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Conserved domains on  [gi|568919041|ref|XP_006500547|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2 [Mus musculus]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1695 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1041.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEN-------QVLQEARELEKPMQSKPQSPVIQATA 225
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELMEPAEKSDSDTSMTQFVQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  226 GSpkFSRLKQS-QAQSKPTTPEKAelpNGDHAQSGlgkvslengeAPRERGSPVSGRAEPSREAAEKHGLpepDRALGAL 304
Cdd:PLN03076  250 GF--ITKIMQDiDGVLNPATAGKS---SGSGAHDG----------AFETTATVETTNPADLLDSTDKDML---DAKYWEI 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  305 ECQECAVPPGVDENSQTNGIADDrqslssadnlEPDVQghqvaarFSHILQKDAFLVFRSLCKLSMK-PLGEGPPDPKSh 383
Cdd:PLN03076  312 SMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSMKtPPKEALADPQL- 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  384 eLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFK 463
Cdd:PLN03076  374 -MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFP 452

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  464 EIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RSGHELGMTPLQEL 541
Cdd:PLN03076  453 MIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEA 532

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  542 SLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-LDMARRCSVTSVESTVSSGTQTAIQDDPE 619
Cdd:PLN03076  533 AMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGSDSHSELSSETSDAA 608

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  620 QFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQL 699
Cdd:PLN03076  609 TIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSF 688

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  700 DFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKE 779
Cdd:PLN03076  689 DFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSAD 766

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  780 QYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQSVASEKQ-----------RRLLYNVEMEQ-- 846
Cdd:PLN03076  767 DFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQSANSNRIlgldsilniviRKRGEDSYMETsd 842

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  847 --MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLE 924
Cdd:PLN03076  843 dlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTH 922

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  925 RDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTG------------ 992
Cdd:PLN03076  923 RDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGappdatffaapq 999

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  993 --------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDKRQMAS------FQESVGETSsqsvvvaV 1056
Cdd:PLN03076 1000 nesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnlnMLEQVGSFE-------M 1072

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1057 DRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNED 1136
Cdd:PLN03076 1073 NRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLS 1152

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1137 VAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQA 1216
Cdd:PLN03076 1153 IAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTA 1232

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1217 ASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYT 1296
Cdd:PLN03076 1233 AYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRN 1312

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1297 SDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFR 1360
Cdd:PLN03076 1313 KDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFE 1392

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1361 IV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVFTQFYEALHEvLLSDVFAQLQWCVKQ 1422
Cdd:PLN03076 1393 SVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTVNP-LLKKVLMLLVSFIKR 1471

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1423 DNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWRPAGMEEEVSDrhlDVDLDRQSLSSIDRN 1502
Cdd:PLN03076 1472 PHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ---DSENAEAASSSTADN 1548

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1503 ASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTIdnivfypatskkedaehmvaaqqdtldaeihi 1579
Cdd:PLN03076 1549 DAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV-------------------------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1580 eTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQETSSLACCLRILFRMYVDE 1657
Cdd:PLN03076 1580 -MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDK 1658

                        1770      1780      1790
                  ....*....|....*....|....*....|....*...
gi 568919041 1658 NRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1695
Cdd:PLN03076 1659 PPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1695 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1041.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEN-------QVLQEARELEKPMQSKPQSPVIQATA 225
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELMEPAEKSDSDTSMTQFVQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  226 GSpkFSRLKQS-QAQSKPTTPEKAelpNGDHAQSGlgkvslengeAPRERGSPVSGRAEPSREAAEKHGLpepDRALGAL 304
Cdd:PLN03076  250 GF--ITKIMQDiDGVLNPATAGKS---SGSGAHDG----------AFETTATVETTNPADLLDSTDKDML---DAKYWEI 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  305 ECQECAVPPGVDENSQTNGIADDrqslssadnlEPDVQghqvaarFSHILQKDAFLVFRSLCKLSMK-PLGEGPPDPKSh 383
Cdd:PLN03076  312 SMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSMKtPPKEALADPQL- 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  384 eLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFK 463
Cdd:PLN03076  374 -MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFP 452

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  464 EIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RSGHELGMTPLQEL 541
Cdd:PLN03076  453 MIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEA 532

