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Conserved domains on  [gi|568924311|ref|XP_006502264|]
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sodium/hydrogen exchanger 9B1 isoform X1 [Mus musculus]

Protein Classification

cation:proton antiporter( domain architecture ID 1903467)

cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to NhaP-type Na+/H+ or K+/H+ antiporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NhaP super family cl42993
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
179-546 8.32e-32

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG0025:

Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 128.93  E-value: 8.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 179 GMLLAGFTIrnVPIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIM 258
Cdd:COG0025   31 LLLLAGILL--GPGLGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 259 NFPWQWGFLLGFVLGAVSPAVVVPnmLMLQengYGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSG-SVISNILSS 337
Cdd:COG0025  109 GLPLAAALLLGAILAPTDPVAVSP--ILRR---LGVPKRLRTILEGESLLNDATALVLFVLALAAALGGGfSLGEALLDF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 338 LRDVLIGVLVGIVMGVFVQYFPSGDQERLTQRraFLVLSMCISAVLGCQHigLHGSGGLVT----LVLSFMAAKRW-AEE 412
Cdd:COG0025  184 LLAILGGILVGLLLGWLLGRLLRRLPDPLLEI--LLTLALPFLAYLLAEA--LHGSGVLAVvvagLVLGNAGRRSLsPET 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 413 KVGIQKIVANTWNVFQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSF--ANFRFKEKVFIalSWI- 489
Cdd:COG0025  260 RLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLALrgSRLSWRERLFL--SWGg 337
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568924311 490 PKATVQAVLGPLALETARVMAPHlegyAKAVMTVAFLAILITAPNGALLIGILGPKI 546
Cdd:COG0025  338 PRGIVSLALALSLPLHGGAGFPG----RDLILALAFGVILLTLVLQGLTLPPLARRL 390
 
Name Accession Description Interval E-value
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
179-546 8.32e-32

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 128.93  E-value: 8.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 179 GMLLAGFTIrnVPIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIM 258
Cdd:COG0025   31 LLLLAGILL--GPGLGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 259 NFPWQWGFLLGFVLGAVSPAVVVPnmLMLQengYGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSG-SVISNILSS 337
Cdd:COG0025  109 GLPLAAALLLGAILAPTDPVAVSP--ILRR---LGVPKRLRTILEGESLLNDATALVLFVLALAAALGGGfSLGEALLDF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 338 LRDVLIGVLVGIVMGVFVQYFPSGDQERLTQRraFLVLSMCISAVLGCQHigLHGSGGLVT----LVLSFMAAKRW-AEE 412
Cdd:COG0025  184 LLAILGGILVGLLLGWLLGRLLRRLPDPLLEI--LLTLALPFLAYLLAEA--LHGSGVLAVvvagLVLGNAGRRSLsPET 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 413 KVGIQKIVANTWNVFQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSF--ANFRFKEKVFIalSWI- 489
Cdd:COG0025  260 RLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLALrgSRLSWRERLFL--SWGg 337
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568924311 490 PKATVQAVLGPLALETARVMAPHlegyAKAVMTVAFLAILITAPNGALLIGILGPKI 546
Cdd:COG0025  338 PRGIVSLALALSLPLHGGAGFPG----RDLILALAFGVILLTLVLQGLTLPPLARRL 390
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
191-542 4.30e-20

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 92.32  E-value: 4.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311  191 PIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEAC-SAALFSHFIMNFPWQWGFLLG 269
Cdd:pfam00999  35 PSGLGLISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVlIGLLLYLLGLGIPLLEALLFG 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311  270 FVLGAVSPAVVVPnmlMLQENGyGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSGSvISNILSSLRDVLIGVLVGI 349
Cdd:pfam00999 115 AILSATSPVVVLA---ILKELG-RVPERLGTLLLGESVLNDGVAVVLLAVLLALAQGVGG-GSDLGWLLLIFLVVAVGGL 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311  350 VMGVFVQYFPSGDQERLTQRRAF---LVLSMCISAVLGCQHIGLHGsggLVTLVLSFMAAKRWAEEKVGIQKIVANTWNV 426
Cdd:pfam00999 190 LLGLLIGWLLRLITRFTDDDRELevlLVLLLALLAALLAEALGVSG---ILGAFLAGLVLSEYPFANKLSEKLEPFGYGL 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311  427 FQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSFANFRFKEKVFIALSWIPKATVQAVLGplaleta 506
Cdd:pfam00999 267 FNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLSLREALIIGFGGLQRGAVSLALA------- 339
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 568924311  507 rVMAPHLEGYAKAVMTVAFLAILITAPNGALLIGIL 542
Cdd:pfam00999 340 -AIGPLLGIIARELYPLLIVVVLFTVLVQGITLKPL 374
 
Name Accession Description Interval E-value
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
179-546 8.32e-32

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 128.93  E-value: 8.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 179 GMLLAGFTIrnVPIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIM 258
Cdd:COG0025   31 LLLLAGILL--GPGLGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 259 NFPWQWGFLLGFVLGAVSPAVVVPnmLMLQengYGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSG-SVISNILSS 337
Cdd:COG0025  109 GLPLAAALLLGAILAPTDPVAVSP--ILRR---LGVPKRLRTILEGESLLNDATALVLFVLALAAALGGGfSLGEALLDF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 338 LRDVLIGVLVGIVMGVFVQYFPSGDQERLTQRraFLVLSMCISAVLGCQHigLHGSGGLVT----LVLSFMAAKRW-AEE 412
Cdd:COG0025  184 LLAILGGILVGLLLGWLLGRLLRRLPDPLLEI--LLTLALPFLAYLLAEA--LHGSGVLAVvvagLVLGNAGRRSLsPET 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 413 KVGIQKIVANTWNVFQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSF--ANFRFKEKVFIalSWI- 489
Cdd:COG0025  260 RLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLALrgSRLSWRERLFL--SWGg 337
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568924311 490 PKATVQAVLGPLALETARVMAPHlegyAKAVMTVAFLAILITAPNGALLIGILGPKI 546
Cdd:COG0025  338 PRGIVSLALALSLPLHGGAGFPG----RDLILALAFGVILLTLVLQGLTLPPLARRL 390
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
191-542 4.30e-20

