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Conserved domains on  [gi|568934035|ref|XP_006503926|]
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WD repeat-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12898873)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-389 1.73e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.01  E-value: 1.73e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  54 YTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGAVFLW 133
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 134 D--TGSSVGEITGHNKVINSVDIKQTRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADG 211
Cdd:cd00200   79 DleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 212 QIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVnsvvstfpmgsnvldqqlgclwqkdh 291
Cdd:cd00200  158 TIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-------------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 292 llsislsgyinyldknnpSKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSRM 371
Cdd:cd00200  209 ------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSL 267

                        330
                 ....*....|....*....
gi 568934035 372 TVNESEQ-LVSCSMDDTVR 389
Cdd:cd00200  268 AWSPDGKrLASGSADGTIR 286
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-521 1.83e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 1.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 312 PLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSR-MTVNESEQLVSCSMDDTVRY 390
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDG--KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 391 TNLT----LRDYSG--QGVvkldvqpKCVAVGPGGYTVVVCI--GQIVL--LKDQKKCFSIDNPGYEPEVVAVHPGGDTV 460
Cdd:cd00200   78 WDLEtgecVRTLTGhtSYV-------SSVAFSPDGRILSSSSrdKTIKVwdVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568934035 461 AVGGTDGNVRVYSIlaSTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADG 521
Cdd:cd00200  151 ASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-389 1.73e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.01  E-value: 1.73e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  54 YTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGAVFLW 133
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 134 D--TGSSVGEITGHNKVINSVDIKQTRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADG 211
Cdd:cd00200   79 DleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 212 QIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVnsvvstfpmgsnvldqqlgclwqkdh 291
Cdd:cd00200  158 TIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-------------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 292 llsislsgyinyldknnpSKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSRM 371
Cdd:cd00200  209 ------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSL 267

                        330
                 ....*....|....*....
gi 568934035 372 TVNESEQ-LVSCSMDDTVR 389
Cdd:cd00200  268 AWSPDGKrLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
40-389 1.82e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 1.82e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  40 VILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319   60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR--TLTGHTGAVRSVAFSPDGKTLAS 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 120 VGEGrekfGAVFLWD--TGSSVGEITGHNKVINSVDIkqtRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319  138 GSAD----GTVRLWDlaTGKLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 196 RFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMG 275
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 276 SNVLdqqLGCLWQKD--HLLSISLSGYINYLDKNNPsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSET 353
Cdd:COG2319  288 SGGV---NSVAFSPDgkLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLAT 361

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 568934035 354 GEnDSFSGKGHTNQVSRMTVN-ESEQLVSCSMDDTVR 389
Cdd:COG2319  362 GE-LLRTLTGHTGAVTSVAFSpDGRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-521 1.83e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 1.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 312 PLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSR-MTVNESEQLVSCSMDDTVRY 390
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDG--KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 391 TNLT----LRDYSG--QGVvkldvqpKCVAVGPGGYTVVVCI--GQIVL--LKDQKKCFSIDNPGYEPEVVAVHPGGDTV 460
Cdd:cd00200   78 WDLEtgecVRTLTGhtSYV-------SSVAFSPDGRILSSSSrdKTIKVwdVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568934035 461 AVGGTDGNVRVYSIlaSTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADG 521
Cdd:cd00200  151 ASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 128-276 2.64e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 2.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 128 GAVFLWDTGSS--VGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRfVNCVRFSPD-GNRF 204
Cdd:PLN00181 555 GVVQVWDVARSqlVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSL 633

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568934035 205 ATASADGQIFIYDGKTGE-KVCAL-GESKahdggiyAISWSP--DSTHLLSASGDKTSKIWDVNVN-SVVSTFPMGS 276
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPKlPLCTMiGHSK-------TVSYVRfvDSSTLVSSSTDNTLKLWDLSMSiSGINETPLHS 703
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-217 1.30e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568934035   178 PFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
179-217 7.87e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 7.87e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568934035  179 FKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-389 1.73e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.01  E-value: 1.73e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  54 YTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGAVFLW 133
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 134 D--TGSSVGEITGHNKVINSVDIKQTRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADG 211
Cdd:cd00200   79 DleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 212 QIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVnsvvstfpmgsnvldqqlgclwqkdh 291
Cdd:cd00200  158 TIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-------------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 292 llsislsgyinyldknnpSKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSRM 371
Cdd:cd00200  209 ------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSL 267