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  542 SLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-LDMARRCSVTSVESTVSSGTQTAIQDDPE 619
Cdd:PLN03076  533 AMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGSDSHSELSSETSDAA 608

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  620 QFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQL 699
Cdd:PLN03076  609 TIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSF 688

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  700 DFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKE 779
Cdd:PLN03076  689 DFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSAD 766

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  780 QYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQSVASEKQ-----------RRLLYNVEMEQ-- 846
Cdd:PLN03076  767 DFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQSANSNRIlgldsilniviRKRGEDSYMETsd 842

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  847 --MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLE 924
Cdd:PLN03076  843 dlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTH 922

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  925 RDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTG------------ 992
Cdd:PLN03076  923 RDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGappdatffaapq 999

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  993 --------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDKRQMAS------FQESVGETSsqsvvvaV 1056
Cdd:PLN03076 1000 nesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnlnMLEQVGSFE-------M 1072

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1057 DRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNED 1136
Cdd:PLN03076 1073 NRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLS 1152

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1137 VAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQA 1216
Cdd:PLN03076 1153 IAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTA 1232

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1217 ASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYT 1296
Cdd:PLN03076 1233 AYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRN 1312

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1297 SDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFR 1360
Cdd:PLN03076 1313 KDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFE 1392

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1361 IV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVFTQFYEALHEvLLSDVFAQLQWCVKQ 1422
Cdd:PLN03076 1393 SVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTVNP-LLKKVLMLLVSFIKR 1471

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1423 DNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWRPAGMEEEVSDrhlDVDLDRQSLSSIDRN 1502
Cdd:PLN03076 1472 PHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ---DSENAEAASSSTADN 1548

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1503 ASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTIdnivfypatskkedaehmvaaqqdtldaeihi 1579
Cdd:PLN03076 1549 DAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV-------------------------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1580 eTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQETSSLACCLRILFRMYVDE 1657
Cdd:PLN03076 1580 -MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDK 1658

                        1770      1780      1790
                  ....*....|....*....|....*....|....*...
gi 568919041 1658 NRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1695
Cdd:PLN03076 1659 PPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 627-811 2.00e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 308.23  E-value: 2.00e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   627 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEF 706
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   707 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 786
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 568919041   787 GINDSKDLPEEYLSSIYDEIEGKKI 811
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 627-811 6.71e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 275.64  E-value: 6.71e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  627 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKE 705
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  706 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 785
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 568919041  786 RGINDSKDLPEEYLSSIYDEIEGKKI 811
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 625-811 2.08e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 259.91  E-value: 2.08e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041    625 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLG-AAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCE 703
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041    704 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 783
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 568919041    784 MNRGINDSKDLPEEYLSSIYDEIEGKKI 811
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1695 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1041.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEN-------QVLQEARELEKPMQSKPQSPVIQATA 225
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELMEPAEKSDSDTSMTQFVQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  226 GSpkFSRLKQS-QAQSKPTTPEKAelpNGDHAQSGlgkvslengeAPRERGSPVSGRAEPSREAAEKHGLpepDRALGAL 304
Cdd:PLN03076  250 GF--ITKIMQDiDGVLNPATAGKS---SGSGAHDG----------AFETTATVETTNPADLLDSTDKDML---DAKYWEI 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  305 ECQECAVPPGVDENSQTNGIADDrqslssadnlEPDVQghqvaarFSHILQKDAFLVFRSLCKLSMK-PLGEGPPDPKSh 383
Cdd:PLN03076  312 SMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSMKtPPKEALADPQL- 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  384 eLRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFK 463
Cdd:PLN03076  374 -MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFP 452

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  464 EIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RSGHELGMTPLQEL 541
Cdd:PLN03076  453 MIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEA 532

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  542 SLRKKGLECLVSILKCMVEW-SKDLYVNPNHQAtlgqERLPDQEMGDGKG-LDMARRCSVTSVESTVSSGTQTAIQDDPE 619
Cdd:PLN03076  533 AMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGSDSHSELSSETSDAA 608

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  620 QFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQL 699
Cdd:PLN03076  609 TIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSF 688

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  700 DFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKE 779
Cdd:PLN03076  689 DFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSAD 766

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  780 QYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKehtiATKSTKQSVASEKQ-----------RRLLYNVEMEQ-- 846
Cdd:PLN03076  767 DFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDD----LVPQQKQSANSNRIlgldsilniviRKRGEDSYMETsd 842

