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Conserved domains on  [gi|568942742|ref|XP_006506608|]
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zinc finger protein 467 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-545 2.14e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 2.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 171 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 247
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 248 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCTQCTRSF------THKQHLVRHQRVHDAASRTRSSPDIPVAPHS 321
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 322 PTASLTPSPPGPKPFAcSHCGQSFGwKKNLATHQSLHLTEGRPFGCDECALGTNVDPAAEPSACTPHAPDCGPGSGP--A 399
Cdd:COG5048  196 IPSSSENSPLSSSYSI-PSSSSDQN-LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSqsS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 400 APQRTTSSERSFF-----CPDCGRGFAHGQHLARHRR--VHTGE--RPFAC--AQCGRRFGSRPNLVAHSRAHSGARPFA 468
Cdd:COG5048  274 SPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 469 C--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARCFSSKTNLVRHQAIHTGSRP--FSCPQCAKSFSRKTH 537
Cdd:COG5048  354 EklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433


                 ....*...
gi 568942742 538 LVRHQRIH 545
Cdd:COG5048  434 LIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-545 2.14e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 2.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 171 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 247
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 248 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCTQCTRSF------THKQHLVRHQRVHDAASRTRSSPDIPVAPHS 321
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 322 PTASLTPSPPGPKPFAcSHCGQSFGwKKNLATHQSLHLTEGRPFGCDECALGTNVDPAAEPSACTPHAPDCGPGSGP--A 399
Cdd:COG5048  196 IPSSSENSPLSSSYSI-PSSSSDQN-LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSqsS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 400 APQRTTSSERSFF-----CPDCGRGFAHGQHLARHRR--VHTGE--RPFAC--AQCGRRFGSRPNLVAHSRAHSGARPFA 468
Cdd:COG5048  274 SPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 469 C--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARCFSSKTNLVRHQAIHTGSRP--FSCPQCAKSFSRKTH 537
Cdd:COG5048  354 EklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433


                 ....*...
gi 568942742 538 LVRHQRIH 545
Cdd:COG5048  434 LIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-236 2.62e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.62e-05
                          10        20
                  ....*....|....*....|....*.
gi 568942742  211 HLTRHLRTHTGERPYPCAECGKRFSQ 236
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-545 2.14e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 2.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 171 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 247
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 248 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCTQCTRSF------THKQHLVRHQRVHDAASRTRSSPDIPVAPHS 321
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 322 PTASLTPSPPGPKPFAcSHCGQSFGwKKNLATHQSLHLTEGRPFGCDECALGTNVDPAAEPSACTPHAPDCGPGSGP--A 399
Cdd:COG5048  196 IPSSSENSPLSSSYSI-PSSSSDQN-LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSqsS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 400 APQRTTSSERSFF-----CPDCGRGFAHGQHLARHRR--VHTGE--RPFAC--AQCGRRFGSRPNLVAHSRAHSGARPFA 468
Cdd:COG5048  274 SPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 469 C--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARCFSSKTNLVRHQAIHTGSRP--FSCPQCAKSFSRKTH 537
Cdd:COG5048  354 EklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433


                 ....*...
gi 568942742 538 LVRHQRIH 545
Cdd:COG5048  434 LIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-572 1.34e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 251 RPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCTQCT----RSFTHKQHlvRHQRVHDAASRTRSSPDIPVAPHSPTASL 326
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdksFSRPLELS--RHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 327 TPSPP--GPKPFACSHCGQSFGWKKNLA--THQSLHLTEGRPFGCDECALGTNVDPAAEPSACTPHAPDCGPGSGPAAPQ 402
Cdd:COG5048  110 LSSSSsnSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 403 -RTTSSERSFFCPDCGRGFAHGQHLARHRRVHTGERPFACAQCGRRFGSRPNLVAHSRAHSGARPFACAQCGR------R 475
Cdd:COG5048  190 sNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRsslptaS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 476 FSRKSHLGRHQAVHTG-SRPHACAVCARCFSSKTNLVRHQ--AIHTGS--RPFSCP--QCAKSFSRKTHLVRHQRIHGDa 548
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS- 348

                        330       340
                 ....*....|....*....|....
gi 568942742 549 ALPAPASNLSAPAWSNPSEVVPPP 572
Cdd:COG5048  349 ISPAKEKLLNSSSKFSPLLNNEPP 372
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-236 2.62e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.62e-05
                          10        20
                  ....*....|....*....|....*.
gi 568942742  211 HLTRHLRTHTGERPYPCAECGKRFSQ 236
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-292 1.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 568942742  267 HLIRHQRIHTGERPYQCTQCTRSFTH 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 7.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 568942742  509 NLVRHQAIHTGSRPFSCPQCAKSFSR 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 197-219 9.36e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 9.36e-04
                          10        20
                  ....*....|....*....|...
gi 568942742  197 FPCSECDKRFSKKAHLTRHLRTH 219
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-262 3.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.47e-03
                          10        20
                  ....*....|....*....|.
gi 568942742  242 SHQKTHTGERPFPCTECEKRF 262
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 281-303 4.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.04e-03
                          10        20
                  ....*....|....*....|...
gi 568942742  281 YQCTQCTRSFTHKQHLVRHQRVH 303
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-208 4.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 568942742  183 HMLLHQRSHRGERPFPCSECDKRFSK 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 253-275 4.45e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.45e-03
                          10        20
                  ....*....|....*....|...
gi 568942742  253 FPCTECEKRFRKKTHLIRHQRIH 275
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 523-545 4.96e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.96e-03
                          10        20
                  ....*....|....*....|...
gi 568942742  523 FSCPQCAKSFSRKTHLVRHQRIH 545
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-299 5.25e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 168 PCACPDCGRSFTQRAHMLLHQRS--HRGE--RPFPCSE--CDKRFSKKAHLTRHLRTHTGERPYPC-------------- 227
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfsplln 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942742 228 -----------------------AECGKRFSQKIHLGSHQKTHTGERP--FPCTECEKRFRKKTHLIRHQRIHTGERPYQ 282
Cdd:COG5048  369 neppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 568942742 283 CtQCTRSFTHKQHLVRH 299
Cdd:COG5048  449 C-SILKSFRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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