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Conserved domains on  [gi|568919039|ref|XP_006500546|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [Mus musculus]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1717 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1041.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPMQskpqsPVIQATAGSPkfsr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  233 lkqsqaqskpttPEKAELPNGDhAQSGLGKVSlengeaprergspvsgraepsrgtdsgaqEVVKDIleDVVTSAVKAAE 312
Cdd:PLN03076  235 ------------AEKSDSDTSM-TQFVQGFIT-----------------------------KIMQDI--DGVLNPATAGK 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  313 KHGLPEPDRALGALECQECAVPPGVDENSQ--------------TNGIADDRQSLSSADnLEPDvqgHQVAARFSHILQK 378
Cdd:PLN03076  271 SSGSGAHDGAFETTATVETTNPADLLDSTDkdmldakyweismyKSALEGRKGELADGE-VEKD---DDLEVQIGNKLRR 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  379 DAFLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDV 457
Cdd:PLN03076  347 DAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMII 424

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  458 FELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIF 536
Cdd:PLN03076  425 FQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIF 504

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  537 ERLVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-L 613
Cdd:PLN03076  505 ERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsL 580

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  614 DMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEER 693
Cdd:PLN03076  581 PVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASG 660

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  694 LDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASAD 773
Cdd:PLN03076  661 LNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSAD 738

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  774 TAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQSVA 853
Cdd:PLN03076  739 TAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQSAN 814

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  854 SEKQ-----------RRLLYNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNC 918
Cdd:PLN03076  815 SNRIlgldsilniviRKRGEDSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQS 894

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  919 DDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEI 998
Cdd:PLN03076  895 DDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHI 971

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  999 LKCISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDK 1056
Cdd:PLN03076  972 LTCVSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTS 1051

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1057 RQMAS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNM 1130
Cdd:PLN03076 1052 EQMNNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNM 1124

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1131 NRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVI 1210
Cdd:PLN03076 1125 NRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELII 1204

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1211 RCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFP 1290
Cdd:PLN03076 1205 RCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNK 1284

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1291 DTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVR 1354
Cdd:PLN03076 1285 DISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIR 1364

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1355 TRGLTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAIC 1416
Cdd:PLN03076 1365 KSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVV 1444

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1417 DVFTQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWR 1496
Cdd:PLN03076 1445 DLFVKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVS 1523

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1497 PAGMEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTIdniv 1573
Cdd:PLN03076 1524 GEYMPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV---- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1574 fypatskkedaehmvaaqqdtldaeihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGK 1652
Cdd:PLN03076 1580 -----------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQ 1630

                        1770      1780      1790      1800      1810      1820
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568919039 1653 SK-PNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1717
Cdd:PLN03076 1631 MQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1717 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1041.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPMQskpqsPVIQATAGSPkfsr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  233 lkqsqaqskpttPEKAELPNGDhAQSGLGKVSlengeaprergspvsgraepsrgtdsgaqEVVKDIleDVVTSAVKAAE 312
Cdd:PLN03076  235 ------------AEKSDSDTSM-TQFVQGFIT-----------------------------KIMQDI--DGVLNPATAGK 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  313 KHGLPEPDRALGALECQECAVPPGVDENSQ--------------TNGIADDRQSLSSADnLEPDvqgHQVAARFSHILQK 378
Cdd:PLN03076  271 SSGSGAHDGAFETTATVETTNPADLLDSTDkdmldakyweismyKSALEGRKGELADGE-VEKD---DDLEVQIGNKLRR 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  379 DAFLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDV 457
Cdd:PLN03076  347 DAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMII 424

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  458 FELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIF 536
Cdd:PLN03076  425 FQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIF 504

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  537 ERLVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-L 613
Cdd:PLN03076  505 ERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsL 580

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  614 DMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEER 693
Cdd:PLN03076  581 PVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASG 660

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  694 LDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASAD 773
Cdd:PLN03076  661 LNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSAD 738

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  774 TAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQSVA 853
Cdd:PLN03076  739 TAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQSAN 814

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  854 SEKQ-----------RRLLYNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNC 918
Cdd:PLN03076  815 SNRIlgldsilniviRKRGEDSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQS 894

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  919 DDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEI 998
Cdd:PLN03076  895 DDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHI 971

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  999 LKCISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDK 1056
Cdd:PLN03076  972 LTCVSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTS 1051

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1057 RQMAS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNM 1130
Cdd:PLN03076 1052 EQMNNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNM 1124

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1131 NRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVI 1210
Cdd:PLN03076 1125 NRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELII 1204

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1211 RCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFP 1290
Cdd:PLN03076 1205 RCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNK 1284

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1291 DTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVR 1354
Cdd:PLN03076 1285 DISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIR 1364

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1355 TRGLTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAIC 1416
Cdd:PLN03076 1365 KSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVV 1444

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1417 DVFTQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWR 1496
Cdd:PLN03076 1445 DLFVKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVS 1523

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1497 PAGMEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTIdniv 1573
Cdd:PLN03076 1524 GEYMPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV---- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1574 fypatskkedaehmvaaqqdtldaeihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGK 1652
Cdd:PLN03076 1580 -----------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQ 1630

