVLGGTKVREDvDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15158  112 VTVKKARIVCVGIWIFV-TLTSSPFLMSGSHDTET-NKTKCFEPPQSNQQLTKLLVLNYISLVVGFIIPFLVILICYAMI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLksVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTP------IHIFILVEALGSTSHSTAALSSYYFCIALGYTNS 234
Cdd:cd15158  190 IRTL--LKNTMKARKQQSSRKKAIRMIIIVLLAFLVSFMPyhiqrtIHLHFLSRKDSTCEEVLYMQKSVVITLCLAAANC 267
                        250
                 ....*....|....*..
gi 568905270 235 SLNPVLYAFLDENFKRC 251
Cdd:cd15158  268 CFDPLLYFFSGENFRRR 284
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
1-250 2.88e-33

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 123.06  E-value: 2.88e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15183   31 LRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15183  111 RTVTFGIITSIITWALAILASMPCLYF--FKSQWEFTHHTCSAHFPRKSLIRWKRFQALKLNLLGLILPLLVMIICYTGI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKsvrllsgsREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA------LGYTNS 234
Cdd:cd15183  189 INILL--------RRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSCEQSQQLDLAlqvtevIAYTHC 260
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15183  261 CVNPVIYVFVGERFRK 276
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
1-250 4.16e-33

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 122.45  E-value: 4.16e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALd 79
Cdd:cd15389   31 MHTATNLFIVNLAVSDILITLlNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIALDRHRVILHPLKPR- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 fRTPLKAKIINICIWLLASSVGISAIVLggTKVRE-----DVDVIECSLQFPDDEYSWWDlFMKICVFVFAFVIPVLIII 154
Cdd:cd15389  110 -ITPCQGVVVIAIIWIMASCLSLPHAIY--QKLVEfeysnERTRSRCLPSFPEPSDLFWK-YLDLATFILQYVLPLLIIG 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKSVRLLSGSREK-----DRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAAlssYYFCIAL 229
Cdd:cd15389  186 VAYTRVAKKLWLRNAIGDVTTEqyvaqRRKKKKTIKMLMLVVLLFAICWLPLNCYHVLLSSHPIRSNSAL---FFAFHWL 262
                        250       260
                 ....*....|....*....|.
gi 568905270 230 GYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15389  263 AMSSTCYNPFIYCWLNDSFRS 283
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
2-252 1.18e-32

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 121.54  E-value: 1.18e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd14969   32 RTPLNLFLLNLALADLLMSVvGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 rTPLKAKIINICIWLLASS------VGISAIVLGGTKVRedvdvieCSLQFPDDEYSwwDLFMKICVFVFAFVIPVLIII 154
Cdd:cd14969  112 -SKRRALILIAFIWLYGLFwalpplFGWSSYVPEGGGTS-------CSVDWYSKDPN--SLSYIVSLFVFCFFLPLAIII 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKSV-------RLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYyfCI 227
Cdd:cd14969  182 FCYYKIYRTLRKMskraarrKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVSFGGESTIPPLLATI--PA 259
                        250       260
                 ....*....|....*....|....*
gi 568905270 228 ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14969  260 LFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
1-252 1.65e-32

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 120.53  E-value: 1.65e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15053   31 LQTATNYFIVSLAVADLLVAIlVMPFAVYVEVNGGkWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLasSVGISAIVLGGTKVREDVDVIECSLQFPDdeyswwdlFMkICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15053  111 RQKNSKRVLLTIAIVWVV--SAAIACPLLFGLNNVPYRDPEECRFYNPD--------FI-IYSSISSFYIPCIVMLLLYY 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKsvrllsgsREkdrnlRRITKLVLVVVAVFIICWTP---IHIFILVEALGSTSHSTAALSSYYFCIALGYTNSS 235
Cdd:cd15053  180 RIFRALR--------RE-----KKATKTLAIVLGVFLFCWLPfftLNILNAICPKLQNQSCHVGPALFSLTTWLGYVNSF 246
                        250
                 ....*....|....*..
gi 568905270 236 LNPVLYAFLDENFKRCF 252
Cdd:cd15053  247 LNPIIYTIFNIEFRKAF 263
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
2-243 3.81e-32

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 119.91  E-value: 3.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15122   34 RSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKIcvfVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15122  114 KKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPCHASRGHAIFHYTFET---LVAFVLPFGVILFSYSVIL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLLSGSrekdrnlrRITKLVLVVVAVFIICWTPIHIFILVEALG-------STSHSTAALSSYYFCIALGYTNS 234
Cdd:cd15122  191 VRLKGARFRRRA--------RVEKLIAAIVVAFALLWVPYHVVNLLQVVAnlapgevLEKLGGAAKAARAGATALAFFSS 262

                 ....*....
gi 568905270 235 SLNPVLYAF 243
Cdd:cd15122  263 SVNPLLYVF 271
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
5-249 4.02e-32

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 119.86  E-value: 4.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVTTTMP-FQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd14987   35 THLYILNLAIADLCVVATLPvWVVSLVQHNQWPMGEFTCKITHLIFSINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMilr 163
Cdd:cd14987  115 IVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRSFYPEESFKEWLIGMELVSIVLGFVIPFPIIAVFYFLL--- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 lksVRLLSGSREKDRNLRRitKLVLVVVAVFIICWTPIHIFILVEALGS----------------TSHSTAALSSYYFCI 227
Cdd:cd14987  192 ---ARAISASSDQERKSSR--KIIFSYVVVFLVCWLPYHTVVLLDILSFlhlipfscqlenflyaALHVTQCFSLVHCCV 266
                        250       260
                 ....*....|....*....|..
gi 568905270 228 algytnsslNPVLYAFLDENFK 249
Cdd:cd14987  267 ---------NPILYSFINRNYR 279
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
2-250 4.47e-32

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 119.82  E-value: 4.47e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSA-VYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15114   31 RSVNAVWFLNLAVADLLCCLSLPILAVpIAQDGHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWdlFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15114  111 RRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKTVCVVDYGGSTGVEW--AVAIIRFLLGFLGPLVVIASCHGVL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRllsgsREKDrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHST--AALSSYYFCIALGYTNSSLNP 238
Cdd:cd15114  189 LVRTWSRR-----RQKS---RRTLKVVTAVVVGFFLCWTPYHVVGLIIAASAPNSRLlaNALKADPLTVSLAYINSCLNP 260
                        250
                 ....*....|..
gi 568905270 239 VLYAFLDENFKR 250
Cdd:cd15114  261 IIYVVAGRGFRK 272
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
3-252 4.79e-32

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 119.97  E-value: 4.79e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkaLDFR 81
Cdd:cd15055   33 TPTNLLLLSLAVADFLVgLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDP---LLYP 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICI---WLLASSVGISAIVLGGTK---VREDVDVIECSLQFpddEYSWWdlfmkICVFVFAFVIPVLIIIV 155
Cdd:cd15055  110 TKITIRRVKICIclcWFVSALYSSVLLYDNLNQpglIRYNSCYGECVVVV---NFIWG-----VVDLVLTFILPCTVMIV 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYT-LMILRLKSVRLLSGSREKDRNLRRITKLVL-----------VVVAVFIICWTPIHIFILVEALGSTShstaaLSSY 223
Cdd:cd15055  182 LYMrIFVVARSQARAIRSHTAQVSLEGSSKKVSKkserkaaktlgIVVGVFLLCWLPYYIVSLVDPYISTP-----SSVF 256
                        250       260
                 ....*....|....*....|....*....
gi 568905270 224 YFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15055  257 DVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
5-243 4.98e-32

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 119.51  E-value: 4.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd14975   35 TMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLggtkvREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRL 164
Cdd:cd14975  115 LAHKVLAIIWLLAVLLATPVIAF-----RHVEETVENGMCKYRHYSDGQLVFHLLLETVVGFAVPFTAVVLCYSCLLRRL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 KSVRLLSGsrekdrnlRRITKLVLVVVAVFIICWTPIHIFILVEA---LGSTSHSTAALSSY-----YFCIALGYTNSSL 236
Cdd:cd14975  190 RRRRFRRR--------RRTGRLIASVVVAFAACWLPYHVGNLLEVvseLIGGSKMAGTLGKVaeagrPIAGALAFLSSSI 261

                 ....*..
gi 568905270 237 NPVLYAF 243
Cdd:cd14975  262 NPLLYAF 268
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
7-250 5.07e-32

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 119.80  E-value: 5.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15160   37 VYLLNLSLSDLLYILTLPLWIDYTANhHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRF 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLAssVGISAIVLG-GTKVREDVDVIECSLQFPDDEYSWWDLFMKICVfvfAFVIPVLIIIVCYtLMILRl 164
Cdd:cd15160  117 ALKVSASIWVLE--LGTHSVFLGhDELFRDEPNHTLCYEKYPMEGWQASYNYARFLV---GFLIPLSLILFFY-RRVLR- 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 kSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHS------TAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15160  190 -AVRQSPSLEREEK--RKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNglcgfeKRVFTAYQISLCLTSLNCVADP 266
                        250
                 ....*....|..
gi 568905270 239 VLYAFLDENFKR 250
Cdd:cd15160  267 ILYIFVTEDVRQ 278
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
1-252 6.20e-32

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 118.98  E-value: 6.20e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15059   31 LRAPQNWFLVSLAVADILVgLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQfpddEYSWWDLFMKIcvfvFAFVIPVLIIIVCYtl 159
Cdd:cd15059  111 KRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQCELS----DDPGYVLFSSI----GSFYIPLLIMIIVY-- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 milrlksVRLLSGSREKDrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALssYYFCIALGYTNSSLNPV 239
Cdd:cd15059  181 -------ARIYRAAKRKE---RRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTCGVPELL--FKFFFWLGYCNSALNPV 248
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15059  249 IYTIFNKDFRRAF 261
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 9.33e-32

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 119.42  E-value: 9.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKalD 79
Cdd:cd15208   31 MRTVTNYFIVNLSLADFLVIIIcLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLM--F 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVlggtkvredvdVIECSLQFPDDEY---------SWWD----LFMKICVFVFAF 146
Cdd:cd15208  109 KSTAKRARVSILIIWIVSLLIMIPQAI-----------VMECSRVVPLANKtilltvcdeRWSDsiyqKVYHICFFLVTY 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 147 VIPVLIIIVCYTLMILRL------------------KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIF-IL- 206
Cdd:cd15208  178 LLPLCLMILAYFQIFRKLwcrqipgtssvvqrkwnkPRKSAVAAEEKQLRSRRKTAKMLIVVVIMFAICYLPVHLLnILr 257
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568905270 207 -VEALGSTSHSTA---ALSSYYFCialgYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15208  258 yVFGLFTVDRETIyawFLFSHWLV----YANSAINPIIYNFMSGKFREEF 303
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
2-249 1.62e-31

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 118.33  E-value: 1.62e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15179   32 RTMTDKYRLHLSVADLLFVLTLPFW-AVDAAANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15179  111 KLLAEKVVYVGVWLPALLLTVPDLVF--AKVSELDDRYICDRIYPEDTFELWVVAFRFQHILVGLVLPGLVILTCYCIII 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLksvrllsgSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEA---LGSTSHSTAALSSYYFCI----ALGYTNS 234
Cdd:cd15179  189 SKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTfmlLEIIKQSCEMEQTVHKWIsiteALAFFHC 260
                        250
                 ....*....|....*
gi 568905270 235 SLNPVLYAFLDENFK 249
Cdd:cd15179  261 CLNPILYAFLGAKFK 275
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
4-250 3.80e-31

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 117.45  E-value: 3.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   4 ATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15159   34 STTLYLINLAVSDILFTLALPGRIAYYALGfDWPFGDWLCRLTALLFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLASSVGISAIVLGGTKvrEDVDVIECsLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMIL 162
Cdd:cd15159  114 VKVVRYICVFVWVLVFLQTLPLLFMPMTK--EMGGRITC-MEYPNFEKIKRLPLILLGACVIGFGVPVGIILFCYSQITL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 RLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYT------NSSL 236
Cdd:cd15159  191 KLCRTAKENPLTEKSGHHKKACNVILLVLLVFVVCFSPYHLNIIQFMIRKLLYQPSCSELKAFKISLQITvclmnlNCCL 270
                        250
                 ....*....|....
gi 568905270 237 NPVLYAFLDENFKR 250
Cdd:cd15159  271 DPFIYFFACKGYKK 284
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
1-252 5.93e-31

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 116.78  E-value: 5.93e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15172   31 TKSMTDVYLLNMAIADILFVLTLPFW-AVYEAHQWIFGNFSCKLLRGIYAINFYSGMLLLACISVDRYIAIVQATKSFRL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 R--TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDE-YSWWDLFMKICVFVFAFVIPVLIIIVCY 157
Cdd:cd15172  110 RsrTLAYSKLICAAVWLLAILISLPTFIFSEVYDFGLEEQYVCEPKYPKNStAIMWKLLVLSLQVSLGFFIPLLVMIFCY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKSVRllSGSREKdrnlrrITKLVLVVVAVFIICWTPIHIFILVEA-----LGSTSHSTAALSSYYFCIALGYT 232
Cdd:cd15172  190 SFIIKTLLQAQ--NSQRHK------AVRVVVAVVLVFLVCQVPYNIVLLIEAinlgeQQSCSSEKAVAYAKTITECLAFF 261
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd15172  262 HCCLNPVLYAFIGVKFRNYF 281
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
1-252 7.78e-31

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 116.17  E-value: 7.78e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15321   37 LRAPQNLFLVSLAAADILVATlIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNS 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLqfpdDEYSWWDLFMKICvfvfAFVIPVLIIIVCYtl 159
Cdd:cd15321  117 KRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKL----NEEAWYILSSSIG----SFFAPCLIMILVY-- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 miLRlksVRLLSGSREKdrnlrRITKLVLVVVAVFIICWTPihiFILVEALGS--TSHSTAALSSYYFCIALGYTNSSLN 237
Cdd:cd15321  187 --LR---IYLIAKNREK-----RFTFVLAVVIGVFVLCWFP---FFFSYSLGAicPELCKVPHSLFQFFFWIGYCNSSLN 253
                        250
                 ....*....|....*
gi 568905270 238 PVLYAFLDENFKRCF 252
Cdd:cd15321  254 PVIYTIFNQDFRRAF 268
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
3-250 9.03e-31

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 116.51  E-value: 9.03e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15925   34 PPIDVFVFNLALADFGFALTLPFWAVESALDfHWPFGGAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKvrEDVDVIECSLQFPDDeysWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15925  114 STFWAKIITLALWAAALLATVPTAIFATEG--EVCGVELCLLKFPSN---YWLGAYHLQRVVVAFVVPLGVITTSYLLLL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLLSGSREKDrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGST-----SHSTAALSSYYFCIA--LGYTNS 234
Cdd:cd15925  189 SFLQQHKVNQNNRQRQ---SVIARSVRLVVASFFLCWFPNHVVTFWGVLVKFravpwNSTFYFIHTYVFPVTtcLAHSNS 265
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15925  266 CLNPVLYCLMRREFRQ 281
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
3-252 1.05e-30

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 115.50  E-value: 1.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTT-TMPFqSAVY-LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15064   33 TPANYLIASLAVADLLVAVlVMPL-SAVYeLTGRWILGQVLCDIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSwwdlfmkicvFVFAFVIPVLIIIVCYTlM 160
Cdd:cd15064  112 RTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECLISQDIGYTIFS----------TFGAFYIPLLLMLILYW-K 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRlksvrllSGSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyFCIALGYTNSSLNPVL 240
Cdd:cd15064  181 IYR-------AAARE-----RKAAKTLGIILGAFIVCWLPFFLVALIVPLCSHCWIPLALKS--FFLWLGYFNSLINPLI 246
                        250
                 ....*....|..
gi 568905270 241 YAFLDENFKRCF 252
Cdd:cd15064  247 YTFFNKDFRKAF 258
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
1-252 1.79e-30

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 115.22  E-value: 1.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15050   31 LHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASS-----VGISAIVLGGTKVREDVdviECSLQFPDDeySWWdlfmKICVFVFAFVIPVLIII 154
Cdd:cd15050  111 YRTKTRASLMISGAWLLSFLwvipiLGWHHFARGGERVVLED---KCETDFHDV--TWF----KVLTAILNFYIPSLLML 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMilrLKSVRllsgsREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALgstSHSTAALSSYYFCIALGYTNS 234
Cdd:cd15050  182 WFYAKI---FKAVN-----RE-----RKAAKQLGFIMAAFILCWIPYFILFMVIAF---CKNCCNENLHMFTIWLGYINS 245
                        250
                 ....*....|....*...
gi 568905270 235 SLNPVLYAFLDENFKRCF 252
Cdd:cd15050  246 TLNPFIYPLCNENFKKTF 263
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
1-252 3.29e-30

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 115.02  E-value: 3.29e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15155   31 MRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTI 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVieCSLQFpdDEYSWWDLFMKICVF--VFAFVIPVLIIIVCYT 158
Cdd:cd15155  111 RTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTT--CFEGF--SKSIWKTYLSKITIFieVVGFIIPLLLNLTCSS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRLLSgsrEKDRNLRRITKLVLVVVAVFIICWTP------IHIFILVEALGSTSHSTAALSSYYFCIALGYT 232
Cdd:cd15155  187 LVLRTLRKPATLS---QIGTNKEKVLKMILVHVAIFVVCFVPynsilfLYALVRSQAIANCGVERFARTMYPITLCLATL 263
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd15155  264 NCCFDPFVYYFTSESFQKSF 283
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
1-252 4.85e-30

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 114.71  E-value: 4.85e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15048   31 LRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVL-----GGTKVREDvdviECSLQFPDDEYswwdlfMKICVFVFAFVIPVLIII 154
Cdd:cd15048  111 KQTKRRTVLLMALVWILAFLLYGPAIIGwdlwtGYSIVPTG----DCEVEFFDHFY------FTFITSVLEFFIPFISVS 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMIL---------RLKSVRLLSGSREKDRNL-----------RRITKLVLVVVAVFIICWTPIHIFILVEALGSTS 214
Cdd:cd15048  181 FFNLLIYLnirkrsrrrPLRSVPILPASQNPSRARsqreqvklrrdRKAAKSLAILVLVFLICWAPYTILTIIRSFCSGS 260
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568905270 215 HSTAALssYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15048  261 CVDSYL--YEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
1-246 5.64e-30

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 114.56  E-value: 5.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15156   31 VRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKTL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEysWWDLFMKICVFV--FAFVIPVLIIIVCYT 158
Cdd:cd15156  111 RTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSETCFENFSSKT--WKTYLSKIVIFIeiVGFFIPLILNVTCST 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRLLSGSRekdRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGST------SHSTAALSSYYFCIALGYT 232
Cdd:cd15156  189 MVLKTLRRPNTLSRSK---LNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTqtfkncSVVAAVRTMYPITLCIAVS 265
                        250
                 ....*....|....
gi 568905270 233 NSSLNPVLYAFLDE 246
Cdd:cd15156  266 NCCFDPIVYYFTSE 279
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
1-252 6.92e-30

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 114.37  E-value: 6.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd14979   31 LRTTTNYYLFSLAVSDLLIlLVGLPVELYNFWWQyPWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIVLGGTK-----VREDVDVI-ECSLQFPDDEYSwwdLFMKICVFVFaFVIPVLI 152
Cdd:cd14979  111 TLVTKRRVKRFILAIWLVSILCAIPILFLMGIQylngpLPGPVPDSaVCTLVVDRSTFK---YVFQVSTFIF-FVLPMFV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 153 IIVCYTLMILRLKSVRLL-----------SGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGS---TSHSTA 218
Cdd:cd14979  187 ISILYFRIGVKLRSMRNIkkgtraqgtrnVELSLSQQARRQVVKMLGAVVIAFFVCWLPFHAQRLMFSYASkedTFLFDF 266
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568905270 219 ALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14979  267 YQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
7-243 8.01e-30

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 113.71  E-value: 8.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15369   37 IYMLNLACADLLFVLLLPFKIAYHFSgNDWLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGISAIVLGGTKVREDVDVIEC-SLQFPDDEYSWWDLFMKICVFVFaFVIPVLIIIVCYTLMILRL 164
Cdd:cd15369  117 ASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGITTChDVLNEQLLMGYYVYYFSIFSCLF-FFVPLIITTVCYVSIIRCL 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 KSVRLLSGSREKDRNLrritKLVLVVVAVFIICWTPIHIFILVE--ALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYA 242
Cdd:cd15369  196 SSSSDVANSSKKTRAL----FMAVAVFCVFVICFGPTNVLLLAHyvRFAYTSTNDASYFAYLLCVCVGSISCCLDPLIYY 271

                 .
gi 568905270 243 F 243
Cdd:cd15369  272 Y 272
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
2-250 2.14e-29

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 113.07  E-value: 2.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15926   33 KSSINLFVTSLAVTDFQFVLTLPFWAVENALDfTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGI-SAIVLGGTKVREDVdviECSLQFPD---DEYSWWDLFMKICVfVFAFVIPVLIIIVC 156
Cdd:cd15926  113 RGCCSAKWLCVLIWVLAILASLpNAIFSTTATVSNEE---LCLVKFPDnrgNAQFWLGLYHAQKV-LLGFLIPLGIISLC 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YtLMILRLKSVRLLSGSREKDRNlrRITKLVLVVVAVFIICWTPIH------IFILVEALG-STSHSTAALSSYYFCIAL 229
Cdd:cd15926  189 Y-LLLVRFITDKNITGSSTKRRS--KVTKSVTIVVLSFFLCWLPNQalttwgILIKLNVVHfSYEYFTTQVYIFPITVCL 265
                        250       260
                 ....*....|....*....|.
gi 568905270 230 GYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15926  266 AHSNSCLNPILYCLMRREFRK 286
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
1-252 2.33e-29

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 112.03  E-value: 2.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15049   31 LRTVNNYFLLSLACADLIIgLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKV-REDVDVIECSLQFPDDEYswwdlfMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15049  111 KRTPKRAILMIALAWVISFVLWAPAILGWQYFVgERTVPDGQCYIQFLDDPA------ITFGTAIAAFYLPVLVMTILYW 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMilrlksvrllsgSREKDRNlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALS-SYYFCialgYTNSSLN 237
Cdd:cd15049  185 RI------------YRETARE-RKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLWSfGYWLC----YINSTIN 247
                        250
                 ....*....|....*
gi 568905270 238 PVLYAFLDENFKRCF 252
Cdd:cd15049  248 PFCYALCNKTFRKTF 262
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
1-252 2.66e-29

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 112.14  E-value: 2.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15302   31 IRQPSNYFIASLAVSDLLIgLESMPFYTVYVLNGDyWPLGWVLCDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAKYR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVI--ECSLQFPDDEYswWDLFMKICVfvfaFVIPVLIIIVC 156
Cdd:cd15302  111 NWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQGRSLPegECYVQFMTDPY--FNMGMYIGY----YWTTLIVMLIL 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YTLMILRLKSVRllsgsrekdRNLRRITklvlVVVAVFIICWTPIHIFILVEAL---GSTSHSTAALSSYYFCialgYTN 233
Cdd:cd15302  185 YAGIYRAANRAR---------KALRTIT----FILGAFVICWTPYHILATIYGFceaPPCVNETLYTISYYLC----YMN 247
                        250
                 ....*....|....*....
gi 568905270 234 SSLNPVLYAFLDENFKRCF 252
Cdd:cd15302  248 SPINPFCYALANQQFKKTF 266
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
2-250 2.95e-29

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 112.53  E-value: 2.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFqSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15181   32 RRTTENYLLHLALADLLLLLTFPF-SVVESIAGWVFGTFLCKLVGAIHKLNFYCSSLLLACISVDRYLAIVHAIHSYRHR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSL-QFPDDEYSWWdLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15181  111 RLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRTSCSFhQYGIHESNWW-LTSRFLYHVVGFFLPLLIMGYCYATI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLksvRLLSGSREKDRNLRritkLVLVVVAVFIICWTPIHIFILVEA---LGSTSHSTAALSSYYFCI----ALGYTN 233
Cdd:cd15181  190 VVTL---CQSSRRLQKQKAIR----VAILVTLVFCLCWLPYNIVIFLDTlddLKAVVKNCKLNDLLDAAItvteSLGFSH 262
                        250
                 ....*....|....*..
gi 568905270 234 SSLNPVLYAFLDENFKR 250
Cdd:cd15181  263 CCLNPILYAFIGVKFRN 279
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
1-252 4.94e-29

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 111.40  E-value: 4.94e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15173   31 LRTLTDIFLVNLAVADLLFLCTLPFW-AYSAAHEWIFGTVMCKITNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNC 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 --RTPLKAKIINICIWLLASSVGISAIVLGGTKvreDVDVIECSLQFPDDEYSWWDLFMKICVfvfAFVIPVLIIIVCYT 158
Cdd:cd15173  110 haKKMRWGKVVCTLVWVISLLLSLPQFIYSEVR---NLSSKICSMVYPPDAIEVVVNIIQMTV---GFFLPLLAMIICYS 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLksvrLLSGSREKDRNLrritKLVLVVVAVFIICWTPIHIFILVEALGstSHSTAALSSYYFCI---ALGYTNSS 235
Cdd:cd15173  184 VIIKTL----LHAKGFQKHKSL----KIIFVVVAVFILTQLPYNIMKLIRTLH--IENTDSTNFKYAILiteAIAYLHAC 253
                        250
                 ....*....|....*..
gi 568905270 236 LNPVLYAFLDENFKRCF 252
Cdd:cd15173  254 LNPILYAFVGVKFRKNF 270
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
6-250 5.22e-29

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 111.77  E-value: 5.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTTMPF-QSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVchpVKALD---FR 81
Cdd:cd15193   36 DTFVLNLAVADLVFVLTLPFwAASTALGGQWLFGEGLCKLSSFIIAVNRCSSILFLTGMSVDRYLAV---VKLLDsrpLR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDvdvieCSlqfpDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15193  113 TRRCALITCCIIWAVSLVLGIPSLVYRNLINESV-----CV----EDSSSRFFQGISLATLFLTFVLPLIVILFCYCSIL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKsvRLLSGSREKDRNLRRITKLVLVVVAVFIICWTP------IHIFILVEALGSTSHSTAALS---SYYFCIAlgYT 232
Cdd:cd15193  184 VRLR--RHFHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPfntlkaVRLLLELGGGVLPCHTTVAIRqglTITACLA--FV 259
                        250
                 ....*....|....*...
gi 568905270 233 NSSLNPVLYAFLDENFKR 250
Cdd:cd15193  260 NSCVNPLIYSLLDRHFRR 277
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
2-250 5.50e-29

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 111.77  E-value: 5.50e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15174   32 KTMTDVYLLNLAIADLLFLCTLPFW-ATAASSGWVFGTFLCKVVNSMYKINFYSCMLLLTCISVDRYIAIVQATKAHNSK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TP--LKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPDDEyswwDLFMKICVFV----FAFVIPVLIIIV 155
Cdd:cd15174  111 NKrlLYSKLVCFFVWLLSTILSLPEILF--SQSKEEESVTTCTMVYPSNE----SNRFKVAVLAlkvtVGFFLPFVVMVI 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMILRLKSVRllsgSREKDRNLrritKLVLVVVAVFIICWTPIHIFILVEALGS---TSHSTAALSSYYFCI----A 228
Cdd:cd15174  185 CYTLIIHTLLQAK----RFQKHKAL----KVIIAVVTVFVLSQLPYNSILLIKTINAyniTITDCATSQNLDIAGqvtqS 256
                        250       260
                 ....*....|....*....|..
gi 568905270 229 LGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15174  257 IAFLHSCLNPFLYVFVGVRFRK 278
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
2-249 5.97e-29

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 111.84  E-value: 5.97e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALdf 80
Cdd:cd15391   32 RTDLNYYLINLAVSDLIMALfCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSR-- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVR--EDVDVIECSLQFPDDEYswWDLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15391  110 HTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYgqYSEGRVLCGESWPGPDT--SRSAYTVFVMLLTYIIPLLILTSTYG 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSvRLLSGSREKDRNL------RRITKLVLVVVAVFIICWTPIHIFILV----EALGSTSHSTaALSSYYFCIA 228
Cdd:cd15391  188 YVGFRLWN-RTAPGNADKGRDDmqikskRKVIKMLVFVVLMFGICWLPLHLFNLVqdfsTVFRNMPQHT-TRLIYGACHW 265
                        250       260
                 ....*....|....*....|.
gi 568905270 229 LGYTNSSLNPVLYAFLDENFK 249
Cdd:cd15391  266 IAMSNSFVNPIIYLFMNDSFR 286
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
1-252 7.53e-29

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 111.27  E-value: 7.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15051   31 LRNLTNYFIVSLAVTDLLLgLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLG----GTKVREDVDVIECSLQfpddeyswWDLFMKICVFVFAFVIPVLIIIV 155
Cdd:cd15051  111 RVTPRRVAIALAAIWVVSLAVSFLPIHLGwntpDGRVQNGDTPNQCRFE--------LNPPYVLLVAIGTFYLPLLIMCG 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMIL-------RLKSVRLLSGSREKDRNL----RRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSsyy 224
Cdd:cd15051  183 VYLRIFRiareqakRINALTPASTANSSKSAAtareHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGDNINETALS--- 259
                        250       260
                 ....*....|....*....|....*...
gi 568905270 225 FCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15051  260 VVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
1-249 9.40e-29

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 111.04  E-value: 9.40e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQ-SAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15928   31 MRTTTNLYLSSLAVSDLLIFLVLPLDlYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHITALSVERYLAICHPLRAKV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLAS-SVGISAIVLGGTKVREDVDVIECSLQfpDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15928  111 LVTRGRVKLLIAVIWAVAIvSAGPALVLVGVEHIQGQQTPRGFECT--VVNVSSGLLSVMLWVSTSFFFVPMVCLSLLYG 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRLLS---GSREKDRNLRRITKLVLVVVAVFIICWTPIHI--FILVEALGSTSHsTAALSSYYFCIA--LGY 231
Cdd:cd15928  189 LIGRALWDRRQRSrtaGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVgrVIFNHSRASTKH-LHYVSQYFNLVSfvLFY 267
                        250
                 ....*....|....*...
gi 568905270 232 TNSSLNPVLYAFLDENFK 249
Cdd:cd15928  268 LSAAINPILYNLMSKRYR 285
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
4-250 1.06e-28

