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Conserved domains on  [gi|568949506|ref|XP_006507348|]
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coronin-1A isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-461 1.06e-114

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 346.11  E-value: 1.06e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506   9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFMALICEASGGGAflVLPLGKTGRVDKNVPLVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAV 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 168 LTLgpDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDrPHEGTRPVHAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 327 LEVNKCEIARFYKLHERKCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 405 RVNRGLDSARRRaTPEPSGT----------------------PSSDTVSRLEEDV-----RNLNAI---VQKLQERLDRL 454
Cdd:PTZ00421 394 ELMGASALSPSG-KPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGIlderlGRLQALsekLRTQHEEIKRC 472


                 ....*..
gi 568949506 455 EETVQAK 461
Cdd:PTZ00421 473 REALQKK 479
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-461 1.06e-114

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 346.11  E-value: 1.06e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506   9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFMALICEASGGGAflVLPLGKTGRVDKNVPLVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAV 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 168 LTLgpDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDrPHEGTRPVHAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 327 LEVNKCEIARFYKLHERKCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 405 RVNRGLDSARRRaTPEPSGT----------------------PSSDTVSRLEEDV-----RNLNAI---VQKLQERLDRL 454
Cdd:PTZ00421 394 ELMGASALSPSG-KPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGIlderlGRLQALsekLRTQHEEIKRC 472


                 ....*..
gi 568949506 455 EETVQAK 461
Cdd:PTZ00421 473 REALQKK 479
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 2.10e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 2.10e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568949506    4 QVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-302 2.53e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 2.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  78 CGHTAPVLDIAWCPHnDNVIASGSEDCTVMVWEIPDGglvlplrEPVITLEGHTKRVGIVAWHPTAQnVLLSAGCDNVIL 157
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 158 VWDVGTGAAVLTLGPdvHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEkdrpHEG-TRPVHAVFVS--EGKI 234
Cdd:cd00200  119 VWDVETGKCLTTLRG--HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGhTGEVNSVAFSpdGEKL 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568949506 235 LTTGfsrmSERQVALWDTKhleeplSLQELDTSSGVLLPF----FDPDTNIVyLCGKGDSSIRYFEITSEAP 302
Cdd:cd00200  193 LSSS----SDGTIKLWDLS------TGKCLGTLRGHENGVnsvaFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
79-293 3.70e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 3.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglvlplrEPVITLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319  202 GHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRL 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 159 WDVGTGAAVLTLGPdvHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVaekdRPHEG-TRPVHAV-FVSEGKILT 236
Cdd:COG2319  273 WDLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL----RTLTGhTGAVRSVaFSPDGKTLA 346

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568949506 237 TGFsrmSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVYLCGkGDSSIR 293
Cdd:COG2319  347 SGS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 4.01e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.01e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568949506    79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-461 1.06e-114

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 346.11  E-value: 1.06e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506   9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFMALICEASGGGAflVLPLGKTGRVDKNVPLVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAV 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 168 LTLgpDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDrPHEGTRPVHAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 327 LEVNKCEIARFYKLHERKCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 405 RVNRGLDSARRRaTPEPSGT----------------------PSSDTVSRLEEDV-----RNLNAI---VQKLQERLDRL 454
Cdd:PTZ00421 394 ELMGASALSPSG-KPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGIlderlGRLQALsekLRTQHEEIKRC 472


                 ....*..
gi 568949506 455 EETVQAK 461
Cdd:PTZ00421 473 REALQKK 479
PTZ00420 PTZ00420
coronin; Provisional
 18-394 2.57e-67

