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Conserved domains on  [gi|568941236|ref|XP_006505882|]
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lactosylceramide alpha-2,3-sialyltransferase isoform X3 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 107-316 2.66e-148

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467711  Cd Length: 211  Bit Score: 415.68  E-value: 2.66e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDF 186
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 KWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATH 266
Cdd:cd23983   82 AWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLATH 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941236 267 LCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 316
Cdd:cd23983  162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 107-316 2.66e-148

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 415.68  E-value: 2.66e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDF 186
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 KWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATH 266
Cdd:cd23983   82 AWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLATH 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941236 267 LCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 316
Cdd:cd23983  162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 72-321 2.55e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 272.94  E-value: 2.55e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236   72 KYDPPFgfrkfsSKVQSLLDMLPEhdfPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGN 151
Cdd:pfam00777  17 EWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  152 KTTIRMTYPEGAPLSDV-------EYYANDLFVTVLFKSVDFKWLQAMVKNESLPF-WVRLFFWKQVaeKVPLQPKHFRI 223
Cdd:pfam00777  88 KTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVLF 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  224 LNPVIIKETAFDILQYSEPQSRfwghdknIPTIGVIAVVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVM 303
Cdd:pfam00777 166 LHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGV 238

                         250
                  ....*....|....*...
gi 568941236  304 HNVTTETKFLLKLLKEGV 321
Cdd:pfam00777 239 HDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 107-316 2.66e-148

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 415.68  E-value: 2.66e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDF 186
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 KWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATH 266
Cdd:cd23983   82 AWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLATH 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941236 267 LCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 316
Cdd:cd23983  162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 107-316 5.05e-117

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 336.19  E-value: 5.05e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDF 186
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 KWLQAMVKNESLPFWVrlFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRfwghDKNIPTIGVIAVVLATH 266
Cdd:cd23967   82 LWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNGKQ----GKNVPTTGIIAIVMALH 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941236 267 LCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 316
Cdd:cd23967  156 YCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 72-321 2.55e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 272.94  E-value: 2.55e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236   72 KYDPPFgfrkfsSKVQSLLDMLPEhdfPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGN 151
Cdd:pfam00777  17 EWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  152 KTTIRMTYPEGAPLSDV-------EYYANDLFVTVLFKSVDFKWLQAMVKNESLPF-WVRLFFWKQVaeKVPLQPKHFRI 223
Cdd:pfam00777  88 KTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVLF 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  224 LNPVIIKETAFDILQYSEPQSRfwghdknIPTIGVIAVVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVM 303
Cdd:pfam00777 166 LHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGV 238

                         250
                  ....*....|....*...
gi 568941236  304 HNVTTETKFLLKLLKEGV 321
Cdd:pfam00777 239 HDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 106-316 3.55e-71

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 219.79  E-value: 3.55e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 106 ACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVD 185
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 186 FKWLQAMVKNESlpfwVRLF--FWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYsePQSRFWGHDKNIPTIGVIAVVL 263
Cdd:cd23981   81 FKWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGL--PFNNGLMGRGNIPTLGSVAITM 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568941236 264 ATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 316
Cdd:cd23981  155 ALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 107-316 2.23e-66

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 207.21  E-value: 2.23e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYAND-LFVTVLFKSVD 185
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDtLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 186 FKWLQAMVKNESLpfwVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSrfwghDKNIPTIGVIAVVLAT 265
Cdd:cd23982   82 FYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQRK-----KKQKPTTGLLAITLAL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568941236 266 HLCDEVSLAGFGY-DLSQPRTPLHYFDSQCMGAMHwQVMHNVTTETKFLLKL 316
Cdd:cd23982  154 HLCDEVHIAGFGYpDNGNSNQPIHYYNQITLKSMA-NSGHNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 106-316 8.09e-61

