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Conserved domains on  [gi|568929772|ref|XP_006503471|]
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tetratricopeptide repeat protein 4 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 220-379 8.54e-75

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


:

Pssm-ID: 439174  Cd Length: 153  Bit Score: 230.91  E-value: 8.54e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 220 EALLQAIKARNIRLVSESAGEDEDSASNGPaeilldglSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDT 299
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLSLLEP--------CHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 300 RFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDRAELYQVSPDSTLLQVLQHPRCCVKALTPAFLVCVGSSPFCRNYL 379
Cdd:cd21380   73 TFIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFL 152
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 6.17e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 6.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  64 LQSMIFDDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568929772 144 KKLKPGHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
 
Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 220-379 8.54e-75

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 230.91  E-value: 8.54e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 220 EALLQAIKARNIRLVSESAGEDEDSASNGPaeilldglSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDT 299
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLSLLEP--------CHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 300 RFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDRAELYQVSPDSTLLQVLQHPRCCVKALTPAFLVCVGSSPFCRNYL 379
Cdd:cd21380   73 TFIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFL 152
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 270-354 8.38e-23

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 92.67  E-value: 8.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  270 DDQGRLSWPVLFLYPEYAQSDFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDeDRAELYQVSPDSTLLQ 349
Cdd:pfam18972   4 DPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPWDTKKEYTPKNVEVYMET-RTGGLVKVGKKVPLRK 82


                  ....*
gi 568929772  350 VLQHP 354
Cdd:pfam18972  83 VLSSA 87
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 6.17e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 6.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  64 LQSMIFDDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568929772 144 KKLKPGHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 73-218 1.37e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 60.38  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772   73 RYPEEQAKTY----KDEGNDYFKEKDYKKAVLSYSEGLKKKcADPdlnaVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKP 148
Cdd:TIGR00990 117 NLSEEERKKYaaklKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKVVEDTTAALELDP 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  149 GHLKAIIRGALCHLELKHFAEAvnwcdeglqidakekkLLEIRA-------KADKLKRMEERDLRK---AKLKEKKEQHQ 218
Cdd:TIGR00990 192 DYSKALNRRANAYDGLGKYADA----------------LLDLTAsciidgfRNEQSAQAVERLLKKfaeSKAKEILETKP 255
TPR_11 pfam13414
TPR repeat;
86-131 6.36e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 34.37  E-value: 6.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568929772   86 GNDYFKEKDYKKAVLSYSEGLKKkcaDPDlNAVLYTNRAAAQYYLG 131
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKL---DPD-NPEAYYNLGLAYYKLG 42
 
Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 220-379 8.54e-75

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 230.91  E-value: 8.54e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 220 EALLQAIKARNIRLVSESAGEDEDSASNGPaeilldglSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDT 299
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLSLLEP--------CHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 300 RFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDRAELYQVSPDSTLLQVLQHPRCCVKALTPAFLVCVGSSPFCRNYL 379
Cdd:cd21380   73 TFIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFL 152
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 220-380 1.68e-43

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


Pssm-ID: 439173  Cd Length: 159  Bit Score: 150.18  E-value: 1.68e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 220 EALLQAIKARNIRLvsesagededsasnGPAEilldgLSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDT 299
Cdd:cd21377    1 KALLSALKSRGIKL--------------GPPL-----YDEELTGERKPYLDEDGELHWPVLLLYPEVGQSDFIEDFSEDD 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 300 RFIDHLMAMFSE---APSWDSEHKYHPENLEVYFED--------------EDRAELYQVSPDSTLLQVLQHPRCCVKALT 362
Cdd:cd21377   62 TLGDHLDVMFPEpapPLPWDTEGEYTRDNLEVYYETnavkplpsesskagPKEKKWVRVDPDTTLGDVLAHPDYYVIPGI 141

                        170
                 ....*....|....*...
gi 568929772 363 PAFLVCVGSSPFCRNYLQ 380
Cdd:cd21377  142 PVFYVVPKGSPFEKRFLK 159
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 270-354 8.38e-23

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 92.67  E-value: 8.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  270 DDQGRLSWPVLFLYPEYAQSDFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDeDRAELYQVSPDSTLLQ 349
Cdd:pfam18972   4 DPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPWDTKKEYTPKNVEVYMET-RTGGLVKVGKKVPLRK 82


                  ....*
gi 568929772  350 VLQHP 354
Cdd:pfam18972  83 VLSSA 87
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 211-354 6.62e-22

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439175  Cd Length: 150  Bit Score: 91.42  E-value: 6.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 211 KEKKEQhqneALLQAIKARNIRLV-SESAGEDEDsasngPAEILLdglssENPygarLSIDDQgrLSWPVLFLYPEYAQS 289
Cdd:cd21381    1 KERKKK----TLKAALKARNITTRtTSQPPELLE-----DAKILL-----EDP----LDPESQ--LIFPALLLYPLHLQS 60

