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Conserved domains on  [gi|568920166|ref|XP_006500652|]
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voltage-gated purine nucleotide uniporter SLC17A9 isoform X1 [Mus musculus]

Protein Classification

ACS family MFS transporter( domain architecture ID 13024350)

anion:cation symporter (ACS) family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes in a sodium dependent manner of specific anions such as inorganic phosphate and ascorbate, among others

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 42-377 3.18e-126

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 368.04  E-value: 3.18e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLLAHlgsGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:cd17380   61 FGGKKVLLLAVALWSLATLLTPLLAY---SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLG 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLnekdlvlalgflaqglpvtkpskvpwrqlfrkaSVWAAIC 201
Cdd:cd17380  138 TLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP---------------------------------PVWAIIV 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 SQLCSACSFFILLSWLPTFFKETF-PNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIF 280
Cdd:cd17380  185 AHFCMNWGFYILLSWLPTYFHEVLvPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALF 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 281 ALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFH 360
Cdd:cd17380  265 LLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFV 344

                        330
                 ....*....|....*..
gi 568920166 361 LVAIISNLGLGTFLVFG 377
Cdd:cd17380  345 LAAVVNLVGAVVFLLFG 361
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 42-377 3.18e-126

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 368.04  E-value: 3.18e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLLAHlgsGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:cd17380   61 FGGKKVLLLAVALWSLATLLTPLLAY---SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLG 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLnekdlvlalgflaqglpvtkpskvpwrqlfrkaSVWAAIC 201
Cdd:cd17380  138 TLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP---------------------------------PVWAIIV 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 SQLCSACSFFILLSWLPTFFKETF-PNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIF 280
Cdd:cd17380  185 AHFCMNWGFYILLSWLPTYFHEVLvPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALF 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 281 ALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFH 360
Cdd:cd17380  265 LLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFV 344

                        330
                 ....*....|....*..
gi 568920166 361 LVAIISNLGLGTFLVFG 377
Cdd:cd17380  345 LAAVVNLVGAVVFLLFG 361
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-381 4.25e-25

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 104.95  E-value: 4.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:COG2271   72 FGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYyvyryllnekdlvlalgflaqglpvtkpskvpwrqlfrkASVWAAIC 201
Cdd:COG2271  147 GALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL---------------------------------------LRFWLLAL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 SQLCSACSFFILLSWLPTFFKET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVrkfmqvmGLGLSSI 279
Cdd:COG2271  188 AYFLVYFALYGFLTWLPTYLVEVrgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI-------GLLLAAL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 280 FALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGsWTCV 358
Cdd:COG2271  261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAA 339

                        330       340
                 ....*....|....*....|...
gi 568920166 359 FHLVAIISNLGLGTFLVFGKAQR 381
Cdd:COG2271  340 FLLLAALALLAALLALLLLRETR 362
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 74-383 8.14e-23

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 99.43  E-value: 8.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166   74 AFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQC-GWQSVFYFSG----GL 148
Cdd:TIGR00894 132 ALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGivgcAW 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  149 TLLWAYYVYRY-------LLNEKDlvlALGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFF 221
Cdd:TIGR00894 212 SLLWFVFPADDpsihpciSKFEKK---YINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFI 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  222 KET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGY-RVITVRKFMQVMGLGLSSIFALCLGHTTS-FLKAMIFA 297
Cdd:TIGR00894 289 SWVlrVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTlSLTAARKIFNGIGGLGPGIFAYALPYLSAaFYLTIIIL 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  298 SASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIET--TGSWTCVFHLVAIISNLGLGTFLV 375
Cdd:TIGR00894 369 TLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKNVWLIVFLIMAFVNILCVIFYLI 448