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 111.05  E-value: 1.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   4 ATNIYIFNLALADALVTTTMPFQSAVYL-MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15374   34 PTTVYMFHLALSDTLYVLSLPTLIYYYAdHNHWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRALRWVK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLASSVGISAIVLGGTKvREDVDVIECSLQFPDDeyswWDLFMKIC--VFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15374  114 PRHAYLICASVWLVVTVCLVPNLIFVTTS-RKDNITLCHDTTRPEE----FDHYVHYSsaVMVLLFGIPCLVIVVCYGLM 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHI----FILVEALGSTSHSTAALS-SYYFCIALGYTNSS 235
Cdd:cd15374  189 ARRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHItrtlYYVARLLKADCDTLNIINvTYKVTRPLASANSC 268
                        250
                 ....*....|....*
gi 568905270 236 LNPVLYAFLDENFKR 250
Cdd:cd15374  269 LDPILYFLAGDKYRR 283
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
1-252 1.15e-28

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 111.23  E-value: 1.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPfqsaVYLMNS-----WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHP 74
Cdd:cd14997   31 MRTPTNIFLVNLSVADLLVlLVCMP----VALVETwarepWLLGEFMCKLVPFVELTVAHASVLTILAISFERYYAICHP 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  75 VKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVD---VIECSLQFpddeYSWWDLFMKICVFVFAFVIPVL 151
Cdd:cd14997  107 LQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDgtpVAVCRTPA----DTFWKVAYILSTIVVFFVVPLA 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 152 IIIVCYTLMILRL------KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFIL---------VEALGSTSHs 216
Cdd:cd14997  183 ILSGLYSVICRRLvghpalESRRADAANRHTLRSRRQVVYMLITVVVLFFVCLLPFRVVTLwiifapdedLQALGLEGY- 261
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568905270 217 taaLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14997  262 ---LNLLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
3-210 2.07e-28

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 110.12  E-value: 2.07e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYlMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15165   33 TESTIYMINLALNDLLLLLSLPFKMHSS-KKQWPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHPFLAKRLRS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLASSVGISAIVLGGtkvrEDVDVIECSLQFPDDEYSWWDLfmkICVFVFAFVIPVLIIIVCytlmil 162
Cdd:cd15165  112 PRKAAIVCLTIWVFVWAGSIPIYSFHD----KPTNNTRCFHGFSNKTWSKKVI---VVVEEFGFLIPMAVMVFC------ 178
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568905270 163 RLKSVRLLSGSREKDRNLRRITKLVLVVVA---VFIICWTPIHIFILVEAL 210
Cdd:cd15165  179 SVQIIRTLLDMRRPEQPKVKQNKSVKIVLSnlvVFLVCFTPYHLGIFLQFL 229
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
4-250 2.69e-28

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 109.84  E-value: 2.69e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   4 ATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15373   34 ASTTYMFNLAISDTLYVLSLPLLVYYYADeNDWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVRSLRWLK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLASsvGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKIcVFVFAFVIPVLIIIVCYTLMIL 162
Cdd:cd15373  114 VRYARIVSVVVWVIVL--ACQSPVLYFVTTSDKGGNITCHDTSSPELFDQFVVYSSV-MLVLLFCVPFVVILVCYALMVR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 RLKSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIF-ILVEALGSTSHSTAALSS----YYFCIALGYTNSSLN 237
Cdd:cd15373  191 KLLKPSAGTSTNSRSK--KKSVKMIIIVLAVFILCFLPFHVTrTLYYSFRSMDLSCGTLNAinlaYKVTRPLASANSCLD 268
                        250
                 ....*....|...
gi 568905270 238 PVLYAFLDENFKR 250
Cdd:cd15373  269 PILYFLAGQSFRS 281
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
2-243 4.12e-28

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 109.14  E-value: 4.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15121   32 RSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLgGTKVREDVDVIECSLQFPDDEYswwDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15121  112 TKRSVRALLLAIWIVAFLLSLPMPFY-RTVLKKNINMKLCIPYHPSVGH---EAFQYLFETITGFLLPFTAIVTCYSTIG 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLlsgsrekdRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHST-------AALSSYYFCIALGYTNS 234
Cdd:cd15121  188 RRLRSARF--------RRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAgnasvlkAAKLARPNVTALAFLSS 259

                 ....*....
gi 568905270 235 SLNPVLYAF 243
Cdd:cd15121  260 SVNPVLYAF 268
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
4-252 5.23e-28

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 108.98  E-value: 5.23e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   4 ATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15201   34 SSTVYLFNLAVADFLLIICLPFRTDYYLRGKhWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSIS 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLAssVGISAIVLGGTKVREDVDVIECS----LQFPDDEYSWWDLFmkicvFVFAFVIPVLIIIVCYT 158
Cdd:cd15201  114 VRKAAIIACGLWLLT--IAMTVYLLTKKHLFPRGNATQCEsfniCTGTDSSSNWHEAM-----FLLEFFLPLAIILYCSV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRLlsgsrEKDRNLRRITKLVLVVVAVFIICWTP-----IHIFILVEALGSTS-HSTAALSSYYFCIALGYT 232
Cdd:cd15201  187 RIIWQLRGRQL-----DRHAKIKRAVQFIMVVAIVFIICFLPsnvtrIAIWILKHTSNEDCqYYRSVDLAFYITISFTYF 261
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd15201  262 NSMLDPVVYYFSSPSFKNFY 281
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
3-252 5.92e-28

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 108.70  E-value: 5.92e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15923   33 TETNIYMTNLAVADLLLLISLPFK-MHSYRRESAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRARELRS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLASSVGISAIVLGGTkvredVDVIECSLQFPDDeyswWDLFMKICVFVFAFVIPVLIIIVCYTLMIL 162
Cdd:cd15923  112 PRKAAVVCAVIWVLVVTISIPYFLLDSS-----NEKTMCFQRTKQT----ESLKVFLLLEIFGFLLPLIIMTFCSARVIH 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 RLKSVRLLSGSREKdrnLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSS----YYFCIALGYTNSSLNP 238
Cdd:cd15923  183 TLQKRLDDVGSRSE---TKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSYSCDSKLIihffLQSAFCLSDMNCCLDA 259
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15923  260 FCYYFATKEFREAY 273
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
1-252 7.21e-28

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 108.22  E-value: 7.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15061   30 LRTITNCYIVSLATADLLVGVlVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISLDRYFAITYPLKYRT 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDviECSLQfPDDEYswwdlfmKICVFVFAFVIPVLIIIVCYtl 159
Cdd:cd15061  110 KRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLG--SCYYT-YDKGY-------RIYSSMGSFFLPLLLMLFVY-- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 milrLKSVRLLsgSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALgstSHSTAALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15061  178 ----LRIFRVI--AKE-----RKTAKTLAIVVGCFIVCWLPFFIMYLIEPF---CDCQFSEALSTAFTWLGYFNSVINPF 243
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15061  244 IYAFYNKDFRRAF 256
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
3-250 8.20e-28

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 108.71  E-value: 8.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15968   33 TRTAIYMVNLALADLLYALSLPLLIYNYAMrDRWLFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKE 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVieCSLQFPDDEYSWWDLFmKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15968  113 TRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTV--CYDLAPPALFPHYVPY-GMALTVSGFLLPFSIILWCYCLVV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLksVRLLSGSREKDRNLRRIT-KLVLVVVAVFIICWTPIH----IFILVEALGSTSHSTAALSSYYFCIA--LGYTNS 234
Cdd:cd15968  190 RTL--CRTLGPAEPPAQARRRKSiRTIVTVTLLFALCFLPFHitrtIYLAVRVTPGVPCHVLEAVAACYKITrpLASANS 267
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15968  268 VLNPLLYFLTKKKFGR 283
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
1-252 8.67e-28

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 107.96  E-value: 8.67e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15062   31 LRTPTHYFIVNLAVADLLLSfTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVlgGTKVREDVDVIECSLqfpdDEYSWWDLFMKICvfvfAFVIPVLIIIVCYTL 159
Cdd:cd15062  111 IVTARRATVALLIVWVLSLVISIGPLL--GWKEPAPADEQACGV----NEEPGYVLFSSLG----SFYLPLAIILVMYCR 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MIlrlksVRLLSGSREKdrnlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALssYYFCIALGYTNSSLNPV 239
Cdd:cd15062  181 VY-----VVAFKFSREK-----KAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLKPPEPV--FKVVFWLGYFNSCLNPI 248
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15062  249 IYPCSSREFKRAF 261
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
1-252 9.32e-28

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 107.83  E-value: 9.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15067   30 LRTVTNYFIVSLAVADLLVgSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYP 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSlqFPDDE-YswwdLFMKICVfvfAFVIPVLIIIVCY 157
Cdd:cd15067  110 SRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQCL--FTDDSgY----LIFSSCV---SFYIPLVVMLFTY 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TlMILRlksvrllSGSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLN 237
Cdd:cd15067  181 Y-RIYR-------AAAKE-----QKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCVSNPDILFPLVTWLGYINSGMN 247
                        250
                 ....*....|....*
gi 568905270 238 PVLYAFLDENFKRCF 252
Cdd:cd15067  248 PIIYACSSRDFRRAF 262
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
1-252 1.73e-27

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 106.97  E-value: 1.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15329   31 LRTPSNYLIVSLAVSDLLVALlVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYAV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSlqfpddeyswwDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15329  111 KRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGVCQVSQ-----------DFGYQIYATFGAFYIPLIVMLVLYYK 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MilrlksvrLLSGSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTA-ALSSYYFCIALGYTNSSLNP 238
Cdd:cd15329  180 I--------YRAAKSE-----RKAIKTLGIIMGAFTLCWLPFFILALLRPFLKPIKCSCiPLWLSRLFLWLGYANSFLNP 246
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15329  247 IIYAKFNREFRTPF 260
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
1-252 4.39e-27

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 106.32  E-value: 4.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADA--LVTTTMPFQSAVYL-MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA 77
Cdd:cd14995   31 MRTPTNCYLVSLAVADLmvLVAAGLPNEIESLLgPDSWIYGYAGCLLITYLQYLGINASSLSITAFTIERYIAICHPMKA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMkiCVFVFAFVIPVLIIIVCY 157
Cdd:cd14995  111 QFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYGDDIVVRCGYKVSRHYYLPIYL--ADFVLFYVIPLLLAIVLY 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMilrlksVRLLSGSRekdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHstaaLSSYY--FCIALGYTNSS 235
Cdd:cd14995  189 GLI------GRILFSSR------KQVTKMLAVVVVLFALLWMPYRTLVVYNSFASPPY----LDLWFllFCRTCIYLNSA 252
                        250
                 ....*....|....*..
gi 568905270 236 LNPVLYAFLDENFKRCF 252
Cdd:cd14995  253 INPILYNLMSQKFRAAF 269
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
1-252 4.42e-27

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 106.13  E-value: 4.42e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15326   31 LRIPTNYFIVNLAIADLLLSFTvLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVlgGTKVREDVDVIECSLQfpddEYSWWDLFMKICvfvfAFVIPVLIIIVCYT- 158
Cdd:cd15326  111 IVTRKRAILALLGVWVLSTVISIGPLL--GWKEPAPPDDKVCEIT----EEPFYALFSSLG----SFYIPLIVILVMYCr 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSvrllsgSREKdrnlrRITKLVLVVVAVFIICWTPihiFILVEALGS-TSHSTAALSSYYFCIALGYTNSSLN 237
Cdd:cd15326  181 VYIVALKF------SREK-----KAAKTLGIVVGMFILCWLP---FFIALPLGSlFSHLKPPETLFKIIFWLGYFNSCLN 246
                        250
                 ....*....|....*
gi 568905270 238 PVLYAFLDENFKRCF 252
Cdd:cd15326  247 PIIYPCSSKEFKRAF 261
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
1-252 4.72e-27

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 106.65  E-value: 4.72e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYL-MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15134   31 MHTATNYYLFSLAVSDLLLLILgLPFELYTIWqQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLAS--------SVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWdlfMKICVFVFaFVIPV 150
Cdd:cd15134  111 TMSKLSRAIRIIIAIWIIAFvcalpfaiQTRIVYLEYPPTSGEALEESAFCAMLNEIPPITPV---FQLSTFLF-FIIPM 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLMILRLKSVRLL-------SGSREKDRNLRRITKLVLVVVAVFIICWTPIHI--FILVEALGSTS-HSTAAL 220
Cdd:cd15134  187 IAIIVLYVLIGLQLRRSTLLrrgqrsvSGGRRSSQSRRTVLRMLVAVVVAFFICWAPFHAqrLLTVYAKNMTPpYLFINR 266
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568905270 221 SSYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15134  267 ILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
1-252 5.05e-27

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 105.76  E-value: 5.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15327   31 LQTVTNYFIVNLAIADLLLSTTvLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLlaSSVGISAIVLGGTKVREDVDVIECSLQfpddEYSWWDLFMKicvfVFAFVIPVLIIIVCYTL 159
Cdd:cd15327  111 IMTERKAGVILVLLWV--SSMVISIGPLLGWKEPPPPDESICSIT----EEPGYALFSS----LFSFYLPLMVILVMYFR 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MIlrlksVRLLSGSREKdrnlrRITKLVLVVVAVFIICWTPihiFILVEALGSTSHSTAALSSYYFCIA-LGYTNSSLNP 238
Cdd:cd15327  181 VY-----VVALKFSREK-----KAAKTLAIVVGVFILCWFP---FFFVLPLGSFFPALKPSEMVFKVIFwLGYFNSCVNP 247
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15327  248 IIYPCSSKEFKRAF 261
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
6-249 5.97e-27

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 106.03  E-value: 5.97e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15199   36 AVYLLNLVLADVLLLICLPFKAYFYLNgNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQ 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLGGTKVREdvdviECSLQFPDDEYSWWDLFMKIcVFVFAFVIPVLIIIVCYTLMILRL 164
Cdd:cd15199  116 AAPYISFLVWLLLVGLTIPTLLASQPKNFT-----ECNSFSPKDDEDFSDTWQEA-VFFLQFLLPFGLIVFCTVRIIRRL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 KSVRLLSGSREKdrnLRRITKLVLVVVAVFIICWTP-------IHIFilvEALGSTSHSTAALSSYYFCIALGYTNSSLN 237
Cdd:cd15199  190 KKRLRDVGKQPK---LQRAMALVTSVVVVFGFCFLPcflarvlMLIF---QNKESCNALNIAVHTYDVTMCLTYLNSVLD 263
                        250
                 ....*....|..
gi 568905270 238 PVLYAFLDENFK 249
Cdd:cd15199  264 PIVYCFSSPTFR 275
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
1-252 9.20e-27

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 106.16  E-value: 9.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15123   31 MQTVPNIFITSLAFGDlLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLELQT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVD---VIECSLQFPDDEYSWWDLFMKICVFVFaFVIPVLIIIVC 156
Cdd:cd15123  111 SDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEkntTFEACAPYPVSEKILQEIHSLLCFLVF-YIIPLSIISVY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YTLMILRL-KSVRLL-----SGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALgsTSHSTAALSSYYFCI--- 227
Cdd:cd15123  190 YFLIARTLyKSTFNMpaeehSHARKQIESRKRVAKTVLVLVALFAFCWLPNHILYLYRSF--TYHTSVDSSAFHLIAtif 267
                        250       260
                 ....*....|....*....|....*..
gi 568905270 228 --ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15123  268 srVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
4-251 1.09e-26

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 105.43  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   4 ATNIYIFNLALADALVTTTM-PFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15074   34 PAELLTVNLAVSDLGISVFGyPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAISIYRYLKICHPPYGPKLSR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIInICIWLLASSVGISAIVLGGTKVREDVDVIeCSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMIL 162
Cdd:cd15074  114 RHVCIVI-VAIWLYALFWAVAPLVGWGSYGPEPFGTS-CSIDWTGASASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIR 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 RLKSVRLL---SGSREKDRNL--RRITKLVLVVVAVFIICWTPIHIFILVEALGStSHSTAALSSYYFCIaLGYTNSSLN 237
Cdd:cd15074  192 KVKSSRKRvagFDSRSKRQHKieRKVTKVAVLICAGFLIAWTPYAVVSMWSAFGS-PDSVPILASILPAL-FAKSSCMYN 269
                        250
                 ....*....|....
gi 568905270 238 PVLYAFLDENFKRC 251
Cdd:cd15074  270 PIIYLLFSSKFRQD 283
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
3-253 1.31e-26

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 105.40  E-value: 1.31e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKaldFR 81
Cdd:cd15314   33 TPTNYLILSLAVADLLVgGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLL---YR 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICI---WLLASSVGISAIVLGGTKVREDVDVIECSlqfpDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15314  110 SKITVRVVLVMIlisWSVSALVGFGIIFLELNIKGIYYNHVACE----GGCLVFFSKVSSVVGSVFSFYIPAVIMLCIYL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 -LMILRLKSVRLLSGSREKDRNL-----RRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYyfcIALGYT 232
Cdd:cd15314  186 kIFLVAQRQARSIQSARTKSGASsskmeRKATKTLAIVMGVFLLCWTPFFLCNIIDPFINYSIPPVLIEVL---NWLGYS 262
                        250       260
                 ....*....|....*....|.
gi 568905270 233 NSSLNPVLYAFldenFKRCFR 253
Cdd:cd15314  263 NSTLNPFIYAF----FYSWFR 279
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
2-250 1.36e-26

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 105.23  E-value: 1.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQsAVYLM--NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15368   32 KTPSIIFMINLSLTDLMLACFLPFQ-IVYHIqrNHWIFGKPLCNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIEC-----SLQFPDDEYswWDLFMkICVFVFAFVIPVLIII 154
Cdd:cd15368  111 WRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITTCfdvlkWTMLPNIAA--WAAFL-FTLFILLFLIPFIITV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKSVRLLSGSREKdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNS 234
Cdd:cd15368  188 YCYVLIILKLVQTSERYGREQK----RRAIYLALIVLLVFITCFAPNNFILLAHMVSRLFYGKSLYHAYKLTLSLSCLNS 263
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15368  264 CLDPFIYYFASKEFRK 279
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
1-252 1.72e-26

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 104.78  E-value: 1.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15206   31 MRTVTNVFLLNLAVSDLLLAVfCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYswwDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15206  111 WQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHKCREVWPNEIA---EQAWYVFLDLMLLVIPGLVMSVAYGL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKSVRllsgsrekdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALS-SYYFCIALGYTNSSLNP 238
Cdd:cd15206  188 ISWTLLEAK------------KRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPSAARYVSStTISLIQLLAYISSCVNP 255
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15206  256 ITYCFMNKRFRQAF 269
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
1-252 1.72e-26

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 104.63  E-value: 1.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15323   31 LRAPQNLFLVSLASADILVATlVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVlggTKVREDVDVIECSLQFPDDeySWWDLFMKICvfvfAFVIPVLIIIVCYtl 159
Cdd:cd15323  111 KRTPRRVKAIIVTVWLISAVISFPPLI---SMYRDPEGDVYPQCKLNDE--TWYILSSCIG----SFFAPCLIMILVY-- 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 miLRLKSVrllSGSREKdrnlrRITKLVLVVVAVFIICWTPihiFILVEALGSTSHSTAALSS--YYFCIALGYTNSSLN 237
Cdd:cd15323  180 --IRIYRV---AKAREK-----RFTFVLAVVMGVFVVCWFP---FFFSYSLYGICREACEVPEplFKFFFWIGYCNSSLN 246
                        250
                 ....*....|....*
gi 568905270 238 PVLYAFLDENFKRCF 252
Cdd:cd15323  247 PVIYTIFNQDFRRSF 261
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
2-250 3.15e-26

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 104.14  E-value: 3.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAvYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15186   32 KSITDIYLLNLALSDLLFVATLPFWTH-YLINEWGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLggTKVREDvdviECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15186  111 TVQHGVTISLGVWAAAILVAVPQFMF--TKMKEN----ECLGDYPEVLQEIWPVLRNVELNFLGFLLPLLIMSYCYFRII 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVrllsgsreKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG------STSHSTAALSSYYFCIALGYTNSS 235
Cdd:cd15186  185 QTLFSC--------KNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKlydffpSCDMKKDLRLALSVTETIAFSHCC 256
                        250
                 ....*....|....*
gi 568905270 236 LNPVLYAFLDENFKR 250
Cdd:cd15186  257 LNPLIYAFAGEKFRR 271
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
6-250 3.58e-26

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 104.17  E-value: 3.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTTMP-FQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15194   36 DIFISNLAASDFIFLVTLPlWVDKEVVLGPWRSGSFLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKH 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISaiVLGGTKVREDVDVIECSlqfpDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRL 164
Cdd:cd15194  116 NAKVCCTCVWMLSCLLGLP--TLLSRELKKYEEKEYCN----EDAGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 KSVRLLSGsrEKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA------LGYTNSSLNP 238
Cdd:cd15194  190 CHHYQKSG--KHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIASGLQVEVTCLPYTLAQLGmevsapLAFANSCANP 267
                        250
                 ....*....|..
gi 568905270 239 VLYAFLDENFKR 250
Cdd:cd15194  268 FIYYFFDRYIRR 279
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
1-250 3.64e-26

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 104.09  E-value: 3.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWpFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15177   31 LRSMTDVYLLNLALADLLLLLTLPFAAAETLQGWI-FGNAMCKLIQGLYAINFYSGFLFLTCISVDRYVVIVRATSAHRL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 R--TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVieCSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15177  110 RpkTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSS--CRMIFPEVVSRTVKGATALTQVVLGFAIPLIVMAVCYA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMIlrlksvRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEA---LGSTSHSTAALSSYYFCI----ALGY 231
Cdd:cd15177  188 AIG------RTLLAARGWER--HRALRVIAALVVAFVLFQLPYSVVLLLDTadlLATLELSCSQSKRKDIALlvtsGLAY 259
                        250
                 ....*....|....*....
gi 568905270 232 TNSSLNPVLYAFLDENFKR 250
Cdd:cd15177  260 VRCCLNPLLYAFVGVRFRR 278
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
3-250 4.40e-26

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 104.22  E-value: 4.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15377   33 SGISVYMFNLALADFLYVLTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLAsSVGISAIVL-GGTKVREDvDVIECSLQFPDDEYSWWDLFmKICVFVFAFVIPVLIIIVCYTlM 160
Cdd:cd15377  113 KKKNAICISVLVWLIV-VVAISPILFySGTGVRKN-KTITCYDTTSDEYLRSYFIY-SMCTTVAMFCVPFILILGCYG-L 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRIT-KLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAAL--------SSYYFCIALGY 231
Cdd:cd15377  189 IVRALIYKDMKYTEENNAPLRRKSiYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPAMcafndrvyATYQVTRGLAS 268
                        250
                 ....*....|....*....
gi 568905270 232 TNSSLNPVLYAFLDENFKR 250
Cdd:cd15377  269 LNSCVDPILYFLAGDTFRR 287
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
2-249 4.41e-26

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 103.72  E-value: 4.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15370   32 KHPAVIYMANLALADLLFVIWFPLKIAYHINgNNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMSHSRK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLkAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15370  112 KANI-AIGISLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTAVAYVLM 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSgSREKDRNlrRITKLVLVVVAVFIICWTPIHIFILVE-ALGSTSHSTAALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15370  191 IRALKSSINDE-SIEKKRK--RAIKLIVTVLVMYLICFTPSNLLLVVHyFLLKNQGQSSVYAFYITALCLSTLNSCIDPF 267
                        250
                 ....*....|
gi 568905270 240 LYAFLDENFK 249
Cdd:cd15370  268 VYYFVSHDFR 277
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
1-249 6.22e-26

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 103.31  E-value: 6.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15175   31 LKTMTDIYLLNLALADILFLLTLPFW-AASAAKKWVFGEEMCKAVYCLYKMSFFSGMLLLMCISIDRYFAIVQAASAHRH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 R--TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVieCSLqFPDDEYSWWdLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15175  110 RsrAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGT--CSI-FTNNKQTLS-VKIQISQMVLGFLVPLVVMSFCYS 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMIlrlksvRLLSGSREKDRNlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALS-------SYYFCIALGY 231
Cdd:cd15175  186 VII------KTLLQARNFEKN--KAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNTTDCDysknldfALDVTYSLAC 257
                        250
                 ....*....|....*...
gi 568905270 232 TNSSLNPVLYAFLDENFK 249
Cdd:cd15175  258 FRCCLNPFLYAFIGVKFR 275
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
1-249 9.33e-26

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 105.48  E-value: 9.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFqsAVY-LMNSWPFGDVLCKiVISIDYY-NMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:PHA02638 128 IKTITDIYIFNLAISDLIFVIDFPF--IIYnEFDQWIFGDFMCK-VISASYYiGFFSNMFLITLMSIDRYFAILYPISFQ 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGI--------SAIVLGGTKVREDVDVIECSLqFPDDEYSWWDLFMKICVF---VFAFV 147
Cdd:PHA02638 205 KYRTFNIGIILCIISWILSLIITSpayfifeaSNIIFSAQDSNETISNYQCTL-IEDNEKNNISFLGRILQFeinILGMF 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 148 IPVLIIIVCYTLMILRLKSVRllsgSREKDRNLRritkLVLVVVAVFIICWTPIHIFILVEALGSTsHSTAALSSYYFC- 226
Cdd:PHA02638 284 IPIIIFAFCYIKIILKLKQLK----KSKKTKSII----IVSIIIICSLICWIPLNIVILFATMYSF-KGFNSIISEHICg 354
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568905270 227 -IALGY----------TNSSLNPVLYAFLDENFK 249
Cdd:PHA02638 355 fIKLGYammlaeaislTHCCINPLIYTLIGENFR 388
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
6-249 1.96e-25

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 102.08  E-value: 1.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15967   36 NVFVLNLGLADLLYLLTLPFLVVYYLKGRkWIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTT 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLAS-----SVGISAIVLGGTKVREDVDviecslQFPDDEYswwdLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15967  116 HSVVISALVWLLVViqslpDLFFSKTNSNGTKCFDTTF------NDYLESY----LTYSLGWTVTGFVIPLLIILGCYGH 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILrlksvrLLSGSREKDRNLR-RITKLVLVVVAVFIICWTPIHIF----ILVEALGSTSHSTAALSSYYfcIA------ 228
Cdd:cd15967  186 VVV------VLCRNNNVDKGLKqRCLKLVIILIVLFSVCYIPYHVFrnlnLLSRILQKQGSCTQWFRGIY--IAhqvsrg 257
                        250       260
                 ....*....|....*....|.
gi 568905270 229 LGYTNSSLNPVLYAFLDENFK 249
Cdd:cd15967  258 LVCLNSALNPLVYLMGSEDIL 278
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 3.34e-25

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 101.55  E-value: 3.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVY-LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAld 79
Cdd:cd16003   31 MRTVTNYFLVNLAFSDASMAAFNTLINFIYaLHSEWYFGEAYCRFHNFFPITSVFASIYSMTAIAVDRYMAIIDPLKP-- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 fRTPLKA-KIINICIWLLASSVGISAIVLGGTKVREDVDVieCSLQFP---DDEYSWwdlfmKICVFVFAFVIPVLIIIV 155
Cdd:cd16003  109 -RLSATAtKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTL--CFVAWPggpDQHFTY-----HIIVIVLVYCLPLLVMGI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMILRLKSVRLLSGS----REKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA-LG 230
Cdd:cd16003  181 TYTIVGITLWGGEIPGDTsdkyHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYQQLNRWKYIQQVYLASFwLA 260
                        250       260
                 ....*....|....*....|..
gi 568905270 231 YTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd16003  261 MSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
6-249 4.66e-25

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 101.30  E-value: 4.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTpl 84
Cdd:cd14986   36 NIFILNLAIADLVVAfFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFASTYILVSMSLDRYQAIVKPMSSLKPRK-- 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLGGTKVREDVdVIECSLQFPDDEYswWDLFMKICVFVfAFVIPVLIIIVCYTLMIL-- 162
Cdd:cd14986  114 RARLMIVVAWVLSFLFSIPQLVIFVERELGDG-VHQCWSSFYTPWQ--RKVYITWLATY-VFVIPLIILSYCYGRILRti 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 --RLKSVRLLSGSREKDRNLR----------------RITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYY 224
Cdd:cd14986  190 wiRSRQKTDRPIAPTAMSCRSvscvssrvslisrakiKTIKMTLVIILAFILCWTPYFIVQLLDVYAGMQQLENDAYVVS 269
                        250       260
                 ....*....|....*....|....*
gi 568905270 225 FCIALgyTNSSLNPVLYAFLDENFK 249
Cdd:cd14986  270 ETLAS--LNSALNPLIYGFFSSHLS 292
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
3-249 6.81e-25

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 100.41  E-value: 6.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQsAVYLMNSWPfGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15164   33 TETRVYMINLAVADCCLLFSLPFV-LYFLKHSWP-DDELCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLassVGISAIVLGGTKVREDVDVIECSLQFPDdeyswwdlFMKICVFVFAFVIPVLIIIVCYTLMIL 162
Cdd:cd15164  111 PRKAALTCGLLWVL---VIISVSLRLAWEEQEENFCFGKTSTRPS--------KRTLIFSLLGFFIPLIILSFCSIQVIR 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 RLKsvRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVE-ALGSTSHSTAALSSY--YFCIA--LGYTNSSLN 237
Cdd:cd15164  180 SLK--KKKKTNPHEEKLIQKAIYIVSANLIVFIVCFLPLHIGLLVRfVMESNKASCSLIQNIrnFIYVAscLANANCCLD 257
                        250
                 ....*....|..
gi 568905270 238 PVLYAFLDENFK 249
Cdd:cd15164  258 AICYYFVAKEFQ 269
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-247 7.30e-25

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 100.81  E-value: 7.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMN--SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA 77
Cdd:cd15204   31 LRTLTNLLIANLALSDFLVAVfCLPFEMDYYVVRqrSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLKP 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LdfRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMkICVFVFAFVIPVLIIIVCY 157
Cdd:cd15204  111 R--MKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQGKIFCGQIWPVDQQAYYKAYY-LFLFVLEFVLPVLIMTLCY 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 tLMILRLKSVRLLSGS-----REKDRNLRRITKLVLVVVAVFIICWTPIHIFILV-----EALGSTSHSTAAlssYYFCI 227
Cdd:cd15204  188 -LRIVRKVWFRRVPGQqteqiRRRLRRRRRKVRLLVVILTAFVLCWAPYYGYAIVrdffpTLLSKEKLNTTI---FYIVE 263
                        250       260
                 ....*....|....*....|
gi 568905270 228 ALGYTNSSLNPVLYAFLDEN 247
Cdd:cd15204  264 ALAMSNSMINTVVYVAFNNN 283
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
1-252 1.02e-24