                        330
                 ....*....|....*....
gi 568934035 372 TVNESEQ-LVSCSMDDTVR 389
Cdd:cd00200  268 AWSPDGKrLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
40-389 1.82e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 1.82e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  40 VILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319   60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR--TLTGHTGAVRSVAFSPDGKTLAS 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 120 VGEGrekfGAVFLWD--TGSSVGEITGHNKVINSVDIkqtRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319  138 GSAD----GTVRLWDlaTGKLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 196 RFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMG 275
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 276 SNVLdqqLGCLWQKD--HLLSISLSGYINYLDKNNPsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSET 353
Cdd:COG2319  288 SGGV---NSVAFSPDgkLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLAT 361

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 568934035 354 GEnDSFSGKGHTNQVSRMTVN-ESEQLVSCSMDDTVR 389
Cdd:COG2319  362 GE-LLRTLTGHTGAVTSVAFSpDGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
67-520 2.85e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.31  E-value: 2.85e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  67 APSGFYIASGDISGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAVVGEGREkfGAVFLWDTGSSVGEITGHN 146
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLL--LLLGLAAAVASLAASPDGARLAAGAGDLT--LLLLDAAAGALLATLLGHT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 147 KVINSVDIKQTRPyRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCA 226
Cdd:COG2319   79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 227 LgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGSNVL-------DQQLgclwqkdhLLSISLSG 299
Cdd:COG2319  158 L---TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrsvafspDGKL--------LASGSADG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 300 YINYLDKNNPsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGENDSFSGkGHTNQVSRMTVN-ESEQ 378
Cdd:COG2319  227 TVRLWDLATG-KLLRTLTGHSGSVRSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSpDGKL 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 379 LVSCSMDDTVRYTNLTlrdysgqgvvkldvQPKCVAVGPGGYTVVVCigqivllkdqkkcfsidnpgyepevVAVHPGGD 458
Cdd:COG2319  303 LASGSDDGTVRLWDLA--------------TGKLLRTLTGHTGAVRS-------------------------VAFSPDGK 343

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568934035 459 TVAVGGTDGNVRVYSIlaSTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVAD 520
Cdd:COG2319  344 TLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-473 1.34e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 1.34e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 182 KFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 262 DVNVNSVVSTFPM-GSNVldqqLGCLWQKDH--LLSISLSGYINyLDKNNPSKPLRVIKGHSKSIQCLTVHRNGGksYIY 338
Cdd:cd00200   79 DLETGECVRTLTGhTSYV----SSVAFSPDGriLSSSSRDKTIK-VWDVETGKCLTTLRGHTDWVNSVAFSPDGT--FVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 339 SGSHDGHINYWDSETGE-NDSFsgKGHTNQVSRMTV-NESEQLVSCSMDDTVRYTNLTLRDYSGQGVVKLDvQPKCVAVG 416
Cdd:cd00200  152 SSSQDGTIKLWDLRTGKcVATL--TGHTGEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN-GVNSVAFS 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568934035 417 PGGYTVVVCIGQIVL----LKDQKKCFSIdnPGYEPEV--VAVHPGGDTVAVGGTDGNVRVYS 473
Cdd:cd00200  229 PDGYLLASGSEDGTIrvwdLRTGECVQTL--SGHTNSVtsLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-264 1.60e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.60e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  40 VILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLlkYEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLAS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 120 VGEGrekfGAVFLWD--TGSSVGEITGHNKVINSVDIkqtRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319  264 GSAD----GTVRLWDlaTGELLRTLTGHSGGVNSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568934035 196 RFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVN 264
Cdd:COG2319  337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
129-521 4.64e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 4.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 129 AVFLWDTGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPfKFKFTIGDHSRFVNCVRFSPDGNRFATAS 208
Cdd:COG2319   19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 209 ADGQIFIYDGKTGEkvcALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNvnsvvstfpmgsnvldqqlgclwq 288
Cdd:COG2319   98 ADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA------------------------ 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 289 kdhllsislSGyinyldknnpsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQV 368
Cdd:COG2319  151 ---------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAV 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 369 SRMTVN-ESEQLVSCSMDDTVRYTNLTlrdySGQGVVKLdvqpkcvavgpggytvvvcigqivllkdqkkcfsidnPGYE 447
Cdd:COG2319  208 RSVAFSpDGKLLASGSADGTVRLWDLA----TGKLLRTL-------------------------------------TGHS 246

