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Conserved domains on  [gi|568923815|ref|XP_006502029|]
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intraflagellar transport protein 80 homolog isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-293 9.50e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 9.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  28 LYSCSDDHQIVKWNLLTSEtsLIVKLPDDIYPI-DLHWFPKSlgikkqtqaESFVLTSSDGKFHLIS-KLGRVEKSVEAH 105
Cdd:COG2319  135 LASGSADGTVRLWDLATGK--LLRTLTGHSGAVtSVAFSPDG---------KLLASGSDDGTVRLWDlATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 106 CGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVL 182
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSadGTVRLWDLATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 183 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTG 259
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDlATG 362

                        250       260       270
                 ....*....|....*....|....*....|....
gi 568923815 260 WSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
Cdd:COG2319  363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-293 9.50e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 9.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  28 LYSCSDDHQIVKWNLLTSEtsLIVKLPDDIYPI-DLHWFPKSlgikkqtqaESFVLTSSDGKFHLIS-KLGRVEKSVEAH 105
Cdd:COG2319  135 LASGSADGTVRLWDLATGK--LLRTLTGHSGAVtSVAFSPDG---------KLLASGSDDGTVRLWDlATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 106 CGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVL 182
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSadGTVRLWDLATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 183 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTG 259
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDlATG 362

                        250       260       270
                 ....*....|....*....|....*....|....
gi 568923815 260 WSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
Cdd:COG2319  363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-287 8.96e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 8.96e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSETSLIVKLPDDIYPiDLHWFPKSlgikkqtqaESFVLTSSDGKFHL 91
Cdd:cd00200    8 HTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVR-DVAASADG---------TYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  92 -ISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGKQ 169
Cdd:cd00200   78 wDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 170 LIIKPLQPNAKVLQW--KAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRVLYGS-QPHEHPITSVAWAPDGELFAV 246
Cdd:cd00200  157 GTIKLWDLRTGKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568923815 247 GSF-HTLRLcdktgWSYALEKPN------TGSIFNIAWSIDGTQIAGA 287
Cdd:cd00200  237 GSEdGTIRV-----WDLRTGECVqtlsghTNSVTSLAWSPDGKRLASG 279
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-134 6.46e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568923815    96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS 134
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
181-216 6.89e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 6.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568923815  181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-293 9.50e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 9.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  28 LYSCSDDHQIVKWNLLTSEtsLIVKLPDDIYPI-DLHWFPKSlgikkqtqaESFVLTSSDGKFHLIS-KLGRVEKSVEAH 105
Cdd:COG2319  135 LASGSADGTVRLWDLATGK--LLRTLTGHSGAVtSVAFSPDG---------KLLASGSDDGTVRLWDlATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 106 CGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVL 182
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSadGTVRLWDLATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 183 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTG 259
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDlATG 362

                        250       260       270
                 ....*....|....*....|....*....|....
gi 568923815 260 WSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
Cdd:COG2319  363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
96-293 4.63e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 4.63e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGKQLIIK- 173
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDlATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRl 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 174 -PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSY-GRVLYGSQPHEHPITSVAWAPDGELFAVGSF-H 250
Cdd:COG2319  189 wDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdG 268