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 193.42  E-value: 8.09e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 106 ACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVD 185
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 186 FKWLQAMVKNESlpfwVRLF-FWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEpqsRFWGHDKNI-PTIGVIAVVL 263
Cdd:cd23984   81 LRWLLDLLMGKK----VSAKgFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPK---RFPKEKKPKhPTTGIIAITL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568941236 264 ATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 316
Cdd:cd23984  154 ALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 72-322 9.78e-40

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 141.24  E-value: 9.78e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  72 KYDPPFGFRKFS-SKVQSLLDML--PEHDFPEHLRA--KACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYS 146
Cdd:cd23964   42 HYKLPFGWGGLNrEVVERLLRNLnlTSSRYMFVLRGgrPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 147 EHVGNKTTIRMTYPEGAPLSDVEYYAND---LFVTVLFKSVDFKWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRI 223
Cdd:cd23964  122 KDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVRL 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 224 LNPviiketafDILQYSepqsrFWGH----DKNIPTIGVIAVVLATHLCDEVSLAGFGYDlsqPRTPLHYFDSQcmgamh 299
Cdd:cd23964  202 LHP--------DFIRYL-----FNRWlnssTSYRPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKT------ 259

                        250       260
                 ....*....|....*....|....*....
gi 568941236 300 WQVM------HNVTTETKFLLKLLKEGVV 322
Cdd:cd23964  260 FVKFtvfyanHDFTNERKLWRKLHEEGII 288
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 35-320 1.36e-34

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 127.40  E-value: 1.36e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  35 CRPRYAKTAMALLFEDRYSINLEPfvqkVPTASEAELKYD--------PPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKA 106
Cdd:cd23966    1 CRRCVQEGGDSDWFDERFNPSIEP----LLTRKNKELPPDvlkwwlslQSSKNSDLREVLEKLFQVVPGENPYRTRDPNR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAplsdVEYYANDLFVTVLFKSVDF 186
Cdd:cd23966   77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHLVLVPFKVLDL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 KWLQAMVKNESLpfwvrLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQysepqsrfwGHDKnIPTIGVIAVVLATH 266
Cdd:cd23966  153 QWLISALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTE---------HHGR-YPSTGFLALIFALH 217

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941236 267 LCDEVSLAGFGYDlSQPRTPlHYFD-SQCMGAMHWQVMHNVTTETKFLLKLLKEG 320
Cdd:cd23966  218 ICDEVSVFGFGAD-SKGNWH-HYWEkNRSAGAFRKTGVHDADFESDIIKKLAKEG 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 110-316 3.80e-32

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 118.62  E-value: 3.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 110 CVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdvEYYANDLFVTVLFKSvdfKWL 189
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAG----FYLRGPRCGCHPLPL---EEE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 190 QAMVKnesLPFWVRLFFWkqVAEKVPLQPKhfrilNPVIIKETAFDILQY---SEPQSR-FWGHDKNIPTIGVIAVVLAT 265
Cdd:cd19952   74 VVLIL---SRAAAADFKR--LKRRKKRHDN-----AVLLLTDPAPDLLSYvrkRLEKLGlKSFFGGNAPSSGLLAVLLAL 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568941236 266 HLCDEVSLAGFGYD-LSQPRTPLHYFDSQCMGAMHWQvmHNVTTETKFLLKL 316
Cdd:cd19952  144 QLCDSVDLYGFGVDsGHAPKVPYHYYDLVEAEEGTAV--HSFDLEAELLRAL 193
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 87-322 1.89e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 97.33  E-value: 1.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  87 QSLLDMLPEHDfpeHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKT--------TIRMT 158
Cdd:cd23963   46 KSLYELLPKTS---PFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 159 YPEGAPLSDVEYYANDLfvtvlfksvdfKWLQAMVkneslpFWVRLFFWKQVAEKVPLQPKHFRILNPVIikETAFDILQ 238
Cdd:cd23963  123 YNSLKKNRDRDKFLNRL-----------KEYNGSI------LWYPKFSFKSSTNLLLKAARALKKNGLNL--TVVYSNPE 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 239 YSEPQSRFWG--HDKNIPTIGVIAVVLATHLCDEVSLAGF---GYDlSQPRT-PLHYFDSqcMGAMHWQVMHNVTTETKF 312
Cdd:cd23963  184 HFLAVQKFWKrrGLEKRPSTGLYLVSLALTFCDEIHLYGFwpfPTD-PNGRPvPYHYYDD--LSPSTKNKVHNMPEEFKL 260