                  ....*...
gi 568920166  376 FGKAQRVD 383
Cdd:TIGR00894 449 FGSAERQD 456
MFS_1 pfam07690
Major Facilitator Superfamily;
55-341 3.79e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.56  E-value: 3.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166   55 WGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLD 134
Cdd:pfam07690  67 IGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  135 QCGWQSVFYFSGGLTLLWAYYVYRYLLNEKDlvlalGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSqLCSACSFFILL 214
Cdd:pfam07690 147 LFGWRAAFLILAILSLLAAVLLLLPRPPPES-----KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  215 SWLPTFFKET-FPNSKGWVFNVVPWMLAIPASLFSGFISDRLisqgyrVITVRKFMQVMGLGLSSIFALCLGHTTSFLKA 293
Cdd:pfam07690 221 TYLPLYQEVLgLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL------GRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568920166  294 MIFASASIGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVG 341
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALG 343
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 42-218 1.20e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 46.88  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLLAHLGSghlafLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:PRK11551  77 IGRKRILIVSVALFGLFSLATAQAWDFPS-----LLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLNEKDLVLALGFLAQGLPVtkpskvpWRQLF---RKASVWA 198
Cdd:PRK11551 152 GALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPV-------LRALFgegRATATLL 224

                        170       180
                 ....*....|....*....|
gi 568920166 199 AICSQLCSACSFFILLSWLP 218
Cdd:PRK11551 225 LWISYFFTLIVLYFLLNWLP 244
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 42-377 3.18e-126

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 368.04  E-value: 3.18e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLLAHlgsGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:cd17380   61 FGGKKVLLLAVALWSLATLLTPLLAY---SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLG 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLnekdlvlalgflaqglpvtkpskvpwrqlfrkaSVWAAIC 201
Cdd:cd17380  138 TLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP---------------------------------PVWAIIV 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 SQLCSACSFFILLSWLPTFFKETF-PNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIF 280
Cdd:cd17380  185 AHFCMNWGFYILLSWLPTYFHEVLvPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALF 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 281 ALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFH 360
Cdd:cd17380  265 LLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFV 344

                        330
                 ....*....|....*..
gi 568920166 361 LVAIISNLGLGTFLVFG 377
Cdd:cd17380  345 LAAVVNLVGAVVFLLFG 361
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 31-377 5.48e-86

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 266.02  E-value: 5.48e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  31 PGLWLeqeGGCIGGEKVILLSASAWGFITVTTPLLAHlgsGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFT 110
Cdd:cd17318   75 PGGYL---AEKYGAKRVLGYSILITALLTLLTPLAAR---GGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 111 YSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRyllnekdLVLAlgflaqglpvtkpskvpwrql 190
Cdd:cd17318  149 TSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFF-------LVLP--------------------- 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 191 frkasVWAAICSQLCSACSFFILLSWLPTFFKET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQG-YRVITVRK 267
Cdd:cd17318  201 -----VWAIVVAHFGHNWGFYTLLTELPTYMSDVlhFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRK 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 268 FMQVMGLGLSSIFALCLGHTTS-FLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSG 346
Cdd:cd17318  276 LFTSIGFLGPGVFLIALGYLGSnATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVG 355

                        330       340       350
                 ....*....|....*....|....*....|....
gi 568920166 347 YLI---ETTGSWTCVFHLVAIISNLGLGTFLVFG 377
Cdd:cd17318  356 AIVkndQTIGQWRIVFFISAAIYILGAIFYLIFG 389
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 71-377 1.95e-33

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 128.23  E-value: 1.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  71 GHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTL 150
Cdd:cd17382  102 VHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGI 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 151 LWAyyvyryllnekdlvlaLGFLAQGLPVtkpskvpwrqlfrkasvWAAICSQLCSACSFFILLSWLPTFFKETF--PNS 228
Cdd:cd17382  182 IWY----------------MFWMLVSMPV-----------------YAIIVANFCRSWTFYLLLISQPAYFKEVFgfDIS 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 229 KGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVIT-VRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFN 307
Cdd:cd17382  229 KVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTaVRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFA 308

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568920166 308 HSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLI--ETTGSWTCVFHLVAIISNLGLGTFLVFG 377
Cdd:cd17382  309 ISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVHFFGVIFYAIFA 380
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 58-377 1.60e-32

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 126.05  E-value: 1.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  58 ITVTTPLLAHLGSGHLAFLtfsRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCG 137
Cdd:cd17381  108 FTLLTPLAADLGAGYLIAV---RALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLD 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 138 WQSVFYFSGGLTLLWAYYVYRyllnekdLVLALgflaqglpvtkpskvpwrqlfrkasvWAAICSQLCSACSFFILLSWL 217
Cdd:cd17381  185 WTYVFYIFGAVGLLWFFLWIW-------LVMPL--------------------------WAIVVAHFSYNWTFYTLLTLL 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 218 PTFFKET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLIS-QGYRVITVRKFMQVMGLGLSSIFALCLGHT-TSFLKA 293
Cdd:cd17381  232 PTYMKEIlrFDIQENGFLSALPYLGCWLFMILSGQIADNLREkQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTgCNYSLA 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 294 MIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIE--TTGSWTCVFHLVAIISNLGLG 371
Cdd:cd17381  312 VAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTHnnTVEEWQTVFYISAAINVFGAI 391