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 225.21  E-value: 2.57e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  18 PAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRvdkNVPLVC--GHTAPVLDIAWCPHNDN 95
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  96 VIASGSEDCTVMVWEIP-DGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLgpdV 174
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI---N 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 175 HPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVvAEKDRPHEGTRPVHAVFV-----SEGKILTTGFSRMSERQVAL 249
Cdd:PTZ00420 166 MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 250 WDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRGLEV 329
Cdd:PTZ00420 245 WDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDV 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568949506 330 NKCEIARFYK-LHERKCEPIAMTVPRK-SDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKD 394
Cdd:PTZ00420 323 YKCEIGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD 389
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 2.10e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 2.10e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568949506    4 QVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-302 2.53e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 2.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  78 CGHTAPVLDIAWCPHnDNVIASGSEDCTVMVWEIPDGglvlplrEPVITLEGHTKRVGIVAWHPTAQnVLLSAGCDNVIL 157
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 158 VWDVGTGAAVLTLGPdvHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEkdrpHEG-TRPVHAVFVS--EGKI 234
Cdd:cd00200  119 VWDVETGKCLTTLRG--HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGhTGEVNSVAFSpdGEKL 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568949506 235 LTTGfsrmSERQVALWDTKhleeplSLQELDTSSGVLLPF----FDPDTNIVyLCGKGDSSIRYFEITSEAP 302
Cdd:cd00200  193 LSSS----SDGTIKLWDLS------TGKCLGTLRGHENGVnsvaFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
79-293 3.70e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 3.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglvlplrEPVITLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319  202 GHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRL 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 159 WDVGTGAAVLTLGPdvHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVaekdRPHEG-TRPVHAV-FVSEGKILT 236
Cdd:COG2319  273 WDLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL----RTLTGhTGAVRSVaFSPDGKTLA 346

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568949506 237 TGFsrmSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVYLCGkGDSSIR 293
Cdd:COG2319  347 SGS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
79-303 3.53e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 3.53e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglvlplrEPVITLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319  118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 159 WDVGTGAAVLTLgpDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAekdRPHEGTRPVHAVFVS-EGKILTT 237
Cdd:COG2319  189 WDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSpDGRLLAS 263

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568949506 238 GfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVyLCGKGDSSIRYFEITSEAPF 303
Cdd:COG2319  264 G---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-296 1.62e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 1.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  79 GHTAPVLDIAWCPHNDnVIASGSEDCTVMVWEIPDGglvlplrEPVITLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:cd00200   91 GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 159 WDVGTGAAVLTLgpDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKdRPHEGtrPVHAV-FVSEGKILTT 237
Cdd:cd00200  162 WDLRTGKCVATL--TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHEN--GVNSVaFSPDGYLLAS 236

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568949506 238 GFsrmSERQVALWDTKHLEEPLSLQEldTSSGVLLPFFDPDTNIVYLCGKgDSSIRYFE 296
Cdd:cd00200  237 GS---EDGTIRVWDLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSA-DGTIRIWD 289
Trimer_CC pfam08954
trimerization motif; This domain is predominantly found in the structural protein coronin, and ...
 410-461 2.31e-27

trimerization motif; This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It appears to have the function of stabilising the topology of short coiled-coils in proteins.


Pssm-ID: 462646  Cd Length: 52  Bit Score: 103.47  E-value: 2.31e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568949506  410 LDSARRRATPEPSGTPSSDTVSRLEEDVRNLNAIVQKLQERLDRLEETVQAK 461
Cdd:pfam08954   1 LDSGRRRATPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK 52
WD40 COG2319
WD40 repeat [General function prediction only];
79-202 2.66e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 2.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglvlplrEPVITLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319  286 GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRL 356

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568949506 159 WDVGTGAAVLTLgpDVHPDTIYSVDWSRDGALICTSCRDKRVRV 202
Cdd:COG2319  357 WDLATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 345-387 7.82e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 82.18  E-value: 7.82e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568949506  345 CEPIAMTVPRKS-DLFQEDLYPPTAGPDPALTAEEWLGGRDAGP 387
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-299 8.79e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 8.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 123 PVITLEGHTKRVGIVAWHPTaQNVLLSAGCDNVILVWDVGTGAAVLTLGpdVHPDTIYSVDWSRDGALICTSCRDKRVRV 202
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 203 IEPRKGTVVAEKdRPHEGtrPVHAV-FVSEGKILTTGfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNI 281
Cdd:cd00200   78 WDLETGECVRTL-TGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTF 149