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568934035 448 PEV--VAVHPGGDTVAVGGTDGNVRVYSilASTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADG 521
Cdd:COG2319  247 GSVrsVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-262 3.99e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 3.99e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  38 KCVILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRI 117
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 118 AVVGEGrekfGAVFLWD--TGSSVGEITGHNKVINSVDIKQTRpYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:cd00200  151 ASSSQD----GTIKLWDlrTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568934035 196 RFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:cd00200  226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-521 1.83e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 1.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 312 PLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSR-MTVNESEQLVSCSMDDTVRY 390
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDG--KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 391 TNLT----LRDYSG--QGVvkldvqpKCVAVGPGGYTVVVCI--GQIVL--LKDQKKCFSIDNPGYEPEVVAVHPGGDTV 460
Cdd:cd00200   78 WDLEtgecVRTLTGhtSYV-------SSVAFSPDGRILSSSSrdKTIKVwdVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568934035 461 AVGGTDGNVRVYSIlaSTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADG 521
Cdd:cd00200  151 ASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 128-276 2.64e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 2.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 128 GAVFLWDTGSS--VGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRfVNCVRFSPD-GNRF 204
Cdd:PLN00181 555 GVVQVWDVARSqlVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSL 633

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568934035 205 ATASADGQIFIYDGKTGE-KVCAL-GESKahdggiyAISWSP--DSTHLLSASGDKTSKIWDVNVN-SVVSTFPMGS 276
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPKlPLCTMiGHSK-------TVSYVRfvDSSTLVSSSTDNTLKLWDLSMSiSGINETPLHS 703
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-217 1.30e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568934035   178 PFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 202-366 1.82e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 1.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 202 NRFATASADGQIFIYDGKTGEKVCalgESKAHDGGIYAISWSP-DSTHLLSASGDKTSKIWDVNVNSVVSTFPMGSNVLD 280
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVT---EMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICC 622

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 281 QQlgclWQKDHLLSISLSGY---INYLDKNNPSKPLRVIKGHSKSIQCLtvhRNGGKSYIYSGSHDGHINYWD---SETG 354
Cdd:PLN00181 623 VQ----FPSESGRSLAFGSAdhkVYYYDLRNPKLPLCTMIGHSKTVSYV---RFVDSSTLVSSSTDNTLKLWDlsmSISG 695

                        170
                 ....*....|....
gi 568934035 355 ENDS--FSGKGHTN 366
Cdd:PLN00181 696 INETplHSFMGHTN 709
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-262 4.57e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.57e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568934035   231 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
179-217 7.87e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 7.87e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568934035  179 FKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
231-262 2.60e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.60e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568934035  231 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-350 3.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568934035   309 PSKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWD 350
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG--KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
310-350 9.80e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 9.80e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568934035  310 SKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWD 350
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG--KLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 195-267 1.34e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 48.11  E-value: 1.34e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568934035  195 VRFSPDGNRFATAS-ADG--QIFIYDGKTGEKVCALGESKahDGGIYAISWSPDSTHLlsASGDKTSKIWDVNVNS 267
Cdd:COG4946   348 PAWSPDGKSIAYFSdASGeyELYIAPADGSGEPKQLTLGD--LGRVFNPVWSPDGKKI--AFTDNRGRLWVVDLAS 419
PTZ00421 PTZ00421
coronin; Provisional
 195-335 1.35e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 195 VRFSP-DGNRFATASADGQIFIY----DGKTGEKVCALGESKAHDGGIYAISWSPDSTHLLSASG-DKTSKIWDVNVNSV 268
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWgipeEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKA 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568934035 269 VSTFpmgSNVLDQQLGCLWQKDHLLSISLSgyinyldknnPSKPLRVIKGHSKSIQCLTVHRNGGKS 335
Cdd:PTZ00421 161 VEVI---KCHSDQITSLEWNLDGSLLCTTS----------KDKKLNIIDPRDGTIVSSVEAHASAKS 214
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 187-395 1.77e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 187 DHSRFVNCVRFSPDGNRFATASADGQIFIYDG----KTGEKVCALGESKAHDGGIYAISW-SPDSTHLLSASGDKTSKIW 261
Cdd:PLN00181 481 NSSNLVCAIGFDRDGEFFATAGVNKKIKIFECesiiKDGRDIHYPVVELASRSKLSGICWnSYIKSQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 262 DVNVNSVVSTfpmgsnvLDQQLGCLWQKDH-------LLSISLSGYINyLDKNNPSKPLRVIKGHSkSIQCLTVHRNGGK 334
Cdd:PLN00181 561 DVARSQLVTE-------MKEHEKRVWSIDYssadptlLASGSDDGSVK-LWSINQGVSIGTIKTKA-NICCVQFPSESGR 631