                 ....*.
gi 568920166 372 TFLVFG 377
Cdd:cd17381  392 FFTIFG 397
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 42-375 3.77e-27

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 110.35  E-value: 3.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLLahlgSGHLAFLTFsRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:cd17319   65 FGARKVLAVSMLLWSLFTALTGFA----TSLTSLYVL-RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLNekdlvlalgflaqglpvtkpskvpwrqlfrkasVWAAIC 201
Cdd:cd17319  140 AAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------------------------------VWGLAL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 SQLCSACSFFILLSWLPTFFKET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQgyrvitVRKFMQVMGLGLSSI 279
Cdd:cd17319  187 GYFGINYALYGLLTWLPTYLKQArgFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAV 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 280 FALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCV 358
Cdd:cd17319  261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAA 340

                        330
                 ....*....|....*..
gi 568920166 359 FHLVAIISNLGLGTFLV 375
Cdd:cd17319  341 FLFLAAVALLAALLVLL 357
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-381 4.25e-25

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 104.95  E-value: 4.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:COG2271   72 FGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYyvyryllnekdlvlalgflaqglpvtkpskvpwrqlfrkASVWAAIC 201
Cdd:COG2271  147 GALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL---------------------------------------LRFWLLAL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 SQLCSACSFFILLSWLPTFFKET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVrkfmqvmGLGLSSI 279
Cdd:COG2271  188 AYFLVYFALYGFLTWLPTYLVEVrgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI-------GLLLAAL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 280 FALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGsWTCV 358
Cdd:COG2271  261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAA 339

                        330       340
                 ....*....|....*....|...
gi 568920166 359 FHLVAIISNLGLGTFLVFGKAQR 381
Cdd:COG2271  340 FLLLAALALLAALLALLLLRETR 362
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 74-383 8.14e-23

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 99.43  E-value: 8.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166   74 AFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQC-GWQSVFYFSG----GL 148
Cdd:TIGR00894 132 ALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGivgcAW 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  149 TLLWAYYVYRY-------LLNEKDlvlALGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFF 221
Cdd:TIGR00894 212 SLLWFVFPADDpsihpciSKFEKK---YINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFI 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  222 KET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGY-RVITVRKFMQVMGLGLSSIFALCLGHTTS-FLKAMIFA 297
Cdd:TIGR00894 289 SWVlrVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTlSLTAARKIFNGIGGLGPGIFAYALPYLSAaFYLTIIIL 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  298 SASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIET--TGSWTCVFHLVAIISNLGLGTFLV 375
Cdd:TIGR00894 369 TLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKNVWLIVFLIMAFVNILCVIFYLI 448


                  ....*...
gi 568920166  376 FGKAQRVD 383
Cdd:TIGR00894 449 FGSAERQD 456
MFS_1 pfam07690
Major Facilitator Superfamily;
55-341 3.79e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.56  E-value: 3.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166   55 WGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLD 134
Cdd:pfam07690  67 IGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  135 QCGWQSVFYFSGGLTLLWAYYVYRYLLNEKDlvlalGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSqLCSACSFFILL 214
Cdd:pfam07690 147 LFGWRAAFLILAILSLLAAVLLLLPRPPPES-----KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  215 SWLPTFFKET-FPNSKGWVFNVVPWMLAIPASLFSGFISDRLisqgyrVITVRKFMQVMGLGLSSIFALCLGHTTSFLKA 293
Cdd:pfam07690 221 TYLPLYQEVLgLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL------GRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568920166  294 MIFASASIGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAGVVG 341
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALG 343
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
42-381 9.57e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 81.08  E-value: 9.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFitvttPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:COG2223   67 FGPRRVLLIGLLLLGI-----GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLG 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLNEKdlvlalgflAQGLPVTKPSKVPWRQLFRKASVWAAIC 201
Cdd:COG2223  142 AAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPP---------AGAAAAAKASLRDQLEALRDPRFWLLSL 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 SQLCSACSFFILLSWLPTFFKETFPNSK--GWVFNVVPWMLAIPASLFSGFISDRLisQGYRVITVrkFMQVMGLGLsSI 279
Cdd:COG2223  213 LYFGTFGSFIGFSSWLPPYLVDQFGLSAatAGLLAALFALLGALGRPLGGWLSDRI--GGRRVLLI--VFALMALGL-LL 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 280 FALCLGHTTSFLKAMIFASASIGFqtfnhsGISVNIQDLA----PSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSW 355
Cdd:COG2223  288 LALALGSLWLFLVLFLLLGLALGG------GNGAVFALVPdifpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSY 361