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 100.57  E-value: 1.02e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADAL-VTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVC--HPVKA 77
Cdd:cd14977   31 MRSVPNILIASLALGDLLlLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAVnsMPMQT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LDFRTPLKAKIinICIWLLASSVGISAIVL----------GGTKVREDVDVIECSLQFPDDEYSWWdlfmkicVFVFAFV 147
Cdd:cd14977  111 IGACLSTCVKL--AVIWVGSVLLAVPEAVLstvaressldNSSLTVCIMKPSTPFAETYPKARSWW-------LFGCYFC 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 148 IPVLIIIVCYTLMILRLKSVRLLSGSREKDR--NLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSH----STAALS 221
Cdd:cd14977  182 LPLAFTAVCYLLMARTLIRAAKEYTRGTKKHmkQRRQLAKTVLCLVLVFAFCWLPEHISNILRATLYNEVlidtRSTLDI 261
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568905270 222 SYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14977  262 LDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 1.42e-24

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 99.94  E-value: 1.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVT---TTMPFQSAVYlmNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA 77
Cdd:cd16002   31 MRTVTNYFLVNLAFAEASMSafnTVINFTYAIH--NEWYYGLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQP 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 ldfRTPLKAKIINIC-IWLLASSVGISAIVLGGTKVREDVDVieCSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVC 156
Cdd:cd16002  109 ---RLSATATKVVICvIWVLAFLLAFPQGYYSDTEEMPGRVV--CYVEWPEHEERKYETVYHVCVTVLIYFLPLLVIGCA 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YTLMILRLKSVRLLSGSR----EKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA-LGY 231
Cdd:cd16002  184 YTVVGITLWASEIPGDSSdryhEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYFHPELYEQKFIQQVYLAIMwLAM 263
                        250       260
                 ....*....|....*....|.
gi 568905270 232 TNSSLNPVLYAFLDENFKRCF 252
Cdd:cd16002  264 SSTMYNPIIYCCLNDRFRVGF 284
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
1-249 1.55e-24

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 99.96  E-value: 1.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQ-SAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15131   31 MRTTTNLYLSSMAFSDLLIFLCMPLDlYRLWQYRPWNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAICFPLRAKV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSlQFPDDEYSWWDLFMKICVFVFA--FVIPVLIIIVCY 157
Cdd:cd15131  111 VVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTN-ECKATEYAVRSGLLTIMVWVSSvfFFLPVFCLTVLY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLM---ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHI--FILVEALGSTSHSTAALSSYYFCIA--LG 230
Cdd:cd15131  190 SLIgrkLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVgrYLFSKSFEAGSLEIALISQYCNLVSfvLF 269
                        250
                 ....*....|....*....
gi 568905270 231 YTNSSLNPVLYAFLDENFK 249
Cdd:cd15131  270 YLSAAINPILYNIMSKKYR 288
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
1-249 1.89e-24

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 99.43  E-value: 1.89e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSA-VYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15394   31 MHNVTNFLIGNLAFSDMLMCATcVPLTLAyAFEPRGWVFGRFMCYFVFLMQPVTVYVSVFTLTAIAVDRYYVTVYPLRRR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRtPLKAKIInICIWLLasSVGISAIVLGGTKVRE--DVDVIECSLQFPDDE-----YSWWDLFMkicvfvfAFVIPVL 151
Cdd:cd15394  111 ISR-RTCAYIV-AAIWLL--SCGLALPAAAHTYYVEfkGLDFSICEEFWFGQEkqrlaYACSTLLI-------TYVLPLL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 152 IIIVCYTLMILRLKSvRLLSGS-----REKDRNLRRIT-KLVLVVVAVFIICWTPIHIFILVEALgstshSTAALSSYYF 225
Cdd:cd15394  180 AISLSYLRISVKLRN-RVVPGSmtqsqAEWDRARRRKTfRLLVVVVVAFAICWLPLHIFNVIRDI-----DIDLIDKQYF 253
                        250       260       270
                 ....*....|....*....|....*....|
gi 568905270 226 ------CIALGYTNSSLNPVLYAFLDENFK 249
Cdd:cd15394  254 nliqllCHWLAMSSACYNPFLYAWLHDSFR 283
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
3-250 2.15e-24

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 99.45  E-value: 2.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd16001   33 TCSTIYLVNLAVADLLYVCSLPLLIVNYAMrDRWPFGDFLCKLVRFLFYTNLYGSILFLTCISVHRFLGVCYPIRSLAYR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIEcSLQFPDDEYSWWDLFMKICvfVFAFVIPVLIIIVCYTLMI 161
Cdd:cd16001  113 TRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCY-DLTSPDNFGNYFPYGMVLT--VTGFLIPFLIILLCYCLMI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHI------FILVEALGSTSHSTAALSSYYFCIALGYTNSS 235
Cdd:cd16001  190 KSLIRSEEAAGVGKAAR--AKSIRTILLVCGLFALCFVPFHItrtiylFVRVYLVQDCPLLQFVSLAYKIWRPLVSFNSC 267
                        250
                 ....*....|....*
gi 568905270 236 LNPVLYAFLDENFKR 250
Cdd:cd16001  268 INPLLYFLSGDSNRL 282
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
2-249 2.67e-24

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 99.06  E-value: 2.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd14991   32 WKANTVYLFNLVLADFLLLICLPFRIDYYLRgEHWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYS--WWDlfmkiCVFVFAFVIPVLIIIVCYT 158
Cdd:cd14991  112 MSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSirWHN-----ALFLLEFFLPLGLIVFCSV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSvrllSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIF----ILVEALGSTSHSTAALSSYYFCIALGYTNS 234
Cdd:cd14991  187 RIACNLRI----RQSLGKQARVQRAIRLVFLVVIVFVLCFLPSIIAgllaLVFKNLGSCRCLNSVAQLFHISLAFTYLNS 262
                        250
                 ....*....|....*
gi 568905270 235 SLNPVLYAFLDENFK 249
Cdd:cd14991  263 ALDPVIYCFSSPWFR 277
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
2-246 2.99e-24

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 98.70  E-value: 2.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQsAVYLMN--SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15365   32 KNELGVYLFNLSLSDLLYIVILPLW-IDYLWNgdNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGiSAIVLGGTKVREDVDVIECSLQFPDDEyswWDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15365  111 LRTIRTALSVSVAIWLLEICFN-AVILTWEDSFHESSSHTLCYDKFPLED---WQARLNLFRICLGYLLPLLIILFCYWK 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MilrLKSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEAL---GSTSHSTAALSSYYFCIALGYTNSSL 236
Cdd:cd15365  187 I---YQAVRSNQATEDQEK--KKIFKLLLLITVTFVICFTPYHVVLLIRSIvepCDCRNAKWLYTLYKITVALTSLNCIA 261
                        250
                 ....*....|
gi 568905270 237 NPVLYAFLDE 246
Cdd:cd15365  262 DPFLYCFVTE 271
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
1-252 3.78e-24

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 99.07  E-value: 3.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQsaVYLM-NSWPF--GDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVK 76
Cdd:cd15358   31 MRTPTNYYLFSLAVSDLLVLLLgMPLE--LYEMwSNYPFllGAGGCYFKTLLFETVCFASILNVTALSVERYIAVVHPLK 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 ALDFRTPLKAKIINICIWLLA--------SSVGISAIVLGGTKVREDVDVieCSLQFPDDEYSwwdLFMKICVFVFaFVI 148
Cdd:cd15358  109 AKYVVTRTHAKRVIGAVWVVSilcsipntSLHGIFQLTVPCRGPVPDSAT--CMLVKPRWMYN---LIIQITTLLF-FFL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 149 PVLIIIVCYTLMILRLKSVRLLSG----------------SREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGS 212
Cdd:cd15358  183 PMGTISVLYLLIGLQLKREKMLLVleakgskagdsyqhrrIQQEKRRRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFIS 262
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568905270 213 TSHSTAALSSYYFCIALG---YTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15358  263 QWTGELHLAFQYVHIISGvffYLSSAANPVLYNLMSTRFREMF 305
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
1-249 4.40e-24

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 98.28  E-value: 4.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVchpVKALDF 80
Cdd:cd15176   31 LKTKTDVYILNLAVADLLLLFTLPFW-AADAVNGWVLGTAMCKITSALYTMNFSCGMQFLACISVDRYVAI---TKATSR 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 -RTPLKAKIINICIWLLASSVGISAIVLggTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15176  107 qFTGKHCWIVCLCVWLLAILLSIPDLVF--STVRENSDRYRCLPVFPPSLVTSAKATIQILEVLLGFVLPFLVMVFCYSR 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MilrlksVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEALGST-SHSTAALSSYYFCIALGYTNS---- 234
Cdd:cd15176  185 V------ARALSRTPNVKK--SRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIyLLITDCSMSKTLDIAIQVTESialf 256
                        250
                 ....*....|....*..
gi 568905270 235 --SLNPVLYAFLDENFK 249
Cdd:cd15176  257 hsCLNPVLYVFMGASFK 273
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
7-252 7.63e-24

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 97.91  E-value: 7.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQ-SAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15367   37 IYLCNLTVADLLYIFSLPFWlQYVLQHDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGISAIVLGGTKVREDVDVIeCSLQFPDDEyswWDLFMKICVFVFAFVIPVLIIIVCYTLMilrLK 165
Cdd:cd15367  117 ATLVSTVIWLKELMTCVFFFLHGEISKDKENHSV-CFEHYPIKA---WEHNINYYRFYAGFLFPIFLLSFSYCRI---LR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 166 SVRLLSGSREKDRNlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAA--LSSYYFCIALGYTNSSLNPVLYAF 243
Cdd:cd15367  190 AVRKSHGTQKSQKI--QIKRLVLSTVVIFLVCFGPYHILLLVRSVFERDCNFAEgiFNYYHFSLLLTSFNCVADPVLYCF 267

                 ....*....
gi 568905270 244 LDENFKRCF 252
Cdd:cd15367  268 ASESTYHDF 276
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
1-252 1.29e-23

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 96.97  E-value: 1.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15330   31 LQNVANYLIGSLAVTDLMVSVlVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVN 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVlgGTKVREDVDVIECSLQFPDDEYSWWDLFMkicvfvfAFVIPVLIIIVCYTL 159
Cdd:cd15330  111 KRTPRRAAVLISLTWLIGFSISIPPML--GWRTPEDRSDPDACTISKDPGYTIYSTFG-------AFYIPLILMLVLYGR 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MilrlksvrLLSGSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALgstSHSTAALSSYYFCIA--LGYTNSSLN 237
Cdd:cd15330  182 I--------FKAAARE-----RKTVKTLGIIMGTFILCWLPFFIVALVLPF---CESTCHMPELLGAIInwLGYSNSLLN 245
                        250
                 ....*....|....*
gi 568905270 238 PVLYAFLDENFKRCF 252
Cdd:cd15330  246 PIIYAYFNKDFQSAF 260
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
1-250 1.48e-23

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 96.57  E-value: 1.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADAL-VTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15210   31 LRTRTNAFIINLSISDLLfCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLasSVGISAIVLGGTKVREDVDVIECSLQFPDDEYswwDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15210  111 IYTRRGLALMIAGTWIF--SFGSFLPLWLGIWGRFGLDPKVCSCSILRDKK---GRSPKTFLFVFGFVLPCLVIIICYAR 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 milrlksvrllsgsrekdRNLRRITKLVLVVVAVFIICWTPIHIFILVEALgsTSHSTAALSSYyfciALGYTNSSLNPV 239
Cdd:cd15210  186 ------------------REDRRLTRMMLVIFLCFLVCYLPITLVNVFDDE--VAPPVLHIIAY----VLIWLSSCINPI 241
                        250
                 ....*....|.
gi 568905270 240 LYAFLDENFKR 250
Cdd:cd15210  242 IYVAMNRQYRQ 252
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
1-252 1.78e-23

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 97.16  E-value: 1.78e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15205   31 MRTATNIFICSLALSDLLITFfCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDV---DVIECSLQfpddeySWWDLFMK----ICVFVFAFVIPVLI 152
Cdd:cd15205  111 QYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKYDFlyeKRHVCCLE------RWYSPTQQkiytTFILVILFLLPLTT 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 153 IIVCYTLMILRL---------KSVRLLSGSREKD--RNLRRITKLVLVVVAVFIICWTPIH-IFILVEALGSTSHSTAAL 220
Cdd:cd15205  185 MLFLYSRIGYELwikkrvgdaSVLQTIHGIEMSKisRKKKRAVKMMVTVVLLFAVCWAPFHvVHMMIEYSNLENKYDGVT 264
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568905270 221 SSYYFCI--ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15205  265 IKLIFAIvqLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
2-249 1.86e-23

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 96.78  E-value: 1.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQsAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15188   33 KKMTEVYLLNLAVSDLLFLVTLPFW-AMYVAWHWVFGSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLggTKVREDVD-VIECSLQFpDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15188  112 TRRKSLLVLVAVWVLSIALSVPDMVF--VQTHHTNNgVWVCHADY-GGHHTIWKLVFQFQQNLLGFLFPLLAMVFFYSRI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLlsgsrekdRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNS------ 234
Cdd:cd15188  189 ACVLTRLRP--------PGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVIGNCERSRHLDYALQVTESlafvhc 260
                        250
                 ....*....|....*
gi 568905270 235 SLNPVLYAFLDENFK 249
Cdd:cd15188  261 CLNPLLYAFVSKRFR 275
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
1-252 2.01e-23

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 96.12  E-value: 2.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15325   31 LQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSlqfpddEYSWWDLFMKicvfVFAFVIPVLIIIVCYTL 159
Cdd:cd15325  111 IMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETICQIT------EEPGYALFSA----LGSFYLPLAIILVMYCR 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MIlrlksVRLLSGSREKdrnlrRITKLVLVVVAVFIICWTPihiFILVEALGSTsHSTAALSSYYFCIA--LGYTNSSLN 237
Cdd:cd15325  181 VY-----VVALKFSREK-----KAAKTLGIVVGCFVLCWLP---FFLVMPIGSI-FPAYKPSDTVFKITfwLGYFNSCIN 246
                        250
                 ....*....|....*
gi 568905270 238 PVLYAFLDENFKRCF 252
Cdd:cd15325  247 PIIYPCSSQEFKKAF 261
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
1-251 2.70e-23

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 96.36  E-value: 2.70e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAV-YLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15012   30 MRTITNFFLANLAVADLCVGIFCVLQNLSiYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGT----KVREDVDVIECSLQFPDDEYSWWDLFMkicvFVFAFVIPVLIIIV 155
Cdd:cd15012  110 LLTAARLRVTIVTVWLTSAVYNTPYFVFSQTveilVTQDGQEEEICVLDREMFNSKLYDTIN----FIVWYLIPLLIMTV 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMilrlkSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFIL----VEALGSTSHSTAALSSYYFCIAlgY 231
Cdd:cd15012  186 LYSKI-----SIVLWKSSSIEAR--RKVVRLLVAVVVSFALCNLPYHARKMwqywSEPYRCDSNWNALLTPLTFLVL--Y 256
                        250       260
                 ....*....|....*....|
gi 568905270 232 TNSSLNPVLYAFLDENFKRC 251
Cdd:cd15012  257 FNSAVNPLLYAFLSKRFRQS 276
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
4-252 3.26e-23

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 95.84  E-value: 3.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   4 ATNIYIFNLALADALVTT-TMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15052   34 VTNYFLMSLAIADLLVGLlVMPLSILTELFGGvWPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDdeyswwdlfMKICVFVFAFVIPVLIIIVCYTLmi 161
Cdd:cd15052  114 SRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNVLNNGTCVLFNPN---------FVIYGSIVAFFIPLLIMVVTYAL-- 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 lrlkSVRLLsgsrekdRNLRRITKLVLVVVAVFIICWTPihIFILVEALGSTSHSTAALSSYYFCIA--LGYTNSSLNPV 239
Cdd:cd15052  183 ----TIRLL-------SNEQKASKVLGIVFAVFVICWCP--FFITNILTGLCEECNCRISPWLLSVFvwLGYVSSTINPI 249
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15052  250 IYTIFNKTFRRAF 262
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 4.50e-23

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 96.06  E-value: 4.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQsaVYLM---NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVK 76
Cdd:cd15133   31 MRTPTNYYLFSLAVSDLLVLLLgMPLE--LYELwqnYPFLLGSGGCYFKTFLFETVCLASILNVTALSVERYIAVVHPLA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 ALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDV--DVIECSLQFPDDEYswwDLFMKICVFVFaFVIPVLIII 154
Cdd:cd15133  109 ARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGvpASAQCTVRKPQAIY---NMIPQHTGHLF-FVLPMAVIS 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKSVRLLS-------------GSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVeaLGSTSHSTAALS 221
Cdd:cd15133  185 VLYLLMALRLARERGLDatgagskigtrtgQLLQHPRTRAQVTKMLFILVVVFAICWAPFHIDRLM--WSFISDWTDNLH 262
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568905270 222 SYYFCI-----ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15133  263 EVFQYVhiisgVFFYLSSAVNPILYNLMSTRFREMF 298
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
6-269 4.67e-23

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 96.51  E-value: 4.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTTMPFQSAVYLmNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKaldfrtpLK 85
Cdd:PHA02834  63 DVYLFNIAMSDLMLVFSFPFIIHNDL-NEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATK-------IK 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGISAIVLGGTKVREDVD----VIECSLQFPDDEYSWWdLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:PHA02834 135 NKSISLSVLLSVAAWVCSVILSMPAMVLYYVDntdnLKQCIFNDYHENFSWS-AFFNFEINIFGIVIPLIILIYCYSKIL 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRllsgsrekDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTS-------HSTAALSSYYFCIALGYTNS 234
Cdd:PHA02834 214 YTLKNCK--------NKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSVGlidigcyHFKKIVYSIDIAELISFVHC 285
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKRCFRD-FCFPIKMRMERQSTN 269
Cdd:PHA02834 286 CVNPIIYAFVGKNFKKVFKNmFCRTNNIFIRQSSNN 321
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
2-242 6.99e-23

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 95.34  E-value: 6.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPfqsaVYLMNS----WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA 77
Cdd:cd15079   32 RTPSNMLVVNLAISDFLMMIKMP----IFIYNSfyegWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LDFrTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEysWWDLFMKICVFVFAFVIPVLIIIVCY 157
Cdd:cd15079  108 NPL-TRGKALLLILFIWLYALPWALLPLLFGWGRYVPEGFLTSCSFDYLTRD--WNTRSFVATIFVFAYVIPLIIIIYCY 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMI---------LR-----LKSVRLLSGSREKDRNLR-RITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSS 222
Cdd:cd15079  185 SFIVkavfahekaLReqakkMNVVSLRSNADANKQSAEiRIAKVALTNVFLWFIAWTPYAVVALIGAFGNQSLLTPLVSM 264
                        250       260
                 ....*....|....*....|
gi 568905270 223 YYFCIAlgYTNSSLNPVLYA 242
Cdd:cd15079  265 IPALFA--KTAACYNPIVYA 282
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
1-250 1.34e-22

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 94.62  E-value: 1.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGD------VLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHP 74
Cdd:cd14978   30 MRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFlsyfyaYFLPYIYPLANTFQTASVWLTVALTVERYIAVCHP 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  75 VKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDE---YSWWDLFMKICVFVFAFVIPVL 151
Cdd:cd14978  110 LKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLrqnETYLLKYYFWLYAIFVVLLPFI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 152 IIIVCYTLMILRLK--------SVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSY 223
Cdd:cd14978  190 LLLILNILLIRALRkskkrrrlLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIYQLL 269
                        250       260
                 ....*....|....*....|....*...
gi 568905270 224 -YFCIALGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd14978  270 gDISNLLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
5-241 1.35e-22

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 94.48  E-value: 1.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15371   34 TAIFYANLAISDLLFCITLPFKIVYHLNgNNWVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPFIYRSLPKK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEY-SWWDLFMKICVFVFAFVIPVLIIIVCYTLMIl 162
Cdd:cd15371  114 TYAVLICALVWTIVFLYMLPFFILKQTYYLKELNITTCHDVLPECEQnSNFQFYYFISMAVFGFLIPLVITIFCYISII- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 rlksvRLLSGSREKDRNLRRITKLVLVvvaVFIICWTPIHIFILVEALGSTSHSTAALSSYYF-CIALGYTNSSLNPVLY 241
Cdd:cd15371  193 -----RTLNAYEHKWFWYVKITALVLI---IFTICFAPSNVILIIHHFNYYYFNNDNLYSIYLiALCLGSLNSCLDPFLY 264
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
1-252 1.38e-22

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 93.86  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15322   31 LKAPQNLFLVSLASADILVATlVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVlGGTKVREDVDVIECSLqfpdDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTl 159
Cdd:cd15322  111 KRTPRRIKCIIFIVWVISAVISFPPLI-TIEKKSGQPEGPICKI----NDEKWYIISSCIGSFFAPCLIMVLVYIRIYQ- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 milrlksvrlLSGSREKdrnlrRITKLVLVVVAVFIICWTPihiFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15322  185 ----------IAKNREK-----RFTFVLAVVIGVFVICWFP---FFFTYTLTAVCDCSVPETLFKFFFWFGYCNSSLNPV 246
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15322  247 IYTIFNHDFRRAF 259
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
1-252 1.53e-22

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 94.54  E-value: 1.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQsaVYLM-NSWPF--GDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVK 76
Cdd:cd15357   31 MKTPTNYYLFSLAVSDLLVLLfGMPLE--VYEMwSNYPFlfGPVGCYFKTALFETVCFASILSVTTVSVERYVAILHPFR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 ALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVRE------DVDVIECSLQFPDDEYSWwdlFMKICVFVFaFVIPV 150
Cdd:cd15357  109 AKLNSTRERALKIIVVLWVLSVLFSIPNTSIHGIKLQYfpngtlIPDSATCTVVKPLWIYNL---IIQITSLLF-YVLPM 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLMILRLKSVRLLSgSREKDRNLRR-----ITKLVLVVVAVFIICWTPIHI------FILV--EALGSTSHST 217
Cdd:cd15357  185 GVISVLYYLMGLKLRGDKSLE-ADEMNVNIQRpsrksVTKMLFVLVLVFAICWAPFHVdrlffsFVVEwtEPLANVFNLI 263
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568905270 218 AALSSYYFcialgYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15357  264 HVVSGVFF-----YLSSAVNPIIYNLLSRRFRTAF 293
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
2-252 2.24e-22

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 94.00  E-value: 2.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15195   32 KSHIQILIMHLALADLMVTfFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSPLSANQA 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RtpLKAKIINICIWLLASSVGISAIVL--GGTKVREDVDVIEC-SLQFPDDEYSWWDLFMkiCVFVFAFVIPVLIIIVCY 157
Cdd:cd15195  112 R--KRVKIMLTVAWVLSALCSIPQSFIfsVLRKMPEQPGFHQCvDFGSAPTKKQERLYYF--FTMILSFVIPLIITVTCY 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRL-----------KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHST--AALSSYY 224
Cdd:cd15195  188 LLILFEIskmakrardtpISNRRRSRTNSLERARMRTLRMTALIVLTFIVCWGPYYVLGLWYWFDKESIKNlpPALSHIM 267
                        250       260
                 ....*....|....*....|....*...
gi 568905270 225 FciALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15195  268 F--LLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 2.85e-22

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 93.75  E-value: 2.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVY-LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALd 79
Cdd:cd16004   31 MRTVTNYFIVNLALADLSMAAFNTAFNFVYaSHNDWYFGLEFCRFQNFFPITAMFVSIYSMTAIAADRYMAIIHPFKPR- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 fRTPLKAKIINICIWLLAssVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd16004  110 -LSAGSTKVVIAGIWLVA--LALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKHQLTYHLAVIVLIYLLPLAVMFVTYSI 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKSvRLLSGSREKDRNL------RRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCI-ALGYT 232
Cdd:cd16004  187 IGITLWR-SAVPGHQAHGAYHrqlqakKKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDIYCQKYIQQVYLAIfWLAMS 265
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd16004  266 STMYNPIIYCCLNQRFRSGF 285
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
10-252 4.25e-22

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 93.24  E-value: 4.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  10 FNLALADALVTTTMPFQSAVY-LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKI 88
Cdd:cd15922   40 FNLALSDAIITPAAPLLIAYFsLGSHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKK 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  89 INICIWLLASSVGISaiVLGGTKVREDVDVIECsLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM---ILRLK 165
Cdd:cd15922  120 LCLGVWLLLFVQGLP--FFFVLKTSVIDGKTKC-LSIHQSELSLLYFVWNFVLLILGFLLPFGVSLTCYALLgasIAKMN 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 166 SvRLLSGSREKDRNLRRITklvlVVVAVFIICWTPIHIFILVEALGSTSHSTAALS------SYYFCIALGYTNSSLNPV 239
Cdd:cd15922  197 S-NNARGRAMKAKSLQMIG----ISLVIFIICFVPLHVTRTVGVVVKLFYPESCTLlhkvevAYYISWVLTGVNCCLDPL 271
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15922  272 LYCFASEKFRKSF 284
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 4.82e-22

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 93.09  E-value: 4.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPV---- 75
Cdd:cd15125   31 MRSVPNIFISSLAAGDLLLlVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMdiqt 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  76 KALDFRTPLKAkiinICIWLLASSVGISAIVLGGTKVREDVD--VIECSLQFPDDEyswwDLFMKI---CVFVFAFVIPV 150
Cdd:cd15125  111 SSAVLRTCLKA----IAIWVVSVLLAVPEAVFSEVAHIMPDDntTFTACIPYPQTD----EMHPKIhsvLIFLVYFLIPL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLMILRL-KSVRLLSG-----SREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG------STSHSTA 218
Cdd:cd15125  183 AIISIYYYHIAKTLiKSAHNIPGeysehSKRQMETRKRLAKIVLVFVGLFAFCWFPNHVLYMYRSFNyneidsSLGHMIV 262
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568905270 219 ALSSYyfciALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15125  263 TLVAR----VLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
2-249 5.00e-22

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 92.91  E-value: 5.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPF-QSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd14988   32 KNLVNLYILNMAIADLGVVLTLPVwMLEVMLDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQ 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVlgGTKVREDVDVIeCSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd14988  112 HQHRIRRALCAGIWVLSAIIPLPEVV--HMQLLDGVEPM-CLFLAPFETYDEWALAVSLLTLIIGFLIPFSIIAVFNVLT 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSvrllSGSREKdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHS---TAALSSYYF-----CIALgyT 232
Cdd:cd14988  189 ARYIRT----AGRPES----RRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHISlhcNLVHFLYFFydvidCFSL--L 258
                        250
                 ....*....|....*..
gi 568905270 233 NSSLNPVLYAFLDENFK 249
Cdd:cd14988  259 HCVANPILYNFLSKSFR 275
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
6-250 5.10e-22

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 93.20  E-value: 5.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTpl 84
Cdd:cd15383   37 RILILHLAAADLLVTfVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARR-- 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLGGT-KVREDVDVIECSLQ--FPDDeysWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15383  115 RNRIMLCAAWGLSALLALPQLFLFHTvTATPPVNFTQCATHgsFPAH---WQETLYNMFTFFCLFLLPLLIMIFCYTRIL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRL-KSVRLLSGSREKDRNLR-----------RITKLVLVVVAVFIICWTPIHI------FILVEALGSTSHStaaLSSY 223
Cdd:cd15383  192 LEIsRRMKEKKDSAKNEVALRsssdnipkarmRTLKMTIVIVSSFIVCWTPYYLlglwywFSPEMLEQTVPES---LSHI 268
                        250       260
                 ....*....|....*....|....*..
gi 568905270 224 YFCiaLGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15383  269 LFL--FGLLNACLDPLIYGLFTISFRR 293
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
3-252 5.46e-22

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 92.90  E-value: 5.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkaLDFR 81
Cdd:cd15317   33 SPTNMLVLSLATADFLLgLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDP---LRYP 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICI---WLLASSVGISAIVLGG--TKVREDVDVIECslqfpddEYSWWDLFMKICVFV--FAFVIPVLIII 154
Cdd:cd15317  110 SKITVQVAWRFIaigWLVPGIYTFGLIYTGAndEGLEEYSSEISC-------VGGCQLLFNKIWVLLdfLTFFIPCLIMI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYT-LMILRLKSVRLLSGSREKDRNL------------RRITKLVLVVVAVFIICWTPIHIFILVEALgstSHSTAALS 221
Cdd:cd15317  183 GLYAkIFLVARRQARKIQNMEDKFRSSeensskasasreRKAAKTLAIVMGIFLFCWLPYFIDTIVDEY---SNFITPAI 259
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568905270 222 SYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15317  260 VFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
1-250 6.67e-22

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 92.77  E-value: 6.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTM--PFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15337   31 LRTPSNMFIINLAISDFGFSAVNgfPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAM 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVdviECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15337  111 KKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGF---QTSCTFDYLSRDLNNRLFILGLFIFGFLCPLLIIIFCYV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKS---------VRLLSGSREKDRNLRR----ITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYF 225
Cdd:cd15337  188 NIIRAVRNhekemtqtaKSGMGKDTEKNDARKKaeirIAKVAIILISLFLLSWTPYAVVALLGQFGPAYWITPYVSELPV 267
                        250       260
                 ....*....|....*....|....*
gi 568905270 226 CIAlgYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15337  268 MFA--KASAIYNPIIYALSHPKFRA 290
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
2-243 8.42e-22

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 92.49  E-value: 8.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVY-LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALdf 80
Cdd:cd15197   32 KSRMNFFITQLAIADLCVGLINVLTDIIWrITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFS-- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGtKVREDVDVIECSLQFPDDEYswWDLFMKiCVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15197  110 QSGRQARVLICVAWILSALFSIPMLIIFE-KTGLSNGEVQCWILWPEPWY--WKVYMT-IVAFLVFFIPATIISICYIII 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 I--------LRLKSVRLLSGSREKDRNLRR---------ITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSY 223
Cdd:cd15197  186 VrtiwkkskIQVTINKAGLHDGSSRRSSSRgiiprakikTIKMTFVIVTVFIICWSPYFVFDLLDVFGLLPRSKTKIAAA 265
                        250       260
                 ....*....|....*....|
gi 568905270 224 YFCIALGYTNSSLNPVLYAF 243
Cdd:cd15197  266 TFIQSLAPLNSAINPLIYCL 285
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
1-252 9.86e-22