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 92.32  E-value: 4.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311  191 PIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEAC-SAALFSHFIMNFPWQWGFLLG 269
Cdd:pfam00999  35 PSGLGLISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVlIGLLLYLLGLGIPLLEALLFG 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311  270 FVLGAVSPAVVVPnmlMLQENGyGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSGSvISNILSSLRDVLIGVLVGI 349
Cdd:pfam00999 115 AILSATSPVVVLA---ILKELG-RVPERLGTLLLGESVLNDGVAVVLLAVLLALAQGVGG-GSDLGWLLLIFLVVAVGGL 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311  350 VMGVFVQYFPSGDQERLTQRRAF---LVLSMCISAVLGCQHIGLHGsggLVTLVLSFMAAKRWAEEKVGIQKIVANTWNV 426
Cdd:pfam00999 190 LLGLLIGWLLRLITRFTDDDRELevlLVLLLALLAALLAEALGVSG---ILGAFLAGLVLSEYPFANKLSEKLEPFGYGL 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311  427 FQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSFANFRFKEKVFIALSWIPKATVQAVLGplaleta 506
Cdd:pfam00999 267 FNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLSLREALIIGFGGLQRGAVSLALA------- 339
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 568924311  507 rVMAPHLEGYAKAVMTVAFLAILITAPNGALLIGIL 542
Cdd:pfam00999 340 -AIGPLLGIIARELYPLLIVVVLFTVLVQGITLKPL 374
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
146-529 9.64e-11

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 63.63  E-value: 9.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 146 LFGLVVIFYSAFLGGKILEFIRIPVVPplppliGMLLAGFTIRnvPIIYEFVHiPTTWSSALRNTALTIILVRAGLGLDP 225
Cdd:COG0475    6 LLQLGLLLLAAVLAGLLARRLGLPSVL------GYILAGILLG--PSGLGLIE-DSEALELLAELGVVLLLFLIGLELDL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 226 QALKHLKGVCLRLSFGPCFLEACSAALFShFIMNFPWQWGFLLGFVLGAVSPAVVVPnmlMLQENGYgVEKGIPTLLVAA 305
Cdd:COG0475   77 KRLRKMGRRALGIGLLQVLLPFLLGFLLA-LLLGLSLAAALFLGAALAATSTAIVLK---VLKELGL-LKTPLGQLILGV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 306 SSMDDIVAITGFnTFLSIVFSSGSVISNILSSLRDVLIGVLVGIVMGVFV--QYFPSGDQERLTQRRAFLVLSMCISAVL 383
Cdd:COG0475  152 ALFDDIAAILLL-ALVPALAGGGSVAGSLLLALLKALLFLALLLLVGRYLlrRLFRLVARTRSRELFLLFALLLVLLAAA 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 384 GCQHIGLHGSGG--LVTLVLSFMAAKRWAEEKVGIQKivantwNVFQPLLFGLVGTEVSVESLeSKTIGMCLATLGLALS 461
Cdd:COG0475  231 LAELLGLSAALGafLAGLVLAESEYRHELEEKIEPFG------DLFLPLFFVSVGLSLDLSAL-LSNPLLALLLVLAAIV 303
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568924311 462 VRILSTFVLMSFANFRFKEKVFIALSWIPKATVQAVLGPLALEtARVMAPHLegYAKAVMTVAFLAIL 529
Cdd:COG0475  304 GKLLGAYLAARLFGLSRREALRIGLLLAPRGEFALVLASLGLS-AGLISPEL--FAALVLVVLLTTLL 368
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
209-488 7.14e-05

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 45.49  E-value: 7.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 209 NTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIMNFPWQWGFLLGFVLGAVSPAVVvpnMLMLQ 288
Cdd:COG3263   64 SLALAVILFDGGLRTRWSSFRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAV---FSILR 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 289 ENGYGVEKGIPTLLVAASSMDDIVAItgfntFLSIVFSS------GSVISNILSSLRDVLIGVLVGIVMGVFVQyfpsgd 362
Cdd:COG3263  141 SKGLNLKERLASTLELESGSNDPMAV-----FLTIALIElitgggASGWSLLLLFVLQMGLGALVGLAGGWLGV------ 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924311 363 qeRLTQRRAF--------LVLSMCISAVLGCQHigLHGSGGLVTLVLSFMAAKRWAEEKVGIQKIV-ANTWnVFQPLLFG 433
Cdd:COG3263  210 --WLLNRIRLpaeglypvLVLALALLAFGATAL--LGGSGFLAVYLAGLVLGNRRLPHKKSILRFHdGLAW-LAQIGMFL 284
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568924311 434 LVGTEVSVESLeSKTIGMCLA-TLGLALSVRILSTFVLMSFANFRFKEKVFIalSW 488
Cdd:COG3263  285 MLGLLVFPSRL-LPVALPALLiALFLIFVARPLAVFLSLLPFRFSWREKLFI--SW 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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