                        250
                 ....*....|
gi 568941236 313 LLKLLKEGVV 322
Cdd:cd23963  261 LRELHKKGVL 270
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 86-279 6.86e-23

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 96.10  E-value: 6.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  86 VQSLLDMLP-EHDFPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEgap 164
Cdd:cd23980   59 IRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE--- 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 165 lSDVEYYANDLFVTVLFKSVDFKWLQAMVKNESLPfwvrlFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQysepqs 244
Cdd:cd23980  136 -SFRELAQNVSMILVPFKTLDLEWVISATTTGTIS-----HTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQ------ 203

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568941236 245 rfwGHDKnIPTIGVIAVVLATHLCDEVSLAGFGYD 279
Cdd:cd23980  204 ---GHGR-YPSTGILSVIFSLHVCDEVDLYGFGAD 234
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 35-323 1.67e-22

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 94.94  E-value: 1.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  35 CRPRYAKTAMALLFEDRYSINLEPFVQKVPTASEAELKY-----DPPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKACKR 109
Cdd:cd23979    3 CRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYwwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 110 CVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdvEYYANDLFVTVLFKSVDFKWL 189
Cdd:cd23979   83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAK----NLPANVSFVLVPFKTLDLLWI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 190 QAMVKNESLPfwvrlFFWKQVAEKVPLQPKHFRILNPVIIKETafdilqysepQSRFWGHDKNIPTIGVIAVVLATHLCD 269
Cdd:cd23979  159 TSALSTGQIR-----FTYAPVKQFLRVDKDKVQIYNPAFFKYI----------HDRWTEHHGRYPSTGMLVLFFALHVCD 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568941236 270 EVSLAGFGYDlsqPRTPLHYF--DSQCMGAMHWQVMHNVTTETKFLLKLLKEGVVE 323
Cdd:cd23979  224 EVNVYGFGAD---SRGNWHHYweNNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIK 276
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 88-322 1.05e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 90.15  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  88 SLLDMLPEHdfpEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplSD 167
Cdd:cd23970   52 NLRSLLPEV---SPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 168 VEYYANDLFvTVLFKSvdfKWLQAMVKNESLPFWVRLFFWKQVAEKvplqpkhFRILNPVIIK-------ETAF--DILQ 238
Cdd:cd23970  124 LEKYYNNLL-TIQDRN---NFFLSLKKLDGAILWIPAFFFHTSATV-------TRTLVDFFVEhrgqlkvQLAWpgNIMQ 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 239 YSepqSRFW----GHDKNIPTiGVIAVVLATHLCDEVSLAGF---GYDLSQPRTPLHYFDSQ-CMGAMHWQVMHNVTTET 310
Cdd:cd23970  193 HV---NRYWktkhLSPKRLST-GILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLPAEF 268

                        250
                 ....*....|..
gi 568941236 311 KFLLKLLKEGVV 322
Cdd:cd23970  269 VLLYKMHGAGVL 280
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 108-325 5.93e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 87.71  E-value: 5.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 108 KRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLSDVEYYANDLFV--TV 179
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRlinsqiLSKPEFNFLTDPLYRNVTLLVwdPS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 180 LFKSVDFKWLqamvKNESLPFWVRLFFWKQVAEKvplqpKHFRILNPVIIKEtAFDILQYSEPQSRFwghdKNIPTIGVI 259
Cdd:cd23968  126 SYNVNLEKWY----KKPDFDFFPNYIKYRRRHPE-----EPFYLIDPRFLWR-LWDILQEYTPEKIK----PNPPSSGFI 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941236 260 AVVLATHLCDEVSLagFGYDLSQPRTPL-HYFDSQC-----MGAmhWqvmHNVTTEtKFLLKLLKEGVVEDL 325
Cdd:cd23968  192 GIVLMLHLCDWVDV--YEYVPSVRQTDRcHYYDVEKdlactLGA--W---HPLAAE-KLLVRHLNVGSDDDI 255
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 91-325 1.19e-19