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 92.17  E-value: 9.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkald 79
Cdd:cd15056   31 LRKKTNYFVVSLAVADLLVAVlVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYYAICCQ----- 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 frtPLKAKIINICIWLLASS-----VGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDL---FMKICVFVfAFVIPVL 151
Cdd:cd15056  106 ---PLVYKMTPLRVAVMLGGcwvipTFISFLPIMQGWNHIGIEDLIAFNCASGSTSCVFMVnkpFAIICSTV-AFYIPAL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 152 IIIVCY----------TLMILRLKSVRLLSGSREKDRNLR-----RITKLVLVVVAVFIICWTPIHIFILVEALgstSHS 216
Cdd:cd15056  182 LMVLAYyriyvaareqAHQIRSLQRAGSSNHEADQHRNSRmrtetKAAKTLGIIMGCFCVCWAPFFVTNIVDPF---IGY 258
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568905270 217 TAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15056  259 RVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
3-252 1.64e-21

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 91.72  E-value: 1.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDvLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15057   34 KVTNYFIVSLAVSDLLVAiLVMPWAAVNEVAGYWPFGS-FCDVWVSFDIMCSTASILNLCVISVDRYWAISSPFRYERRM 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLasSVGISAI-VLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYT-- 158
Cdd:cd15057  113 TRRRAFIMIAVAWTL--SALISFIpVQLGWHRADDTSEALALYADPCQCDSSLNRTYAISSSLISFYIPVAIMIVTYTri 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRL-------------LSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEA---LGSTSHSTAALSS 222
Cdd:cd15057  191 YRIARRQIRRIaaleraaqestnpDSSLRSSLRRETKALKTLSIIMGVFVCCWLPFFILNCVLPfcdLRTAQFPCVPDTT 270
                        250       260       270
                 ....*....|....*....|....*....|
gi 568905270 223 YYFCIALGYTNSSLNPVLYAFlDENFKRCF 252
Cdd:cd15057  271 FIVFVWLGWANSSLNPIIYAF-NADFRKAF 299
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-249 2.05e-21

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 91.40  E-value: 2.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQ-SAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15132   31 MRTTTNLYLSSMAVSDLLILLCLPFDlYRLWKSRPWIFGEFLCRLYHYISEGCTYATILHITALSIERYLAICFPLRAKV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFA--FVIPVLIIIVCY 157
Cdd:cd15132  111 LVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSRECKHTPYAVSSGLLGIMIWVTTtyFFLPMLCLSFLY 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRL-KSVRLLSG--SREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEAlgSTSHSTAALSSYYFCIA---LGY 231
Cdd:cd15132  191 GFIGRKLwKSKNDLRGpnAAARERSHRQTVRILAVVVLAFIICWLPFHIGRILFA--NTEDYRTMMFSQYFNIVamqLFY 268
                        250
                 ....*....|....*...
gi 568905270 232 TNSSLNPVLYAFLDENFK 249
Cdd:cd15132  269 LSASINPILYNLISRKYR 286
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
5-252 4.36e-21

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 90.49  E-value: 4.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15065   34 SNLFIVSLAVADLLVALlVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLGGTKVREdvDVIECSLQFPDDEYS-WWDLFMKICVF--VFAFVIPVLIIIVCYTLM 160
Cdd:cd15065  114 RRALVVIASVWILSALISFLPIHLGWHRLSQ--DEIKGLNHASNPKPScALDLNPTYAVVssLISFYIPCLVMLLIYSRL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 IL-------RLKSVRLLSGSREKDRNLRRITK-------------LVLVVVAVFIICWTPIHIFILVEALGSTSHStaaL 220
Cdd:cd15065  192 YLyarkhvvNIKSQKLPSESGSKFQVPSLSSKhnnqgvsdhkaavTLGIIMGVFLICWLPFFIINIIAAFCKTCIP---P 268
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568905270 221 SSYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15065  269 KCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
1-252 4.83e-21

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 90.26  E-value: 4.83e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15979   31 LRTVTNSFLLSLALSDLMLAVfCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVD---VIECSLQFPDDEY--SWWDLFMKICvfvfaFVIPVLIII 154
Cdd:cd15979  111 WQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDrprGHQCRHAWPSAQVrqAWYVLLLLIL-----FFIPGVVMI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMilrlksvrllsgSREKDRNL---RRITKLVLVVVAVFIICWTPIHIFILVEAL-GSTSHSTAALSSYYFCIALG 230
Cdd:cd15979  186 VAYGLI------------SRELYRGLlakKRVIRMLVVIVAMFFLCWLPIFSANTWRAFdPLSAHRALSGAPISFIHLLS 253
                        250       260
                 ....*....|....*....|..
gi 568905270 231 YTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15979  254 YTSACVNPLVYCFMNRRFRKAF 275
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
2-249 5.46e-21

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 90.24  E-value: 5.46e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15153   32 KNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYASICFLTCISIQRCFFLLHPFKARDWK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKiINICIWLLASSVGI-------SAIVLGGTKVREDVDVIECSLQFPddeyswwdLFMKICVFVFAFVIPVLIII 154
Cdd:cd15153  112 RRYDVG-ISAAVWIVVGLACLpfpllrsKSLSNNNRSCFADLGMKKLNFGAA--------IAMMTVAELFGFVIPLFIIA 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKSV-RLLSGSREKDRNLRritkLVLVVVAVFIICWTPIHI----FILVEA--LGSTSHSTAALSSYYFCI 227
Cdd:cd15153  183 WCTWKTENSLRQRnKQQQSTSEKQKALR----MVRMCAAVFFICFAPYHInflfYLMVSEsiITNCEVSQVILQFHPISL 258
                        250       260
                 ....*....|....*....|..
gi 568905270 228 ALGYTNSSLNPVLYAFLDENFK 249
Cdd:cd15153  259 CLASLNCCLDPILYYFMTSEFQ 280
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
1-252 5.73e-21

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 89.86  E-value: 5.73e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15063   31 LRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAITRPIRYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVL---GGTKVREDVDVIECSLQFPDDEYSWWDLFMKICvfvfAFVIPVLIIIVC 156
Cdd:cd15063  111 LMSTKRAKCLIAGVWVLSFVICFPPLVGwndGKDGIMDYSGSSSLPCTCELTNGRGYVIYSALG----SFYIPMLVMLFF 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YtLMILRlksvrllSGSREKdrnlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFciaLGYTNSSL 236
Cdd:cd15063  187 Y-FRIYR-------AARMET-----KAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPPLLFSVFFW---LGYCNSAL 250
                        250
                 ....*....|....*.
gi 568905270 237 NPVLYAFLDENFKRCF 252
Cdd:cd15063  251 NPCIYALFSRDFRFAF 266
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
1-252 6.34e-21

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 90.27  E-value: 6.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkald 79
Cdd:cd15981   31 MRTVTNMFILNLAVSDLLVGIfCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHP----- 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FR---TPLKAKIINICIWLLASSVGI-SAIVLGGTKVREDVDVIECSLQFPddEYSWWDLF--------MKICVFVFAFV 147
Cdd:cd15981  106 FRqklTLRKAIVTIVIIWVLALIIMCpSAVTLTVTREEHHFMVDDYNNSYP--LYSCWEAWpdtemrkiYTTVLFSHIYL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 148 IPVLIIIVCYTLMILRL-KSVRLLSGSREKDRNLRRITK-------LVLVVVAVFIICWTPIHIFILVEALGSTS-HSTA 218
Cdd:cd15981  184 APLTLIVIMYARIAFKLfKSSAPIRGSQGEEEEGRRVSKrkikvinMLIIVALFFTLSWLPLWTLMLLTDYGHLSeDQLN 263
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568905270 219 ALSSYYFCIA--LGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15981  264 LVTVYVFPFAhwLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
1-250 6.94e-21

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 90.08  E-value: 6.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15083   31 LRTPANYLIINLAISDFLMCILnCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIeCSLQF-PDDEYSWWDLfmkICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15083  111 RISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTS-CSFDYlSRDDANRSYV---ICLLIFGFVLPLLIIIYCYS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRL------------KSVRLLSGSREKDRNLR-RITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYF 225
Cdd:cd15083  187 FIFRAVrrhekamkemakRFSKSELSSPKARRQAEvKTAKIALLLVLLFCLAWTPYAVVALIGQFGYLEVLTPLATAIPA 266
                        250       260
                 ....*....|....*....|....*
gi 568905270 226 CIAlgYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15083  267 AFA--KTSAIYNPVIYAFSHPKFRR 289
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
1-241 8.28e-21

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 89.35  E-value: 8.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVchpVKALD 79
Cdd:cd15213   31 MRSAINLLLANLAFSDIMLSlVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLII---VQRQD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVlGGTKVREDVDVIECSLQFPDDEYswwDLFMKICVFVFAFVIPVLIIIVCYtL 159
Cdd:cd15213  108 KLNPHRAKILIAVSWVLSFCVSFPPLV-GWGKYEFPPRAPQCVLGYTESPA---DRIYVVLLLVAVFFIPFLIMLYSY-F 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRlksvrllsgsreKDRNLR-RITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYyfCIALGYTNSSLNP 238
Cdd:cd15213  183 CILN------------TVRSFKtRAFTTILILFIGFSVCWLPYTVYSLLSVFSRYSSSFYVISTC--LLWLSYLKSAFNP 248

                 ...
gi 568905270 239 VLY 241
Cdd:cd15213  249 VIY 251
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
1-252 1.17e-20

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 89.57  E-value: 1.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15124   31 MRNVPNLFISSLALGDLLLlVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVRED----VDVIECSLQFPDDEYSwwDLFMKICVFVFAFVIPVLIIIV 155
Cdd:cd15124  111 SNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDkstnKTFVSCAPYPHSNELH--PKIHSMASFLIFYVIPLSIISV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLM---ILRLKSVRLLSG---SREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA- 228
Cdd:cd15124  189 YYYFIaknLIRSAYNLPVEGnvhVRRQIESRKRLAKTVLVFVGLFAFCWLPNHIIYLYRSYHYSEVDTSMLHFVSSICAr 268
                        250       260
                 ....*....|....*....|....*
gi 568905270 229 -LGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15124  269 iLAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
6-249 1.68e-20

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 88.62  E-value: 1.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15378   36 NIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHILQKKRS 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSwwdLFMKICVFVFAFVIPvLIIIVCYTLMILRLK 165
Cdd:cd15378  116 AVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSGDATNS---LIYSLFLTVTGFLIP-LCVMCFFYYKIALFL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 166 SVRllSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEaLGSTSHSTAAL--------SSYYFCIALGYTNSSLN 237
Cdd:cd15378  192 KNR--NRQLANATSFEKPLTLVILAVVIFSVLFTPYHVMRNVR-IASRLDSIGVSectliiikSLYIVTRPIAFLNSVIN 268
                        250
                 ....*....|..
gi 568905270 238 PVLYAFLDENFK 249
Cdd:cd15378  269 PVFYFLMGDHFR 280
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
1-252 1.84e-20

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 88.10  E-value: 1.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFqsAVYLM---NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVK 76
Cdd:cd15310   31 LQTTTNYLVVSLAVADLLVATlVMPW--VVYLEvtgGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 ALDFRTPLKAKIINICI---WLLASSVgiSAIVLGGTKVREDVDVieCSLQFPDdeyswWDLFMKICVFVFAFVIPVLII 153
Cdd:cd15310  109 YQHGTGQSSCRRVSLMItavWVLAFAV--SCPLLFGFNTTGDPTV--CSISNPD-----FVIYSSVVSFYLPFGVTLLVY 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 154 IVCYTLMilrlksvrllsgSREKdrnlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALssYYFCIALGYTN 233
Cdd:cd15310  180 VRIYVVL------------LREK-----KATQMLAIVLGAFIVCWLPFFLTHILNTHCQACHVPPEL--YSATTWLGYVN 240
                        250
                 ....*....|....*....
gi 568905270 234 SSLNPVLYAFLDENFKRCF 252
Cdd:cd15310  241 SALNPVIYTTFNIEFRRAF 259
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
1-252 2.00e-20

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 88.34  E-value: 2.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15301   31 LQTISNYFLFSLAVADfAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIW----LLASSVGISAIVLGGtkvREDVDVIECSLQFPDDeyswwDLFMKICVFVFAFVIPVLIIIV 155
Cdd:cd15301  111 RRTTKKAAVMIASAWiislLLWPPWIYSWPYIEG---KRTVPAGTCYIQFLET-----NPYVTFGTALAAFYVPVTIMCI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMILRLKsvrllsgsREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAAL---SSYYFCialgYT 232
Cdd:cd15301  183 LYWRIWRETK--------KRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFPCSDTIPTElwdFSYYLC----YI 250
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd15301  251 NSTINPLCYALCNAAFRRTY 270
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
1-252 2.03e-20

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 88.79  E-value: 2.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALd 79
Cdd:cd15980   31 MRTVTNLFILNLAISDLLVGIfCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYPFKQK- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 fRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVI-----------ECSLQFPDDEYSwwdLFMKICVFVFAFVI 148
Cdd:cd15980  110 -LTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVlgsqnktspvyWCREDWPNQEMR---KIYTTVLFANIYLA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 149 PVLIIIVCYTLMILRLKSVRLLSGSREK-------DRNLRRITKLVLVVVAVFIICWTPI-HIFILVEALGSTSHSTAAL 220
Cdd:cd15980  186 PLSLIVIMYARIGITLFKTAMPHTGKHNqeqrhvvSRKKQKVIKMLLIVALLFILSWLPLwTLMMLSDYANLSPNQLQII 265
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568905270 221 SSYYFCIA--LGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15980  266 NIYIYPFAhwLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
7-251 3.50e-20

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 87.83  E-value: 3.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15376   38 VFSFNLAVSDLLYALSLPLLAAYYYPPkNWRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKH 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLAssVGISAIVLG--GTKVREDvDVIECsLQFPDDE----YSWWDLFMKicvfVFAFVIPVLIIIVCYTL 159
Cdd:cd15376  118 AKLVSLAVWLLV--AALSAPVLSfsHLEVERH-NKTEC-LGTAVDSrlptYLPYSLFLA----VVGCGLPFLLTLASYLA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MI---LRLKSVRLLsgsrEKdrnlRRITKLVLVVVAVFIICWTPIHIF--ILVEALGSTSHSTAAL---SSYYFCIALGY 231
Cdd:cd15376  190 IVwavLRSPGITTL----EK----RKVAALVAVVVALYAVSFVPYHILrnLNLYRRLQWLKAAASLriyFAYQVTKGLVT 261
                        250       260
                 ....*....|....*....|
gi 568905270 232 TNSSLNPVLYAFLDENFKRC 251
Cdd:cd15376  262 LNMCIHPLLYMAVADSIRLC 281
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
2-241 4.10e-20

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 87.88  E-value: 4.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALdf 80
Cdd:cd15384   32 RRTIYSLLLHLAIADLLVTFfCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTYITVLISLDRCVAILYPMKRN-- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15384  110 QAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCVTYGFYTAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSV-----RLLSGSREKDRNLRRI--------TKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFci 227
Cdd:cd15384  190 FITLSKSsrdfqGLEIYTRNRGPNRQRLfhkakvksLRMSAVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIF-- 267
                        250
                 ....*....|....
gi 568905270 228 ALGYTNSSLNPVLY 241
Cdd:cd15384  268 FFGMSNSCVNPLIY 281
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
7-252 5.53e-20

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 87.44  E-value: 5.53e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15375   37 IIMLNLALTDLLYVTSLPFLIYYYINgESWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRW 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGISAIVLGGTKvreDVDVIECSLQF----PDDEYSWWDLFMKicvfVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15375  117 AIVACAVVWVISLAEVSPMTFLITTK---EKNNRTICLDFtssdNLNTIWWYNWILT----VLGFLLPLVIVTLCYTRII 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRL-KSVRLLSGSREKDRnlrritKLVLVVVAVFIICWTPIHIFILVEALG-----STSHSTAALSSYYFCIALGYTNSS 235
Cdd:cd15375  190 YTLaKGPHTGSASKQKAR------RLIILILLVFYVCFLPFHILRVVRIETrlppvSCCLKHQVHAIYIITRPLAALNTF 263
                        250
                 ....*....|....*..
gi 568905270 236 LNPVLYAFLDENFKRCF 252
Cdd:cd15375  264 GNLLLYVVSGDNFQQAF 280
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
1-255 5.96e-20

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 87.27  E-value: 5.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15305   31 LQNATNFFLMSLAVADMLVgILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIVLGgtkVREDVDVIECSLQFPDDEyswwdLFMKICVFVfAFVIPVLIIIVCYT 158
Cdd:cd15305  111 RFNSRTKAMMKIAAVWTISIGISMPIPVIG---LQDDEKVFVNGTCVLNDE-----NFVLIGSFV-AFFIPLIIMVITYC 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKsvrllsgSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYY-FCIALGYTNSSLN 237
Cdd:cd15305  182 LTIQVLQ-------RQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKLMEELLnVFVWVGYVSSGIN 254
                        250
                 ....*....|....*...
gi 568905270 238 PVLYAFLDENFKRCFRDF 255
Cdd:cd15305  255 PLVYTLFNKTYRRAFSNY 272
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
1-252 6.21e-20

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 86.95  E-value: 6.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd17790   31 LKTVNNYFLLSLACADLIIgAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVRE-DVDVIECSLQFpddeyswwdLFMKICVF---VFAFVIPVLIIIV 155
Cdd:cd17790  111 KRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGErTVLAGQCYIQF---------LSQPIITFgtaIAAFYLPVTIMII 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTlmilrlksvRLLSGSREKDRNLRRITKLVLvvvaVFIICWTPIHIFILVEALGSTSHSTAALS-SYYFCialgYTNS 234
Cdd:cd17790  182 LYW---------RIYRETIKEKKAARTLSAILL----AFILTWTPYNIMVLVSTFCKDCVPKTLWElGYWLC----YVNS 244
                        250
                 ....*....|....*...
gi 568905270 235 SLNPVLYAFLDENFKRCF 252
Cdd:cd17790  245 TVNPMCYALCNKSFRDTF 262
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
1-252 6.45e-20

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 87.13  E-value: 6.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15154   31 LHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIW--LLASSVGiSAIVLGGTKVRE-DVDVIECSLQFPDDEysWWDLF-MKICVFVFAFVIPVLIIIVC 156
Cdd:cd15154  111 RRPKVARLLCLAVWalILGGSVP-AAIVHSSSDCLLhGEKVYRCFESFSDND--WKGLLpLVVLAEILGFLLPLAAVLYC 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YTLMILRLKSVRLLSGSREkdrnlRRITKLVLVVVAVFIICWTP----IHIFILVEA--LGSTSHSTAALSSYYFC-IAL 229
Cdd:cd15154  188 SCRIFVELCRTQEPQQGRR-----RKTVRLLLVNLVIFLICFVPynttLAVYGLLRAnlVEDTWNIKDTLRKVLSVtVLL 262
                        250       260
                 ....*....|....*....|...
gi 568905270 230 GYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15154  263 ASTNCALDPLVYYFSTEGFRNTL 285
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
1-250 9.57e-20

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 86.72  E-value: 9.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15397   31 KTNVTNILIANLSFSDILVCLvCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSILSLVLIALERHQLIINPTGWKP 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 frTPLKAKIINICIWLLA---SSVGISAIVLGGTKVRE-------DVDVIECSLQFPDDEYSwwdLFMKICVFVFAFVIP 149
Cdd:cd15397  111 --SVSQAYLAVVVIWMLAcfiSLPFLAFHILTDEPYKNlshffapLADKAVCTESWPSEHHK---LAYTTWLLLFQYCLP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 150 VLIIIVCYTLMILRL-KSVRLLSGSREKDR---NLRRITKLVLVVVAVFIICWTPIHIFILV-----EALGSTSHSTAal 220
Cdd:cd15397  186 LLFILVCYLRIYLRLrRRKDMLERRGEYNRragHSKRINVMLVSLVAAFALCWLPLNVFNAIadwnhEAIPHCQHNLI-- 263
                        250       260       270
                 ....*....|....*....|....*....|
gi 568905270 221 ssYYFCIALGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15397  264 --FSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
7-246 1.06e-19

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 86.39  E-value: 1.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYL-MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15366   37 VYLLNLSVSDLLYIATLPLWIDYFLhRDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKT 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGiSAIVLGGTKVREDVDVIECSLQFPDDEYSWWdlfMKICVFVFAFVIPVLIIIVCYTLMilrLK 165
Cdd:cd15366  117 AVAVSAVVWAIEIGAN-SAPLFHDELFRDRYNHTFCFEKYPMEDWVAW---MNLYRVFVGFLFPWVLMLFSYRGI---LR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 166 SVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEAL------GSTSHSTAALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15366  190 AVRGNVSTEQQEK--AKIKRLALSLIAIVLLCFAPYHVLLLSRSVvylgkpCDCGFEERVFTAYHVSLALTSLNCVADPI 267

                 ....*..
gi 568905270 240 LYAFLDE 246
Cdd:cd15366  268 LYCLVNE 274
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
2-249 1.41e-19

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 85.61  E-value: 1.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYlmnsWPFGDVL-CKIVISIDYY-NMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15163   32 KTTSVIYTINLVVTDLLVGLSLPTRIVMY----YSAGNCLtCSFVHIFSYFvNMYCSILFLTCICVDRYLAIVQVEASRR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISaiVLGGTKVredvdviecslqfpddeYSWWDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15163  108 WRNPNYAKGICVFIWLFAIVVTFS--ILTTAIK-----------------FASCCLSKLFALTVFEFFLPLLIITFFTIR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKSVRLLSGSREKDrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15163  169 IMCALSRPGLMHQSRERR---MRAVQLLITVLIIFMICFTPFHVRQVAVAFNPDIPHHTSLIVYHVTVTLSSLNSCMDPI 245
                        250
                 ....*....|
gi 568905270 240 LYAFLDENFK 249
Cdd:cd15163  246 VYCFVTNNFQ 255
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
1-250 1.62e-19

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 86.41  E-value: 1.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkaLD 79
Cdd:cd15395   31 MHNVTNILIVNLSFSDLLMTIMcLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLVLIAIERHQLIINP---RG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINIC-IWLLASSVGISAIV--------LGGTKVRED--VDVIECSLQFPDDEYSwwdLFMKICVFVFAFVI 148
Cdd:cd15395  108 WRPNNRHAYVGIAvIWVLAVLTSLPFLIfqvltdepFKNVNVSLDayKGKYVCLDQFPSDTIR---LSYTTCLLVLQYFG 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 149 PVLIIIVCYTLMILRLKS----VRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILV-----EALGSTSHSTAa 219
Cdd:cd15395  185 PLCFIFICYLKIYIRLKRrnnmMDKMRDNKYRSSETKRINIMLISIVVAFAVCWLPLNIFNAVfdwnhEAIATCNHNLL- 263
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568905270 220 lssYYFCIALGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15395  264 ---FLICHLTAMISTCVNPIFYGFLNKNFQR 291
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
1-252 1.95e-19

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 85.40  E-value: 1.95e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15297   31 LQTVNNYFLFSLACADLIIgVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAI-----VLGGTKVREDvdviECSLQFpddeysWWDLFMKICVFVFAFVIPVLIII 154
Cdd:cd15297  111 KRTTKMAGMMIAAAWVLSFILWAPAIlfwqfIVGGRTVPEG----ECYIQF------FSNAAVTFGTAIAAFYLPVIIMT 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYtLMILRlksvrllSGSREKdrnlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTS-HSTAALSSYYFCialgYTN 233
Cdd:cd15297  181 VLY-WQISR-------ASSREK-----KVTRTILAILLAFIITWTPYNVMVLINTFCASCiPNTVWTIGYWLC----YIN 243
                        250
                 ....*....|....*....
gi 568905270 234 SSLNPVLYAFLDENFKRCF 252
Cdd:cd15297  244 STINPACYALCNATFKKTF 262
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
7-250 2.25e-19

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 85.96  E-value: 2.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQsAVYLMN--SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15147   39 IFMVNLTIADLLFLITLPFW-IVYYHNegNWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRK 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLGGTKVrEDVDVIECSLQFPDDEYSWWDLFMKICVF-VFAFVIPVLIIIVCyTLMILR 163
Cdd:cd15147  118 RGIIISVAIWVIIVASASYFLFMDSTNT-VKIDSGNFTRCFEGYEKDNSKPVLIIHFIiIGLFFLVFLLILVC-NLVIAR 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 LKSVRLLSGSREKDRNlRRITKLVLVVVAVFIICWTPIHIFILVEALG--------STSHSTAALSSYYFCIALGYTNSS 235
Cdd:cd15147  196 TLLSQPVQGQRNAGVK-RRALWMVCTVLAVFVICFVPHHVVQGPWTLAvlqqwrywDCQFRQALNDAHQITLCLMSTNCV 274
                        250
                 ....*....|....*
gi 568905270 236 LNPVLYAFLDENFKR 250
Cdd:cd15147  275 LDPVIYCFLTKKFRK 289
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
5-256 4.21e-19

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 84.49  E-value: 4.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15295   35 SNYFFLNLAISDFFVgAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 -LKAKIINICIWLLASSVGISAIVLGGTKVREDVdviECSLQFpddeYSWWDLFMkiCVFVFAFVIPVlIIIVCYTLMIL 162
Cdd:cd15295  115 tLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDG---ECEPEF----FSNWYILA--ITSVLEFLVPV-ILVAYFNTQIY 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 RLKSVRLLSgsrekdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTaalSSYYFCIALGYTNSSLNPVLYA 242
Cdd:cd15295  185 WSLWKRLRD---------RKLAKSLAIILGTFAICWAPYSLFTIIRAACEKHRGS---PWYNFAFWLQWFNSFINPFLYP 252
                        250
                 ....*....|....*
gi 568905270 243 FLDENFKRCF-RDFC 256
Cdd:cd15295  253 LCHKRFRKAFlKIFC 267
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
1-242 4.30e-19

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 85.15  E-value: 4.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTmpfQSAVYLMNS----WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVK 76
Cdd:cd15336   31 LRTPANYFIINLAVSDFLMSLT---QSPIFFVNSlhkrWIFGEKGCELYAFCGALFGITSMITLLAISLDRYLVITKPLA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 ALDFRTPLKAKIINICIWL------LASSVGISAIVLGGTKvredvdvIECSLQFPDDEYSWWDLFMKICVFVfaFVIPV 150
Cdd:cd15336  108 SIRWVSKKRAMIIILLVWLyslawsLPPLFGWSAYVPEGLL-------TSCTWDYMTFTPSVRAYTMLLFCFV--FFIPL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLMILRLKS------------VRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTA 218
Cdd:cd15336  179 GIIIYCYLFIFLAIRStgrevqklgsqdRKEKAKQYQRMKNEWKMAKIAFVVILLFVLSWSPYACVALIAWAGYAHLLTP 258
                        250       260
                 ....*....|....*....|....
gi 568905270 219 ALSSYYFCIAlgYTNSSLNPVLYA 242
Cdd:cd15336  259 YMKSVPAVIA--KASAIYNPIIYA 280
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
1-252 5.80e-19

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 84.49  E-value: 5.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkald 79
Cdd:cd15399   31 MRTVTNFFIANLAVADLMVNTlCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTLTVIALDRHRCIVYH----- 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 frtpLKAKIIN-ICIWLLASSVGISAIVLGGTKVREDVDVIE---------CSLQFPDDEYSWWDLFmKICVFVFAFVIP 149
Cdd:cd15399  106 ----LESKISKkISFLIIGLTWAASALLASPLAIFREYSVIEispdfkiqaCSEKWPNGTLNDGTIY-SVSMLLIQYVLP 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 150 VLIIIVCYTLMILRLKSVRLLSGSREKDRNLRR-ITKLVLVVVAVFIICWTPIHIFILVEALGSTS---HSTAALSSYYF 225
Cdd:cd15399  181 LAIISYAYIRIWTKLKNHVSPGGGNDHYHQRRRkTTKMLVCVVVVFAVSWLPFHAFQLASDIDSKVldlKEYKLIYTIFH 260
                        250       260
                 ....*....|....*....|....*..
gi 568905270 226 CIALGYTNSslNPVLYAFLDENFKRCF 252
Cdd:cd15399  261 VIAMCSTFA--NPLLYGWMNNNYRTAF 285
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
2-252 6.41e-19

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 84.85  E-value: 6.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISID----YYNMFTSIFTLTMMSVDRY-IAVCH-- 73
Cdd:cd14996   32 KTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFyWKYQSTQCRIANFFGtlviHVSMCVSILILSWIAISRYaTLMKHds 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  74 ------------PVKALD-FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIEC---SLQFPDDEYSWWDLFM 137
Cdd:cd14996  112 atqkqscyekifYGHFLKrFRQPKFARYLCIYIWGVVLCIIIPVVVYYSVREADEDGESLCynrQVELGAKGSQIAGLIA 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 138 KICVFVFAfvipvLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHST 217
Cdd:cd14996  192 TTFFFLFF-----LVVLLSYYSFVNHLRRIQKNTCISEKDLIYRSVKRNILIIQALLVVCFLPYHIFKPVFYVLHQREDC 266
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568905270 218 AALSSYY----FCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14996  267 QQLNYLIetknILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
5-252 7.15e-19

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 83.96  E-value: 7.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15066   34 TNYFVVSLAMADMLVAlCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLGGTKVREDVdviECSLQFPDdeyswwdlfmkICVFV-----------FAFVIPVLI 152
Cdd:cd15066  114 RRVAIMLANVWISPALISFLPIFLGWYTTEEHL---QYRKTHPD-----------QCEFVvnkiyalisssVSFWIPCIV 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 153 IIVCYTLMILRLKsvrllsgsREkdrnlRRITKLVLVVVAVFIICWTPIHI-FILVEALGSTSHSTAALSSYYFCIalGY 231
Cdd:cd15066  180 MIFTYYRIYLEAK--------RE-----HKAAKTLGIIMGAFILCWLPFFLwYVTTTLCGDACPYPPILVSILFWI--GY 244
                        250       260
                 ....*....|....*....|.
gi 568905270 232 TNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15066  245 FNSTLNPLIYAYFNRDFREAF 265
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
3-249 8.98e-19

