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Conserved domains on  [gi|568940823|ref|XP_006505680|]
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interleukin-12 receptor subunit beta-2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-120 4.86e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 79.59  E-value: 4.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823   28 CKLGTVTVqPAPVIPLGSAANISCSLNPKQgCSHYPSSNELILLKFVNdvlvENLHGKKVHDHTGHSSTFQVTNLSLGMT 107
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKENC-CSHLGVEAQIIVWKLGL----ELIPGSQYTVLNDTVSSVTLPNLNSTRA 74

                          90
                  ....*....|...
gi 568940823  108 LFVCKLNCSNSQK 120
Cdd:pfam06328  75 LLTCCLLWGGQLQ 87
fn3 pfam00041
Fibronectin type III domain;
438-526 2.61e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823  438 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSitkfPPHWLRIPPDNMSALISeNIKPYICYEIRVHAL 517
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGE----PWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 568940823  518 SESQGGCSS 526
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-332 8.92e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 8.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 240 PLPPWDIRINflNASGSRGTLQWE----DEGQVVLNQLRYQPLNSTSWNMVNATNAKG-KYDLRDLRPFTEYEFQISSKl 314
Cdd:cd00063    1 PSPPTNLRVT--DVTSTSVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 568940823 315 hlSGGSWSNWSESLRTRT 332
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-630 1.87e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 536 PVSGPHITAITekKERLFISWThiPFPEQRGCILHYRIYWKERDSTaQPELCEIQyRRSQNSHPISSLQPRVTYVLWMTA 615
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 568940823 616 VTAAGESPQGNEREF 630
Cdd:cd00063   77 VNGGGESPPSESVTV 91
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-120 4.86e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 79.59  E-value: 4.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823   28 CKLGTVTVqPAPVIPLGSAANISCSLNPKQgCSHYPSSNELILLKFVNdvlvENLHGKKVHDHTGHSSTFQVTNLSLGMT 107
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKENC-CSHLGVEAQIIVWKLGL----ELIPGSQYTVLNDTVSSVTLPNLNSTRA 74

                          90
                  ....*....|...
gi 568940823  108 LFVCKLNCSNSQK 120
Cdd:pfam06328  75 LLTCCLLWGGQLQ 87
fn3 pfam00041
Fibronectin type III domain;
438-526 2.61e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823  438 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSitkfPPHWLRIPPDNMSALISeNIKPYICYEIRVHAL 517
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGE----PWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 568940823  518 SESQGGCSS 526
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-332 8.92e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 8.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 240 PLPPWDIRINflNASGSRGTLQWE----DEGQVVLNQLRYQPLNSTSWNMVNATNAKG-KYDLRDLRPFTEYEFQISSKl 314
Cdd:cd00063    1 PSPPTNLRVT--DVTSTSVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 568940823 315 hlSGGSWSNWSESLRTRT 332
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-630 1.87e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 536 PVSGPHITAITekKERLFISWThiPFPEQRGCILHYRIYWKERDSTaQPELCEIQyRRSQNSHPISSLQPRVTYVLWMTA 615
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 568940823 616 VTAAGESPQGNEREF 630
Cdd:cd00063   77 VNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 438-525 3.56e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 438 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSITKFPPHwlriPPDNMSALISeNIKPYICYEIRVHAl 517
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVT----PGSETSYTLT-GLKPGTEYEFRVRA- 76


                 ....*...
gi 568940823 518 sESQGGCS 525
Cdd:cd00063   77 -VNGGGES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 536-622 1.53e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823   536 PVSGPHITAITekKERLFISWTHIPFPEQRGCILHYRIYWKERDSTAQpelcEIQYRRSQNSHPISSLQPRVTYVLWMTA 615
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK----EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 568940823   616 VTAAGES 622
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
536-623 1.94e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 1.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823  536 PVSGPHITAITEKKerLFISWTHIPFPeqRGCILHYRIYWKERDSTaQPELcEIQYRRSQNSHPISSLQPRVTYVLWMTA 615
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPPDG--NGPITGYEVEYRPKNSG-EPWN-EITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 568940823  616 VTAAGESP 623
Cdd:pfam00041  76 VNGGGEGP 83
fn3 pfam00041
Fibronectin type III domain;
242-325 5.97e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 5.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823  242 PPWDIRinFLNASGSRGTLQWE--DEGQVVLN--QLRYQPLNSTS-WNMVNATNAKGKYDLRDLRPFTEYEFQISSklhL 316
Cdd:pfam00041   2 APSNLT--VTDVTSTSLTVSWTppPDGNGPITgyEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQA---V 76


                  ....*....
gi 568940823  317 SGGSWSNWS 325
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
407-627 6.30e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 6.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 407 AWTASVSAANSKGASAPTHINIVDLCGTGLLAPHQVSAKSENMDNILVTWQPPKKADsaVREYIVEWRALQPGSitkfpp 486
Cdd:COG3401  204 TYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP------ 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 487 hWLRIPPDNMSALISENIKP---YiCYEIRVHALSESQGGCS---SIRGDSKHKAPVSGPHITAITEKKERLfiSWThip 560
Cdd:COG3401  276 -FTKVATVTTTSYTDTGLTNgttY-YYRVTAVDAAGNESAPSnvvSVTTDLTPPAAPSGLTATAVGSSSITL--SWT--- 348