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 86.68  E-value: 1.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  91 DMLPEHDFPEHLRAkaCKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAP 164
Cdd:cd23985   31 GYLPKKSLREEVGP--LGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 165 LSDVEYYANDLFVtvlfksvdfkWLQAmVKNESLPFWVR----LFF--WKQVAEKVPLQPkhFRILNPVIIKETaFDILQ 238
Cdd:cd23985  109 LKDSLYNEGILIV----------WDPA-PYHSDIPEWYKnpdyNFFenYKTYRRLNPNQP--FYILHPQMQWEL-WDIIQ 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 239 YSEPQSRfwghDKNIPTIGVIAVVLATHLCDEVSLAGFgydL-SQPRTPL-----HYFDSQC-MGAMHwQVMHNvttetK 311
Cdd:cd23985  175 ENSPEEI----QPNPPSSGMLGIILMMTLCDQVDVYEF---LpSKRKTDVchyyqKFFDRACtMGAYH-PLLYE-----K 241

                        250
                 ....*....|....
gi 568941236 312 FLLKLLKEGVVEDL 325
Cdd:cd23985  242 NLVKHLNQGTDEDI 255
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 73-291 6.17e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 85.57  E-value: 6.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  73 YDPPFGFRKFS----SKVQSLLDMLPEHDFPEHLRAKA--CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYS 146
Cdd:cd23973   43 FNPPFGFMGLNytlvKEVVELIPKPKEQQLLALSPPGGdgCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 147 EHVGNKTTI-----------RMTYPE----GAPL-SDVEYyandlfVTVLFKSVDFKWLQAMVKNESLPfwvRLFFWKQV 210
Cdd:cd23973  123 EDVGTRTSFyvhtahsitssLMILQKrgfkNIPQdKDIKY------ILFPEGPRDYQWLEALLKNKTIP---SGAYYGRR 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 211 AEKV---PLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKniPTIGVIAVVLATHLCDEVSLAGF---GYDlsqpR 284
Cdd:cd23973  194 PRSYfsgDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR--PTTGAFLLLTALHLCDTVSAYGFiteDYR----K 267


                 ....*..
gi 568941236 285 TPLHYFD 291
Cdd:cd23973  268 YPDHYYD 274
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 87-323 5.33e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 82.29  E-value: 5.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  87 QSLLDMLPEhdfPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplS 166
Cdd:cd23987   47 QNLYELLPR---TSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP-----S 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 167 DVEYYANDLfvtvlfksVDFKWLQAMVK-----NESLpFWVRLFFWKQVAEKVplqpkhfRILNPVIIK-----ETAFDI 236
Cdd:cd23987  119 VVQRAFEDL--------VNETWKEKFLQrlqslNGSI-LWIPAFMAKGGEERV-------EWVNDLILKhhinvRTAYPS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 237 LQYSEPQSRFWGHDK---NIPTIGVIAVVLATHLCDEVSLAG---FGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTET 310
Cdd:cd23987  183 LRLLHAVRGYWLTNKvhiKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEF 262

                        250
                 ....*....|...
gi 568941236 311 KFLLKLLKEGVVE 323
Cdd:cd23987  263 KALKNLHQQGALK 275
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 87-321 2.56e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 74.76  E-value: 2.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  87 QSLLDMLPEHDfPehLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPls 166
Cdd:cd23969   47 QDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIP-- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 167 dvEYYANDLFVTVLFKSVDfkwlqamvkneslpfwvRLffwKQVAEKVPLQP--------KHFRILNPVIIKE-----TA 233
Cdd:cd23969  122 --HAYGDLVNATDKEKFVE-----------------RL---RQLGDSILWIPafvskggeEHVQWTNEIILKHklnvkTA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 234 FDILQYSEPQSRFWGHDK---NIPTIGVIAVVLATHLCDEVSLAG---FGYDLSQPRTPLHYFDSQCMGAMHWQvmHNVT 307
Cdd:cd23969  180 YPPLRLNHAIRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLTTARP--HKMP 257