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 83.72  E-value: 8.98e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQsaVYLMNSWPFG-DVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd14989   33 TIPDLYFVNLAVADLILVADSLIE--VFNLNEKYYDiAVLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSSPLR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLAssvgISAIVLGGTKVREDvDVIECSLQFPD-DEYSWWDLfmkicvfVFAFVIPVLIIIVCYTLM 160
Cdd:cd14989  111 TMQHARLSCGLIWMAS----ISATLLPFTAVQAQ-HTGEVHFCFADvREIQWLEV-------TLGFIIPFSIIGLCYSLI 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ilrlksVRLLSGSrEKDRNLR----RITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAA----------LSSYYFC 226
Cdd:cd14989  179 ------VRVLVRA-QKHRRLRprrqKALRMILVVVLVFFICWLPENVFISIQLLQGTQEPSESydesfrhnhpLTGHIVN 251
                        250       260
                 ....*....|....*....|...
gi 568905270 227 IAlGYTNSSLNPVLYAFLDENFK 249
Cdd:cd14989  252 LA-AFSNSCLNPLIYSFLGETFR 273
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
3-252 1.31e-18

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 83.56  E-value: 1.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVK-ALDF 80
Cdd:cd15312   33 SPTNFLILSLAITDFLLgFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHyRTKI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICiW----LLASSVGISAIVLGGTKvrEDVDVIECSlqfpddeYSWWDLFMKI---CVFVFAFVIP--VL 151
Cdd:cd15312  113 TTPVIKVFLVIS-WsvpcLFAFGVVFSEVNLEGIE--DYVALVSCT-------GSCVLIFNKLwgvIASLIAFFIPgtVM 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 152 IIIVCYTLMILRlKSVRLLS--------GSREK--DRNLRRITKLVLVVVAVFIICWTPIHIFILVEALgsTSHSTAALs 221
Cdd:cd15312  183 IGIYIKIFFVAR-KHAKVINnrpsvtkgDSKNKlsKKKERKAAKTLSIVMGVFLLCWLPFFVATLIDPF--LNFSTPVD- 258
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568905270 222 SYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15312  259 LFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
1-252 1.51e-18

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 82.92  E-value: 1.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15333   35 LHTPANYLIASLAVTDLLVSIlVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHLCVIALDRYWAITDAVEYSK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDviECSLQFPDDEYSWWDLFMkicvfvfAFVIPVLIIIVCYTl 159
Cdd:cd15333  115 KRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVS--ECVVNTDHILYTVYSTVG-------AFYIPTLLLIALYG- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 milrlksvRLLSGSREKDrnlRRITKLVLVVVAVFIICWTPIHIFILVEALgSTSHSTAALSSYYFCIALGYTNSSLNPV 239
Cdd:cd15333  185 --------RIYVEARARE---RKATKTLGIILGAFIVCWLPFFIISLVLPI-CKDACWFHLAIFDFFTWLGYLNSLINPI 252
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15333  253 IYTMSNEDFKQAF 265
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
1-253 2.07e-18

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 83.08  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15307   31 LQNVTNYFLMSLAITDLMVAVlVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKvrEDVDVIECSLQFPDDEYswwdlfmKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15307  111 NKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKD--HASVLVNGTCQIPDPVY-------KLVGSIVCFYIPLGVMLLTYCL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 milrlkSVRLLSGSREKD-RNLR---RITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSS 235
Cdd:cd15307  182 ------TVRLLARQRSRHgRIIRleqKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSM 255
                        250
                 ....*....|....*...
gi 568905270 236 LNPVLYAFLDENFKRCFR 253
Cdd:cd15307  256 VNPIFYTIFNKVFRQAFK 273
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
3-250 2.11e-18

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 83.00  E-value: 2.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15379   33 SRTTIYMLNLATADLLYVCSLPLLIYNYTQkDYWPFGDFTCRLVRFQFYTNLHGSILFLTCISVQRYLGICHPLASWHKK 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAK-IINICIWLLASSVGISAIVLGGTKVREDVDVieC-SLQFPDDEYSWWDLFMKICvfVFAFVIPVLIIIVCYTL 159
Cdd:cd15379  113 KGKKLTwLVCGAVWLVVIAQCLPTFVFASTGTQRNRTV--CyDLSPPARSTAYFPYGITLT--RTGFLLPFAARLACYCS 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRL-KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA------LGYT 232
Cdd:cd15379  189 MATILcRVVIAVAVVAAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQVRSWDGGPCTTRQAFAEAykrtrpFASM 268
                        250
                 ....*....|....*...
gi 568905270 233 NSSLNPVLYAFLDENFKR 250
Cdd:cd15379  269 NSVLDPILFYFTQSKFRP 286
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
5-250 3.23e-18

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 82.74  E-value: 3.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTp 83
Cdd:cd15382   36 VNILLMHLAIADLLVTfIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVCISLDRYFAILKPLRLSDARR- 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 lKAKIINICIWLLASSVGISAIVLGGTKVREDVD-VIECSL--QFPDDEYswwDLFMKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15382  115 -RGRIMLAVAWVISFLCSIPQSFIFHVESHPCVTwFSQCVTfnFFPSHDH---ELAYNIFNMITMYALPLIIIVFCYSLI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRL----KSVRLLSGSREKDRNLRRIT------------KLVLVVVAVFIICWTPIHIFILVEALGSTSHS--TAALSS 222
Cdd:cd15382  191 LCEIsrksKEKKEDVSEKSSSVRLRRSSvgllerarsrtlKMTIVIVLVFIICWTPYFIMSLWYWFDRESASkvDPRIQK 270
                        250       260
                 ....*....|....*....|....*...
gi 568905270 223 YYFCIALgyTNSSLNPVLYAFLDENFKR 250
Cdd:cd15382  271 GLFLFAV--SNSCMNPIVYGYFSIDLRR 296
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
1-241 4.05e-18

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 82.50  E-value: 4.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15058   31 LQTMTNIFITSLACADLVMgLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVrEDVDVIECslqFPDDEYSWWDLFMKICVF--VFAFVIPVLIIIVCY 157
Cdd:cd15058  111 LLTKRRARVIVCVVWIVSALVSFVPIMNQWWRA-NDPEANDC---YQDPTCCDFRTNMAYAIAssVVSFYIPLLIMIFVY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMIL-RLKSVRLLSGSREKDRN-----------------LRRITKLVL----------VVVAVFIICWTPIHIFILVEA 209
Cdd:cd15058  187 ARVFLiATRQLQLIDKRRLRFQSecpapqttspegkrssgRRPSRLTVVkehkalktlgIIMGTFTLCWLPFFIANIINV 266
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568905270 210 LGStSHSTAALSSYYFCiaLGYTNSSLNPVLY 241
Cdd:cd15058  267 FNR-NLPPGEVFLLLNW--LGYINSGLNPIIY 295
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
1-252 4.36e-18

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 81.46  E-value: 4.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15324   31 LRAPQNLFLVSLASADILVATlVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLlassvgISAIVLGGTKVREDVDVIECSLqfpdDEYSWWDLFMkicvFVFAFVIPVLIIIVCYtL 159
Cdd:cd15324  111 KRTPKRIKRMIAVVWV------ISAVISFPPLLMTKHDEWECLL----NDETWYILSS----CTVSFFAPGLIMILVY-C 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLKSVRllsgsrekdrnLRRITKLVLVVVAVFIICWTPIHIFILVEAL-GSTSHSTAALSSYYFCIalGYTNSSLNP 238
Cdd:cd15324  176 KIYRVAKMR-----------EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVcRKRCGIPDALFNLFFWI--GYCNSSVNP 242
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15324  243 IIYTIFNRDFRKAF 256
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
7-250 4.69e-18

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 82.08  E-value: 4.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRtplKA 86
Cdd:cd15152   37 IFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCK---RK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  87 KIINICI--WLLassVGISAIVLGGTKVREDVDVIECSLQFPDDEYSW-WDLFMKICVFVFAFVIPVLIIIVCYTLMILR 163
Cdd:cd15152  114 CDVYISIagWLV---VCVGCLPFPLLRQSQDTNPTCCFADLPLRNVGLtTSVIMLTIAELTGFVTPLLIVLYCSWKTVMS 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 LK-SVRLLSGSREKDRNLrritKLVLVVVAVFIICWTPIHI------FILVEALGSTSHSTAALSSYYFCIALGYTNSSL 236
Cdd:cd15152  191 LReKTPVLQDLGEKKKAL----KMILTCAVVFLICFAPYHIsfpldfLVKSNKIKSCTARKVILIFHPVALCLASLNSCL 266
                        250
                 ....*....|....
gi 568905270 237 NPVLYAFLDENFKR 250
Cdd:cd15152  267 DPVIYYFTTDEFKR 280
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 4.87e-18

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 82.26  E-value: 4.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADAL-VTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15977   31 MRNGPNVLIASLALGDLLyILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALSIDRYRAVASWSRIRG 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGI-SAIVLGGTKVR-EDVDVIECSL---------QFPDDEYSWWdlfmkicVFVFAFVI 148
Cdd:cd15977  111 IGIPVWKAVEVTLIWAVAIIVAVpEAIAFDMVEIDyRGQTLLVCMLpmeqtssfmRFYQDVKDWW-------LFGFYFCL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 149 PVLIIIVCYTL----MILRLKSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYY 224
Cdd:cd15977  184 PLACTGVFYTLmsceMLSIKNGMRIALNDHMKQR--REVAKTVFCLVVIFALCWLPLHLSRILKKTIYDVKDPQRCELLS 261
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568905270 225 FCIALGYT-------NSSLNPVLYAFLDENFKRCF 252
Cdd:cd15977  262 FLLVMDYTginmaslNSCINPVALYFVSRKFKNCF 296
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
5-252 5.55e-18

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 82.36  E-value: 5.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDvLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15320   37 TNFFVISLAVSDLLVAVlVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLGGTKVRED--VDVIECSLQFPDDEY-SWWDLFMKICVFVFAFVIPVLIIIVCYTlM 160
Cdd:cd15320  116 KVAFIMISVAWTLSVLISFIPVQLNWHKAKPTsfLDLNASLRDLTMDNCdSSLNRTYAISSSLISFYIPVAIMIVTYT-R 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRL--KSVRLLSG----------------------SREKDRNLR-------RITKLVLVVVAVFIICWTPIHIF-ILVE 208
Cdd:cd15320  195 IYRIaqKQIRRISAleraavhakncqnstgnrgsgdCQQPESSFKmsfkretKVLKTLSVIMGVFVCCWLPFFILnCMVP 274
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568905270 209 ALGSTSHSTAALSSYYF--CIALGYTNSSLNPVLYAFlDENFKRCF 252
Cdd:cd15320  275 FCKPTSTEPFCISSTTFdvFVWFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
2-250 5.64e-18

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 81.73  E-value: 5.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYL-MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15924   31 KSSFIIYLKNTVVADLLMILTFPFKILSDAgLGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFP 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDvDVIECSLQFPDDEYSWWDLFMKICVFVfaFVIPVLIIIVCYTLM 160
Cdd:cd15924  111 KSVSFAKILSVVVWALMFLLSLPNMILTNQQPREK-NVKKCSFLKSELGLKWHEIVNYICQVI--FWIVFLLMIVCYTAI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRL-KSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIfilVEALGSTSHSTAALSSYY---------FCIALG 230
Cdd:cd15924  188 TKKVyRSYRRVFRSSSSRR--KKSNVKIFIIVAVFFVCFVPYHF---ARIPYTLSQTRDVFDCTAenilfyvkeATLFLS 262
                        250       260
                 ....*....|....*....|
gi 568905270 231 YTNSSLNPVLYAFLDENFKR 250
Cdd:cd15924  263 ALNVCLDPIIYFFLCKSFRE 282
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
1-252 9.13e-18

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 80.83  E-value: 9.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15298   31 LQTVNNYFLFSLACADLIIGAfSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKV-REDVDVIECSLQFPDDEYswwdlfMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15298  111 RRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVgKRTVPDNQCFIQFLSNPA------VTFGTAIAAFYLPVVIMTVLYI 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMIlrlksvrlLSGSREKdrnlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALS-SYYFCialgYTNSSLN 237
Cdd:cd15298  185 HIS--------LASARER-----KVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSiGYWLC----YVNSTIN 247
                        250
                 ....*....|....*
gi 568905270 238 PVLYAFLDENFKRCF 252
Cdd:cd15298  248 PACYALCNATFKKTF 262
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
1-252 1.43e-17

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 80.68  E-value: 1.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15978   31 MRTVTNIFLLSLAVSDlMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTFNLVAISLERYSAICKPLKSRV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSV----GISAIVLGGTKVREDVDVIeCSLQFPDD--EYSWWDLFMKICvfvfaFVIPVLII 153
Cdd:cd15978  111 WQTKSHALKVIAATWCLSFTImlpyPIYSNLVPFTRINNSTGNM-CRLLWPNDvtQQSWYIFLLLIL-----FLIPGIVM 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 154 IVCYTLMILRL-KSVRLLSGSRekdrnlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSH----STAALSsyyFCIA 228
Cdd:cd15978  185 MTAYGLISLELyRGIKFLMAKK-------RVIRMLIVIVILFFLCWTPIFSANAWRAFDTRSAdrllSGAPIS---FIHL 254
                        250       260
                 ....*....|....*....|....
gi 568905270 229 LGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15978  255 LSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
2-252 1.68e-17

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 80.38  E-value: 1.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALV-TTTMPFqsAVYLMNSWPFGDVLCKIVISIdyYNMFT--SIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd14968   32 RTVTNYFIVSLAVADILVgALAIPL--AILISLGLPTNFHGCLFMACL--VLVLTqsSIFSLLAIAIDRYLAIKIPLRYK 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIV----LGGTKVREDVDVIECS-LQFPDDEYSWWDLFmkicvfvFAFV-IPVLI 152
Cdd:cd14968  108 SLVTGRRAWGAIAVCWVLSFLVGLTPMFgwnnGAPLESGCGEGGIQCLfEEVIPMDYMVYFNF-------FACVlVPLLI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 153 IIVCYTLMILR----LKSVRLLSGSREKDRNLRR---ITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALssYYF 225
Cdd:cd14968  181 MLVIYLRIFRVirkqLRQIESLLRSRRSRSTLQKevkAAKSLAIILFLFALCWLPLHIINCITLFCPECKVPKIL--TYI 258
                        250       260
                 ....*....|....*....|....*..
gi 568905270 226 CIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14968  259 AILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
1-250 1.75e-17

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 80.17  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHP--VKA 77
Cdd:cd15073   31 LRTPTNALIINLAVTDlGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPdlGRK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LDFRTPLK---AKIINICIWLLASSVGISAIVLggtkvreDVDVIECSLQFPDDEYSWWDLFMKicVFVFAFVIPVLIII 154
Cdd:cd15073  111 MTTNTYTVmilLAWTNAFFWAAMPLVGWASYAL-------DPTGATCTINWRKNDSSFVSYTMS--VIVVNFIVPLAVMF 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKSV---RLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSsyyfCIALGY 231
Cdd:cd15073  182 YCYYNVSRFVKKVlasDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEPKKIPPWMA----IIPPLF 257
                        250       260
                 ....*....|....*....|.
gi 568905270 232 TNSS--LNPVLYAFLDENFKR 250
Cdd:cd15073  258 AKSStfYNPCIYVIANKKFRR 278
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
38-250 1.89e-17

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 79.97  E-value: 1.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  38 GDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFrTPLKAKIINICIWLLASSVGISAIVLgGTKVREDVD 117
Cdd:cd15196   69 GDLLCRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLFI-FSYQEVGSG 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 118 VIECSLQFPDD----EYSWWdlfmkicVFVFAFVIPVLIIIVCYTLMIL-----RLKSVrllsgsrekdrnlrritKLVL 188
Cdd:cd15196  147 VYDCWATFEPPwglrAYITW-------FTVAVFVVPLIILAFCYGRICYvvwraKIKTV-----------------KLTL 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568905270 189 VVVAVFIICWTPihiFILVEaLGSTSHSTAALSSYYFCIA--LGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15196  203 VVVACYIVCWTP---FFVVQ-MWAAWDPTAPIEGPAFVIImlLASLNSCTNPWIYLAFSGNLRR 262
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
3-243 2.00e-17

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 80.61  E-value: 2.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTtmpFQSAVYLMNSWPF----GDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15386   33 SRMHLFVLHLALTDLVVAL---FQVLPQLIWEITYrfqgPDLLCRAVKYLQVLSMFASTYMLIMMTVDRYIAVCHPLRTL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 dfRTPLKAKIINICI-WLLASSVGISAI-VLGGTKVREDVDVIECSLQFpddEYSWWDLFMKICVFVFAFVIPVLIIIVC 156
Cdd:cd15386  110 --QQPSRQAYLMIGAtWLLSCILSLPQVfIFSLREVDQGSGVLDCWADF---GFPWGAKAYITWTTLSIFVLPVAILIVC 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YTLMILRL-KSVRLLS-GSREKDRNLR-------------------RITKLVLVVVAVFIICWTP---IHIFILVEALGS 212
Cdd:cd15386  185 YSLICYEIcKNLKGKTqTSRSEGGGWRtqgmpsrvssvrtisrakiRTVKMTFVIVLAYIACWAPffsVQMWSVWDENAP 264
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568905270 213 TSHSTAALssYYFCIALGYTNSSLNPVLYAF 243
Cdd:cd15386  265 DEDSSDFA--FTITMLLASLSSCCNPWIYMF 293
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
6-253 2.21e-17

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 79.61  E-value: 2.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTT-TMPFqSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15334   36 NYLICSLAVTDFLVAVlVMPF-SIMYIVKeTWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTP 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVL-GGTKVREDvdviECSLQFPDDEYSWWDLFMkicvfvfAFVIPVLIIIVCYtLMIL 162
Cdd:cd15334  115 KHAGIMIAVVWIISIFISMPPLFWrHQTTSRED----ECIIKHDHIVFTIYSTFG-------AFYIPLALILILY-YKIY 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 RlksvrllSGSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyFCIALGYTNSSLNPVLYA 242
Cdd:cd15334  183 R-------AATRE-----RKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMSN--FLTWLGYINSLINPLIYT 248
                        250
                 ....*....|.
gi 568905270 243 FLDENFKRCFR 253
Cdd:cd15334  249 IFNEDFKKAFQ 259
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
1-255 3.09e-17

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 79.49  E-value: 3.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15306   31 LQYATNYFLMSLAVADLLVGLfVMPIALLTILFEAmWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQAS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQfpDDEYSWWDLFMKICvfvfAFVIPVLIIIVCYT 158
Cdd:cd15306  111 QYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLT--KERFGDFILFGSLA----AFFTPLAIMIVTYF 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKsvrllsgsREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15306  185 LTIHALR--------KQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQTTLQMLMEIFVWIGYVSSGVNP 256
                        250
                 ....*....|....*..
gi 568905270 239 VLYAFLDENFKRCFRDF 255
Cdd:cd15306  257 LVYTLFNKTFRDAFGRY 273
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
8-252 3.19e-17

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 79.61  E-value: 3.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   8 YIFNLALADALVT-TTMPFQ--SAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15130   41 HLGSLALSDLLILlLAMPVElyNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRS 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQ-FPDDEYSWWDLFMKICVFVfAFVIPVLIIIVCYTLMILR 163
Cdd:cd15130  121 RTKKFISAIWLASALLAIPMLFTMGLQNESDDGTHPGGLVcTPIVDTATLKVVIQVNTFM-SFLFPMLVTSILNTVIANK 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 LKsvrllsgsrekdRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCI-----ALGYTNSSLNP 238
Cdd:cd15130  200 LV------------QALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFymltnALFYVSSAINP 267
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15130  268 ILYNLVSANFRQVF 281
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
1-252 3.31e-17

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 79.90  E-value: 3.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADAL-VTTTMPFQSAVYLMNSWPFGD-----VLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHP 74
Cdd:cd15975   31 MRNGPNALIASLALGDLIyIVIDIPINVYKLLAQKWPFDDssfgvFLCKLVPFLQKASVGITVLNLCALSVDRYRAVASW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  75 VKALDFRTPLKAKIINICIWLLASSVGI-SAIVLGGTKVREDVDVIECSLQFPDDEYS--------WWdlfmkicVFVFA 145
Cdd:cd15975  111 SRVQGIGIPLITAIEIFSIWVLSFILAIpEAIGFVMVPFEYNGEQYRTCMLNATTKFMnfyvdakdWW-------LFGFY 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 146 FVIPVLIIIVCYTLMIL-----RLKSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEALG--STSHSTA 218
Cdd:cd15975  184 FCVPLACTAIFYTLMTCemlnrRKGSLRIALSEHLKQR--REVAKTVFCLVVIFALCWFPLHLSRILKKTVynENDPRRC 261
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568905270 219 ALSSY-----YFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15975  262 ELLSFllvmdYISINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
1-252 4.10e-17

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 78.92  E-value: 4.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15300   31 LKTVNNYYLLSLACADLIIGIfSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKV-REDVDVIECSLQFpddeysWWDLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15300  111 KRTPKRAGIMIGLAWLISFILWAPPILCWQYFVgKRTVPERECQIQF------LSEPTITFGTAIAAFYIPVSVMTILYC 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMIlrlksvrllsgsREKDRNlRRITKLVLVVVAVFIICWTPIHIFILVEALGStshSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15300  185 RIY------------KETIKE-RKAAQTLSAILLAFIITWTPYNIMVLVSTFCS---DCIPLTLWHLGYWLCYVNSTVNP 248
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15300  249 MCYALCNKTFRKTF 262
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
1-252 4.59e-17

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 78.72  E-value: 4.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMP-FQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15308   31 LKTTTNYFIVSLAVADLLLALlVLPlYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYN 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGiSAIVLGGTKVReDVDVIECSLQfpDDEYSwwdLFMKICvfvfAFVIPVLIIIVCYT 158
Cdd:cd15308  111 RRQGSVRQLLLISATWILSFAVA-SPVIFGLNNVP-NRDPAVCKLE--DNNYV---VYSSVC----SFFIPCPVMLVLYC 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLksvrllsgSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyFCIALGYTNSSLNP 238
Cdd:cd15308  180 AMFRGL--------GRE-----RKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQLIS--IVTWLGYVNSALNP 244
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15308  245 VIYTVFNAEFRNVF 258
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
1-253 5.65e-17

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 78.84  E-value: 5.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15299   34 LKTVNNYFLLSLACADLIIgVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRA 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKV-REDVDVIECSLQFPDDEyswwdlFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15299  114 KRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVgKRTVPPDECFIQFLSEP------IITFGTAIAAFYLPVTIMTILYW 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 lmilrlksvRLLSGSREKDRNLRRITKLVLvvvaVFIICWTPIHIFILVEAL-GSTSHSTAALSSYYFCialgYTNSSLN 237
Cdd:cd15299  188 ---------RIYKETIKEKKAAQTLSAILL----AFIITWTPYNIMVLVNTFcDSCIPKTYWNLGYWLC----YINSTVN 250
                        250
                 ....*....|....*.
gi 568905270 238 PVLYAFLDENFKRCFR 253
Cdd:cd15299  251 PVCYALCNKTFRTTFK 266
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
1-252 6.36e-17

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 78.63  E-value: 6.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15060   31 LRIVQNFFIVSLAVADLAVAIfVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINYAQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLasSVGISAIVLGGTKVREDVDVIECSLQFPDDEyswwdLFMkICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15060  111 KRTLKRVLLMIVVVWAL--SALISVPPLIGWNDWPENFTETTPCTLTEEK-----GYV-IYSSSGSFFIPLLIMTIVYVK 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MilrlksvrLLSGSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyFCIALGYTNSSLNPV 239
Cdd:cd15060  183 I--------FIATSKE-----RRAARTLGIIMGVFVVCWLPFFLMYVILPFCETCSPSAKVVN--FITWLGYVNSALNPV 247
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15060  248 IYTIFNLDFRRAF 260
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
3-253 1.05e-16

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 78.07  E-value: 1.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQ--SAVYLMnSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15170   34 TPIDILLLNLTVSDLIFLLFLPFKmaEAASGM-IWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLAS---SVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWdLFMKICVFVFAFVIPVLIIIVCY 157
Cdd:cd15170  113 RRPLYAVIASVFFWVLAFshcSIVYIVEYHIDSENTSVTNNSRCYDNFTPEQLKIL-LPVRLELFLVLFCIPFLITCFCY 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKSVRLLSGSREkdrnlRRITKLVLVVVAVFIICWTPIHIFILVealGSTSHSTAALSSYYFCiaLGYTNSSLN 237
Cdd:cd15170  192 INFIRILSSLPHISRQRK-----QRAIGLAVATLLNFIVCFAPYNISHVV---GFIQRKSPEWRMYALL--LSTLNACLD 261
                        250
                 ....*....|....*.
gi 568905270 238 PVLYAFLDENFKRCFR 253
Cdd:cd15170  262 PIIFYFSSSAVRRAFK 277
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
7-250 1.97e-16

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 77.55  E-value: 1.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQS-AVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15150   36 IFLKNTVISDLLMILTFPFKIlSDAKLGSWPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLG 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGISAIVLgGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIpvLIIIVCYTLMILRL- 164
Cdd:cd15150  116 AKILSTVIWASMFALSLPNMIL-TNRQPTPKNVKKCSLLKSEFGLVWHEIVNYICQVIFWVNF--LIVIVCYTLITKELy 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 KSVRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTS---HSTAALSSYYF---CIALGYTNSSLNP 238
Cdd:cd15150  193 KSYKRTRGVGKVSR--KKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRdvfDCTAKNTLFYVkesTLWLTSLNACLDP 270
                        250
                 ....*....|..
gi 568905270 239 VLYAFLDENFKR 250
Cdd:cd15150  271 FIYFFLCKSFRN 282
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
1-252 2.07e-16

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 77.58  E-value: 2.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQ--SAVYLMNSWPFGDVLCKivisiDYYNM-----FTSIFTLTMMSVDRYIAVC 72
Cdd:cd15355   34 LQSTVHYHLASLALSDLLIlLLAMPVElyNFIWVHHPWAFGDAACR-----GYYFLrdactYATALNVASLSVERYLAIC 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  73 HPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVR--EDVDVIECSlqfPDDEYSWWDLFMKICVFVfAFVIPV 150
Cdd:cd15355  109 HPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTMGEQNRsgTHPGGLICT---PIVDTSTLKVVIQVNAFL-SFLFPM 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLMILRL-------------------KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG 211
Cdd:cd15355  185 LVISVLNTLIANQLtvmvnqaeqenqvctiggqRTVLSVSMEPGRVQSLRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYV 264
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568905270 212 STSHSTAALSSYYFCI-----ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15355  265 SDEQWTTFLYDFYHYFymltnVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
5-250 2.99e-16

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 77.18  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkaldfrTP 83
Cdd:cd15396   35 TNILIANLSLSDVLVCVMcIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAIERYQLIVNP-------RG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINIC-----IWLLASSVGISAIVLggtkvREDVDVIECSLQFPDDEYS-------WW-----DLFMKICVFVFAF 146
Cdd:cd15396  108 WKPSASHAYwgivlIWLFSLMISIPFLIF-----HQLTDEPFRNLSSHSDFYKdkvvcieAWpseteRLIFTTSLLVFQY 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 147 VIPVLIIIVCYTLMILRLKSVR-LLSGSREKDRNL---RRITKLVLVVVAVFIICWTPIHIFILV-----EALGSTSHST 217
Cdd:cd15396  183 FVPLGFIFICYLKIFVCLKKRNsKIDRMRENESRLsenKRINTMLISIVVTFAACWLPLNIFNVVfdwnhEVLMSCHHNL 262
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568905270 218 AalssYYFCIALGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15396  263 V----FTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
3-250 3.66e-16

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 76.73  E-value: 3.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15200   33 KSNTMYLLSLVVADFFLIINLPFRIDYYLRNEvWRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPHHQLSKA 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIW----LLASSVGISAIVLGGTKvredvdvieCSLQFPDDEYSWWDLFMKIcVFVFAFVIPVLIIIVCY 157
Cdd:cd15200  113 SVGCAAKVAAGLWililLLNIHLLLLDHVQSNST---------CLSYDHGTDPSASDRWHRI-LFFLEFFLPLGIILFCI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKSVRLLSGSRekdrnLRRITKLVLVVVAVFIICWTPIHIF----ILVEALGSTSHSTAALSSYYFCIALGYTN 233
Cdd:cd15200  183 FSIILTLKQRKLAKQAG-----PQRAVKVLAVIVLVYTVCFLPSILFalasLVAFKVSQCRSLDLCTQLFHGSLAFTYLN 257
                        250
                 ....*....|....*..
gi 568905270 234 SSLNPVLYAFLDENFKR 250
Cdd:cd15200  258 SALDPVLYCFSSPSFLN 274
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-252 4.07e-16

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 76.87  E-value: 4.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15959   31 LQTMTNVFVTSLACADLVMgLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSlqfpDDEyswwdlfmKICVFV-----------FAFVI 148
Cdd:cd15959  111 LVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGADEEAQRCY----DNP--------RCCDFVtnmpyaivsstVSFYV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 149 PVLIIIVCYT-LMILRLKSVRLLSG------------SREKDRNLRRITKLVL-----------VVVAVFIICWTPIHIF 204
Cdd:cd15959  179 PLLVMIFVYVrVFVVATRQVRLIRKdkvrfppeesppAESRPACGRRPSRLLAikehkalktlgIIMGTFTLCWLPFFVA 258
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568905270 205 ILVEALGStshSTAALSSYYFCIALGYTNSSLNPVLYAfLDENFKRCF 252
Cdd:cd15959  259 NIIKVFCR---SLVPDPAFLFLNWLGYANSAFNPIIYC-RSPDFRSAF 302
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
2-249 4.37e-16

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 76.40  E-value: 4.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15166   32 RTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKELK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLasSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15166  112 NTPKAVLACVGVWIM--TLASTFPLLFLYEDPDKASNFTTCLKMLDIIHLKEVNVLNFTRLIFFFLIPLFIMIGCYLVII 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLlsgSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyFCIALGYTNSSLNPVLY 241
Cdd:cd15166  190 HNLVHGRT---SKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAFLMLQNGDNSYNPWAA--FTTFLMNLSTCLDVILY 264

                 ....*...
gi 568905270 242 AFLDENFK 249
Cdd:cd15166  265 YIVSKQFQ 272
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
1-250 6.01e-16