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568934035 335 SYIYsGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVNESEQLVSCSMDDTVRYTNLTL 395
Cdd:PLN00181 632 SLAF-GSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSM 691
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 196-276 2.51e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.58  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 196 RFSPDGNRFATASADG---QIFIYDGKTgekvcalGESKAHDGGIYAISWSPDSTHLL-SASGDKTSKIWDVNVNSVVST 271
Cdd:COG0823   81 SWSPDGKRLAFVSRSDgrfDIYVLDLDG-------GAPRRLTDGPGSPSWSPDGRRIVfSSDRGGRPDLYVVDLDGRKRR 153


                 ....*
gi 568934035 272 FPMGS 276
Cdd:COG0823  154 LTPAS 158
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-243 3.97e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 3.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568934035  192 VNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWS 243
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF---SAGSDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 182-246 9.87e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 9.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568934035  182 KFTIGDHSRFVNcVRFSPDGNRFATASADGQIFIYDGKTGE--KVcalgESKAHDGGIYAISWSPDS 246
Cdd:COG4946   382 QLTLGDLGRVFN-PVWSPDGKKIAFTDNRGRLWVVDLASGKvrKV----DTDGYGDGISDLAWSPDS 443
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 168-264 1.02e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.33  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035  168 DNCAAFFEgPPFKFKFTIGDHSRfvNCVRFSPDGNRFATA---SADGQIFIYDGKTGEKVCALGESKAHDggiyaISWSP 244
Cdd:pfam08662  82 PAKVSFFD-LKGNVIHSFGEQPR--NTIFWSPFGRLVLLAgfgNLAGDIEFWDVVNKKKIATAEASNATL-----CEWSP 153

                          90       100
                  ....*....|....*....|....*.
gi 568934035  245 DSTHLLSASG------DKTSKIWDVN 264
Cdd:pfam08662 154 DGRYFLTATTaprlrvDNGFKIWHYN 179
PTZ00421 PTZ00421
coronin; Provisional
 188-297 1.70e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934035 188 HSRFVNCVRFSPDG-NRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVN 266
Cdd:PTZ00421 124 HTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568934035 267 SVVSTFPMGSNVLDQQlgCLWQKDHLLSISL 297
Cdd:PTZ00421 201 TIVSSVEAHASAKSQR--CLWAKRKDLIITL 229
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 205-276 3.79e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 3.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568934035  205 ATASADGQIFIYDGKtGEKVCALGESKaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGS 276
Cdd:pfam12894  11 ALATEDGELLLHRLN-WQRVWTLSPDK-EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 185-235 8.62e-03

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 38.59  E-value: 8.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568934035  185 IGDHSRFVnCVRFSPDGNRFATASADG-----QIFIYDGKtgEKVCaLGESKAHDG 235
Cdd:pfam16529 183 IEEHSLLV-DAAFSPDGTALATASLDGevkffQIYLFDNR--NPRC-LHEWKPHDG 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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