                        250
                 ....*....|....
gi 568941236 308 TETKFLLKLLKEGV 321
Cdd:cd23969  258 EEFRALRSLHQRGA 271
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 80-291 3.73e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 74.22  E-value: 3.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  80 RKFSSKVQSLLDMLPEhdfPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVG--------N 151
Cdd:cd23988   40 RRTLNISQNLHSLLPE---VSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdfitmN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 152 KTTIRMTYPEGAPLSDVEYYANDLfvTVLFKSVdfKWLQA-MVKNESlpfwvrlffwkqvaekvplqpKHFRILNPVIIK 230
Cdd:cd23988  117 PSVVQRAFGGFRNESDREKFVHRL--SMLNDSV--LWIPAfMVKGGE---------------------KHVEWVNALILK 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941236 231 -----ETAFDILQYSEPQSRFWGHDK-NI--PTIGVIAVVLATHLCDEVSLAG---FGYDLSQPRTPLHYFD 291
Cdd:cd23988  172 nklkvRTAYPSLRLIHAVRGYWLTNKvNIkrPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYD 243
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 70-322 9.16e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 73.06  E-value: 9.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  70 ELKYDppfGFRKFSSKV-QSLLDMLPEhDFPehLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEgYSEH 148
Cdd:cd23971   32 KIHYE---GERKKTITVnEKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKD 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 149 VGNKT----------TIRMTYPEGAPLSDVE---YYANDLFVTVLFksvdfkwlqAMVKNESLPFwvRLFFwkqVAEKVP 215
Cdd:cd23971  105 VGSKTnlvtanpsilREKFHNLKKRRRPFVErmkVYGNALLLLPAF---------SYTSNTEPSL--RALY---TLEDFG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 216 LQPKHFrILNPviiketafdilQYSEPQSRFWgHDKNIPTI----GVIAVVLATHLCDEVSLAGF---GYDLSQPRTPLH 288
Cdd:cd23971  171 SPQKVL-FFNP-----------EYLRNLSRYW-KSKGLKARrlstGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHH 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 568941236 289 YFDSQCMGamhwQVMHNVTTETKFLLKLLKEGVV 322
Cdd:cd23971  238 YYDNVLPK----KGVHAMPEEFLRYLKLHSQGVL 267
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 72-323 1.12e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 73.32  E-value: 1.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  72 KYDPPFGFRKFSSK-VQSLLDMLPEHD----FPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYS 146
Cdd:cd23972   42 QRKVPYGWKGLSHQvVASTLSLLNDSAnaklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 147 EHVGNKTTIRMTYPEGAPLSDVEYYA---------NDL-FVTVLFKSVDFKWLQAMVKNESLPF-------WVRLFFWKQ 209
Cdd:cd23972  122 EDVGTKTSFYGFTVNTMKNSLISYWNlgftrtpqgQDLqYIFIPSDIRDYVMLRSAILGVPVPEgldkgdrPHKYFGPEA 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 210 VAEKvplqpkhFRILNPVIIKETAFDILQySEPQSRFWGHdKNIPTIGVIAVVLATHLCDEVSLAGFGYDlSQPRTPLHY 289
Cdd:cd23972  202 SAKK-------FKLLHPDFISYLTDRFLK-SKLLNTHYGH-LYMPSTGALMLLTALHTCDQVSAYGFITS-NYWKFSDHY 271