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 76.10  E-value: 6.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15402   31 LRNAGNIFVVSLAVADLVVAIyPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGgtKVREDVDVIECSL-QFPDDEYSwwdlfmkICVFVFAFVIPVLIIIVCY- 157
Cdd:cd15402  111 LYSDKNSLCYVLLIWVLTVAAIVPNLFVG--SLQYDPRIYSCTFaQSVSSAYT-------IAVVFFHFILPIIIVTFCYl 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 ---TLMILRLKSVRLLSGSREKDRNLRRITKLvLVVVAVFIICWTPIHIFILVEALGSTS-----HSTAALSSYYfciaL 229
Cdd:cd15402  182 riwILVIQVRRRVKPDNKPKLKPHDFRNFVTM-FVVFVLFAVCWAPLNFIGLAVAVDPETivpriPEWLFVASYY----M 256
                        250       260
                 ....*....|....*....|.
gi 568905270 230 GYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15402  257 AYFNSCLNAIIYGLLNQNFRR 277
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
2-245 6.73e-16

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 75.54  E-value: 6.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPF-GDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd14964   30 PRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGANLASIWTTLVLTYHRYFALCGPLKYTRL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFvipvLIIIVCYTLM 160
Cdd:cd14964  110 SSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYLTWGFLLVSFLLPLVAF----LVIFSRIVLR 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRiTKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFciALGYTNSSLNPVL 240
Cdd:cd14964  186 LRRRVRAIRSAASLNTDKNLKA-TKSLLILVITFLLCWLPFSIVFILHALVAAGQGLNLLSILAN--LLAVLASTLNPFI 262

                 ....*
gi 568905270 241 YAFLD 245
Cdd:cd14964  263 YCLGN 267
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
6-252 8.15e-16

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 75.35  E-value: 8.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15335   36 NYLICSLAVTDFLVAVlVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLasSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMkicvfvfAFVIPVLIIIVCYTlmilRL 164
Cdd:cd15335  116 RAGLMILTVWTI--SIFISIPPLFWRNHHDANIPSQCIIQHDHVIYTIYSTFG-------AFYIPLTLILILYY----RI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 KSvrllSGSREkdRNLRRITKLVLvvvAVFIICWTPihiFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFL 244
Cdd:cd15335  183 YH----AASRE--RKAARILGLIL---GAFILSWLP---FFIKELIVGLSVMTVSPEVADFLTWLGYVNSLVNPLLYTSF 250

                 ....*...
gi 568905270 245 DENFKRCF 252
Cdd:cd15335  251 NEDFKLAF 258
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
1-250 1.09e-15

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 75.28  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkaLD 79
Cdd:cd15318   31 LHTPTNFLLLSLALADMLLgLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDP---LL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICI---WLLASS-----VGISAIVLGGTKVREDVDVI-ECSLQFpDDEYSWWDLFMkicvfvfaFVIPV 150
Cdd:cd15318  108 YPSKFTIRVACIFIaagWLVPTVytsvfLYTKAVEEGLAELLTSVPCVgSCQLLY-NKLWGWLNFPV--------FFIPC 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYT-LMILRLKSVR----LLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALgstSHSTAALSSYYF 225
Cdd:cd15318  179 LIMIGLYVkIFIVAKRQARaiasLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSL---LNFITPPLLFDI 255
                        250       260
                 ....*....|....*....|....*
gi 568905270 226 CIALGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15318  256 IIWFAYFNSACNPLIYVFSYPWFRK 280
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 1.15e-15

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 75.64  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADAL-VTTTMPFQSAVYLMNSWPFGD-----VLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHP 74
Cdd:cd15128   31 MRNGPNALIASLALGDLLyIVIDLPINVYKLLAMDWPFGDqpfgqFLCKLVPFIQKASVGITVLNLCALSVDRYRAVASW 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  75 VKALDFRTPLKAKIINICIWLLASSVGISAiVLGGTKVR---EDVDVIECSL-------QFPDDEYSWWdlfmkicVFVF 144
Cdd:cd15128  111 SRIQGIGIPMWTAVEIVMIWMLSAVLAVPE-AIGFDMVRfnyKGVTLRTCLLrpetsfmKFYIDVKDWW-------LFGF 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 145 AFVIPVLIIIVCYTLM---ILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEAL--GSTSHSTAA 219
Cdd:cd15128  183 YFCLPLVCTAIFYTLMtceMLRKRNGMLRIALNEHLKQRREVAKTVFCLVVIFALCWLPLHLSRILKLTvyDQNDPNRCE 262
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568905270 220 LSSY-----YFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15128  263 LLSFllvldYFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
1-251 1.16e-15

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 75.27  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKIV-ISIDYYNMfTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15085   31 LRNPINIFILNLSFSDLMMALCgTTIVTVTNYEGYFYLGDAFCIFQgFAVNYFGI-VSLWSLTLLAYERYNVVCKPMGGL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIInICIWLLASSVGISAIVLGGTKVREDVDViECSLQFpdDEYSWWDLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15085  110 KLSTKRGYQGL-LFIWLFCLFWAVAPLFGWSSYGPEGVQT-SCSIGW--EERSWSNYSYLILYFLMCFVIPVAIIGFSYG 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRL----KSVRLLSGSREKDRNlRRITKLVLVVVAVFIICWTPIHIFILVEALG---STSHSTAALSSYyfciaLGY 231
Cdd:cd15085  186 NVLRSLhklnKKIEQQGGKNCPEEE-ERAVIMVLAMVIAFLICWLPYTVFALIVVVNpelSISPLAATMPTY-----FAK 259
                        250       260
                 ....*....|....*....|
gi 568905270 232 TNSSLNPVLYAFLDENFKRC 251
Cdd:cd15085  260 TSPVYNPIIYIFLNKQFRES 279
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
5-252 1.69e-15

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 75.38  E-value: 1.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGdVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15319   36 TNIFIVSLAVSDLFVALlVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQ 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMK----ICVFVFAFVIPVLIIIVCYT- 158
Cdd:cd15319  115 RVALVMISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNSSISRQVEENCDSSLNrtyaISSSLISFYIPVAIMIVTYTr 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 ------LMILRL----------KSVRLLSGSREKDRNLR-------RITKLVLVVVAVFIICWTPIHIFILVEAL--GST 213
Cdd:cd15319  195 iyriaqIQIRRIssleraaehaQSCRSNRIDCHHHTSLRtsikketKVLKTLSVIMGVFVCCWLPFFILNCMVPFcdRPP 274
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568905270 214 SHSTAAL-----SSYYFCIALGYTNSSLNPVLYAFlDENFKRCF 252
Cdd:cd15319  275 ADPDAGLpcvseTTFDVFVWFGWANSSLNPIIYAF-NADFRKVF 317
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
2-250 1.99e-15

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 74.44  E-value: 1.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQ-SAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15969   31 KTSFIFYLKNIVIADLLMTLTFPFKiIQDSGLGPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRM 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDvDVIECSLQFPDDEYSWWDLFMKICVFVfaFVIPVLIIIVCYtLM 160
Cdd:cd15969  111 YSITFTKVLSACVWLIMAFLSLPNIILTNGQPTED-NIHDCSKLKSPLGVKWHTAVSYINICI--FVAVLVILIVCY-IS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRL--KSVRLLSGSREKDrnlRRITKLVLVVVAVFIICWTPIH---IFILVEALGSTSHSTAALSSYY---FCIALGYT 232
Cdd:cd15969  187 ISRYiyKSSKQFISSSSRT---RKHNQSIRVVVAVFFVCFLPYHlcrIPFTFSQLDKILDCTIKTILYYckeATLFLSAC 263
                        250
                 ....*....|....*...
gi 568905270 233 NSSLNPVLYAFLDENFKR 250
Cdd:cd15969  264 NVCLDPIIYFFMCRSFSQ 281
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
1-251 2.40e-15

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 74.48  E-value: 2.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPfGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15171   31 LKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSL-GNPTCKVLVALSSVGLHSEALFNVLLTVQASRVFFHGRLASSA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKII-NICIWLLASSVGISAIVLggTKVREDVDVIECS---LQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVC 156
Cdd:cd15171  110 RRVAPCGIIaSVLAWLTAFLVTLPEFVF--YKPQMDSQKSKCAfsrPHFLPAEETFWKYFLTLKMNIVVLVFPLLVFIIC 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 YtlmilrlksVRLLSGSREKDRNlRRITKLVLVVVAVFIICWTPIHIFILVEAL---------GSTSHSTAalsSYYFCI 227
Cdd:cd15171  188 C---------VQLRKTQRFRERQ-RDLSKLVFAIMVVFLLMWAPYNIALFLSAFkehfslrdcKSSYHLDA---SVQVTK 254
                        250       260
                 ....*....|....*....|....
gi 568905270 228 ALGYTNSSLNPVLYAFLDENFKRC 251
Cdd:cd15171  255 LIATTHCCVNPLLYALLDPAFRRR 278
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
1-252 2.98e-15

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 73.81  E-value: 2.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNS--WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15304   31 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyrWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIVLGgtkVREDVDVI-ECSLQFPDDEyswwdlFMKICVFVfAFVIPVLIIIVCY 157
Cdd:cd15304  111 RFNSRTKAFLKIIAVWTISVGISMPIPVFG---LQDDSKVFkEGSCLLADEN------FVLIGSFV-AFFIPLTIMVITY 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKsvrllsgsrEKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTS---HSTAALSSYYfcIALGYTNS 234
Cdd:cd15304  181 FLTIKSLQ---------QSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKEScneVVIGGLLNVF--VWIGYLSS 249
                        250
                 ....*....|....*...
gi 568905270 235 SLNPVLYAFLDENFKRCF 252
Cdd:cd15304  250 AVNPLVYTLFNKTYRSAF 267
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
7-250 6.87e-15

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 72.89  E-value: 6.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSaVYLMNS--WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVchpVKALDFRTPL 84
Cdd:cd15364   37 VYLFSLSLCELLYLGTLPLWT-IYVSNNhkWPWGSLACKITGYIFFCNIYISILLLCCISIDRFVAV---VYALESRGRR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVfvfAFVIPvLIIIVCYTLMILRL 164
Cdd:cd15364  113 RQRIAAFISFLIFIVVGLVHSPVFIMREGQTEGSHTCFETLQMDTQVAGFYYARFCI---GFAIP-LAILIFTNYRIFRS 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 KSVRLLSGSREKdrnlRRITKLVLVVVAVFIICWTPIHIFILVEAL-------GSTSHSTAALSSYYFCIALGYTNSSLN 237
Cdd:cd15364  189 IQTSTSLTPHQK----AKVKYLAIAVIVIFLICFAPYHLVLLVRAIafslypnGMCGFEERIYTPSVIFLCLSTVNSVAD 264
                        250
                 ....*....|...
gi 568905270 238 PVLYAFLDENFKR 250
Cdd:cd15364  265 PIIYVLVSENVRQ 277
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
1-250 8.83e-15

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 72.64  E-value: 8.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKaLD 79
Cdd:cd15401   31 LRNAGNIFVVSLSVADLVVAVyPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLR-YD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTkVREDVDVIECSL-QFPDDEYSwwdlfmkICVFVFAFVIPVLIIIVCY- 157
Cdd:cd15401  110 KLYNMKKTCCYVCLTWVLTLAAIVPNFFVGS-LQYDPRIYSCTFaQTVSSSYT-------ITVVVVHFIVPLSIVTFCYl 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 ---TLMILRLKSVRLLSGSREKDRNLRRITKLvLVVVAVFIICWTPIHiFILVEALGSTSHSTAALSSYYFCIA--LGYT 232
Cdd:cd15401  182 riwVLVIQVKHRVRQDSKQKLKANDIRNFLTM-FVVFVLFAVCWGPLN-FIGLAVAINPLKVAPKIPEWLFVLSyfMAYF 259
                        250
                 ....*....|....*...
gi 568905270 233 NSSLNPVLYAFLDENFKR 250
Cdd:cd15401  260 NSCLNAVIYGVLNQNFRK 277
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
1-250 1.06e-14

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 72.50  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKaLD 79
Cdd:cd15209   31 LRNAGNIFVVSLSVADLVVAIyPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAINRYCYICHSLQ-YD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTkVREDVDVIECSLQFPDDEYswwdlfMKICVFVFAFVIPVLIIIVCY-- 157
Cdd:cd15209  110 RLYSLRNTCCYLCLTWLLTVLAVLPNFFIGS-LQYDPRIYSCTFAQTVSTV------YTITVVVIHFLLPLLIVSFCYlr 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 --TLMILRLKSVRLLSGSREKDRNLRRITKLvLVVVAVFIICWTPIHIFILVEALGSTSHSTAA-----LSSYYfciaLG 230
Cdd:cd15209  183 iwVLVLQVRQRVKPDQRPKLKPADVRNFLTM-FVVFVLFAVCWAPLNFIGLAVAINPKEMAPKIpewlfVASYF----MA 257
                        250       260
                 ....*....|....*....|
gi 568905270 231 YTNSSLNPVLYAFLDENFKR 250
Cdd:cd15209  258 YFNSCLNAIIYGLLNQNFRK 277
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 1.90e-14

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 71.81  E-value: 1.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADAL-VTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15976   31 MRNGPNILIASLALGDLLhIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKG 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAiVLGGTKVREDV---DVIECSL---------QFPDDEYSWWdlfmkicVFVFAFV 147
Cdd:cd15976  111 IGVPKWTAVEIVLIWVVSIILAVPE-AIGFDMITMDYkgeLLRICLLhpiqktafmQFYKTAKDWW-------LFSFYFC 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 148 IPVLIIIVCYTLM---ILRLKS-VRLLSGSREKDRnlRRITKLVLVVVAVFIICWTPIHI--FILVEALGSTSHSTAALS 221
Cdd:cd15976  183 LPLACTAVFYTLMtceMLRKKNgMQIALNDHLKQR--REVAKTVFCLVLVFALCWLPLHLsrILKLTIYDEKDPNRCELL 260
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568905270 222 SY-----YFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15976  261 SFflvldYIGINMASLNSCINPIALYLVSKRFKNCF 296
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
1-250 2.00e-14

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 71.81  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADaLVTTTMPFQSAVY--LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVkAL 78
Cdd:cd15400   31 LRNSGNVFVVSLALAD-LVVALYPYPLVLVaiFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRYCYICHSF-AY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINIC-IWLLASSVGISAIVLGGTKVreDVDVIECSL-QFPDDEYSwwdlfmkICVFVFAFVIPVLIIIVC 156
Cdd:cd15400  109 DKLYSRWNTLLYVClIWALTVVAIVPNFFVGSLEY--DPRIYSCTFvQTASSSYT-------IAVVVIHFIVPITVVSFC 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 157 Y----TLMILRLKSVRLLSGSREKDRNLRRITKLvLVVVAVFIICWTPIHIFILVEALgSTSHSTAALSSYYFCIA--LG 230
Cdd:cd15400  180 YlriwVLVIQVRRKVKSESKPRLKPSDFRNFLTM-FVVFVIFAICWAPLNLIGLAVAI-NPQEMAPKVPEWLFVVSyfMA 257
                        250       260
                 ....*....|....*....|
gi 568905270 231 YTNSSLNPVLYAFLDENFKR 250
Cdd:cd15400  258 YFNSCLNAIIYGLLNQNFRK 277
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
1-250 2.07e-14

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 71.81  E-value: 2.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkaLD 79
Cdd:cd15316   31 LHSPTNFLIASLACADFLVgVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTDP---LV 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICI---WLLASSVGISAIVLGGTK--VREDVDVIEC--SLQFPDDEyswwdlfMKICVFVFAFVIPVLI 152
Cdd:cd15316  108 YPTKFTVSVSGICIsvsWIFSLTYSFSVFYTGVNDdgLEELVNALNCvgGCQIILNQ-------NWVLVDFLLFFIPTFA 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 153 IIVCYT----------LMILRLKSVRLLSGSREKDRNLRR---ITKLVLVVVAVFIICWTPIHIFILVEALgsTSHSTAA 219
Cdd:cd15316  181 MIILYGkiflvakqqaRKIEMTSSKAESSSESYKDRVARRerkAAKTLGITVIAFLVSWLPYLIDVLIDAF--MNFITPP 258
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568905270 220 LsSYYFCIALGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15316  259 Y-IYEICCWCAYYNSAMNPLIYALFYPWFRK 288
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
7-249 4.14e-14

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 71.03  E-value: 4.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQ--SAVYLmNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15149   36 VYLKNIVFADLLMSLTFPFKilSDVEL-GPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVG 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWLLASSVGISAIVLGGTKVREdVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIII---VCYTLMI 161
Cdd:cd15149  115 YSKALSVVVWMLMAVLSVPNIILTNQSFHE-ANYTKCARLKSELGIQWHKASNYICVSIFWVVFLLLIIFyvaISRKIYK 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLLSGSREKdrnlrrITKLVLVVVAVFIICWTPIHIFIL------VEALGSTSHSTAALSSYYFCIALGYTNSS 235
Cdd:cd15149  194 SNQKFRRNSTNMKAK------SSRNIFSILFVFFVCFVPYHALRIpytlsqTGADYSCQSKTILYYMKEFTLLLSAANVC 267
                        250
                 ....*....|....
gi 568905270 236 LNPVLYAFLDENFK 249
Cdd:cd15149  268 LDPIIYFFLCQPFR 281
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
1-252 6.77e-14

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 70.35  E-value: 6.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVL---CKIVISIDyynmfTSIFTLTMMSVDRYIAVCHPVK 76
Cdd:cd15069   31 LQTPTNYFLVSLAAADVAVGLfAIPFAITISLGFCTDFHSCLflaCFVLVLTQ-----SSIFSLLAVAVDRYLAIKVPLR 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 ALDFRTPLKAKIINICIWLLASSVGISAIvLGGTKVREDVDvieCSLQFPDDEYSWWDLFMKiCVF----------VFAF 146
Cdd:cd15069  106 YKSLVTGKRARGVIAVLWVLAFGIGLTPF-LGWNKAMSATN---NSTNPADHGTNHSCCLIS-CLFenvvpmsymvYFNF 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 147 ----VIPVLIIIVCYTLMIL----RLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTA 218
Cdd:cd15069  181 fgcvLPPLLIMLVIYIKIFLvacrQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSK 260
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568905270 219 ALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15069  261 PKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
2-250 7.41e-14

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 70.21  E-value: 7.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAvYLMNSWPFgdVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15920   32 ETSISVYMRNLALADLLLVLCLPFRVA-YQNTAGPL--SFCKIVGAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIH 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDvdviECSLQFPDDEYSWWDLFMkicVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15920  109 TVPWSSAASGGVWLLLLACMIPFLFESRNEGPCD----NKCFHFRSKGLTAGGINL---TAVVIFYILSLLFLYFYAKIS 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA------LGYTNSS 235
Cdd:cd15920  182 HKLYKVSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHIVRVPYVLAQIDVISSLPWKQTLHIAnelvlcLSALNSC 261
                        250
                 ....*....|....*
gi 568905270 236 LNPVLYAFLDENFKR 250
Cdd:cd15920  262 LDPIIYFFLSSSFRR 276
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
1-252 1.14e-13

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 69.43  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15296   31 LRTQGNFFFLNLAISDFLVGGfCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIIN-ICIWLLASSVGISAI-----VLGGTKVREDvdviECSLQFpddEYSWWDLFMKICVFVFAFVIPVLII 153
Cdd:cd15296  111 QKGMTRQAVLKmVLVWVLAFLLYGPAIisweyIAGGSIIPEG----ECYAEF---FYNWYFLMTASTLEFFTPFISVTYF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 154 IVCYTLMILRlksvRLLSGSREKdrnlrRITKLVLVVVAVFIICWTPIHIFILVEAlgsTSHSTAALSSYY-FCIALGYT 232
Cdd:cd15296  184 NLSIYLNIQK----RRFRLSRDK-----KVAKSLAIIVCVFGLCWAPYTLLMIIRA---ACHGHCVPDYWYeTSFWLLWV 251
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd15296  252 NSAINPVLYPLCHMSFRRAF 271
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
1-249 1.21e-13

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 69.31  E-value: 1.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKaLDF 80
Cdd:cd15072   31 LRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGFFTALASICSSAAIAWDRYHHYCTRSK-LQW 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTplkAKIINICIWLlaSSVGISAIVLGGTKVRE-DVDVIECSLQFP--DDEYSWWDLFMKIcvfvFAFVIPVLIIIVCY 157
Cdd:cd15072  110 ST---AISLVLFVWL--FSAFWAAMPLLGWGEYDyEPLGTCCTLDYSkgDRNYVSYLFTMAF----FNFILPLFILLTSY 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKSVrllsgsrekdrnlRRITKLVLVVVAVFIICWTP---IHIFILVEALGSTSHSTAAlssyyFCIALGYTNS 234
Cdd:cd15072  181 SSIEQKLKKE-------------GHLRFNTGLPLLTLLICWGPyaiLALYAAITDVTSISPKLRM-----VPALLAKTSP 242
                        250
                 ....*....|....*
gi 568905270 235 SLNPVLYAFLDENFK 249
Cdd:cd15072  243 TINAILYALGNENYR 257
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
7-252 1.42e-13

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 69.24  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIF--NLALADALVTTTMPFQSAVYL-------MNSWPFgdVLCKIVISidyynMFTSIFTLTMMSVDRYIAVCHPVKA 77
Cdd:cd14972   33 MYILiaNLAAADLLAGIAFVFTFLSVLlvsltpsPATWLL--RKGSLVLS-----LLASAYSLLAIAVDRYISIVHGLTY 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDvieCSLQFPDDEYSWWdlfmkICVFVFAFvIPVLIIIVCY 157
Cdd:cd14972  106 VNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQES---CSPLGPGLPKSYL-----VLILVFFF-IALVIIVFLY 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLK---SVRLLSGSREKDRNLRRITKL---VLVVVAVFIICWTPIHIFILVEALGSTSHSTAAlsSYYFCIALGY 231
Cdd:cd14972  177 VRIFWCLWrhaNAIAARQEAAVPAQPSTSRKLaktVVIVLGVFLVCWLPLLILLVLDVLCPSVCDIQA--VFYYFLVLAL 254
                        250       260
                 ....*....|....*....|.
gi 568905270 232 TNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14972  255 LNSAINPIIYAFRLKEMRRAV 275
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-241 2.34e-13

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 68.74  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15957   31 LQTVTNYFITSLACADLVMgLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDvDVIECSlqfpdDEYSWWDLFMK----ICVFVFAFVIPVLIIIV 155
Cdd:cd15957  111 LLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQ-EAINCY-----AEETCCDFFTNqayaIASSIVSFYVPLVIMVF 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMIL----RLKSVRLLSGsREKDRNL-----------RRITKLVL----------VVVAVFIICWTPIHIFILVEAL 210
Cdd:cd15957  185 VYSRVFQeakrQLQKIDKSEG-RFHNQNIdqngsgggggnRRRSKFCLkehkalktlgIIMGTFTLCWLPFFIVNIVHVI 263
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568905270 211 GSTSHSTAAlssYYFCIALGYTNSSLNPVLY 241
Cdd:cd15957  264 QDNLIRKEV---YILLNWIGYVNSGFNPLIY 291
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
1-251 3.93e-13

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 67.93  E-value: 3.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCkiVISIDYYNMF--TSIFTLTMMSVDRYIAVCHpVKA 77
Cdd:cd15078   31 LRTPTNLLLVNISLSDLLVSLLgVTFTFMSCVRGRWVFDVAGC--VWDGFSNSLFgiVSIMTLTVLAYERYIRVVH-AKV 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LDFRTPLKAkIINICIWLLASSvgiSAIVLGGTKVREDVDVIECSLQFPDDEYSwwDLFMKICVFVFAFVIPVLIIIVCY 157
Cdd:cd15078  108 VNFSWSWRA-ITYIWLYSLAWT---GAPLLGWNRYTLEVHGLGCSFDWKSKDPN--DTSFVLLFFLGCLVVPLGIMAYCY 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLM---ILRLKSVRLLSGSREKD--RNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTS--HSTAALSSYYFCIAlg 230
Cdd:cd15078  182 GHIlyeIRMLRSVEDLQTFQVIKilKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSGYSKlvTPTIAIIPSLFAKS-- 259
                        250       260
                 ....*....|....*....|.
gi 568905270 231 ytNSSLNPVLYAFLDENFKRC 251
Cdd:cd15078  260 --STAYNPVIYIFMIRKFRQC 278
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
39-243 4.08e-13

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 68.31  E-value: 4.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  39 DVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPlKAKIINICIWLLasSVGISA---IVLGGTKVRED 115
Cdd:cd15385   70 DFLCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPTK-RSYLMIGSAWAL--SFILSTpqyFIFSLSEIENG 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 116 VDVIECSLQFpddeYSWWDLFMKIC-VFVFAFVIPVLIIIVCYTLMI------LRLKSVRLLSGSREKDRNLR------- 181
Cdd:cd15385  147 SGVYDCWANF----IVPWGIKAYITwITISIFVVPVIILLTCYGFICyniwrnIKCKTRRGLSDNALKNILLAvcvssvk 222
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568905270 182 -------RITKLVLVVVAVFIICWTPIHI----------FILVEALGSTSHSTAALSSYyfcialgytNSSLNPVLYAF 243
Cdd:cd15385  223 tisrakiRTVKMTFVIVLAYIVCWAPFFTiqmwsvwdqnFPWDESENTAVTITALLASL---------NSCCNPWIYMF 292
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-241 4.52e-13

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 68.00  E-value: 4.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15958   31 LQTLTNLFITSLACADLVMgLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFRYQS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDV-----IECSLQFPDDEYSwwdlfmkICVFVFAFVIPVLIII 154
Cdd:cd15958  111 LLTRARAKGIVCTVWAISALVSFLPIMMHWWRDEDDQALkcyedPGCCDFVTNRAYA-------IASSIISFYIPLLIMI 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLK---------SVRLLSGSREKDRNLRRITKLVL------------VVVAVFIICWTPihiFILVEALGST 213
Cdd:cd15958  184 FVYLRVYREAKkqikkidkcEGRFHNTLTGLGRKCKRRPSRILalreqkalktlgIIMGVFTLCWLP---FFLVNVVNVF 260
                        250       260
                 ....*....|....*....|....*...
gi 568905270 214 SHSTAALSSYYFCIALGYTNSSLNPVLY 241
Cdd:cd15958  261 NRELVPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
7-250 6.38e-13

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 67.50  E-value: 6.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAV-YLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK 85
Cdd:cd15151   36 VYLKNTLVADLIMTLMLPFKILSdSGLGPWQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRF 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  86 AKIINICIWLLASSVGISAIVLGGTKVREDvDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIpvLIIIVCYTlmILRLK 165
Cdd:cd15151  116 AKILSGAVWLVMFLLSVPNMILSNKPATPI-SVKKCASLKSPLGLKWHEVVNYICQFIFWGVF--ALMVLFYT--IISKK 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 166 SVRLLSGSREKDRNLRRITKL-VLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIA------LGYTNSSLNP 238
Cdd:cd15151  191 VYESYKKSRSKDNKASKKTKAkVFIIVAVFFVCFAPFHFVRVPYTLSQTGKITDCQLQNLLYIAkeitlwLAATNVCLDP 270
                        250
                 ....*....|..
gi 568905270 239 VLYAFLDENFKR 250
Cdd:cd15151  271 LIYIFLCKSFRQ 282
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
1-252 7.34e-13

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 66.98  E-value: 7.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHP-VKAL 78
Cdd:cd15309   31 LQTTTNYLIVSLAVADLLVATlVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPmLYNT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLasSVGISAIVLGGTKvreDVDVIECSLQFPDdeyswWDLFMKICVFVFAFVIPVLIIIVCYT 158
Cdd:cd15309  111 RYSSKRRVTVMISVVWVL--SFAISCPLLFGLN---NTDQNECIIANPA-----FVVYSSIVSFYVPFIVTLLVYVQIYI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMilrlksvrllsgsrekdRNLRRITKLVLVVVAVFIICWTPihiFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15309  181 VL-----------------QKEKKATQMLAIVLGVFIICWLP---FFITHILNMHCDCNIPPALYSAFTWLGYVNSAVNP 240
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15309  241 IIYTTFNIEFRKAF 254
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
1-252 9.31e-13

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 67.07  E-value: 9.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTTMPFQSAVY-LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALd 79
Cdd:cd15000   30 LRTPTNLLIGNMALADLLTLLVCPWMFLVHdFFQNYVLGSVGCKLEGFLEGSLLLASVLALCAVSYDRLTAIVLPSEAR- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 fRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIE--CS--LQFPDdeySWWDLFMKICVFVfafviPVLIIIV 155
Cdd:cd15000  109 -LTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQWKNFLEtyCAenTQVLP---IYWHVIITVLVWL-----PLGIMLI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMILRL---KSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCI----- 227
Cdd:cd15000  180 CYSAIFWKLdkyERRVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYRYKLVPNDNTQNSVSGSFHIlwfas 259
                        250       260
                 ....*....|....*....|....*.
gi 568905270 228 -ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15000  260 kYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
6-252 1.44e-12

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 66.36  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTTMPFQSavYLMNSWPF---GDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd15082   49 NYIIVNLSVADFLVSLTGGTIS--FLTNARGYfflGVWACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQG 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIInICIWLLaSSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSwwDLFMKICVFVFAFVIPVLIIIVCYTLMIL 162
Cdd:cd15082  127 KHAALGL-LFVWTF-SFIWTIPPVLGWSSYTVSKIGTTCEPNWYSGNMH--DHTYIITFFTTCFILPLGVIFVSYGKLLQ 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 163 RLKSVRLLSGSREKDRNL-RRITKLVLVVVAVFIICWTPIHIFILVealgSTSHSTAALSSYYFCIA--LGYTNSSLNPV 239
Cdd:cd15082  203 KLRKVSNTQGRLGNARKPeRQVTRMVVVMIVAFMVCWTPYAAFSIL----VTAHPTIHLDPRLAAIPafFSKTAAVYNPI 278
                        250
                 ....*....|...
gi 568905270 240 LYAFLDENFKRCF 252
Cdd:cd15082  279 IYVFMNKQFRKCL 291
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
1-252 1.45e-12

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 66.50  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAV---YLMNSWPFGDVLCKIVISIDyynmfTSIFTLTMMSVDRYIAVCHPVK 76
Cdd:cd15068   31 LQNVTNYFVVSLAAADIAVgVLAIPFAITIstgFCAACHGCLFIACFVLVLTQ-----SSIFSLLAIAIDRYIAIRIPLR 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 ALDFRTPLKAK-IINICiWLLASSVGISAIvLGGTKVREDVD-----------VIECSLQ--FPDDEYSWWDLFMkiCVF 142
Cdd:cd15068  106 YNGLVTGTRAKgIIAIC-WVLSFAIGLTPM-LGWNNCGQPKEgknhsqgcgegQVACLFEdvVPMNYMVYFNFFA--CVL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 143 VfafviPVLIIIVCYTLMIL----RLKSVRLLSGSREKDRN-LRR---ITKLVLVVVAVFIICWTPIHIfILVEALGSTS 214
Cdd:cd15068  182 V-----PLLLMLGVYLRIFLaarrQLKQMESQPLPGERARStLQKevhAAKSLAIIVGLFALCWLPLHI-INCFTFFCPD 255
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568905270 215 HSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15068  256 CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
3-252 1.55e-12