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568940823 561 fPEQRGCILHYRIYWKERDSTAQPELCEIqyrRSQNSHPISSLQPRVTYVLWMTAVTAAG-ESPQGNE 627
Cdd:COG3401  349 -ASSDADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 240-313 2.95e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 2.95e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568940823   240 PLPPWDIRInfLNASGSRGTLQWE--DEGQVVLNQLRYQPLN---STSWNMVNATNAKGKYDLRDLRPFTEYEFQISSK 313
Cdd:smart00060   1 PSPPSNLRV--TDVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 438-519 9.63e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.75  E-value: 9.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823   438 APHQVSAKSENMDNILVTWQPPKkaDSAVREYIVEWRALQPGSitkfPPHWLRIP-PDNMSALISENIKPYICYEIRVHA 516
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPP--DDGITGYIVGYRVEYREE----GSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ...
gi 568940823   517 LSE 519
Cdd:smart00060  77 VNG 79
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-120 4.86e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 79.59  E-value: 4.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823   28 CKLGTVTVqPAPVIPLGSAANISCSLNPKQgCSHYPSSNELILLKFVNdvlvENLHGKKVHDHTGHSSTFQVTNLSLGMT 107
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKENC-CSHLGVEAQIIVWKLGL----ELIPGSQYTVLNDTVSSVTLPNLNSTRA 74

                          90
                  ....*....|...
gi 568940823  108 LFVCKLNCSNSQK 120
Cdd:pfam06328  75 LLTCCLLWGGQLQ 87
fn3 pfam00041
Fibronectin type III domain;
438-526 2.61e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823  438 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSitkfPPHWLRIPPDNMSALISeNIKPYICYEIRVHAL 517
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGE----PWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 568940823  518 SESQGGCSS 526
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-332 8.92e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 8.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 240 PLPPWDIRINflNASGSRGTLQWE----DEGQVVLNQLRYQPLNSTSWNMVNATNAKG-KYDLRDLRPFTEYEFQISSKl 314
Cdd:cd00063    1 PSPPTNLRVT--DVTSTSVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 568940823 315 hlSGGSWSNWSESLRTRT 332
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-630 1.87e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 536 PVSGPHITAITekKERLFISWThiPFPEQRGCILHYRIYWKERDSTaQPELCEIQyRRSQNSHPISSLQPRVTYVLWMTA 615
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 568940823 616 VTAAGESPQGNEREF 630
Cdd:cd00063   77 VNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 438-525 3.56e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 438 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSITKFPPHwlriPPDNMSALISeNIKPYICYEIRVHAl 517
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVT----PGSETSYTLT-GLKPGTEYEFRVRA- 76


                 ....*...
gi 568940823 518 sESQGGCS 525
Cdd:cd00063   77 -VNGGGES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 536-622 1.53e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823   536 PVSGPHITAITekKERLFISWTHIPFPEQRGCILHYRIYWKERDSTAQpelcEIQYRRSQNSHPISSLQPRVTYVLWMTA 615
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK----EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 568940823   616 VTAAGES 622
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
536-623 1.94e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 1.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823  536 PVSGPHITAITEKKerLFISWTHIPFPeqRGCILHYRIYWKERDSTaQPELcEIQYRRSQNSHPISSLQPRVTYVLWMTA 615
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPPDG--NGPITGYEVEYRPKNSG-EPWN-EITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 568940823  616 VTAAGESP 623
Cdd:pfam00041  76 VNGGGEGP 83
fn3 pfam00041
Fibronectin type III domain;
242-325 5.97e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 5.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823  242 PPWDIRinFLNASGSRGTLQWE--DEGQVVLN--QLRYQPLNSTS-WNMVNATNAKGKYDLRDLRPFTEYEFQISSklhL 316
Cdd:pfam00041   2 APSNLT--VTDVTSTSLTVSWTppPDGNGPITgyEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQA---V 76


                  ....*....
gi 568940823  317 SGGSWSNWS 325
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
407-627 6.30e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 6.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 407 AWTASVSAANSKGASAPTHINIVDLCGTGLLAPHQVSAKSENMDNILVTWQPPKKADsaVREYIVEWRALQPGSitkfpp 486
Cdd:COG3401  204 TYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP------ 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823 487 hWLRIPPDNMSALISENIKP---YiCYEIRVHALSESQGGCS---SIRGDSKHKAPVSGPHITAITEKKERLfiSWThip 560
Cdd:COG3401  276 -FTKVATVTTTSYTDTGLTNgttY-YYRVTAVDAAGNESAPSnvvSVTTDLTPPAAPSGLTATAVGSSSITL--SWT--- 348

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568940823 561 fPEQRGCILHYRIYWKERDSTAQPELCEIqyrRSQNSHPISSLQPRVTYVLWMTAVTAAG-ESPQGNE 627
Cdd:COG3401  349 -ASSDADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 240-313 2.95e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 2.95e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568940823   240 PLPPWDIRInfLNASGSRGTLQWE--DEGQVVLNQLRYQPLN---STSWNMVNATNAKGKYDLRDLRPFTEYEFQISSK 313
Cdd:smart00060   1 PSPPSNLRV--TDVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 438-519 9.63e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.75  E-value: 9.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940823   438 APHQVSAKSENMDNILVTWQPPKkaDSAVREYIVEWRALQPGSitkfPPHWLRIP-PDNMSALISENIKPYICYEIRVHA 516
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPP--DDGITGYIVGYRVEYREE----GSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ...
gi 568940823   517 LSE 519
Cdd:smart00060  77 VNG 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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