                        330       340
                 ....*....|....*....|....*.
gi 568920166 356 TCVFHLVAIISNLGLGTFLVFGKAQR 381
Cdd:COG2223  362 TAAFLVFAVLALVALVLTLLLYRRPR 387
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
46-338 5.24e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.48  E-value: 5.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  46 KVILLSASAWGFITVTTPLlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVT 125
Cdd:COG2814   76 RVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 126 GGVGSVLLDQCGWQSVFYFSGGLTLLWayyvyryllnekdLVLALGFLAQGLPVTKPS-KVPWRQLFRKASVWAAICSQL 204
Cdd:COG2814  151 PLLGGLLADLFGWRWVFLVNAVLALLA-------------LLLLLRLLPESRPAARARlRGSLRELLRRPRLLLLLLLAF 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 205 CSACSFFILLSWLPTFFKETFpnskGWVFNVVPWMLA------IPASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSS 278
Cdd:COG2814  218 LLGFGFFALFTYLPLYLQEVL----GLSASAAGLLLAlfglggVLGALLAGRLADRF---------GRRRLLLIGLLLLA 284

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568920166 279 IFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAP-SCAGFLFGVANTAGALAG 338
Cdd:COG2814  285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNSAFFLGG 345
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 55-376 6.84e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.39  E-value: 6.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  55 WGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLD 134
Cdd:cd17325   66 LGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 135 QCGWQSVFYFSGGLTLLwayyvyryllnekDLVLALGFL-------AQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSA 207
Cdd:cd17325  146 ALGYRAPFLVCAALALL-------------ALVLALLLLpeprpppNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLA 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 208 CSFFILLSWLPTFFKETFPNSK---GWVFNVVPWMLAIpASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSSIFALCL 284
Cdd:cd17325  213 FAFGALEPFLPLYAAELGGLSPaqiGLLFGAQGLASAL-SQPPAGKLSDRI---------GRKPLILIGLLLSAVALLLL 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 285 GHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCA-GFLFGVANTAGALAGVVGVCLSGYLIETTGsWTCVFHLVA 363
Cdd:cd17325  283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAA 361

                        330
                 ....*....|...
gi 568920166 364 IISNLGLGTFLVF 376
Cdd:cd17325  362 ALLLLAAVLFLLL 374
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 49-359 3.53e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 70.27  E-value: 3.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  49 LLSASAWGFITVTtplLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGV 128
Cdd:cd17324   66 LLLVLLLLFILGN---LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPL 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 129 GSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLNekdlvlalgfLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSAC 208
Cdd:cd17324  143 GGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS----------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFG 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 209 SFFILLSWLPTFFKETFPNSKGWvfnvVPWMLAI--PASLFSGFISDRLISQGYRvitvRKFMQVMGLGLSSIFALCLGH 286
Cdd:cd17324  213 GFFALYTYLAPFLTDVPGFSSSA----IIGLLLLfgVAGVVGSPLAGRLADRGGR----RALLIALLLLAAALLLLTLLG 284

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568920166 287 TTSFLKAMIFASASIGFQtFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVF 359
Cdd:cd17324  285 PSPLLLLVGLVLWGLGFF-AAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 55-374 1.47e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 65.14  E-value: 1.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  55 WGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLD 134
Cdd:cd06174   66 LGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 135 QC--GWQSVFYFSGGLTLLWAYYVYRYLLNEKDLVLALGFLAQglpvTKPSKVPWRQLFRKASVWAAICSQLCSACSFFI 212
Cdd:cd06174  146 SLgfGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEAS----SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 213 LLSWLPTFFKETFPNSK--GWVFNVVPWMLAIPASLFSGFISDRLISqgyrvitvRKFMQVMGLGLSSIFALCLGHTTSF 290
Cdd:cd06174  222 FSTLLPLFLLDLGGLSVavAGLLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSL 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 291 LKAMIFAS-ASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLG 369
Cdd:cd06174  294 LLLLLLLLlLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLA 373


