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Conserved domains on  [gi|568923817|ref|XP_006502030|]
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intraflagellar transport protein 80 homolog isoform X3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-256 1.07e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 1.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSEtsLIVKLPDDIYPI-DLHWFPKSlgikkqtqaESFVLTSSDGKFH 90
Cdd:COG2319  161 HSGAVTSVAFSPDGKlLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVrSVAFSPDG---------KLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  91 LIS-KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGK 168
Cdd:COG2319  230 LWDlATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlATGELLRTLTGHSGGVNSVAFSPDG-KLLASGSD 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 169 QLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFA 245
Cdd:COG2319  309 DGTVRlwDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                        250
                 ....*....|..
gi 568923817 246 VGSF-HTLRLCD 256
Cdd:COG2319  389 SGSAdGTVRLWD 400
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 183-472 3.35e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 3.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 183 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCDKTGV 260
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSdKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 261 RNVlndaVDLLEFRDRVIKASLN-HAHLVVSTSLQcyvfstknwNTPLIFDLKEGTVSLILQAERHF---LLVDGGGIYL 336
Cdd:cd00200   84 ECV----RTLTGHTSYVSSVAFSpDGRILSSSSRD---------KTIKVWDVETGKCLTTLRGHTDWvnsVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 337 HS------------YEGRFISSpkFPGMRTDIlnaQTVSLSNDTIAIKDKADEKIIFLFEASTGKPLGDgkLLSHKNEIS 404
Cdd:cd00200  151 ASssqdgtiklwdlRTGKCVAT--LTGHTGEV---NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVN 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568923817 405 EIALDQKGL-----TNDRKIAFIDKNRDLYITSVKrfGKEEQiiklgtmVHTLAWCDTCNILC-GIQDTRFTVW 472
Cdd:cd00200  224 SVAFSPDGYllasgSEDGTIRVWDLRTGECVQTLS--GHTNS-------VTSLAWSPDGKRLAsGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-256 1.07e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 1.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSEtsLIVKLPDDIYPI-DLHWFPKSlgikkqtqaESFVLTSSDGKFH 90
Cdd:COG2319  161 HSGAVTSVAFSPDGKlLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVrSVAFSPDG---------KLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  91 LIS-KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGK 168
Cdd:COG2319  230 LWDlATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlATGELLRTLTGHSGGVNSVAFSPDG-KLLASGSD 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 169 QLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFA 245
Cdd:COG2319  309 DGTVRlwDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                        250
                 ....*....|..
gi 568923817 246 VGSF-HTLRLCD 256
Cdd:COG2319  389 SGSAdGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-254 9.24e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 9.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  17 VSCVGWTTaeELYSCSDDHQIVKWNLLTSEtsLIVKL---PDDIYPIDLHwfpkslgikkqtQAESFVLTSSDGKFHLIS 93
Cdd:cd00200   57 VAASADGT--YLASGSSDKTIRLWDLETGE--CVRTLtghTSYVSSVAFS------------PDGRILSSSSRDKTIKVW 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  94 KL--GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQL 170
Cdd:cd00200  121 DVetGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 171 IIKPLQPNAKVLQW-KAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYG----RVLYGsqpHEHPITSVAWAPDGELFA 245
Cdd:cd00200  201 IKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTgecvQTLSG---HTNSVTSLAWSPDGKRLA 277

                        250
                 ....*....|
gi 568923817 246 VGSF-HTLRL 254
Cdd:cd00200  278 SGSAdGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 183-472 3.35e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 3.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 183 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCDKTGV 260
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSdKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 261 RNVlndaVDLLEFRDRVIKASLN-HAHLVVSTSLQcyvfstknwNTPLIFDLKEGTVSLILQAERHF---LLVDGGGIYL 336
Cdd:cd00200   84 ECV----RTLTGHTSYVSSVAFSpDGRILSSSSRD---------KTIKVWDVETGKCLTTLRGHTDWvnsVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 337 HS------------YEGRFISSpkFPGMRTDIlnaQTVSLSNDTIAIKDKADEKIIFLFEASTGKPLGDgkLLSHKNEIS 404
Cdd:cd00200  151 ASssqdgtiklwdlRTGKCVAT--LTGHTGEV---NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVN 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568923817 405 EIALDQKGL-----TNDRKIAFIDKNRDLYITSVKrfGKEEQiiklgtmVHTLAWCDTCNILC-GIQDTRFTVW 472
Cdd:cd00200  224 SVAFSPDGYllasgSEDGTIRVWDLRTGECVQTLS--GHTNS-------VTSLAWSPDGKRLAsGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-134 5.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.14e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568923817    96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS 134
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
181-216 5.60e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568923817  181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-256 1.07e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 1.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSEtsLIVKLPDDIYPI-DLHWFPKSlgikkqtqaESFVLTSSDGKFH 90
Cdd:COG2319  161 HSGAVTSVAFSPDGKlLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVrSVAFSPDG---------KLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  91 LIS-KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGK 168
Cdd:COG2319  230 LWDlATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlATGELLRTLTGHSGGVNSVAFSPDG-KLLASGSD 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 169 QLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFA 245
Cdd:COG2319  309 DGTVRlwDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                        250
                 ....*....|..
gi 568923817 246 VGSF-HTLRLCD 256
Cdd:COG2319  389 SGSAdGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
28-261 2.86e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 2.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  28 LYSCSDDHQIVKWNLLTSEtsLIVKLPDDIYPI-DLHWFPKSlgikkqtqaESFVLTSSDGKFHLIS-KLGRVEKSVEAH 105
Cdd:COG2319  135 LASGSADGTVRLWDLATGK--LLRTLTGHSGAVtSVAFSPDG---------KLLASGSDDGTVRLWDlATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 106 CGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVL 182
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSadGTVRLWDLATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 183 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCDKTGV 260
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATG 362