                        1770      1780      1790      1800      1810      1820
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568919039 1653 SK-PNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1717
Cdd:PLN03076 1631 MQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 649-833 1.60e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 308.62  E-value: 1.60e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   649 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEF 728
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   729 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 808
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 568919039   809 GINDSKDLPEEYLSSIYDEIEGKKI 833
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 649-833 4.67e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 276.03  E-value: 4.67e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  649 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKE 727
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  728 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 807
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 568919039  808 RGINDSKDLPEEYLSSIYDEIEGKKI 833
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 647-833 1.64e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 260.30  E-value: 1.64e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039    647 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLG-AAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCE 725
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039    726 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 805
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 568919039    806 MNRGINDSKDLPEEYLSSIYDEIEGKKI 833
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1717 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1041.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPMQskpqsPVIQATAGSPkfsr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  233 lkqsqaqskpttPEKAELPNGDhAQSGLGKVSlengeaprergspvsgraepsrgtdsgaqEVVKDIleDVVTSAVKAAE 312
Cdd:PLN03076  235 ------------AEKSDSDTSM-TQFVQGFIT-----------------------------KIMQDI--DGVLNPATAGK 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  313 KHGLPEPDRALGALECQECAVPPGVDENSQ--------------TNGIADDRQSLSSADnLEPDvqgHQVAARFSHILQK 378
Cdd:PLN03076  271 SSGSGAHDGAFETTATVETTNPADLLDSTDkdmldakyweismyKSALEGRKGELADGE-VEKD---DDLEVQIGNKLRR 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  379 DAFLVFRSLCKLSMK-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDV 457
Cdd:PLN03076  347 DAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMII 424

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  458 FELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIF 536
Cdd:PLN03076  425 FQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIF 504

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  537 ERLVNDLSKIAQG-RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-L 613
Cdd:PLN03076  505 ERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsL 580

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  614 DMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEER 693
Cdd:PLN03076  581 PVANGNGDENGEGSDSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASG 660

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  694 LDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASAD 773
Cdd:PLN03076  661 LNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSAD 738

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  774 TAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQSVA 853
Cdd:PLN03076  739 TAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQSAN 814

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  854 SEKQ-----------RRLLYNVEMEQ----MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNC 918
Cdd:PLN03076  815 SNRIlgldsilniviRKRGEDSYMETsddlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQS 894

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  919 DDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEI 998
Cdd:PLN03076  895 DDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHI 971

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  999 LKCISQLELAQLIGTG--------------------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDK 1056
Cdd:PLN03076  972 LTCVSRFEHLHLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTS 1051

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1057 RQMAS------FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNM 1130
Cdd:PLN03076 1052 EQMNNlvsnlnMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNM 1124

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1131 NRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVI 1210
Cdd:PLN03076 1125 NRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELII 1204

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1211 RCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFP 1290
Cdd:PLN03076 1205 RCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNK 1284

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1291 DTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVR 1354
Cdd:PLN03076 1285 DISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIR 1364

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1355 TRGLTVMFEIMKSYGHTFAKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAIC 1416
Cdd:PLN03076 1365 KSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVV 1444

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1417 DVFTQFYEALHEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWR 1496
Cdd:PLN03076 1445 DLFVKFYPTVNP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVS 1523

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1497 PAGMEEEVSDrhlDVDLDRQSLSSIDRNASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTIdniv 1573
Cdd:PLN03076 1524 GEYMPAENIQ---DSENAEAASSSTADNDAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV---- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039 1574 fypatskkedaehmvaaqqdtldaeihieTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGK 1652
Cdd:PLN03076 1580 -----------------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQ 1630

                        1770      1780      1790      1800      1810      1820
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568919039 1653 SK-PNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1717
Cdd:PLN03076 1631 MQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 649-833 1.60e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 308.62  E-value: 1.60e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   649 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEF 728
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   729 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 808
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 568919039   809 GINDSKDLPEEYLSSIYDEIEGKKI 833
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 649-833 4.67e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 276.03  E-value: 4.67e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  649 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKE 727
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  728 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 807
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 568919039  808 RGINDSKDLPEEYLSSIYDEIEGKKI 833
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 647-833 1.64e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 260.30  E-value: 1.64e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039    647 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLG-AAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCE 725
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039    726 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 805
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 568919039    806 MNRGINDSKDLPEEYLSSIYDEIEGKKI 833
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1560-1766 1.36e-58

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 199.77  E-value: 1.36e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  1560 VVQLELIQTIDNIVfypatskkedaehmvaaqqdtldaeihietenQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYE 1639
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  1640 QRTVLWRAGFkGKSKPNLLKQETSSLACCLRILFRMYVDENRR-DSWDEIQQRLLRVCSEALAYFITVN-SESHRE--AW 1715
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEPRtSQREEVEERLIPLCEDILEYYLSLDeEEKQRElaAW 127

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568919039  1716 TSLLLLLLTKTLKISDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFL 1766
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 376-531 1.29e-52

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 181.92  E-value: 1.29e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039   376 LQKDAFLVFRSLCKLS-MKPLGEgpPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSV 454
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568919039   455 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILEtSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLN 531
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 28-197 2.88e-41

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 150.10  E-value: 2.88e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039    28 QHSQLRRACQVALDEIKAELEKQ-------------RL---GAAAPPKANFIEA-DKYFLPFELACQSKSPRVVSTSLDC 90
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRKyppvkeasekgilRLrtvHSSSPLMQNLLSAsEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039    91 LQKLIAYGHITGNApdsgapgkrlIDRIVETICNCFQGPQTdegVQLQIIKALLTAVTSPHIeIHEGTILQTVRTCYNIY 170
Cdd:pfam16213   81 LQKLISHDAISQSA----------APYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 568919039   171 LaSKNLINQTTAKATLTQMLNVIFTRM 197
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1173-1254 1.95e-37

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 135.70  E-value: 1.95e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919039  1173 KFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQ 1252
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 568919039  1253 TT 1254
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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