                 ....*
gi 568920166 370 LGTFL 374
Cdd:cd06174  374 AILLL 378
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 76-349 2.50e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 64.69  E-value: 2.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166   76 LTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYY 155
Cdd:TIGR00895 108 LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  156 VYRYL------LNEKDLVLALGFLAQGLP---------------VTKPSKVPWRQLFRKASVWAAI---CSQLCSACSFF 211
Cdd:TIGR00895 188 LMRFLpesidfLVSKRPETVRRIVNAIAPqmqaeaqsalpeqksTQGTKRSVFKALFQGKTARITVllwLLYFMLLVGVY 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  212 ILLSWLPTFFKET-FPNSKGWVFNVVPWMLAIPASLFSGFISDRLisqGYRVITVrkfmqvmGLGLSSIFALCLGHTTSF 290
Cdd:TIGR00895 268 FLTNWLPKLMVELgFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTAL-------LLLLGAVFAVLVGSTLFS 337

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568920166  291 LKAMIFASASIG-FQTFNHSGISVNIQDL-APSCAGFLFGVANTAGALAGVVGVCLSGYLI 349
Cdd:TIGR00895 338 PTLLLLLGAIAGfFVNGGQSGLYALMALFyPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 70-356 2.85e-10

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 61.14  E-value: 2.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  70 SGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLT 149
Cdd:cd17312   88 STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVG 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 150 LLWAYYVYRYLLNEKDLVLALGFlaqglpvtkpskvpwrqlfrkasvwaaicsqlCSACSF---FILLSWLPTFFKETFP 226
Cdd:cd17312  168 LVVAIILFFFLRDSPPYVWVLSL--------------------------------AYAFVYivrYACLDWGPLYLYEVKG 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 227 NSK---GWVFNVVPwMLAIPASLFSGFISDRLIsQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGF 303
Cdd:cd17312  216 YSLidaGWFSSLYE-VGGIAGTILAGLLSDKLF-GGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGP 293

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568920166 304 QTFNHSGISvniQDLAPSCA-GFLFGVANTAGALAGVVGVCLSGYLIETTGSWT 356
Cdd:cd17312  294 INLIGGAAA---QDIGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYGWST 344
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
42-380 1.99e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 58.73  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSAsawGFITVTTPLLAHLGSghLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESeRAFTYSTVGAGSQVG 121
Cdd:COG2807   80 FGLERTLLLAL---LLLAAGLLLRSLAPS--VALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLG 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLwayyvyrYLLnekdLVLALGFLAQGLPVTKPSKVPWRQLFRKASVWAAIC 201
Cdd:COG2807  154 AALAAGLTVPLAAALGWRGALAVWALLALL-------ALL----LWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTL 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 SQLCSACSFFILLSWLPTFFketfpNSKGWVFNVVPWMLA------IPASLFSGFISDRLISQGYRVITVrkfmqvMGLG 275
Cdd:COG2807  223 FFGLQSLLYYAVVAWLPPIL-----RDAGLSAATAGLLLSlfqlagIPGSLLVPLLADRLGDRRPLLLLL------GLLG 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 276 LSSIFALCLGHTTSFLKAMIFASASIGFqTFnhSGISVNIQDLAPSC--AGFLFGVANTAGALAGVVGVCLSGYLIETTG 353
Cdd:COG2807  292 LAGLLGLLLAPGSLPWLWAVLLGLGQGG-LF--PLALTLIGLRARTPaeAAALSGMAQSVGYLLAALGPLLVGALHDATG 368

                        330       340
                 ....*....|....*....|....*..
gi 568920166 354 SWTCVFHLVAIISNLGLGTFLVFGKAQ 380
Cdd:COG2807  369 SWTAALLLLAALAVLMLVAGLLAGRPY 395
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 54-255 6.08e-09