                 .
gi 568923817 261 R 261
Cdd:COG2319  363 E 363
WD40 COG2319
WD40 repeat [General function prediction only];
96-256 1.48e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGKQLIIK- 173
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDlATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRl 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 174 -PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSY-GRVLYGSQPHEHPITSVAWAPDGELFAVGSF-H 250
Cdd:COG2319  189 wDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdG 268


                 ....*.
gi 568923817 251 TLRLCD 256
Cdd:COG2319  269 TVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-254 9.24e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 9.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  17 VSCVGWTTaeELYSCSDDHQIVKWNLLTSEtsLIVKL---PDDIYPIDLHwfpkslgikkqtQAESFVLTSSDGKFHLIS 93
Cdd:cd00200   57 VAASADGT--YLASGSSDKTIRLWDLETGE--CVRTLtghTSYVSSVAFS------------PDGRILSSSSRDKTIKVW 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  94 KL--GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQL 170
Cdd:cd00200  121 DVetGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 171 IIKPLQPNAKVLQW-KAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYG----RVLYGsqpHEHPITSVAWAPDGELFA 245
Cdd:cd00200  201 IKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTgecvQTLSG---HTNSVTSLAWSPDGKRLA 277

                        250
                 ....*....|
gi 568923817 246 VGSF-HTLRL 254
Cdd:cd00200  278 SGSAdGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-249 2.89e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 2.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSETSLIVKLPDDIYPiDLHWFPKSlgikkqtqaESFVLTSSDGKFHL 91
Cdd:cd00200    8 HTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVR-DVAASADG---------TYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  92 -ISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAGKQ 169
Cdd:cd00200   78 wDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 170 LIIKPLQPNAKVLQW--KAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRVLYGS-QPHEHPITSVAWAPDGELFAV 246
Cdd:cd00200  157 GTIKLWDLRTGKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS 236


                 ...
gi 568923817 247 GSF 249
Cdd:cd00200  237 GSE 239
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-256 1.98e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 1.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 100 KSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKvLYTAG--KQLIIKPLQ 176
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTY-LASGSsdKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD----SYGRVLYGsqpHEHPITSVAWAPDGELFAVGSF-HT 251
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvetgKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQdGT 158


                 ....*
gi 568923817 252 LRLCD 256
Cdd:cd00200  159 IKLWD 163
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-216 6.85e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 6.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  13 HQELVSCVGWTTAEE-LYSCSDDHQIVKWNLLTSETSLIVKL-PDDIYPIDLHWFPKslgikkqtqaesFVLTSS-DGKF 89
Cdd:cd00200   92 HTSYVSSVAFSPDGRiLSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGT------------FVASSSqDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817  90 HLIS-KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSeKVLYTAG 167
Cdd:cd00200  160 KLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDlSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGS 238

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568923817 168 KQLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:cd00200  239 EDGTIRvwDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 183-472 3.35e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 3.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 183 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCDKTGV 260
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSdKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 261 RNVlndaVDLLEFRDRVIKASLN-HAHLVVSTSLQcyvfstknwNTPLIFDLKEGTVSLILQAERHF---LLVDGGGIYL 336
Cdd:cd00200   84 ECV----RTLTGHTSYVSSVAFSpDGRILSSSSRD---------KTIKVWDVETGKCLTTLRGHTDWvnsVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 337 HS------------YEGRFISSpkFPGMRTDIlnaQTVSLSNDTIAIKDKADEKIIFLFEASTGKPLGDgkLLSHKNEIS 404
Cdd:cd00200  151 ASssqdgtiklwdlRTGKCVAT--LTGHTGEV---NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVN 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568923817 405 EIALDQKGL-----TNDRKIAFIDKNRDLYITSVKrfGKEEQiiklgtmVHTLAWCDTCNILC-GIQDTRFTVW 472
Cdd:cd00200  224 SVAFSPDGYllasgSEDGTIRVWDLRTGECVQTLS--GHTNS-------VTSLAWSPDGKRLAsGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
119-256 3.69e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 3.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923817 119 TALVTVGEDGQVKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIK-PLQPNAKVLQWKAHDGIILKVDWN 197
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLlDAAAGALLATLLGHTAAVLSVAFS 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568923817 198 SVNDLILSAGEDCKYKVWD-SYGRVLYGSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD 256
Cdd:COG2319   88 PDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-134 5.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.14e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568923817    96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWS 134
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-216 1.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568923817   181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-256 3.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.12e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568923817   228 HEHPITSVAWAPDGELFAVGSF-HTLRLCD 256
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDdGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
181-216 5.60e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568923817  181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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