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 568923815 251 TLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
Cdd:COG2319  269 TVRLWDlATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-287 8.96e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 8.96e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSETSLIVKLPDDIYPiDLHWFPKSlgikkqtqaESFVLTSSDGKFHL 91
Cdd:cd00200    8 HTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVR-DVAASADG---------TYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  92 -ISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGKQ 169
Cdd:cd00200   78 wDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 170 LIIKPLQPNAKVLQW--KAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRVLYGS-QPHEHPITSVAWAPDGELFAV 246
Cdd:cd00200  157 GTIKLWDLRTGKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568923815 247 GSF-HTLRLcdktgWSYALEKPN------TGSIFNIAWSIDGTQIAGA 287
Cdd:cd00200  237 GSEdGTIRV-----WDLRTGECVqtlsghTNSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-293 3.92e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 3.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 100 KSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKvLYTAG--KQLIIKPLQ 176
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTY-LASGSsdKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD----SYGRVLYGsqpHEHPITSVAWAPDGELFAVGSF-HT 251
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvetgKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQdGT 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568923815 252 LRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
Cdd:cd00200  159 IKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-313 1.59e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 1.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  79 SFVLTSS-DGKFHLIS-KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAW 155
Cdd:cd00200   22 KLLATGSgDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDlETGECVRTLTGHTSYVSSVAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 156 GPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPI 232
Cdd:cd00200  102 SPDG-RILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATLTGHTGEV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 233 TSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFahvveqrWEWKNFQV 310
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSdGTIKLWDlSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-------WDLRTGEC 253


                 ...
gi 568923815 311 TLT 313
Cdd:cd00200  254 VQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-254 1.85e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 1.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  17 VSCVGWTTaeELYSCSDDHQIVKWNLLTSEtsLIVKL---PDDIYPIDLHwfpkslgikkqtQAESFVLTSSDGKFHLIS 93
Cdd:cd00200   57 VAASADGT--YLASGSSDKTIRLWDLETGE--CVRTLtghTSYVSSVAFS------------PDGRILSSSSRDKTIKVW 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  94 KL--GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQL 170
Cdd:cd00200  121 DVetGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 171 IIKPLQPNAKVLQW-KAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYG----RVLYGsqpHEHPITSVAWAPDGELFA 245
Cdd:cd00200  201 IKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTgecvQTLSG---HTNSVTSLAWSPDGKRLA 277

                        250
                 ....*....|
gi 568923815 246 VGSF-HTLRL 254
Cdd:cd00200  278 SGSAdGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
13-216 4.15e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 4.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSEtsLIVKLPDDIYPI-DLHWFPKSlgikkqtqaESFVLTSSDGKFH 90
Cdd:COG2319  203 HTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGK--LLRTLTGHSGSVrSVAFSPDG---------RLLASGSADGTVR 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  91 LIS-KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGK 168
Cdd:COG2319  272 LWDlATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSD 350

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568923815 169 QLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:COG2319  351 DGTVRlwDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
119-293 1.19e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 119 TALVTVGEDGQVKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIK-PLQPNAKVLQWKAHDGIILKVDWN 197
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLlDAAAGALLATLLGHTAAVLSVAFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 198 SVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFN 274
Cdd:COG2319   88 PDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWDlATGKLLRTLTGHSGAVTS 167

                        170
                 ....*....|....*....
gi 568923815 275 IAWSIDGTQIAGACGNGHV 293
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTV 186
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-293 2.72e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 139 LRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSgdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815 217 SYG----RVLYGsqpHEHPITSVAWAPDGELFAVGSFhtlrlcDKTGWSYALEKPN--------TGSIFNIAWSIDGTQI 284
Cdd:cd00200   80 LETgecvRTLTG---HTSYVSSVAFSPDGRILSSSSR------DKTIKVWDVETGKclttlrghTDWVNSVAFSPDGTFV 150


                 ....*....
gi 568923815 285 AGACGNGHV 293
Cdd:cd00200  151 ASSSQDGTI 159
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-216 1.14e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSETSLIVKL-PDDIYPIDLHWFPKslgikkqtqaesFVLTSS-DGKF 89
Cdd:cd00200   92 HTSYVSSVAFSPDGRiLSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGT------------FVASSSqDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923815  90 HLIS-KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAG 167
Cdd:cd00200  160 KLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDlSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGS 238

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568923815 168 KQLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:cd00200  239 EDGTIRvwDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-134 6.46e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568923815    96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS 134
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-216 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568923815   181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-256 4.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.07e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568923815   228 HEHPITSVAWAPDGELFAVGSF-HTLRLCD 256
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDdGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
181-216 6.89e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 6.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568923815  181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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