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 57.26  E-value: 6.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  54 AWGFITVTTPLLAHLGSghlafLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTG----GVG 129
Cdd:cd17327   80 LWGLLTLLTAAVKNFGG-----LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGllayGVF 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 130 SVLLDQ--CGWQSVFYFSGGLTLLWAYYVYRYL---------LNEKDLVLALGFLA---QGLPVTKPSKVPWRQLFRKAS 195
Cdd:cd17327  155 KILGVGglAGWRWLFIIEGLITIIIGLVIFFWLpdnpskawfLTEEEKELAVERLRanqTGKGDQKFKWKQIKEAFKDPR 234

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568920166 196 VWAAICSQLCSACSFFILLSWLPTFFKETFPNS-KGWVFNVVPWMLAIPASLFSGFISDRL 255
Cdd:cd17327  235 TWLLFLFFFCSQITNNGISNFLPLILKSLGFYSlQTNLLSVPIGALGAVSLLIAALLSDRF 295
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
48-353 3.17e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 55.29  E-value: 3.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  48 ILLSASAWGFITVTTPLLAHLG-SGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQES-ERAFTYSTVGAGSQVGTLVT 125
Cdd:COG2211   84 ILIGAIPLALSFVLLFTAPDLSpTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYeERTRLSSWRFAFAGLGGLLA 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 126 GGVGSVLLD------QCGWQSVFYFSGGLTLLwayyvyryllnekdLVLALGFLAQGLPVTKPSKVP----WRQLFRKAS 195
Cdd:COG2211  164 SVLPPPLVAafggdaALGYRLTALIFAVLGLL--------------AFLLTFFGTKERPVPEEEKVSlkesLKALLKNRP 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 196 VWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWV--FNVVPWMLAIPASLFSGFISDRLisqGyRVITVRKFMQVMG 273
Cdd:COG2211  230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVglLLALYFLAALLGAPLWPRLAKRF---G-KKKAFIIGLLLAA 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 274 LGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLA-----PSCAGFLFGVANTAGALAGVVGVCLSGYL 348
Cdd:COG2211  306 LGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGLYFGIFTFAIKLGQALAGALAGLL 385


                 ....*
gi 568920166 349 IETTG 353
Cdd:COG2211  386 LALFG 390
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 81-374 9.69e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 53.40  E-value: 9.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  81 ILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGtlvtGGVGSVLL----DQCGWQSVFYFSGGLTLLWAYYV 156
Cdd:cd17475   92 FLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLG----GALAAALLpplaLHYGWRAAFVVAGLVSILAAVLF 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 157 YRYLLNEKDLVLALgflaqglPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETF---PNSKGWVF 233
Cdd:cd17475  168 WLFYREPPAASAAT-------ESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLglsVVAAGALL 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 234 NVVPWmLAIPASLFSGFISDRLISQGYRVITVrkFMQVMGLGLSSIFALCLGHTTSFLKAMIFASasIGFQTFNHSGISV 313
Cdd:cd17475  241 AVAQL-GGALGRIGLGRVSDRVFGGRRRPVLV--ITAAIAAAALLVLSLLSPGTPLWLLVLLLIL--LGLFAIGWNGLYL 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568920166 314 N-IQDLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFL 374
Cdd:cd17475  316 TlVAESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 42-375 7.53e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 47.58  E-value: 7.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLlahlgSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:cd17365   61 FGRKRVLLVSVALFGLFTLLTAF-----AQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWayyvyryllnekdLVLALGFLAqglpvtkpskvpwrqlfrkasVWAAIc 201
Cdd:cd17365  136 AALGGFLAAALIPAFGWRSVFLLGGVPPLIL-------------LPLLRGTLL---------------------LWVTF- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 202 sqLCSACSFFILLSWLPTFFKET-FPNSKGWVFNVVPWMLAIPASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSSIF 280
Cdd:cd17365  181 --FMGLLLVYLLNSWLPKLMVEAgYSLSQALTITLLLNIGGVIGSLLLGWLADRF---------GPKRVLALFFALGAVS 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 281 ALCLGHTTSFLKAMIFASASIGFQTFnhsGISVNIQDLAP-----SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSW 355
Cdd:cd17365  250 LALLGVSPASLVLLYVLVFLAGACVN---GAQVGLYALAArfyptEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGP 326