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568929772 290 DFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDrAELYQVSPDSTLLQVLQHP 354
Cdd:cd21381   61 DFIKAFSELSTPQEHLEYVLPRPWDWDKHEEYTPKNVECYMETES-GGLVKVGKKVPLLKVLSNG 124
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 6.17e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 6.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  64 LQSMIFDDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568929772 144 KKLKPGHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 73-218 1.37e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 60.38  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772   73 RYPEEQAKTY----KDEGNDYFKEKDYKKAVLSYSEGLKKKcADPdlnaVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKP 148
Cdd:TIGR00990 117 NLSEEERKKYaaklKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKVVEDTTAALELDP 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  149 GHLKAIIRGALCHLELKHFAEAvnwcdeglqidakekkLLEIRA-------KADKLKRMEERDLRK---AKLKEKKEQHQ 218
Cdd:TIGR00990 192 DYSKALNRRANAYDGLGKYADA----------------LLDLTAsciidgfRNEQSAQAVERLLKKfaeSKAKEILETKP 255
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-208 8.79e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 8.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  77 EQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKKkcaDPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIR 156
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL---DPD-DAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568929772 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKA-DKLKRMEE--RDLRKA 208
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDEaiEAYERA 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-267 1.98e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.01  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  77 EQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIR 156
Cdd:COG0457   40 DDAEALYNLGLAYLRLGRYEEALADYEQALE---LDPD-DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKA-DKLKRMEE-RDLRKAKLKEKKEQHQNEALLQAIKARNIRLV 234
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAlEKLGRYEEaLELLEKLEAAALAALLAAALGEAALALAAAEV 195

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568929772 235 SESAGEDEDSASNGPAEILLDGLSSENPYGARL 267
Cdd:COG0457  196 LLALLLALEQALRKKLAILTLAALAELLLLALA 228
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-251 9.14e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 9.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  77 EQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIR 156
Cdd:COG0457   74 DDAEALNNLGLALQALGRYEEALEDYDKALE---LDPD-DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKADKLKRMEERDLRKAKLKEKKEQHQNEALLQAIKARNIRLVSE 236
Cdd:COG0457  150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229

                        170
                 ....*....|....*
gi 568929772 237 SAGEDEDSASNGPAE 251
Cdd:COG0457  230 LLALRLAALALYQYR 244
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 86-192 7.20e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.30  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  86 GNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIRGALCHLELK 165
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALR---LDPD-NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQG 99

                         90       100
                 ....*....|....*....|....*..
gi 568929772 166 HFAEAVNWCDEGLQIDAKEKKLLEIRA 192
Cdd:COG4235  100 DYAEAIAAWQKLLALLPADAPARLLEA 126
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
89-183 2.44e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 2.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  89 YFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLnDVLAAKKLKPGHLKAIIRGALCHLELKHFA 168
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALE---LDPD-NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYD 76

                         90
                 ....*....|....*
gi 568929772 169 EAVNWCDEGLQIDAK 183
Cdd:COG3063   77 EALAYLERALELDPS 91
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
77-165 2.53e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.21  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  77 EQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDLNAVLYtNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIR 156
Cdd:COG4785  105 DLAEAYNNRGLAYLLLGDYDAALEDFDRALE---LDPDYAYAYL-NRGIALYYLGRYELAIADLEKALELDPNDPERALW 180


                 ....*....
gi 568929772 157 GALCHLELK 165
Cdd:COG4785  181 LYLAERKLD 189
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 89-230 4.09e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  89 YFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIRGALCHLELKHFA 168
Cdd:COG2956  120 YEQEGDWEKAIEVLERLLK---LGPE-NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYE 195

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568929772 169 EAVNWCDEGLQIDAKEKKLLEIRAKA-DKLKRMEE--RDLRKAkLKEKKEQHQNEALLQAIKARN 230
Cdd:COG2956  196 EAIAALERALEQDPDYLPALPRLAELyEKLGDPEEalELLRKA-LELDPSDDLLLALADLLERKE 259
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 70-181 5.43e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 42.29  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  70 DDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPG 149
Cdd:COG3914   69 AAAAALLLLAALLELAALLLQALGRYEEALALYRRALA---LNPD-NAEALFNLGNLLLALGRLEEALAALRRALALNPD 144

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568929772 150 HLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG3914  145 FAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 76-181 6.39e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 6.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  76 EEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAII 155
Cdd:COG5010   51 AKAFAIESPSDNLYNKLGDFEESLALLEQALQ---LDPN-NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126

                         90       100
                 ....*....|....*....|....*.
gi 568929772 156 RGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG5010  127 NLAALLLSLGQDDEAKAALQRALGTS 152
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 76-220 1.40e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  76 EEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAII 155
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALE---LDPD-NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARL 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568929772 156 RGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKAdkLKRMEERDLRKAKLKEKKEQHQNE 220
Cdd:COG4783   77 NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA--YRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 79-223 1.56e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929772  79 AKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDLnavlytnrAAAQYYLGNVRSSLNDVLAAK-------KLKPGHL 151
Cdd:COG3914  112 AEALFNLGNLLLALGRLEEALAALRRALA---LNPDF--------AEAYLNLGEALRRLGRLEEAIaalrralELDPDNA 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568929772 152 KAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKK----LLEIRAKADKLKRMEERDLRKAKLKEKKEQHQNEALL 223
Cdd:COG3914  181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADahsnLLFALRQACDWEVYDRFEELLAALARGPSELSPFALL 256
TPR_11 pfam13414
TPR repeat;
86-131 6.36e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 34.37  E-value: 6.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568929772   86 GNDYFKEKDYKKAVLSYSEGLKKkcaDPDlNAVLYTNRAAAQYYLG 131
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKL---DPD-NPEAYYNLGLAYYKLG 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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