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 66.24  E-value: 1.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15104   33 TKSNCFLLNLAIADFLVGLAIPGLATDELLsDGENTQKVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIM 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVieCSL-QFPDDEYSwwdLFMKICVFVFAFVipVLIIIVCYTLM 160
Cdd:cd15104  113 TGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGK--CSFfAAFHPRVL---LVLSCMVFFPALL--LFVFCYCDILK 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKS--VRLLSGSREKDRNLRRITKL------VLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFciALGYT 232
Cdd:cd15104  186 IARVHSraIYKVEHALARQIHPRRTLSDfkaartVAVLIGCFLLSWLPFQITGLVQALCDECKLYDVLEDYLW--LLGLC 263
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd15104  264 NSLLNPWIYAFWQKEVRRAL 283
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
1-252 2.01e-12

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 65.91  E-value: 2.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLMNSWPFGDVLCKivisidYYNMFTSIF------TLTMMSVDRYIAVCH 73
Cdd:cd15086   31 LRSPINLLLLNISLSDLLVCVLgTPFSFAASTQGRWLIGEHGCR------WYGFANSLFgivsliSLAVLSYERYCTLLR 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  74 PVKA--LDFRtplKAKIINICIWLLaSSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSwwDLFMKICVFVFAFVIPVL 151
Cdd:cd15086  105 PTEAdvSDYR---KAWLGVGGSWLY-SLLWTLPPLLGWSSYGPEGPGTTCSVQWTSRSAN--SISYIICLFIFCLLLPFL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 152 IIIVCYTLMILRLKSVRLLSGSREKDRNlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGY 231
Cdd:cd15086  179 VMVYCYGRLLYAIKQVGKINKSTARKRE-QHVLLMVVTMVICYLLCWLPYGVMALLATFGKPGLVTPVASIVPSILAKSS 257
                        250       260
                 ....*....|....*....|.
gi 568905270 232 TnsSLNPVLYAFLDENFKRCF 252
Cdd:cd15086  258 T--VVNPIIYVFMNKQFYRCF 276
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
1-251 2.15e-12

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 66.00  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVT---TTMPFQSAVYLMNSWpfGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA 77
Cdd:cd15077   31 LRSHLNYILVNLAVANLIVVcfgSTTAFYSFSQMYFVL--GPLACKIEGFTATLGGMVSLWSLAVVAFERFLVICKPLGN 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LDFRTPlKAKIINICIWLLASSVGISAIvLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCY 157
Cdd:cd15077  109 FTFRGT-HAIIGCIATWVFGLAASLPPL-FGWSRYIPEGLQCSCGPDWYTTNNKWNNESYVMFLFCFCFGVPLSIIVFSY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKSV-RLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFilveALGSTSHSTAALSSYYFCIALGYTNSS- 235
Cdd:cd15077  187 GRLLLTLRAVaKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASF----ALWVVTNRGEPFDLRLASIPSVFSKASt 262
                        250
                 ....*....|....*..
gi 568905270 236 -LNPVLYAFLDENFKRC 251
Cdd:cd15077  263 vYNPVIYVFMNKQFRSC 279
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
7-251 2.53e-12

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 65.95  E-value: 2.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTtmpFQSAVYLM----NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAldFRT 82
Cdd:cd15388   37 VFMLHLCIADLVVAF---FQVLPQLVwditDRFRGPDVLCRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVT--FQK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPD----DEYSWWDLFMkicvfvfAFVIPVLIIIVCYT 158
Cdd:cd15388  112 GRARWNGPVCVAWAISLILSLPQVFIFSKVEVAPGVYECWACFIEpwglKAYVTWITLV-------VFVLPTLIITVCQV 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 L------MILRLKSVRLLSGSREKDRNLRRIT-------------KLVLVVVAVFIICWTPihiFILVEaLGSTSHSTAA 219
Cdd:cd15388  185 LifkeihINIYLKSQIIVAVVKKKQLLSSRASsvaevskamiktvKMTLVIVLVYVLCWAP---FFLVQ-LWSVWDPKAP 260
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568905270 220 LSSYYFCI--ALGYTNSSLNPVLYAFLDENFKRC 251
Cdd:cd15388  261 TEGATFTIlmLLASLNSCTNPWIYMAFSSSVSKE 294
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
1-252 3.62e-12

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 65.27  E-value: 3.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTtmpFQSAVYLMNS----WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVK 76
Cdd:cd15084   41 LRSPLNYILVNLAVADLLVTL---FGSSVSFSNNivgfFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMG 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 alDFRTPLKAKIINIC-------IWLLASSVGISAIVLGGTKVredvdviECSLQFPDDEYSWWDLFMKIcvFVFAFVIP 149
Cdd:cd15084  118 --DFRFQQRHAVSGCAftwgwslLWTSPPLFGWSSYVPEGLRT-------SCGPNWYTGGTNNNSYILAL--FVTCFALP 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 150 VLIIIVCYTLMILRLKSVRLLSGSREK-DRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG---STSHSTAALSSYYF 225
Cdd:cd15084  187 LSTIIFSYSNLLLTLRAVAAQQKESETtQRAEKEVTRMVIAMVMAFLICWLPYATFAMVVATNkdvVIQPTLASLPSYFS 266
                        250       260
                 ....*....|....*....|....*..
gi 568905270 226 CIALGYtnsslNPVLYAFLDENFKRCF 252
Cdd:cd15084  267 KTATVY-----NPIIYVFMNKQFRSCL 288
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
2-249 4.11e-12

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 65.17  E-value: 4.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15167   32 RKCINIYLINLLTADFLLTLALPVKIAVDLGIaPWKLKIFHCQVTACLIYINMYLSIIFLGFVSIDRYLQLTHSSKLYRI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDV--IECSLQFPDDeysWWDLFMKICVFVFAFVIPVLIIIVCyt 158
Cdd:cd15167  112 QEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVgcADFKTEFGRH---WHVLTNFICMAIFLNFSAIILISNF-- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 LMILRLKSVRllsgSREKDRNLRRITKLVLVVVAVFIICWTPIHI------FILVEALGSTSHSTAALSSYYFCIALGYT 232
Cdd:cd15167  187 LVIRKLYRNK----DSEEYRNARQALVNILLVTAGYVICFVPYHIvripytLSQSEVITDCSLKRSLFLAKESTLLLAVL 262
                        250
                 ....*....|....*..
gi 568905270 233 NSSLNPVLYAFLDENFK 249
Cdd:cd15167  263 NLCFDPILYFHLSKAFR 279
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
8-252 5.07e-12

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 64.89  E-value: 5.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   8 YIFNLALADAL---VTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15356   41 HLVSLALSDLLillISVPIELYNFVWFHYPWVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKR 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWllASSVGIS---AIVLGGTKVREDVD-------------VIECSLQfpddeyswwdLFMKICVFVfAFVI 148
Cdd:cd15356  121 RTKWLLALIW--ASSLGFAlpmAFIMGQKYELETADgepepssrvctvlVSRATLK----------VFIQVNAFV-SFVL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 149 PVLIIIV--CYTLMILRLKSvrllsgsrekdrnLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFC 226
Cdd:cd15356  188 PLALIAFlnGVTVSHLRIQS-------------LQHSVQVLRAIVIAYVICWLPYHARRLMFCYVPDDAWTDSLYNFYHY 254
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568905270 227 I-----ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15356  255 FymltnTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
1-252 1.22e-11

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 63.53  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFqSAVY-LMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHpVKAL 78
Cdd:cd15331   31 LQGVSNYLILSLAVADLMVAVlVMPL-SAVYeVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIALDRYWAVTN-IDYI 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTPLKAKIINICIWLLASSVGISAIvLGGTKVREDVDVIECSLQFPDDEYSWwdlfmKICVFVFAFVIPVLIIIVCYt 158
Cdd:cd15331  109 RRRTAKRILIMIAVVWFVSLIISIAPL-FGWKDEDDLDRVLKTGVCLISQDYGY-----TIFSTVGAFYVPLLLMIIIY- 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 159 lmilrlksVRLLSGSREKdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFciALGYTNSSLNP 238
Cdd:cd15331  182 --------WKIYQAAKRE----RKAARTLAIITGAFVVCWLPFFLVALVMPFCGAWQISRFLESFFL--WLGYFNSLLNP 247
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15331  248 IIYTIFSPDFRGAF 261
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
2-250 1.29e-11

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 63.56  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15148   32 RNSVRIFLINVAIADLLLIICLPFRILYHVNnNQWTLGPLLCKVVGNLFYMNMYISIILLGFISLDRYLKINRSSRRQKF 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGgtkvrEDVDVIECSLQFPDDEYSWWD-LFMKICVFVFAFVIpvLIIIVCYTL 159
Cdd:cd15148  112 LTRKWSIVACGVLWAVALVGFVPMIVLT-----EKNEESTKCFQYKDRKNAKGKaIFNFLIVAMFWLVF--LLLILSYGK 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MilrlkSVRLLSGSREKDR--NLRRITKLV---LVVVAVFIICWTPIHIFILV--------------EALGSTSHSTAAL 220
Cdd:cd15148  185 I-----AKKLLRISRDKPDfpNAAKYNRTArksFFVLFIFTVCFVPYHAFRIFyitsqlqnnscywkEILHKTNEIMLLL 259
                        250       260       270
                 ....*....|....*....|....*....|
gi 568905270 221 SSYyfcialgytNSSLNPVLYAFLDENFKR 250
Cdd:cd15148  260 SAF---------NSCLDPVMYFLLSSSIRK 280
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
5-160 2.22e-11

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 62.55  E-value: 2.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   5 TNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15215   34 ANRFIFNLLVADLLQTVlVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTP 113
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568905270  84 LKAKIINICIWLLaSSVGISAIVLGGTKVREDVDVIECSLQFpDDEYSWwdlfmKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15215  114 RRGYLLIYGTWIV-SVLQSTPPLYGWGQAAFDERNALCSVIW-GSSYSY-----TILSVVSSFVLPVIIMLACYSMV 183
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
11-252 4.18e-11

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 61.89  E-value: 4.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  11 NLALADALVTTTMPFQSAVYLMNS--WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVchpVKALDFRTPLKAKI 88
Cdd:cd15328   41 SMAVSDVLVAALVMPLSLVHELSGrrWQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWSI---TRHLEYTLRTRRRI 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  89 INICI---WLLASSVGISAIVLG-GTKVREDVDVIECSlQFPddEYSWWDLFMkicvfvfAFVIPVLIIIVCYTlmilrl 164
Cdd:cd15328  118 SNVMIaltWALSAVISLAPLLFGwGETYSEDSEECQVS-QEP--SYTVFSTFG-------AFYLPLCVVLFVYW------ 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 ksvRLLSGSREKdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFciaLGYTNSSLNPVLYAFL 244
Cdd:cd15328  182 ---KIYKAAQKE----KRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPPIWKSIFLW---LGYSNSFFNPLIYTAF 251

                 ....*...
gi 568905270 245 DENFKRCF 252
Cdd:cd15328  252 NKNYNNAF 259
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-243 4.31e-11

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 62.14  E-value: 4.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  39 DVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPlkaKIINICIWLLASSVGISAIVLGGTKVREDvDV 118
Cdd:cd15387   70 DFLCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSD---RVYVLFSWLLSLVFSIPQVHIFSLREVGN-GV 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 119 IECSLQF-----PDDEYSWwdlfmkicVFVFAFVIPVLIIIVCYTL-----------------------------MILRL 164
Cdd:cd15387  146 YDCWADFiqpwgPKAYITW--------ITLSVYIIPVLILSVCYGLisfkiwqnvklktrretktplssaasggaALARV 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 165 KSVRLLSGSRekdrnlRRITKLVLVVVAVFIICWTPihiFILVEaLGSTSHSTAALSSYYFCIA--LGYTNSSLNPVLYA 242
Cdd:cd15387  218 SSVKLISKAK------IRTVKMTFVIVLAYIVCWTP---FFFVQ-MWSVWDPNAPKEASPFIIAmlLASLNSCCNPWIYM 287

                 .
gi 568905270 243 F 243
Cdd:cd15387  288 F 288
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
12-250 4.77e-11

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 61.88  E-value: 4.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  12 LALADAL-VTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKII 89
Cdd:cd14981   44 LAITDLLgILLTSPVVLAVYASNfEWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLM 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  90 NICIWLLASSVGISAIVLGGTKVRedvdviecslQFPDD----EYSWWDLFMKICVFVFAF--VIPVLIIIVCYTLMILR 163
Cdd:cd14981  124 LGAVWAFALLIASLPLLGLGSYVL----------QYPGTwcflDFYSKNTGDAAYAYLYSIlgLLILLVTLLCNLLVIIT 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 LKSVRLLSGSREKDRNLRRITK--------LVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALssyYFCIALGYTNSS 235
Cdd:cd14981  194 LLRMRRRKKRHRRSRRSARRQKrneiqmvvLLLAITVVFSVCWLPLMIRVLINATGDSEKNGKTD---LLAVRMASWNQI 270
                        250
                 ....*....|....*.
gi 568905270 236 LNPVLYAFL-DENFKR 250
Cdd:cd14981  271 LDPWVYILLrKEVLRR 286
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
3-252 7.58e-11

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 61.30  E-value: 7.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 82
Cdd:cd14983   34 TPNVIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  83 PLKAKIINICIWLLasSVGISAIVLGGTKVREDVDVIE-------CSLQFPDDEY-SWWDLFMKICVFVfaFVIPVLIII 154
Cdd:cd14983  114 PLYSCLVCVAIWAL--VIFHVTLVFILETSGGTLDINTpvgnsstCYENFTPEQLaLLAPVRLELSLVL--FFLPLAITA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYtlmilrLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVealGSTSHstaaLSSYYFCIAL--GYT 232
Cdd:cd14983  190 FCY------VRCIRILVRSRLHERRKRRAVRVAVSTLLTFVVCFGPYNISHVV---GFVRH----ESVWWRKLALltSTC 256
                        250       260
                 ....*....|....*....|
gi 568905270 233 NSSLNPVLYAFLDENFKRCF 252
Cdd:cd14983  257 NAFLDPLIFYFLSSSMERGF 276
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
3-250 1.34e-10

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 60.68  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVtttmpfqsAVYL---------------------MNSWpfgdvLCKIVISIDYYNMFTSIFTLT 61
Cdd:cd15137   33 KVHSFLIKNLAIADFLM--------GVYLliiasvdlyyrgvyikhdeewRSSW-----LCTFAGFLATLSSEVSVLILT 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  62 MMSVDRYIAVCHPVKALDFRTPlKAKIINICIWLLAssVGISAIVLGGTKVRED---VDVIECSLQFPDD-----EYSww 133
Cdd:cd15137  100 LITLDRFICIVFPFSGRRLGLR-RAIIVLACIWLIG--LLLAVLPLLPWDYFGNfygRSGVCLPLHITDErpagwEYS-- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 134 dLFMKICVFVFAFVipvlIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFiICWTPIHIFILVEALGST 213
Cdd:cd15137  175 -VFVFLGLNFLAFV----FILLSYIAMFISIRRTRKAAASRKSKRDMAVAKRFFLIVLTDF-LCWIPIIVIGILALSGVP 248
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568905270 214 SHSTAALSSYYFCIALgytNSSLNPVLYAFLDENFKR 250
Cdd:cd15137  249 IPGEVYAWVAVFVLPI---NSALNPILYTLSTPKFRK 282
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
2-249 1.91e-10

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 60.17  E-value: 1.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKalDF 80
Cdd:cd15398   32 KTIINFLIGNLAFSDILVVLfCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLMSIAIVRYHMIKHPLS--NH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGT-KVREDVDVIE------CSLQFPDDEYSwwdLFMKICVFVFAFVIPVLII 153
Cdd:cd15398  110 LTANHGYFLLGTVWTLGFTICSPLPVFHKIvDLSETFNLESlknkylCIESWPSDSYR---IAFTISLLFVQYILPLVCL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 154 IVCYTLMILRLKSVRllsgsrekdRNLRRITklvlVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYY-FCIALGYT 232
Cdd:cd15398  187 TVSHTSVCRSVKRSR---------SVFYRLT----IVILAFAVSWMPLHLFHLVTDFNANLISNRHFKLVYcICHLLGML 253
                        250
                 ....*....|....*..
gi 568905270 233 NSSLNPVLYAFLDENFK 249
Cdd:cd15398  254 SCCLNPILYGFLNNGIK 270
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
2-250 2.05e-10

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 60.21  E-value: 2.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTT-TMPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkald 79
Cdd:cd15198   32 KSRMNFLLLQLALADLLVIGgTALSQIIWELLgDRWMAGDVACRLLKLLQASARGASANLVVLLALDRHQAIRAP----- 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLggtkVREDvdviecslqFPDDEYSWWDlFMKICVFVFA-------------- 145
Cdd:cd15198  107 LGQPLRAWKLAALGWLLALLLALPQAYV----FRVD---------FPDDPASAWP-GHTLCRGIFAplprwhlqvyatye 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 146 ----FVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRIT------------------KLVLVVVAVFIICWTPIHI 203
Cdd:cd15198  173 avvgFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKShlratapsalprakvktlKMTLVIALLFVGCSLPYFI 252
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568905270 204 FILVEALGSTSHSTAALSSYYFCIALGytNSSLNPVLYAFLDENFKR 250
Cdd:cd15198  253 AELAAAFGSGDWEPEKVAAALGVMAVA--NSATNPFVFLFFNAGDCR 297
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
54-252 3.78e-10

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 59.18  E-value: 3.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  54 FTSIFTLTMMSVDRYIAVCHPVKALDFrTPLKAKIINICIWLLASSVgISAIVLGGTKVREDVDVIECS-----LQFPDD 128
Cdd:cd14980   93 LMSVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIF-AAIPILYSINQPGDNRLYGYSsicmpSNVSNP 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 129 EYSWWdlfmkICVFVFAFVIPVLIIIVCYTLMILRLKSVRlLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVE 208
Cdd:cd14980  171 YYRGW-----LIAYLLLTFIAWIIICILYILIFISVRKSR-KSARRSSSKRDKRIAIRLALILITDLICWLPYYIVIFSG 244
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568905270 209 ALGSTSHSTAALSsyyFCIALGY-TNSSLNPVLYAFLDENFKRCF 252
Cdd:cd14980  245 LLTSTEIDIHVLQ---FIAILALpLNSAINPYLYTLTTPTFKRDF 286
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
12-252 5.00e-10

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 59.43  E-value: 5.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  12 LALADALVTTT-MP--FQSAVYLMNSWPFGDVLCKIvisidYYNMF-----TSIFTLTMMSVDRYIAVCHPVKALDFRtP 83
Cdd:cd15135   45 LACSDLLVLLLgMPveLYSAIWDPFATPSGNIACKI-----YNFLFeacsyATILNVATLSFERYIAICHPFKYKALS-G 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLGGTK-----------VREDVDVIECSLQFPDDEYSWWDLFMK--ICVFVFAFVIPV 150
Cdd:cd15135  119 SRVRLLICFVWLTSALVALPLLFAMGTEdpleafpsyrgTRHHCQDQKSNLTICTSLSSKWTVFQAsiFSAFVLYLLVLA 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYTLM---ILRLKSVRLLSGSREKDRNLRR-------------ITKLVLVVVAVFiICWTPIHIFILVEALGSTS 214
Cdd:cd15135  199 SVAFMCRRMMralMGSKKGAVAVKGPGGSVQLLRKhesaegktarkqtILFLGLIVGTLA-VCWMPNQIRRIMAAAKPKD 277
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568905270 215 HSTAALSSYYFCI-----ALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15135  278 DWTRSYFRAYIILlpiadTFFYLSSVLNPLLYNLSSQQFRSVF 320
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
2-250 1.09e-09

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 57.92  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPvkaLDF 80
Cdd:cd15008   31 QSTTNYFVVSMACADLLLSvASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSICVDRFYTIVYP---LSF 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPL-KAKIINICIWLLASSVGISAIVLGGTkvredVDVIECSLQFPDdeySWWDLFMKICVFVFAFVIPVLIIIVCYTL 159
Cdd:cd15008  108 KVSReKAKKMIAASWLFDAAFVSPALFFYGS-----NWGPHCNFFLPD---SWDGAAYAIIHLLVGFLVPSILIILFYQK 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILRLksVRLLSGSREKDRNLR-------RITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALssYYFCIALGYT 232
Cdd:cd15008  180 VIKYI--WRIGTDGRTVRRTMNivprtkvKTIKMFLMLNSMFLLSWLPFYVVQLWHPRESDYRQSSLV--FLAVTWISFS 255
                        250
                 ....*....|....*...
gi 568905270 233 NSSLNPVLYAFLDENFKR 250
Cdd:cd15008  256 SSASKPTLYSVYNANFRR 273
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
55-251 1.17e-09

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 57.99  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  55 TSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI-----CIWLLASSVGISAIVLGGTKVREDVDViecslqFPDDE 129
Cdd:cd15081   98 TGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFswvwsAVWCAPPIFGWSRYWPHGLKTSCGPDV------FSGSS 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 130 YSWWDLFMkICVFVFAFVIPVLIIIVCYTLMILRLKSV-RLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVE 208
Cdd:cd15081  172 DPGVQSYM-IVLMITCCIIPLAIIILCYLQVWLAIRAVaQQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPYTFFACFA 250
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568905270 209 AL--GSTSHSTAALSSYYFcialGYTNSSLNPVLYAFLDENFKRC 251
Cdd:cd15081  251 AAnpGYAFHPLAAALPAYF----AKSATIYNPIIYVFMNRQFRNC 291
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
56-252 1.33e-09

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 57.58  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIavchpvkaldfrTPLKAKIIN----ICIWLLASSVGISAIVLGGTKVR--EDVDVIE-CSLQFPdd 128
Cdd:cd15346   86 SVFSLLAIAIERYI------------TMLKMKLHNgsnsFRSFLLISACWVISLILGGLPIMgwNCISALSsCSTVLP-- 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 129 eySWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLL------SGSREKDRNLRrITKLVLVVVAVFIICWTPIH 202
Cdd:cd15346  152 --LYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTfrknirKASRSSEKSMA-LLKTVIIVLSVFIACWAPLF 228
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568905270 203 IFILVEALGSTSHSTAALSSYYFcIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15346  229 ILLLLDVGCKVKTCSILFKAEYF-LVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
1-249 1.85e-09

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 57.55  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVchpVKALD 79
Cdd:cd15403   31 MRSAINLLLATLAFSDIMLSLlCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVLEGVAILLIISVDRFLII---VQRQD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVlGGTKVREDVDVIECSLQFPDdeySWWDLFMKICVFVFAFVIPVLIIIVCY-- 157
Cdd:cd15403  108 KLNPHRAKVMIAISWVLSFCISFPSVV-GWTLVEVPARAPQCVLGYTE---SPADRVYAVLLVVAVFFVPFSIMLYSYlc 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILRLKSVRLLSGSREkdRNLRRITKL------------------------VLVVVAVFIICWTPIHIFILVEALGST 213
Cdd:cd15403  184 ILNTVRRNAVRIHNHADS--LCLSQVSKLglmglqrphqmnvdmsfktrafttILILFVGFSLCWLPHTVFSLLSVFSRR 261
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568905270 214 SHSTAALSSYYFCIA-LGYTNSSLNPVLYAFLDENFK 249
Cdd:cd15403  262 FYYSSSFYPISTCVLwLSYLKSVFNPVIYCWRIKKFR 298
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
1-251 3.09e-09

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 56.76  E-value: 3.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-----TTTMPFQSAVYLMnswpFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPV 75
Cdd:cd15080   31 LRTPLNYILLNLAVADLFMvfggfTTTMYTSMHGYFV----FGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPM 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  76 KalDFRTPLKAKIINICI-WLLASS------VGISAIVLGGTKVREDVDVIECSLQFPDDEYSwwdlfmkICVFVFAFVI 148
Cdd:cd15080  107 S--NFRFGENHAIMGVAFtWVMALAcaapplVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFV-------IYMFVVHFTI 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 149 PVLIIIVCYTLMILRLK-SVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFilveALGSTSHSTAALSSYYFCI 227
Cdd:cd15080  178 PLIVIFFCYGRLVCTVKeAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASV----AFYIFTHQGSDFGPIFMTI 253
                        250       260
                 ....*....|....*....|....*.
gi 568905270 228 ALGYTNSS--LNPVLYAFLDENFKRC 251
Cdd:cd15080  254 PAFFAKSSavYNPVIYILMNKQFRNC 279
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
56-243 3.37e-09

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 56.33  E-value: 3.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIvLGGTKVredVDVIECSLQFPddEYSwwDL 135
Cdd:cd15349   86 STFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPL-LGWNCL---CDFRSCSSLLP--LYS--KS 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 136 FMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSgsREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGStSH 215
Cdd:cd15349  158 YILFCLVIFFIILLTIIGLYFAIYCLVRASGQRVIS--ARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCS-SR 234
                        170       180
                 ....*....|....*....|....*...
gi 568905270 216 STAALSSYYFCIALGYTNSSLNPVLYAF 243
Cdd:cd15349  235 SCKPLFGMEWVLALAVLNSAINPLIYSF 262
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
1-249 3.51e-09

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 56.39  E-value: 3.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVchpVKALD 79
Cdd:cd15404   31 MRSAINILLASLAFADMMLAVlNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVAILLIISIDRFLII---VQKQD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISaIVLGGTKVREDVDVIECSLQFPDDeySWWDLFMKICVFVFaFVIPVLIIIvcYTL 159
Cdd:cd15404  108 KLNPYRAKVLIAVSWAVSFCVAFP-LAVGSPDLQIPSRAPQCVFGYTTN--PGYQAYVILIMLIF-FFIPFMVML--YSF 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILrLKSVRLLSgsrekdrnlRRITKLVLVVVAVFIICWTPIHIFILVEALGST-SHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15404  182 MGI-LNTVRSFK---------TRAFTTILILFIVFTVCWAPFTTYSLVATFNSHfYHKHNFFEISTWLLWLCYLKSALNP 251
                        250
                 ....*....|.
gi 568905270 239 VLYAFLDENFK 249
Cdd:cd15404  252 LIYYWRIKKFR 262
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
2-250 4.46e-09

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 55.93  E-value: 4.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15219   32 KQVPGIFLLNLSFCNLLLTVlNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSYTSK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLlaSSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYtLM 160
Cdd:cd15219  112 MRYRDAALMVGYSWL--HSLTFSLVALFLSWLGYSSLYASCTLHLPREEERRRFAVFTAFFHAFTFLLSLLVLCVTY-LK 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLksvrllsgsrekdRNLRRITKLVLVVVAVFIICWTPIHIFILVEALgstshSTAALSSYYFCIA--LGYTNSSLNP 238
Cdd:cd15219  189 VLKV-------------RRRQRATKKISIFIGTFVLCFAPYVITRLVELL-----PFVTINRYWGIVSkcLTYSKAASDP 250
                        250
                 ....*....|..
gi 568905270 239 VLYAFLDENFKR 250
Cdd:cd15219  251 FVYSLLRQQYRK 262
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
6-251 9.23e-09

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 55.17  E-value: 9.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   6 NIYIFNLALADALVTTtmpfqsavylmnswpFGDVLCKIVISIDYYNM----------------FTSIFTLTMMSVDRYI 69
Cdd:cd15075   36 NYALVNLAVADLGTTV---------------FGGLLSVVTNAVGYFNLgrvgcvlegfavaffgIAALCTVAVIAVDRLF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  70 AVCHPVKALDFRTPLKAKIINIC-----IWLLASSVGISAIVLGGTKVredvdviECSlqfPDdeysWW-----DLFMKI 139
Cdd:cd15075  101 VVCKPLGTLTFQTRHALAGIASSwlwslIWNTPPLFGWGSYQLEGVMT-------SCA---PD----WYsrdpvNVSYIL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 140 CVFVFAFVIPVLIIIVCYTLMILRLKSVRLL----SGSREKDRNlrRITKLVLVVVAVFIICWTPIHIFILVEALGSTSH 215
Cdd:cd15075  167 CYFSFCFAIPFAIILVSYGYLLWTLRQVAKLgvaeGGSTAKAEV--QVARMVVVMVMAFLLCWLPYAAFALTVVSKPDVY 244
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568905270 216 STAALSSyyFCIALGYTNSSLNPVLYAFLDENFKRC 251
Cdd:cd15075  245 INPLIAT--VPMYLAKSSTVYNPIIYIFMNKQFRDC 278
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
7-244 1.24e-08

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 54.57  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAV-------CHPVKald 79
Cdd:cd14973   36 VYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTVGLSLLAAISTERCLSVlfpiwyrCHRPK--- 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 fRTPLkakIINICIWLLASSVGIsaivlggtkvredVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIivcYTL 159
Cdd:cd14973  113 -HLSA---VVCALLWALSLLLSV-------------LESYFCGFLFWKFNESACRTFNFLSALLFLLLFLVMCV---SSL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 160 MILrlksVRLLSGSREkdRNLRRITKLVLVVVAVFIICWTP--IHIFILVEALGSTSHSTAALSSYYFCIalgytNSSLN 237
Cdd:cd14973  173 TLL----IRVQCSSQR--RPPTRLYVVILLTVLVFLLCGLPlgIYWFLLLWFSNYLFHTFHPISDLLSCV-----NSSAN 241

                 ....*..
gi 568905270 238 PVLYAFL 244
Cdd:cd14973  242 PIIYFFV 248
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
37-251 1.62e-08

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 54.44  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  37 FGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPlKAKIINICIWLLASSVGI------SAIVLGGT 110
Cdd:cd15076   68 FGRTVCALEAFVGSLAGLVTGWSLAFLAFERYIVICKPFGNFRFGSK-HALGAVVATWIIGIGVSLppffgwSRYIPEGL 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 111 KVREDVDVIECSLQFPDDEYSWWdlfmkicVFVFAFVIPVLIIIVCYTLMILRLKSV---RLLSGSREKDRnlRRITKLV 187
Cdd:cd15076  147 QCSCGPDWYTVGTKYRSEYYTWF-------LFIFCFIVPLSIIIFSYSQLLGALRAVaaqQQESASTQKAE--REVSRMV 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568905270 188 LVVVAVFIICWTPIHIFilveALGSTSHSTAALSSYYFCIALGYTNSSL--NPVLYAFLDENFKRC 251
Cdd:cd15076  218 VVMVGSFCLCYVPYAAL----AMYMVNNRDHGLDLRLVTIPAFFSKSSCvyNPIIYCFMNKQFRAC 279
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
1-247 1.66e-08