                        330       340
                 ....*....|....*....|
gi 568920166 356 TCVFHLVAIISNLGLGTFLV 375
Cdd:cd17365  327 ESVFLALAIPAALGALAVLL 346
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 42-218 1.20e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 46.88  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSASAWGFITVTTPLLAHLGSghlafLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVG 121
Cdd:PRK11551  77 IGRKRILIVSVALFGLFSLATAQAWDFPS-----LLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLNEKDLVLALGFLAQGLPVtkpskvpWRQLF---RKASVWA 198
Cdd:PRK11551 152 GALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPV-------LRALFgegRATATLL 224

                        170       180
                 ....*....|....*....|
gi 568920166 199 AICSQLCSACSFFILLSWLP 218
Cdd:PRK11551 225 LWISYFFTLIVLYFLLNWLP 244
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 73-365 2.69e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 45.67  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  73 LAFLTFSRILTGLLQGVYFPALTSLLSQKVQESER----AFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGL 148
Cdd:cd17316   89 PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRgfalGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALP 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 149 TLLWAYYVYRyllnekdlvlalgflaqglpvtkpskvpwrqlfrkasVWAAICSQLCSACSFFILLSWLPTFFKETFPNS 228
Cdd:cd17316  169 ALLALLLRRR-------------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLS 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 229 KGWVFNVVPWM--LAIPASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIgfQTF 306
Cdd:cd17316  212 PATSSLYLLLIslGALVGALIAGLLSDRI---------GRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI--LSF 280

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568920166 307 NHSGISVNIQDLAP-----SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAII 365
Cdd:cd17316  281 FVGGVWGALYAYLAelfptEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALL 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 70-359 6.45e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 44.67  E-value: 6.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166   70 SGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQV-GTLVTGGVGSVLLDQCGWQSVFYFSGGL 148
Cdd:TIGR00881  80 STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGII 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  149 TLLWAYYVYRYLLNE-------KDLVLALGFLAQGLPVTKPSKVPWRQLFRKA----SVWAAICSQLCSACSFFILLSWL 217
Cdd:TIGR00881 160 AIIVSLICFLLLRDSpqscglpPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVllnkVLWYISLGYVFVYVVRTGILDWS 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  218 PTFFKET--FPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVrKFMQVMGLGLSSIFalcLGHTTSFLKAMI 295
Cdd:TIGR00881 240 PLYLTQEkgFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAV-FFMALIIVSLLVYW---LNPAANPLMDLI 315

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568920166  296 FAsASIGFQTFN-HSGISVNIQDLAPS-CAGFLFGVANTAGALAGVVGVCLSGYLIETTGsWTCVF 359
Cdd:TIGR00881 316 CL-FALGFLVYGpQMLIGVIASELAPKkAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG-WAGAF 379
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 54-377 1.07e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.74  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  54 AWGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLL 133
Cdd:cd17489   65 LIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLY 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 134 DQCGWQSVFYFSGGLTLLWAYYVyrYLLNEKDLVLALGflaqglpvTKPSKVPWRQLFRKASVWAAICSQLCSAcSFFIL 213
Cdd:cd17489  145 QHLGFAVLFIVAAVLALLALLLV--FLVKDPPPVAAEE--------AEAGTRAFRRLVEKKVLPPALILFLASI-AYGAI 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 214 LSWLPTFFKETFPNSKGWVFNVVPWMLAIpASLFSGFISDRLisqgyrvitVRKFMQVMGLGLSSIFALCLGHTTSFLKA 293
Cdd:cd17489  214 STFLPLYAAERGISNAGLFFTVYAIALLL-SRPFSGKLSDRK---------GPKTVIIPGLLLLALGLLLLSFAGSPWML 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 294 MIFAS-ASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGsWTCVFHLVAIISNLGLGT 372
Cdd:cd17489  284 LLAAVlYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVL 362


                 ....*
gi 568920166 373 FLVFG 377
Cdd:cd17489  363 YIFLL 367
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 81-355 1.39e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.76  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  81 ILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQcGWQSVFYFSGGLTLLWAYYVYRYL 160
Cdd:cd17329   96 VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 161 LNEKdlvlalgfLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSkgwvFNVVPWML 240
Cdd:cd17329  175 PETR--------PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG----ESLLGLLL 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 241 AIPA---SLFSGFISdRLISQGYRvitvRKFMqVMGLGLSSIFALCLGHTTSFLKAMIFAS-ASIGfQTFNHSGISVNIQ 316
Cdd:cd17329  243 ALNAlliVLLQFPVA-RLVERFRL----RKIL-MIGILLFAIGFAVLAFANTLAVLILAMIvLTLG-EMLVFPAVQTLVA 315