                        250       260       270
                 ....*....|....*....|....*....|....
gi 568941236 290 FDSQcMGAMHWQVMHNVTTETKFLLKLLKEGVVE 323
Cdd:cd23972  272 YERK-KKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 74-325 1.16e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 72.95  E-value: 1.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  74 DPPF---GFRKFSSKVQslLDMLPEHDFpehlrakacKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVG 150
Cdd:cd23986   24 EAPFsalGWEKYVPKIP--LSKLHLRGF---------RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 151 NKTTIRMTYPEgaPLSDVEYYANDlfvTVLFKSVdfkwlqAMVKNESLPFWVRLFFW------------KQVAEKVPLQP 218
Cdd:cd23986   93 NKTTIRIINSQ--ILTNPNHHFID---SSLYKDV------ILVAWDPAPYSANLHKWykkpdynlftpyVQYRKRNPNQP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 219 khFRILNPVIIKETaFDILQYSEPQSRfwghDKNIPTIGVIAVVLATHLCDEVSLagFGYDLSQPRTPL-----HYFDSQ 293
Cdd:cd23986  162 --FYILHPKFIWQL-WDIIQENTQEKI----QPNPPSSGFIGILIMMSMCREVHV--YEYIPSVRQTDLchyheRYYDAA 232

                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941236 294 C-MGAMHwQVMHNvttetKFLLKLLKEGVVEDL 325
Cdd:cd23986  233 CtLGAYH-PLLYE-----KLLIQRMNKGTEDDL 259
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 107-292 3.85e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 67.65  E-value: 3.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMtypegaplsdveyyandlfvtVLFKSVDF 186
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRV---------------------VSHSSLPR 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 KWLQAMVKNESLPFWVRLFFW-------KQVAEKVP----LQPKH----FRILNPVIIKETAFDILQY---SEPQSRFWg 248
Cdd:cd23965   60 LLRNAILLLAGTRAPTVVVFWgpetkmnKDGAGKYNllrsLSKKYpdveFYSLTPEKMDYADELFEKEtgkSRIKSGTW- 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568941236 249 hdknIPTiGVIAVVLATHLCDEVSLAGFGYD-----LSQPRTPLHYFDS 292
Cdd:cd23965  139 ----LST-GWFTMLLALDVCDEIKVYGMVPEnycreHPNSKVPYHYYEP 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 107-322 1.25e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 67.47  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIrMTYPEGAPLSDVEYYANDLFvTVLFKSVDF 186
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSF-YTFSTNTLMNSLRAYAGVGF-NGPPQSKET 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 KWLqamvkneSLPFWVRLFFWKQVA------EKVP-------------LQPKHFRILNPviiketafDILQYSepQSRFW 247
Cdd:cd23974  162 RYI-------FLPDHDRDYLLVKAAlthtpiDRGRdkskrpskyfgkdVTAEKFKIYHP--------DFIRYL--RNRFL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 248 GH------DKNI--PTIGVIAVVLATHLCDEVSLAGF---GYDLSQPrtplHYFDSQcMGAMHWQVMHNVTTETKFLLKL 316
Cdd:cd23974  225 WSpilntkQRDIyrPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSD----HYYDKT-YHKVVFYANHDLRLEMQLWQKL 299


                 ....*.
gi 568941236 317 LKEGVV 322
Cdd:cd23974  300 HKAGLI 305
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 59-304 3.89e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 62.55  E-value: 3.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  59 FVQKVPTASEAELKYD-PPFGFRKFSSKVqslLDMLPEhDFPEHlRAKAcKRCVVVGNGGILHGLELGHALNQFDVVIRL 137
Cdd:cd23990   21 FTTQKNTPLGTKLKYEvDTSGIYHINSEI---FKMFPK-DMPYS-RSQF-KKCAVVGNGGILKNSKCGREIDSADFVFRC 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 138 NSAPV-EGYSEHVGNKTTIRMTYPEgaplsdveyyandlFVTVLFKSVDfKWLQamvkneslPFWVRLffwkQVAEKVP- 215
Cdd:cd23990   95 NLPPIsEKYVRDVGVKTDVVTINPS--------------IITERFHKLE-KWRR--------PFYEVL----QVYENASv 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 216 LQPKHFRILNPVIIKETAFDILQYSEPQ-------------SRFWG----HDKNIPTiGVIAVVLATHLCDEVSLAGFG- 277
Cdd:cd23990  148 VLPAFYNTRNTDVSIRVKYVLDDFESQQavyyfhpqyllnvSRFWLrqgvRAKRISS-GLMLVTAALELCEEVHLYGFWa 226