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  847 --MAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLE 924
Cdd:PLN03076  843 dlIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTH 922

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  925 RDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTG------------ 992
Cdd:PLN03076  923 RDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGappdatffaapq 999

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  993 --------VKTRYLSGSGREREGSLKGHSLAGEE--FMGLGLGNLVSGGVDKRQMAS------FQESVGETSsqsvvvaV 1056
Cdd:PLN03076 1000 nesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnlnMLEQVGSFE-------M 1072

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1057 DRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNED 1136
Cdd:PLN03076 1073 NRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLS 1152

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1137 VAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQA 1216
Cdd:PLN03076 1153 IAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTA 1232

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1217 ASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYT 1296
Cdd:PLN03076 1233 AYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRN 1312

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1297 SDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFR 1360
Cdd:PLN03076 1313 KDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFE 1392

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1361 IV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVFTQFYEALHEvLLSDVFAQLQWCVKQ 1422
Cdd:PLN03076 1393 SVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTVNP-LLKKVLMLLVSFIKR 1471

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1423 DNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWRPAGMEEEVSDrhlDVDLDRQSLSSIDRN 1502
Cdd:PLN03076 1472 PHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ---DSENAEAASSSTADN 1548

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1503 ASERGQS-QLSNPTDDSwkgapyahqkllaslliKC--VVQLELIQTIdnivfypatskkedaehmvaaqqdtldaeihi 1579
Cdd:PLN03076 1549 DAEAERSrRLYAAISDA-----------------KCraAVQLLLIQAV-------------------------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041 1580 eTENQGMYK-FMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQETSSLACCLRILFRMYVDE 1657
Cdd:PLN03076 1580 -MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDK 1658

                        1770      1780      1790
                  ....*....|....*....|....*....|....*...
gi 568919041 1658 NRRDSWDEIQQRLLRVCSEALAYFItvnsESHREAWTS 1695
Cdd:PLN03076 1659 PPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 627-811 2.00e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 308.23  E-value: 2.00e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   627 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEF 706
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   707 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 786
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 568919041   787 GINDSKDLPEEYLSSIYDEIEGKKI 811
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 627-811 6.71e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 275.64  E-value: 6.71e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  627 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKE 705
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  706 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 785
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 568919041  786 RGINDSKDLPEEYLSSIYDEIEGKKI 811
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 625-811 2.08e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 259.91  E-value: 2.08e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041    625 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLG-AAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCE 703
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLAnEDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041    704 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 783
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 568919041    784 MNRGINDSKDLPEEYLSSIYDEIEGKKI 811
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1538-1744 1.58e-58

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 199.77  E-value: 1.58e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  1538 VVQLELIQTIDNIVfypatskkedaehmvaaqqdtldaeihietenQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYE 1617
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  1618 QRTVLWRAGFkGKSKPNLLKQETSSLACCLRILFRMYVDENRR-DSWDEIQQRLLRVCSEALAYFITVN-SESHRE--AW 1693
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEPRtSQREEVEERLIPLCEDILEYYLSLDeEEKQRElaAW 127

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568919041  1694 TSLLLLLLTKTLKISDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFL 1744
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 354-509 1.61e-52

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 181.54  E-value: 1.61e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041   354 LQKDAFLVFRSLCKLS-MKPLGEgpPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSV 432
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568919041   433 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILEtSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLN 509
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 28-197 2.63e-41

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 150.10  E-value: 2.63e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041    28 QHSQLRRACQVALDEIKAELEKQ-------------RL---GAAAPPKANFIEA-DKYFLPFELACQSKSPRVVSTSLDC 90
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRKyppvkeasekgilRLrtvHSSSPLMQNLLSAsEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041    91 LQKLIAYGHITGNApdsgapgkrlIDRIVETICNCFQGPQTdegVQLQIIKALLTAVTSPHIeIHEGTILQTVRTCYNIY 170
Cdd:pfam16213   81 LQKLISHDAISQSA----------APYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 568919041   171 LaSKNLINQTTAKATLTQMLNVIFTRM 197
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1151-1232 2.18e-37

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 135.31  E-value: 2.18e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568919041  1151 KFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQ 1230
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 568919041  1231 TT 1232
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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