                        170
                 ....*....|....*...
gi 568949506 282 VYlCGKGDSSIRYFEITS 299
Cdd:cd00200  150 VA-SSSQDGTIKLWDLRT 166
WD40 COG2319
WD40 repeat [General function prediction only];
79-163 2.61e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 2.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGGLVLplrepviTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319  328 GHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLR-------TLTGHTGAVTSVAFSPDGR-TLASGSADGTVRL 398


                 ....*
gi 568949506 159 WDVGT 163
Cdd:COG2319  399 WDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 4.01e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.01e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568949506    79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 121-160 2.88e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.88e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568949506   121 REPVITLEGHTKRVGIVAWHPTaQNVLLSAGCDNVILVWD 160
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
79-110 6.79e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.79e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568949506   79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:pfam00400   9 GHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
121-160 3.50e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.50e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568949506  121 REPVITLEGHTKRVGIVAWHPTaQNVLLSAGCDNVILVWD 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
116-262 4.66e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 4.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 116 LVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGcDNVILVWDVGTGAAVLTLGPdvHPDTIYSVDWSRDGALICTSC 195
Cdd:COG2319   21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAG-DLTLLLLDAAAGALLATLLG--HTAAVLSVAFSPDGRLLASAS 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568949506 196 RDKRVRVIEPRKGTVVAEkDRPHEGtrPVHAVFVS-EGKILTTGFsrmSERQVALWDTKHLEEPLSLQ 262
Cdd:COG2319   98 ADGTVRLWDLATGLLLRT-LTGHTG--AVRSVAFSpDGKTLASGS---ADGTVRLWDLATGKLLRTLT 159
WD40 pfam00400
WD domain, G-beta repeat;
175-202 6.49e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 6.49e-04
                          10        20
                  ....*....|....*....|....*...
gi 568949506  175 HPDTIYSVDWSRDGALICTSCRDKRVRV 202
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-202 9.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 9.57e-04
                           10        20
                   ....*....|....*....|....*...
gi 568949506   175 HPDTIYSVDWSRDGALICTSCRDKRVRV 202
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
133-292 1.46e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 133 RVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDG-ALICTSCRDKRVRVIEPRKGTVV 211
Cdd:COG3391   24 AVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGrRLYVANSGSGRVSVIDLATGKVV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 212 AEKDrphEGTRPVHAVFVSEGKIL--TTGFSRmserQVALWDTKHLEEPLSLQELDTSSGVLlpfFDPDTNIVYLCGKGD 289
Cdd:COG3391  104 ATIP---VGGGPRGLAVDPDGGRLyvADSGNG----RVSVIDTATGKVVATIPVGAGPHGIA---VDPDGKRLYVANSGS 173


                 ...
gi 568949506 290 SSI 292
Cdd:COG3391  174 NTV 176
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
27-235 7.72e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 7.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506  27 DVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAwcpHNDNVIASGSEDCTV 106
Cdd:COG3391   16 LALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGA---DGRRLYVANSGSGRV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949506 107 MVWEIPDGGLVlplrePVITLEGHTKRVgivAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPdtiYSVDWSR 186
Cdd:COG3391   93 SVIDLATGKVV-----ATIPVGGGPRGL---AVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP---HGIAVDP 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568949506 187 DG-ALICTSCRDKR----VRVIEPRKGTVVAekdRPHEGTRPVHAVFVSEGKIL 235
Cdd:COG3391  162 DGkRLYVANSGSNTvsviVSVIDTATGKVVA---TIPVGGGPVGVAVSPDGRRL 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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