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568941236 278 --------------YDLSQPRTPLHYFDSQCMGAMHwqvMH 304
Cdd:cd23990  227 fpmnpsgifithhyYDNVKPRPGFHAMPSEIFNFLH---MH 264
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 107-165 1.88e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 57.18  E-value: 1.88e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 165
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPL 59
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 107-291 2.05e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 57.19  E-value: 2.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTypegaplsdveyyANDLFVTVLFKSVDf 186
Cdd:cd23976   15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-------------AHSSIQRILRNRNE- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 kwLQAMVKNESLPFWVRLFFWKQVAEKvpLQPKHFRILNPVIIKETAFDI-----LQYSEPQSRFWGHDKNIP----TIG 257
Cdd:cd23976   81 --LLNVSQGTVFIFWGPSNYMRRDGKG--LVYNNLQLMNQILPKLKVYTItrhkmLQFDELFKRETGKDRKISntwlSTG 156

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568941236 258 VIAVVLATHLCDEVSLAG-----FGYDLSQPRTPLHYFD 291
Cdd:cd23976  157 WFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 107-157 2.30e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 56.79  E-value: 2.30e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRM 157
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 59-322 3.18e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 57.07  E-value: 3.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236  59 FVQKVPTASEAELKYDPPFGfRKFSSKvQSLLDMLPEHdfpEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLN 138
Cdd:cd23991   21 IVSQNNTPLGTNLTYEVEPK-KKILIT-ENIFRMFPKS---QPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCN 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 139 SAPVEG-YSEHVGNKTT--------IRMTYPE----GAP-LSDVEYYANDLFvtvLFKSVDFKwlqamvKNESLPFWVRL 204
Cdd:cd23991   96 LPPTGGnISKDVGSKTNlvtanpsiISIKYAKlnerRKPfLETVSVYGDAFL---LLPAFSYR------SNTALSFKVYY 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 205 FFWKQVAEKVPLqpkhfrILNPVIIKETAfdilqysepqsRFWG----HDKNIPTiGVIAVVLATHLCDEVSLAG---FG 277
Cdd:cd23991  167 TLEDFKAKQKVI------FFHPIYLKHLA-----------QFWRskgvQVYRLST-GLMITSAALELCEEVKLYGfwpFS 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568941236 278 YDLSQPRTPLHYFDSQcmgaMHWQVMHNVTTETKFLLKLLKEGVV 322
Cdd:cd23991  229 KNTEGKPISHHYYDNQ----LPKPGFHSMPKEFYQLLQLHSKGIL 269
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 107-171 3.28e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 53.40  E-value: 3.28e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941236 107 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL--SDVEYY 171
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLllKNPDYF 67
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 108-322 1.43e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 49.06  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 108 KRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPV-EGYSEHVGNKTTIrmtypegaplsdveYYANDLFVTVLFKSVDF 186
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQL--------------VTANPSIIDKRFQNLLW 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941236 187 KwLQAMVknESLPFWVRLFFW-KQVAEKVPLQPKhFRILNPVIIKETAFDILqYSEPQ-----SRFWG----HDKNIPTi 256
Cdd:cd23989  130 S-RKSFV--ESMKVYGRSYIYmPAFSMKTGTDPS-LRVYYTLADVGANQTVL-FANPNflrnvGKFWKskgvHAKRLST- 203

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568941236 257 GVIAVVLATHLCDEVSLAG---FGYDLSQPRTPLHYFDSQcmgaMHWQVMHNVTTETKFLLKLLKEGVV 322
Cdd:cd23989  204 GLFLVSAALGLCEEVTIYGfwpFSVDLDERTISHHYYDNV----LPDSGFHAMPEEFLQLWHLHKSGVL 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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