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568920166 317 DLAP-SCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSW 355
Cdd:cd17329  316 ALAPpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG 355
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 73-221 1.46e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 43.26  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  73 LAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLW 152
Cdd:COG0477  102 PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLA 181

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568920166 153 AYYVYRyLLNEKDLVLALGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFF 221
Cdd:COG0477  182 LVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
MFS_1 pfam07690
Major Facilitator Superfamily;
200-366 1.50e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  200 ICSQLCSACSFFILLSWLPTFFKETF---PNSKGWVFNVVPWMLAIpASLFSGFISDRlisqgyrvITVRKFMqVMGLGL 276
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLgisPTEIGLLLTLFSLGYAL-AQPLAGRLSDR--------FGRRRVL-LIGLLL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  277 SSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCA-GFLFGVANTAGALAGVVGVCLSGYLIETTGsW 355
Cdd:pfam07690  72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFG-W 150

                         170
                  ....*....|.
gi 568920166  356 TCVFHLVAIIS 366
Cdd:pfam07690 151 RAAFLILAILS 161
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 70-346 1.71e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.32  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  70 SGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLT 149
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 150 LLwayyvyryllnekDLVLALGFlaqglpvtkpskvpwrqlfrkasvWAAICSQLCSACSFFILLSWLPTFFKETFPNSK 229
Cdd:cd17321  161 LV-------------ALLLARTF------------------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSP 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 230 GWV-FNVVPWMLAIP-ASLFSGFISDRLisqGYRVITVRKFMqVMGLGLsSIFALCLGHTTSFLKAMIFASASIGFQTFN 307
Cdd:cd17321  204 LQAgLALLPLALAMLvAAPLAGRLADRF---GPRLVLVAGLL-LTAVGL-LLLALLGADSSVWLLLPGLVLLGLGLGLFA 278

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568920166 308 HSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSG 346
Cdd:cd17321  279 TPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 70-375 5.66e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.79  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  70 SGHLAFLTFSRILTGLLqGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLT 149
Cdd:cd17330   84 SRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 150 LLWAYYVYRYLLnekdlvlalgflaqglpvtkpskvpwrqlfrkaSVWAAICSQLCSACSFFILLSWLPTFFKETFpnsk 229
Cdd:cd17330  163 LLNLVLVLFFLP---------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRF---- 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 230 GWVFNVVPWMLA---IPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTF 306
Cdd:cd17330  206 GFSPSQIGLLLAlvgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPAL 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568920166 307 NhSGISVNiqdLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTcVFHLVAIISNLGLGTFLV 375
Cdd:cd17330  286 S-ALLSKS---VPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGV-PFLLAAGLLLIALFLLSL 349
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
42-353 5.43e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166  42 IGGEKVILLSAsawGFITVTTPLLAHLGSghLAFLTFSRILTGLLQGVYFPALTSLLSQkVQESERAFTYSTVGAGSQVG 121
Cdd:COG0738   70 FGYKRGLLLGL---LLMALGLLLFALAPS--YPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 122 TLVTGGVGSVLLDQ---CGWQSVFYFSGGLTLLWAYYVYRYLLNEkdlvlalgfLAQGLPVTKPSKVPWRQLFRKASVWA 198
Cdd:COG0738  144 ALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPE---------IEEEEEEAAGSAASLKSLLKNPRLLL 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 199 AICSQLCSACSFFILLSWLPTFFKETF--PNSKGWVFNVVPWMLAIPASLFSGFISDRlisqgyrvITVRKFMQVMGLgL 276
Cdd:COG0738  215 GGLAIFLYVGAEGAIGDWLPLYLKDVLglSEATAALGLSLFWGGMTIGRFLGGFLLKR--------FGPVRLLRLSAL-L 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920166 277 SSIFALCLGHTTSFLKAMIFASA-----SIGFQTFNHSGIsvniqDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIET 351
Cdd:COG0738  286 AAVGLLLALLAPGPWLALIGLALvglglSLMFPTIFSLAL-----DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA 360


                 ..
gi 568920166 352 TG 353
Cdd:COG0738  361 FG 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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