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 54.39  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVTTT-MPFQSAVYLM-NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 78
Cdd:cd15212   31 LRTVTNAFILSLSLSDLLTALLcLPFAFLTLFSrPGWLFGDRLCLANGFFNACFGIVSTLTMTLISFDRYYAIVRQPQGK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  79 DFRTplKAKIINICIWLLASSVGISAIVLGGT-KVREDVDVIECSLQFPDDEYSWWDLFmKICVFVFAFVIPVLIIIVCY 157
Cdd:cd15212  111 IGRR--RALQLLAAAWLTALGFSLPWYLLASApEYYEKLGFYHCLYVLHSGPSRLGAAY-SSVLIVLCYLLPFALMCFCH 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 tlmILRLKSVRLlSGSREKDRN-----LR-----RITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyfCI 227
Cdd:cd15212  188 ---YNICKTVRL-SESRVRPVTtyahlLRfysemRTATTVLIMIVFIICCWGPYCLLGLVAAAGGYQFPPLMDTV---AI 260
                        250       260
                 ....*....|....*....|
gi 568905270 228 ALGYTNSSLNPVLYAFLDEN 247
Cdd:cd15212  261 WMAWANGAINPLIYAIRNPN 280
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
56-250 2.91e-08

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 53.76  E-value: 2.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVCHPVKaLDFRTPLK-AKIINICIWLLASS------VGISaivlGGTKVredvdviecSLQFPDD 128
Cdd:cd15136   94 SVFTLTVITLERWYAITHAMH-LNKRLSLRqAAIIMLGGWIFALImallplVGVS----SYSKT---------SICLPFE 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 129 EYSWWDLFMKICVFVFAfVIPVLIIIVCYTLMILRLKsvrllSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVE 208
Cdd:cd15136  160 TETPVSKAYVIFLLLFN-GLAFLIICGCYIKIYLSVR-----GSGRAANSNDTRIAKRMALLVFTDFLCWAPIAFFGLTA 233
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568905270 209 ALGstsHSTAALSSYYFCIALGY-TNSSLNPVLYAFLDENFKR 250
Cdd:cd15136  234 AFG---LPLISVSNAKILLVFFYpLNSCANPFLYAIFTKQFRR 273
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
3-250 8.81e-08

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 52.25  E-value: 8.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTM-PFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15214   32 TLSNKFVFSLTLSNLLLSVLVlPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLlASSVGISAIVLGGTkvredvdviecSLQFpdDEYSW-----WDLFMKICVF--VFAFVIPVLIII 154
Cdd:cd15214  112 TGNRAVLALVYIWL-HSLIGCLPPLFGWS-----------SLEF--DRFKWmcvaaWHKEAGYTAFwqVWCALLPFVVML 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMIlrlksvRLLSGSREKdrnlRRITklVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyFCIALGYTNS 234
Cdd:cd15214  178 VCYGFIF------RVARANQCK----AFIT--ILVVLGAFVTTWGPYMVVISTEALWGKNSVSPQLET--LATWLSFTSA 243
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15214  244 VCHPLIYGLWNKTVRK 259
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
7-245 1.07e-07

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 52.07  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTT-MPFQ--SAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15220   34 AFVCHLCVVDLLAALLlMPLGilSSSPFFLGVVFGEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTI 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWllASSVGISAIVLGGTKV---REDVDVIECSLqfpddeysWWDLFMKICVFV-----FAFVIPVLIIIV 155
Cdd:cd15220  114 GLVAAVLVGVW--VKALLLGLLPVLGWPSyggPAPIAARHCSL--------HWSHSGHRGVFVvlfalVCFLLPLLLILV 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 156 CYTLMIlrlksvRLLSGSRekdrnlrriTKLVLV-VVAVFIICWTPIHIFILVEALGSTSHSTAALSSyyFCIALGYTNS 234
Cdd:cd15220  184 VYCGVF------KVFGGGK---------AALTLAaIVGQFLCCWLPYFAFHLYSALAASPVSGGEAEE--VVTWLAYSCF 246
                        250
                 ....*....|.
gi 568905270 235 SLNPVLYAFLD 245
Cdd:cd15220  247 AVNPFFYGLLN 257
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
136-252 1.08e-07

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 52.13  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 136 FMKICVFVFAfVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRrITKLVLVVVAVFIICWTPIHIFILVEALGSTSH 215
Cdd:cd15345  157 YVAFCISIFI-AILVAIVILYARIYILVKSSSRRVTNHRNSERSMA-LLRTVVIVVGVFIACWSPLFILLLIDVACEVKQ 234
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568905270 216 STAALSSYYFcIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15345  235 CPILYKADWF-IALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
1-252 1.09e-07

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 51.73  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 79
Cdd:cd15054   31 LRNTSNYFLVSLFMSDLMVgLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNLCVISLDRYLLIISPLRYKL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVreDVDVIECSLQFPDDEYSwwdlfmkiCVFV----FAFVIPVL---- 151
Cdd:cd15054  111 RMTPPRALALILAAWTLAALASFLPIELGWHEL--GHERTLPNLTSGTVEGQ--------CRLLvslpYALVASCLtffl 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 152 -IIIVCYTLMILRLKSVRLLSGSREkdrnlrritklVLVVVAVFIICWTPIHIFILVEALGstshSTAALSSYYFCIALG 230
Cdd:cd15054  181 pSGAICFTYCRILLAARKALKASLT-----------LGILLGMFFVTWLPFFVANVVQAVC----DCVSPGLFDVLTWLG 245
                        250       260
                 ....*....|....*....|..
gi 568905270 231 YTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15054  246 YCNSTMNPIIYPLFMRDFKRAL 267
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
1-249 1.37e-07

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 51.70  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALAD-ALVTTTMPFQSAVYLMNSWPFGDVL---CKIVisidyynMFT--SIFTLTMMSVDRYIAVCHP 74
Cdd:cd15070   31 LRTTTFYFIVSLALADiAVGVLVIPLAIVVSLGVTIHFYSCLfmsCLLV-------VFThaSIMSLLAIAVDRYLRVKLT 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  75 VKALDFRTPLKAKIINICIWLLASSVGISAIvLGGTKVREDVDVIECSLQFPDDEYSWWDlFMKICVFVFAFVIPVLIII 154
Cdd:cd15070  104 VRYRIVTTQRRIWLALGLCWLVSFLVGLTPM-FGWNRKPSLESVNTTPLQCQFTSVMRMD-YMVYFSFFTWILIPLVIMC 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYT--LMILRLKSVRLLSGSREKDRNLRR---ITKLVLVVVAVFIICWTPIHIFILVealgSTSHSTAALSSYYFCIAL 229
Cdd:cd15070  182 ALYVdiFYIIRNKLSQNATGFRETGAFYGRefkTAKSLALVLFLFAVCWLPLSIINCV----VYFNPKVPKIALYLGILL 257
                        250       260
                 ....*....|....*....|
gi 568905270 230 GYTNSSLNPVLYAFLDENFK 249
Cdd:cd15070  258 SHANSMMNPIVYACKIKKFK 277
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
140-252 1.51e-07

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 51.32  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 140 CVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREkdRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAA 219
Cdd:cd15102  161 CVTIFAGILAAIVALYARIYCLVRASGRKATRASAS--PRSLALLKTVLIVLLVFIACWGPLFILLLLDVACPVKTCPIL 238
                         90       100       110
                 ....*....|....*....|....*....|...
gi 568905270 220 LSSYYFcIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15102  239 YKADWF-LALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
2-244 2.66e-07

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 50.91  E-value: 2.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   2 KTATNIYIFNLALADALVTTTMPFQSAVYLMNswPFGDV-LCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15106   31 RNAFSVYILNLAAADFLFLCCHIIDSLLRLIN--IFHIIsIPKILTNVMTFPYFAGLSMLSAISTERCLSVLWPIWYRCH 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGIsaivlggtkvredVDVIECSLQFPDDEYSWWDLFMKICVfvfAFVIPVLIIIVCYTLM 160
Cdd:cd15106  109 RPRHLSAVVCVLLWALSLLLSI-------------LEWKFCGFLFSGADSHWCQTFDFITT---AWLIFLFVVLCGSSLA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILrlksVRLLSGSREKDrnLRRITKLVLVVVAVFIICWTPIHIF-ILVEALGSTSHSTAAlSSYYFCIALGYTNSSLNPV 239
Cdd:cd15106  173 LL----VRILCGSRKMP--LTRLYVTILLTVLVFLLCGLPFGIQwFLLLWIHIDLEVLFC-HVYLVSVVLSCLNSSANPI 245

                 ....*
gi 568905270 240 LYAFL 244
Cdd:cd15106  246 IYFFV 250
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
55-252 4.89e-07

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 50.23  E-value: 4.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  55 TSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIV----LGGTKVREDVDVIECSLQFPDDEY 130
Cdd:cd15071   84 SSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFgwnnLNAVERAWAANSSMGELVIKCQFE 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 131 SWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRL--KSVRLLSGSREKDRNLR-----RITKLVLVVVAVFIICWTPIHI 203
Cdd:cd15071  164 TVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFYLirKQLNKKVSSSSSDPQKYygkelKIAKSLALILFLFALSWLPLHI 243
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568905270 204 FILVEALGSTSHSTAALSsyYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15071  244 LNCITLFCPSCKKPMILT--YIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
56-252 1.50e-06

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 48.75  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLasSVGISAIVLGGTKVREDVDVieCSLQFP--DDEYsww 133
Cdd:cd15340   87 SVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTI--AIVIAVLPLLGWNCKKLNSV--CSDIFPliDETY--- 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 134 dlfmkicVFVFAFVIPVLIIIVCYTLMILRLKS----VRLLSGSREKD-------------------RNLRRITKLVLVV 190
Cdd:cd15340  160 -------LMFWIGVTSVLLLFIVYAYMYILWKAhhhaVRMLQRGTQKSiivytsedgkvqttrpdqtRMDIRLAKTLVLI 232
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568905270 191 VAVFIICWTPIHIFILVEALGSTSHSTAALssYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15340  233 LVVLIICWGPLLAIMVYDVFGKMNKLIKTV--FAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
151-252 2.14e-06

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 47.89  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 151 LIIIVCYT--LMILRLKSVRL---LSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYF 225
Cdd:cd15101  170 LVMVVVYAriFVYVRRRTNRMsphTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLCCRQCNVLAVEKFFL 249
                         90       100
                 ....*....|....*....|....*..
gi 568905270 226 CIALgyTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15101  250 LLAE--FNSAVNPIIYSYRDKEMSGTF 274
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
7-243 4.43e-06

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 47.01  E-value: 4.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   7 IYIFNLALADALVTTTMPFQSAVYLM---NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 83
Cdd:cd15110   36 VYILHLAIADFTFLLCIFILSIMYIGpfnFSHSRDYVAMLIFIILFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASSVGISAIVLggtkvredvdvieCSLQFPDDEYSwwdlfmkiCVFVFAFvIPVLIIIVCYTLMILR 163
Cdd:cd15110  116 HQSAIVCGLLWALSVLMTSLEYLM-------------CIDEGFHVRNE--------CRAVLIF-IGILTFLVFTPLMLIS 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 164 LKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHstaaLSSYYFCIALGYTNSSLNPVLYAF 243
Cdd:cd15110  174 SLILFIKVRCNSQRRHPGKLYIIIMLTVIFFLIFAMPMRVLLLLNYLHHSSF----LFSNPVPFLLSTVNSSINPIVYFL 249
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
8-249 5.76e-06

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 46.81  E-value: 5.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   8 YIFNLALADALVTTTMPFQSAV---YLMNSwPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPL 84
Cdd:cd15919   39 YLLALAAADILVLFFIVFVDFLledFILNK-QMPQVLDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  85 KAKIINICIWllassvgisaivlggtkvredvdvIECSLQfpDDEYSWW----------DLFMKICVFVFAFVIPVLIII 154
Cdd:cd15919  118 RTRKVIVSVY------------------------ITCFLT--SIPYYWWpniwiedytsTSMHHVLIWIHCFTVYLVPCS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYY-FCIALGYTN 233
Cdd:cd15919  172 IFFVLNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFAILWAPRIIMILYHLYVSPINNSWLVHIVSdIANMLALLN 251
                        250
                 ....*....|....*.
gi 568905270 234 SSLNPVLYAFLDENFK 249
Cdd:cd15919  252 TAINFFLYCFISKRFR 267
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
8-252 8.44e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 46.05  E-value: 8.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   8 YIFNLALADALVTTTMPFQSAVYLM------NSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15353   38 FICSLAVADMLVSVSNGSETVVITLlngndtDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIM 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  82 TPLKAKIINICIWLLASSVGISAIVLGGTKVredvdVIECslqfpddeyswwdlfmKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15353  118 TVRRAGVIITCIWTACTVSGVLFIIYSDSSV-----VIIC----------------LISMFFTMLALMASLYVHMFLLAR 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVRLL--SGSREKDRNLRRITKLVlVVVAVFIICWTPIHI-FILVEALGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15353  177 LHIKRIAVLpgTGPIRQGANMKGAITLT-ILLGVFVVCWAPFFLhLIFYISCPRNPYCVCFMSHFNMYLILIMCNSVIDP 255
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15353  256 LIYAFRSQELRKTF 269
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
56-242 8.76e-06

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 46.37  E-value: 8.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLasSVGISAIVLGGTKVREDVDVieCSLQFP--DDEY-SW 132
Cdd:cd15099   87 SVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCV--TIIISFLPLMGWRCKTWDSP--CSRLFPyiDRHYlAS 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 133 WDLFMKICVFvfafvipvlIIIVCYTLMILRLKS-VRLLSGSREKDRNLRRITKLVL---------VVVAVFIICWTPIH 202
Cdd:cd15099  163 WTGLQLVLLF---------LIIYAYPYILWKAHRhEANMGGPKLGRQQVKGQARMRMdirlaktlsLILLVLAICWLPVL 233
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 568905270 203 IFILVEALGSTSHSTAALssYYFCIALGYTNSSLNPVLYA 242
Cdd:cd15099  234 AFMLVDVRVTLTNKQKRM--FAFCSMLCLVNSCVNPIIYA 271
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
3-270 8.88e-06

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 46.73  E-value: 8.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATnIYIFNLALADALVTTTMPFqsaVYLMNSWPFGDVL--CKIViSIDYYNMFTSIF-TLTMMSVDRYiAVCHPVKALD 79
Cdd:PHA03235  68 TPT-LYMTNLYLANLLTVFVLPF---IMLSNQGLLSGSVagCKFA-SLLYYASCTVGFaTVALIAADRY-RVIHQRTRAR 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  80 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIE-----CSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIII 154
Cdd:PHA03235 142 SSAYRSTYKILGLTWFASLICSGPAPVYTTVVAHDDVDPEApgyetCVIYFRADQVKTVLSTFKVLLTLVWGIAPVVMMT 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 155 VCYTLMILRLKsvrlLSGSREKDRNLRRITKLVLVvvavFIICWTPIHIFILVEALGSTS------HSTAALSSYYFCIA 228
Cdd:PHA03235 222 WFYTFFYRTLK----RASYKKRSRTLTFVCILLLS----FLCLQTPFVAIMIFDSYATLIwpsdceHINLRDAVSTLSRL 293
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568905270 229 LGYTNSSLNPVLYAFLDENF----KRCFRDFCFPIKMRMERQSTNR 270
Cdd:PHA03235 294 VPNLHCLLNPILYAFLGNDFlkrfRQCFRGELFSRRAFLRSRQKCG 339
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
145-252 1.44e-05

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 45.64  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 145 AFVIPVLIIIVCYtlMILRLKSVRL---LSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALS 221
Cdd:cd15343  168 VFLIMVVVYLRIY--VYVQRKTNVLsphTSGSINRRRTPIKLMKTVMTVLGAFVICWTPGLVVLLLDGLNCTRCGVQHVK 245
                         90       100       110
                 ....*....|....*....|....*....|.
gi 568905270 222 SYYFCIALgyTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15343  246 RWFLLLAL--LNSVMNPIIYSYKDEEMWGTM 274
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
56-252 1.80e-05

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 45.17  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVchpvkaldFRTPLKAKIINICIWLLASSVGISAIVLG-----GTKVREDVDviECSLQFPDDEY 130
Cdd:cd15342   86 SVANLLAIAVERHQTI--------FTMQLHSKMSNQRVVILIFGIWMVALILGlipamGWNCLCDLK--RCSTMAPLYSR 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 131 SWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRrITKLVLVVVAVFIICWTPIHIFILVEAL 210
Cdd:cd15342  156 SYLVFWALSNLLTFLIMVAVYTRIFIYVRRKSQRMSEHHSSHPRYRETVLG-LMKTVVIILGAFVVCWTPGQVVLLLDGL 234
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 568905270 211 GSTSHSTAALSSYYFCIAlgYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15342  235 GCESCNVLAYEKYFLLLA--EINSLVNPIVYSYRDKEMRKTF 274
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
136-250 6.46e-05

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 43.66  E-value: 6.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 136 FMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRR-----ITKLVLVVVAVFIICWTPIHIFILVEAL 210
Cdd:cd15348  157 YILFCITVFLAILAAIVVLYARIYRIVKANSQRLGALPTRKGRARRSqkylaLLKTVTIVLGTFVACWLPLFLLLLLDVS 236
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568905270 211 GSTSHSTAALSSYYFcIALGYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15348  237 CPAQACPVLLKADYF-LGLAMINSLLNPIIYTLTSRDMRR 275
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
3-96 6.73e-05

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 43.46  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   3 TATNIYIFNLALADALVTTTMPFQSAVYLMN-SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR 81
Cdd:cd15169   34 TPSLVYALNLGCSDLLLTVSLPLKAVEALASgAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFR 113
                         90
                 ....*....|....*
gi 568905270  82 TPLKAKIINICIWLL 96
Cdd:cd15169  114 RPCYSWGVCAAIWAL 128
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
8-252 7.01e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 43.63  E-value: 7.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   8 YIFNLALADALVTTTMPFQSAV-------YLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15103   38 FICSLAVADMLVSVSNALETIViillnngYLVPRDSFEQHIDNVIDSMICSSLLASICSLLAIAVDRYITIFYALRYHSI 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGgtkvrEDVDVIECslqfpddeyswwdlfmkicvFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15103  118 MTVRRAGVIITAIWVFCTVCGILFIIYS-----DSVPVIIC--------------------LISMFFAMLVLMASLYVHM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKS-----VRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHI-FILVEALGSTSHSTAALSSYYFCIALGYTNS 234
Cdd:cd15103  173 FLLARShvkkiAALPGQRSTRQRANMKGAVTLTILLGVFIFCWAPFFLhLTLMISCPSNPYCACYMSHFNVYLILIMCNS 252
                        250
                 ....*....|....*...
gi 568905270 235 SLNPVLYAFLDENFKRCF 252
Cdd:cd15103  253 VIDPLIYAFRSQELRKTF 270
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
8-252 1.30e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 42.62  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   8 YIFNLALADALVTTTMPFQS-AVYLMNSW------PFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15354   38 FVCSLAVADMLVSVSNAWETiTIYLLNNRhlviedAFVRHIDNVFDSLICISVVASMCSLLAIAVDRYVTIFYALRYHNI 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGGTKVredvdVIECslqfpddeyswwdlfmKICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15354  118 MTVRRAGIIIACIWTFCTGCGIIFILYSESTY-----VIIC----------------LITMFFAMLFLMVSLYIHMFLLA 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSG-SREKDRNLRRITKLVLVVVAVFIICWTPIHI-FILVEALGSTSHSTAALSSYYFCIALGYTNSSLNP 238
Cdd:cd15354  177 RTHVKRIAALPGyNSVRQRTSMKGAVTLTILLGIFIVCWAPFFLhLILMISCPQNLYCVCFMSHFNMYLILIMCNSVIDP 256
                        250
                 ....*....|....
gi 568905270 239 VLYAFLDENFKRCF 252
Cdd:cd15354  257 LIYAFRSQEMRKTF 270
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
56-243 1.34e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 42.52  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIvLGGTKVREDVDVIECSLQFPDDEYSWWDL 135
Cdd:cd15341   87 SLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPL-MGWNCCPLNSPCSELFPLIPNDYLLSWLL 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 136 FmkicvfvfafvIPVLIIIVCYTLMILRLKSVR-LLSGSREKDRNLRRITKLVL---------VVVAVFIICWTPIHIFI 205
Cdd:cd15341  166 L-----------VAILLSGIIYTYGHVLWKAHKhVVYMEKHQDQQGPGNARMRLdvrlaktlgLVLAVLLICWSPVLALM 234
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568905270 206 LVEALGSTSHSTAalSSYYFCIALGYTNSSLNPVLYAF 243
Cdd:cd15341  235 MHSLFTSLSDHIK--KAFAFCSTLCLVNSMVNPIIYAL 270
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
8-74 1.59e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 42.44  E-value: 1.59e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568905270   8 YIFNLALADAL-VTTTMPF-QSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHP 74
Cdd:cd15005   38 FLLDLCLADGLrSLACFPFvMASVRHGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHH 106
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
8-243 2.13e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 42.08  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   8 YIFNLALAD-------ALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15350   38 FICSLAVSDmlgslykTLENILIILADMGYLNRRGPFETKLDDIMDSLFCLSLLGSIFSILAIAADRYITIFHALRYHNI 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLGgtkvrEDVDVIECslqfpddeyswwdlfmkicvFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15350  118 MTMRRTLVILAIIWTFCGGSGILMILFF-----HFVATVIC--------------------FTVLFFLMLVLILCLYVHM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKS-----VRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEAL-GSTSHSTAALSSYYFCIALGYTNS 234
Cdd:cd15350  173 FLLARSharkiASLPNHHAQHQRSNMRGAITLTILLGVFVCCWAPFVLHLLLMMFcPMNPYCACYRSLFQVNGTLIMSHA 252

                 ....*....
gi 568905270 235 SLNPVLYAF 243
Cdd:cd15350  253 VIDPAIYAF 261
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
56-252 3.02e-04

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 41.55  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVchpvkaldFRTPLKAKIINICIWLLASSVGISAIVLGGTKV---REDVDVIECSLQFP---DDE 129
Cdd:cd15344   86 SVANLLAIAIERHITV--------FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSvgwNCICDIENCSNMAPlysDSY 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 130 YSWWDLFmKICVFVfafvipVLIIIVCYTLMILRLKSVRL---LSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFIL 206
Cdd:cd15344  158 LVFWAIF-NLVTFV------VMVVLYAHIFGYVRQRTMRMsrhSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLL 230
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568905270 207 VEALGSTSHstaALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15344  231 LDVCCPQCD---VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
1-241 3.21e-04

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 41.28  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALV---TTTMPFQSAVYLMNSWpfgDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA 77
Cdd:cd15108   30 RRTPFCVYVLHLAVADLLFllcMASTLSLETSPLVITH---DLAYEVVRRVKYFAYTASLSLLTAISTQRCLSVLFPIWY 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  78 LDFRTPLKAKIINICIWLLASSVGISAIVLggtkvredvdvieCSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIivcy 157
Cdd:cd15108  107 KCHQPRHLSAVVCALLWALSLLMNVLASFF-------------CSEFWHPDEWQCFKVDMVFSFLIMGIFTPVMAL---- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 158 TLMILrlkSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTnSSLN 237
Cdd:cd15108  170 SSLIL---FVRVRRSSRQWRRRPTRLYVVVLASVLVFLACALPLGIYWFLLYWLDLPQEVKTLFSCLSRLSSSVS-SSAN 245

                 ....
gi 568905270 238 PVLY 241
Cdd:cd15108  246 PVIY 249
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
12-247 5.97e-04

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 40.56  E-value: 5.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  12 LALADALVTT-TMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPV-------KALDFRTP 83
Cdd:cd15142   44 LAVTDLLGTClASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLSGLSIICAMSIERYLAINHAYfynhyvdKRLAGLTL 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  84 LKAKIINICIWLLASsvgisaivLGGTKVREDVDVIECSLQFPDDE--YSWWDLFMKICVFVFAFVIPVLIIIVCYTLMI 161
Cdd:cd15142  124 FAIYASNILFCALPS--------MGLGKSKLQYPKTWCFIDWRTNVsvHAAYSYMYAGFSSLLILVTVLCNVLVCGALIR 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 162 LRLKSVR---LLSGSREKD----RNLRRI----TKLVLVVVA---VFIICWTPIHIFILVEALGST-SHSTAALSSYYFC 226
Cdd:cd15142  196 MHRQFVRrtsLGTDQRLSDfrrrRSFRRMagaeIQMVILLIAtsvVVLICSIPLVVRVFVNQLYQPaVEKDLDKNPDLQA 275
                        250       260
                 ....*....|....*....|.
gi 568905270 227 IALGYTNSSLNPVLYAFLDEN 247
Cdd:cd15142  276 IRIASVNPILDPWIYILLRKT 296
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
63-244 3.68e-03

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 38.22  E-value: 3.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  63 MSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIeCSLQFPDDEySWWDLFMKIcVF 142
Cdd:cd15144  102 MAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFRFGRYKPQFPGTW-CFIKVQPPG-SWADVAFAL-LF 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 143 VFAFVIPVLIIIVCYT-----LMILRLKSVRLLSGSREKDRNLRRITKLVLVVVaVFIICWTPIHIFILVEALGSTSHST 217
Cdd:cd15144  179 SLLGLASLLVSLVCNTisgltLVRARLRKKCSCSNRRAKSHDIEMVVQLVGIMV-VSCICWSPLLIFVLISVSRSYERPK 257
                        170       180
                 ....*....|....*....|....*...
gi 568905270 218 AALSSYYFC-IALGYTNSSLNPVLYAFL 244
Cdd:cd15144  258 HQYEKLLFLgVRLASWNQILDPWVYILL 285
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
56-252 3.72e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 38.30  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVCHPVKaLDFRTPLK-AKIINICIWLLASSVGISAIVLGGTKVRedvdvieCSLQFPDDEYSWWD 134
Cdd:cd15360   94 SVYTLTVITLERWHTITYAMQ-LDRKVRLRhAAVIMVGGWIFAFTVALLPIFGISSYMK-------VSICLPMDIESPLS 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 135 LFMKICVFVFAfVIPVLIIIVCYTLMILRLKSVRLLSGSREKdrnlrRITKLVLVVVAVFIICWTPIHIFILVEALG--- 211
Cdd:cd15360  166 QAYIIFILVLN-VLAFLIICACYIKIYLTVRNPNFVSSNSDT-----KIAKRMAVLIFTDFLCMAPISFFAISASLKvpl 239
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 568905270 212 -STSHSTAALSSYYfcialgYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15360  240 iTVSKSKILLVLFY------PINSCANPFLYAIFTKTFRRDF 275
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
56-250 5.40e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 37.58  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  56 SIFTLTMMSVDRYIAVCHPVKaLDFRTPLK-AKIINICIWLLASSVGISAIVLGGTkvredvdVIECSLQFPDDEYSWWD 134
Cdd:cd15964   94 SVYTLTVITLERWYAITFAMR-LDRKIRLRhASAIMLGGWVFCFLLALLPLVGVSS-------YAKVSICLPMDTETPLA 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 135 LFMKICVFVFAfVIPVLIIIVCYTLMILRLKSVRLLSGSREKdrnlrRITKLVLVVVAVFIICWTPIHIF----ILVEAL 210
Cdd:cd15964  166 QAYIVFVLMLN-IIAFVIICACYIKIYITVRNPQYKSGDKDT-----KIAKRMAVLIFTDFICMAPISFYalsaILNKPL 239
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 568905270 211 GSTSHSTAALSSYYfcialgYTNSSLNPVLYAFLDENFKR 250
Cdd:cd15964  240 ITVSNSKILLVLFY------PLNSCANPFLYAIFTKAFRR 273
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
1-252 5.82e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 37.53  E-value: 5.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   1 MKTATNIYIFNLALADALVT-TTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIA---VCHPVK 76
Cdd:cd15127   31 MRSISNSLLANLAFWDFLIIfFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAatnVQMYYE 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  77 ALDFRTPLKAKIinICIWLLASSVGISAIVL---------GGTKVREDVdVIECSLQFPDDEYS----------WWdlfm 137
Cdd:cd15127  111 MIENCTSTTAKL--AVIWVGALLLALPEVVLrqlskedggSGAPPAERC-VVKISTELPDTIYVlaltydgarlWW---- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 138 kicVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGsREKDRNLRRITKLVLVVVAVFII---CWTPIHIFILVEALGSTS 214
Cdd:cd15127  184 ---YFGCYFCLPTLFTITCSLVTARKIRRAEKACT-RGNKRQIQLESQMNCTVVALTILygfCIIPENICNIVTAYMATG 259
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568905270 215 HSTAALSSYYFCIA-LGYTNSSLNPVLYAFLDENFKRCF 252
Cdd:cd15127  260 VSRQTMDLLHLISQfLLFFKSCVTPVLLFCLCRPFSRAF 298
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
8-250 6.79e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 37.46  E-value: 6.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270   8 YIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYY-------NMFTSIFTLTMMSVDRYIAVCHPVKALDF 80
Cdd:cd15351   38 FICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVidtmicsSVVSSLSFLGAIAVDRYITIFYALRYHSI 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270  81 RTPLKAKIINICIWLLASSVGISAIVLggtkvREDVDVIecslqfpddeyswwdlfmkICVFVFAFVIPVLIIIVCYTLM 160
Cdd:cd15351  118 MTLQRAVNAIAGIWLASTVSSTLFIVY-----YNSNAVI-------------------LCLIVFFLFMLVLMLVLYIHMF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568905270 161 ILRLKSVRLLSGSREKDRNLRRITKL-----VLVVVAVFIICWTPIHI-FILVEALGSTSHSTAALSSYYFCIALGYTNS 234
Cdd:cd15351  174 ILACRHSQSISSQQRRQCPHQQTASLkgaitLTILLGIFFLCWGPFFLhLTLIVTCPTHPFCLCYFKYFNLFLILIICNS 253
                        250
                 ....*....|....*.
gi 568905270 235 SLNPVLYAFLDENFKR 250
Cdd:cd15351  254 IIDPLIYAFRSQELRK 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH