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Conserved domains on  [gi|568952670|ref|XP_006508563|]
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mucin-5AC isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 895-1054 4.58e-42

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 152.94  E-value: 4.58e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    895 WQCTDKPCLATCAVYGDGHYITFDGQRYSFNGDCEYTLLQDNcggngSSQDAFRVITENIPCGTTGtTCSKSIKIFLGNY 974
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-----SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    975 ELKLSDSKMEVVQKDVGQEPPYF-------VHQMGNYLVVETDIGLV-LLWDKKTSIFLRLSPEFKGRVCGLCGNFDDNA 1046
Cdd:smart00216   75 EIELKDDNGKVTVNGQQVSLPYKtsdgsiqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*...
gi 568952670   1047 INDFTTRS 1054
Cdd:smart00216  155 EDDFRTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 2707-2875 7.33e-38

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 141.00  E-value: 7.33e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   2707 CCQHYQCQCVCSGWGDPHYITFDGTYYTFLDNCTYVLVQQIvPVFGYFRVLIDNYYCdvGDSVSCPQSIIVEYHQDRVVL 2786
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-SSEPTFSVLLKNVPC--GGGATCLKSVKVELNGDEIEL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   2787 TRRpvsgvmTNQIIFNNKVVS-PGFQQNGIVTSRVGIKMYVTIQEIGV-RVMFSGLI-FSVEVPFnLFANNTEGQCGTCT 2863
Cdd:smart00216   79 KDD------NGKVTVNGQQVSlPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTlLSVQLPS-KYRGKTCGLCGNFD 151

                           170
                    ....*....|..
gi 568952670   2864 NDKKDECRLPGG 2875
Cdd:smart00216  152 GEPEDDFRTPDG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 426-590 1.28e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 125.98  E-value: 1.28e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    426 WSCQDIPCAGTCSVMGGSHMSTFDGRQYTVHGDCTYVLSKPCDSN-AFTVLVELRKCGltESETCLKTVTLNLgGGQTEI 504
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEpTFSVLLKNVPCG--GGATCLKSVKVEL-NGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    505 MVKATGEVFVNQIYTQLPVSTANATF-FRPSTFFIVGETNLGLqLEIQLSPIMQTSVRLKPGLRGLTCGLCGNFNSMQAD 583
Cdd:smart00216   78 LKDDNGKVTVNGQQVSLPYKTSDGSIqIRSSGGYLVVITSLGL-IQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 568952670    584 DFQTISG 590
Cdd:smart00216  157 DFRTPDG 163
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1610-1696 2.58e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.20  E-value: 2.58e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1610 WTNWLDGSYPgSGRNSGDFDTFVNLRSKGyKFCEKPRNVECRAQFFPNTPLEELGQNVTCSREEGLICLNKNQLPPMCYN 1689
Cdd:pfam13330    1 WTPWFDVDNP-SGSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  1690 YEIRIEC 1696
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2281-2367 2.58e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.20  E-value: 2.58e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2281 WTNWLDGSYPgSGRNSGDFDTFVNLRSKGyKFCEKPRNVECRAQFFPNTPLEELGQNVTCSREEGLICLNKNQLPPMCYN 2360
Cdd:pfam13330    1 WTPWFDVDNP-SGSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  2361 YEIRIEC 2367
Cdd:pfam13330   79 YEVRFLC 85
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 77-230 1.36e-28

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 114.42  E-value: 1.36e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670     77 PGHTRRVCSTWGNFHYKTFDGQVFYFPGLCNYVFSAHCGDaYEDFNIQLRRVQESNTTT-LSRVTMKLDGLVVELTKS-- 153
Cdd:smart00216    5 QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS-EPTFSVLLKNVPCGGGATcLKSVKVELNGDEIELKDDng 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    154 SVLVNNHPVQLPFSQSGVLIEL--SNGYLKVVARLGLLFV-WNEDDSLLLELDTKYTNKTCGLCGDFNGSPKsNEFLSNN 230
Cdd:smart00216   84 KVTVNGQQVSLPYKTSDGSIQIrsSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPE-DDFRTPD 162
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1400-1486 1.97e-27

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 107.81  E-value: 1.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1400 WSPWMDVSRPGrGIDSGDFDTLENLRAHGyPICQVPKAVECRAEASPGVPLPELQQHLECSTTVGLICYNSDQLSGLCDN 1479
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  1480 YQIKVQC 1486
Cdd:pfam13330   79 YEVRFLC 85
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 627-697 6.45e-27

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 106.27  E-value: 6.45e-27
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952670    627 EKYAQHWCSLLTNASGPFSQCHATVNPSTFFSNCMYDTCNCEKSEDCMCAALSSYVRACAAKGVLLSDWRD 697
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1091-1165 1.36e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 99.72  E-value: 1.36e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670   1091 KSWAQKQCSIINSE--TFSACHAHVEPAKYYEACVNDACACdsGGDCECFCTTVAAYAQACHEVGVCVS-WRTPDICP 1165
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2442-2532 1.87e-24

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 99.33  E-value: 1.87e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2442 WTKWFDTDFPVpGPHGGDLETYSNIERSGeRLCHREeiTQLQCRAKNYPEREMEDLGQVVKCDPSVGLVCNNRDQGGDsg 2521
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENP--TDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD-- 74

                           90
                   ....*....|.
gi 568952670  2522 MCLNYEVRLLC 2532
Cdd:pfam13330   75 GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1771-1861 1.87e-24

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 99.33  E-value: 1.87e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1771 WTKWFDTDFPVpGPHGGDLETYSNIERSGeRLCHREeiTQLQCRAKNYPEREMEDLGQVVKCDPSVGLVCNNRDQGGDsg 1850
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENP--TDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD-- 74

                           90
                   ....*....|.
gi 568952670  1851 MCLNYEVRLLC 1861
Cdd:pfam13330   75 GCLDYEVRFLC 85
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 268-337 3.73e-16

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 75.11  E-value: 3.73e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   268 ICEMILKGELFSGCAALVDISSYVEACRQDVCLCEslDPSDCICHTLAEYSRQCAHAGGQPQDWRGPNLC 337
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCG--GDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 3312-3384 3.25e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


:

Pssm-ID: 214482  Cd Length: 82  Bit Score: 70.12  E-value: 3.25e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568952670   3312 NCSSEGpVSISYCQGNCGDSismYSLEANKVEHTCECCQELQTSQRNVTLRCDDGSSQTFSYTQVEKCGCLGQ 3384
Cdd:smart00041   12 GCTSVT-VKNAFCEGKCGSA---SSYSIQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 341-397 6.77e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 6.77e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568952670  341 CPLNMQHQECGSPCVDTCSNPQHSQVCEDHCIAGCFCPEGMVLDDINQmgCVPVSQC 397
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGK--CVPPSQC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2920-2983 2.36e-11

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 61.63  E-value: 2.36e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568952670  2920 LCELILSNT-FKLCHDVIPPLQFYQGCLFDYCHM-LDLEVVCSGLELYASLCAAQGVCI-PWRSQTN 2983
Cdd:pfam08742    1 KCGLLSDSGpFAPCHSVVDPEPYFEACVYDMCSCgGDDECLCAALAAYARACQAAGVCIgDWRTPTF 67
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 805-866 2.68e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 44.23  E-value: 2.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568952670  805 CDAPMIYFDChnatpgdtGAGCQKSCHTLD--MTCySSECVPGCVCPNGLVADGNGGCVVTEDC 866
Cdd:cd19941     1 CPPNEVYSEC--------GSACPPTCANPNapPPC-TKQCVEGCFCPEGYVRNSGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 707-764 1.63e-04

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 41.92  E-value: 1.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670  707 CPKSMTYQYHISTCQPTCRALNEkDVTCHVSFIPvdGCTCPKGTFLDDLGKCVQATSC 764
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNA-PPPCTKQCVE--GCFCPEGYVRNSGGKCVPPSQC 55
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1869-2227 3.53e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 3.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1869 SMTTHVTLLSSTSEIVTSS---------TPGTT-----SMHVASSTSMPQTSSPNTgktstiSTTQTSSPNTGKTSTTST 1934
Cdd:pfam05109  413 TTTTHKVIFSKAPESTTTSptlnttgfaAPNTTtglpsSTHVPTNLTAPASTGPTV------STADVTSPTPAGTTSGAS 486

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1935 TQTSSPNTGKTSTISTTQTSSPNTGKASTPsTPHTSSPNTGktstistTQTSSPNTgktsttsttqtSSPNTGKTSTIST 2014
Cdd:pfam05109  487 PVTPSPSPRDNGTESKAPDMTSPTSAVTTP-TPNATSPTPA-------VTTPTPNA-----------TSPTLGKTSPTSA 547

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2015 TQTSSPNTGK---ASTPSTPHTSSPNTGKTSTisttqtsspnTGKASTPsTPQTSSPNTGKTSTISTTQtsspNTGKGST 2091
Cdd:pfam05109  548 VTTPTPNATSptpAVTTPTPNATIPTLGKTSP----------TSAVTTP-TPNATSPTVGETSPQANTT----NHTLGGT 612

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2092 PSTPQTSSPNTGKTSTIsttqtsspNTGKTSTTSTTQtsspNTGKTSTISTTQTSSPNTGKASTPSTPHTSS--PNTGKT 2169
Cdd:pfam05109  613 SSTPVVTSPPKNATSAV--------TTGQHNITSSST----SSMSLRPSSISETLSPSTSDNSTSHMPLLTSahPTGGEN 680

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568952670  2170 STISTTQTSSPNTGKASTPST-PQTSSPNTGKTSTISTTQTSSPNTGKGSTP---STPQTSS 2227
Cdd:pfam05109  681 ITQVTPASTSTHHVSTSSPAPrPGTTSQASGPGNSSTSTKPGEVNVTKGTPPknaTSPQAPS 742
PHA02682 super family cl31817
ORF080 virion core protein; Provisional
 2980-3130 4.16e-04

ORF080 virion core protein; Provisional


The actual alignment was detected with superfamily member PHA02682:

Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 45.24  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670 2980 SQTNNTCSFTCPDNQVYQPCGPSNPhycyrDDSISP--SLTLQEAGPKTEgcfcpdsTTLFSTNDSICVPSCQWCLGPRG 3057
Cdd:PHA02682   19 ADTSSSLFTKCPQATIPAPAAPCPP-----DADVDPldKYSVKEAGRYYQ-------SRLKANSACMQRPSGQSPLAPSP 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670 3058 EPVEPGHTISIDCQDCICKEATLTCQKKACP---QPTCPEPGFVPVPVAleagqccPQFSCACNSSHCP--PPLHCPK 3130
Cdd:PHA02682   87 ACAAPAPACPACAPAAPAPAVTCPAPAPACPpatAPTCPPPAVCPAPAR-------PAPACPPSTRQCPpaPPLPTPK 157
 
Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 895-1054 4.58e-42

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 152.94  E-value: 4.58e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    895 WQCTDKPCLATCAVYGDGHYITFDGQRYSFNGDCEYTLLQDNcggngSSQDAFRVITENIPCGTTGtTCSKSIKIFLGNY 974
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-----SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    975 ELKLSDSKMEVVQKDVGQEPPYF-------VHQMGNYLVVETDIGLV-LLWDKKTSIFLRLSPEFKGRVCGLCGNFDDNA 1046
Cdd:smart00216   75 EIELKDDNGKVTVNGQQVSLPYKtsdgsiqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*...
gi 568952670   1047 INDFTTRS 1054
Cdd:smart00216  155 EDDFRTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 2707-2875 7.33e-38

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 141.00  E-value: 7.33e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   2707 CCQHYQCQCVCSGWGDPHYITFDGTYYTFLDNCTYVLVQQIvPVFGYFRVLIDNYYCdvGDSVSCPQSIIVEYHQDRVVL 2786
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-SSEPTFSVLLKNVPC--GGGATCLKSVKVELNGDEIEL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   2787 TRRpvsgvmTNQIIFNNKVVS-PGFQQNGIVTSRVGIKMYVTIQEIGV-RVMFSGLI-FSVEVPFnLFANNTEGQCGTCT 2863
Cdd:smart00216   79 KDD------NGKVTVNGQQVSlPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTlLSVQLPS-KYRGKTCGLCGNFD 151

                           170
                    ....*....|..
gi 568952670   2864 NDKKDECRLPGG 2875
Cdd:smart00216  152 GEPEDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 906-1054 1.77e-33

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 127.87  E-value: 1.77e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   906 CAVYGDGHYITFDGQRYSFNGDCEYTLLQDnCGGNgsSQDAFRVITENIPCGTTGTtCSKSIKIFLGNYELKLSDSKMEV 985
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD-CSEE--PDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670   986 V-QKDVgqEPPYF-----VHQMGNY---LVVETDIGLVLLWDKKTSIFLRLSPEFKGRVCGLCGNFDDNAINDFTTRS 1054
Cdd:pfam00094   77 VnGQKV--SLPYKsdggeVEILGSGfvvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 426-590 1.28e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 125.98  E-value: 1.28e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    426 WSCQDIPCAGTCSVMGGSHMSTFDGRQYTVHGDCTYVLSKPCDSN-AFTVLVELRKCGltESETCLKTVTLNLgGGQTEI 504
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEpTFSVLLKNVPCG--GGATCLKSVKVEL-NGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    505 MVKATGEVFVNQIYTQLPVSTANATF-FRPSTFFIVGETNLGLqLEIQLSPIMQTSVRLKPGLRGLTCGLCGNFNSMQAD 583
Cdd:smart00216   78 LKDDNGKVTVNGQQVSLPYKTSDGSIqIRSSGGYLVVITSLGL-IQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 568952670    584 DFQTISG 590
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 437-591 3.77e-32

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 124.02  E-value: 3.77e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   437 CSVMGGSHMSTFDGRQYTVHGDCTYVLSKPCDSN-AFTVLVELRKCGLTESETCLKTVTLNLGGgqTEIMVKATGEVFVN 515
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEpDFSFSVTNKNCNGGASGVCLKSVTVIVGD--LEITLQKGGTVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568952670   516 QIYTQLPVSTANATFFRPSTFFIVGETNLGLQLEIQLSPIMQTSVRLKPGLRGLTCGLCGNFNSMQADDFQTISGV 591
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1610-1696 2.58e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.20  E-value: 2.58e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1610 WTNWLDGSYPgSGRNSGDFDTFVNLRSKGyKFCEKPRNVECRAQFFPNTPLEELGQNVTCSREEGLICLNKNQLPPMCYN 1689
Cdd:pfam13330    1 WTPWFDVDNP-SGSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  1690 YEIRIEC 1696
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2281-2367 2.58e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.20  E-value: 2.58e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2281 WTNWLDGSYPgSGRNSGDFDTFVNLRSKGyKFCEKPRNVECRAQFFPNTPLEELGQNVTCSREEGLICLNKNQLPPMCYN 2360
Cdd:pfam13330    1 WTPWFDVDNP-SGSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  2361 YEIRIEC 2367
Cdd:pfam13330   79 YEVRFLC 85
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 77-230 1.36e-28

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 114.42  E-value: 1.36e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670     77 PGHTRRVCSTWGNFHYKTFDGQVFYFPGLCNYVFSAHCGDaYEDFNIQLRRVQESNTTT-LSRVTMKLDGLVVELTKS-- 153
Cdd:smart00216    5 QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS-EPTFSVLLKNVPCGGGATcLKSVKVELNGDEIELKDDng 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    154 SVLVNNHPVQLPFSQSGVLIEL--SNGYLKVVARLGLLFV-WNEDDSLLLELDTKYTNKTCGLCGDFNGSPKsNEFLSNN 230
Cdd:smart00216   84 KVTVNGQQVSLPYKTSDGSIQIrsSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPE-DDFRTPD 162
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 2717-2876 1.92e-27

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 110.54  E-value: 1.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2717 CSGWGDPHYITFDGTYYTFLDNCTYVLVQQIVPVFGyFRVLIDNYYCDVGDSVSCPQSIIVEYHQDRVVLTRRpvsgvmt 2796
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKG------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2797 NQIIFNNKVVSPGFQQNGIVTSRVGIKMYVTIQEIGVRVMFSG---LIFSVEVPFNlFANNTEGQCGTCTNDKKDECRLP 2873
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGdgrGQLFVTLSPS-YQGKTCGLCGNYNGNQEDDFMTP 151


                   ...
gi 568952670  2874 GGS 2876
Cdd:pfam00094  152 DGT 154
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1400-1486 1.97e-27

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 107.81  E-value: 1.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1400 WSPWMDVSRPGrGIDSGDFDTLENLRAHGyPICQVPKAVECRAEASPGVPLPELQQHLECSTTVGLICYNSDQLSGLCDN 1479
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  1480 YQIKVQC 1486
Cdd:pfam13330   79 YEVRFLC 85
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 627-697 6.45e-27

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 106.27  E-value: 6.45e-27
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952670    627 EKYAQHWCSLLTNASGPFSQCHATVNPSTFFSNCMYDTCNCEKSEDCMCAALSSYVRACAAKGVLLSDWRD 697
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 84-228 6.97e-27

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 109.00  E-value: 6.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    84 CSTWGNFHYKTFDGQVFYFPGLCNYVFSAHCGDAYED-FNIQLRRVQESNTTT-LSRVTMKLDGLVVELTKS-SVLVNNH 160
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFsFSVTNKNCNGGASGVcLKSVTVIVGDLEITLQKGgTVLVNGQ 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952670   161 PVQLPFSQSGVLIELSNGYLKVVAR---LGLLFVWNEDDSLLLELDTKYTNKTCGLCGDFNGSPkSNEFLS 228
Cdd:pfam00094   81 KVSLPYKSDGGEVEILGSGFVVVDLspgVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQ-EDDFMT 150
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1091-1165 1.36e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 99.72  E-value: 1.36e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670   1091 KSWAQKQCSIINSE--TFSACHAHVEPAKYYEACVNDACACdsGGDCECFCTTVAAYAQACHEVGVCVS-WRTPDICP 1165
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2442-2532 1.87e-24

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 99.33  E-value: 1.87e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2442 WTKWFDTDFPVpGPHGGDLETYSNIERSGeRLCHREeiTQLQCRAKNYPEREMEDLGQVVKCDPSVGLVCNNRDQGGDsg 2521
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENP--TDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD-- 74

                           90
                   ....*....|.
gi 568952670  2522 MCLNYEVRLLC 2532
Cdd:pfam13330   75 GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1771-1861 1.87e-24

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 99.33  E-value: 1.87e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1771 WTKWFDTDFPVpGPHGGDLETYSNIERSGeRLCHREeiTQLQCRAKNYPEREMEDLGQVVKCDPSVGLVCNNRDQGGDsg 1850
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENP--TDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD-- 74

                           90
                   ....*....|.
gi 568952670  1851 MCLNYEVRLLC 1861
Cdd:pfam13330   75 GCLDYEVRFLC 85
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 633-696 5.08e-21

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 88.98  E-value: 5.08e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568952670   633 WCSLLTNaSGPFSQCHATVNPSTFFSNCMYDTCNCEKSEDCMCAALSSYVRACAAKGVLLSDWR 696
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWR 63
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1097-1164 9.52e-20

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 85.51  E-value: 9.52e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1097 QCSIIN-SETFSACHAHVEPAKYYEACVNDACACdsGGDCECFCTTVAAYAQACHEVGVCV-SWRTPDIC 1164
Cdd:pfam08742    1 KCGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSC--GGDDECLCAALAAYARACQAAGVCIgDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 268-337 3.73e-16

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 75.11  E-value: 3.73e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   268 ICEMILKGELFSGCAALVDISSYVEACRQDVCLCEslDPSDCICHTLAEYSRQCAHAGGQPQDWRGPNLC 337
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCG--GDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 3312-3384 3.25e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 70.12  E-value: 3.25e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568952670   3312 NCSSEGpVSISYCQGNCGDSismYSLEANKVEHTCECCQELQTSQRNVTLRCDDGSSQTFSYTQVEKCGCLGQ 3384
Cdd:smart00041   12 GCTSVT-VKNAFCEGKCGSA---SSYSIQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 341-397 6.77e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 6.77e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568952670  341 CPLNMQHQECGSPCVDTCSNPQHSQVCEDHCIAGCFCPEGMVLDDINQmgCVPVSQC 397
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGK--CVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 341-397 7.76e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 68.18  E-value: 7.76e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568952670   341 CPLNMQHQECGSPCVDTCSNPQHSQVCEDHCIAGCFCPEGMVLDDINQmgCVPVSQC 397
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNSGGK--CVPPSDC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2920-2983 2.36e-11

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 61.63  E-value: 2.36e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568952670  2920 LCELILSNT-FKLCHDVIPPLQFYQGCLFDYCHM-LDLEVVCSGLELYASLCAAQGVCI-PWRSQTN 2983
Cdd:pfam08742    1 KCGLLSDSGpFAPCHSVVDPEPYFEACVYDMCSCgGDDECLCAALAAYARACQAAGVCIgDWRTPTF 67
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 278-337 1.30e-10

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 59.66  E-value: 1.30e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    278 FSGCAALVDISSYVEACRQDVCLCESLdpSDCICHTLAEYSRQCAHAGGQPQDWRGPNLC 337
Cdd:smart00832   18 FAACHSVVDPEPFFENCVYDTCACGGD--CECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2921-2982 2.07e-09

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 56.58  E-value: 2.07e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568952670   2921 CELILSN--TFKLCHDVIPPLQFYQGCLFDYC-HMLDLEVVCSGLELYASLCAAQGVCI-PWRSQT 2982
Cdd:smart00832    8 CGILLSPrgPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCIsPWRTPT 73
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 805-866 2.68e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 44.23  E-value: 2.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568952670  805 CDAPMIYFDChnatpgdtGAGCQKSCHTLD--MTCySSECVPGCVCPNGLVADGNGGCVVTEDC 866
Cdd:cd19941     1 CPPNEVYSEC--------GSACPPTCANPNapPPC-TKQCVEGCFCPEGYVRNSGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 707-764 1.63e-04

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 41.92  E-value: 1.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670  707 CPKSMTYQYHISTCQPTCRALNEkDVTCHVSFIPvdGCTCPKGTFLDDLGKCVQATSC 764
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNA-PPPCTKQCVE--GCFCPEGYVRNSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 805-866 3.04e-04

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 41.22  E-value: 3.04e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568952670   805 CDAPMIYFDCHNAtpgdtgagCQKSCHTL--DMTCySSECVPGCVCPNGLVADGNGGCVVTEDC 866
Cdd:pfam01826    1 CPANEVYSECGSA--------CPPTCANLspPDVC-PEPCVEGCVCPPGFVRNSGGKCVPPSDC 55
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1869-2227 3.53e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 3.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1869 SMTTHVTLLSSTSEIVTSS---------TPGTT-----SMHVASSTSMPQTSSPNTgktstiSTTQTSSPNTGKTSTTST 1934
Cdd:pfam05109  413 TTTTHKVIFSKAPESTTTSptlnttgfaAPNTTtglpsSTHVPTNLTAPASTGPTV------STADVTSPTPAGTTSGAS 486

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1935 TQTSSPNTGKTSTISTTQTSSPNTGKASTPsTPHTSSPNTGktstistTQTSSPNTgktsttsttqtSSPNTGKTSTIST 2014
Cdd:pfam05109  487 PVTPSPSPRDNGTESKAPDMTSPTSAVTTP-TPNATSPTPA-------VTTPTPNA-----------TSPTLGKTSPTSA 547

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2015 TQTSSPNTGK---ASTPSTPHTSSPNTGKTSTisttqtsspnTGKASTPsTPQTSSPNTGKTSTISTTQtsspNTGKGST 2091
Cdd:pfam05109  548 VTTPTPNATSptpAVTTPTPNATIPTLGKTSP----------TSAVTTP-TPNATSPTVGETSPQANTT----NHTLGGT 612

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2092 PSTPQTSSPNTGKTSTIsttqtsspNTGKTSTTSTTQtsspNTGKTSTISTTQTSSPNTGKASTPSTPHTSS--PNTGKT 2169
Cdd:pfam05109  613 SSTPVVTSPPKNATSAV--------TTGQHNITSSST----SSMSLRPSSISETLSPSTSDNSTSHMPLLTSahPTGGEN 680

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568952670  2170 STISTTQTSSPNTGKASTPST-PQTSSPNTGKTSTISTTQTSSPNTGKGSTP---STPQTSS 2227
Cdd:pfam05109  681 ITQVTPASTSTHHVSTSSPAPrPGTTSQASGPGNSSTSTKPGEVNVTKGTPPknaTSPQAPS 742
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 2980-3130 4.16e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 45.24  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670 2980 SQTNNTCSFTCPDNQVYQPCGPSNPhycyrDDSISP--SLTLQEAGPKTEgcfcpdsTTLFSTNDSICVPSCQWCLGPRG 3057
Cdd:PHA02682   19 ADTSSSLFTKCPQATIPAPAAPCPP-----DADVDPldKYSVKEAGRYYQ-------SRLKANSACMQRPSGQSPLAPSP 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670 3058 EPVEPGHTISIDCQDCICKEATLTCQKKACP---QPTCPEPGFVPVPVAleagqccPQFSCACNSSHCP--PPLHCPK 3130
Cdd:PHA02682   87 ACAAPAPACPACAPAAPAPAVTCPAPAPACPpatAPTCPPPAVCPAPAR-------PAPACPPSTRQCPpaPPLPTPK 157
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 707-764 2.19e-03

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 38.52  E-value: 2.19e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952670   707 CPKSMTYQYHISTCQPTCRALNEKDV---TChvsfipVDGCTCPKGTFLDDLGKCVQATSC 764
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVcpePC------VEGCVCPPGFVRNSGGKCVPPSDC 55
 
Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 895-1054 4.58e-42

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 152.94  E-value: 4.58e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    895 WQCTDKPCLATCAVYGDGHYITFDGQRYSFNGDCEYTLLQDNcggngSSQDAFRVITENIPCGTTGtTCSKSIKIFLGNY 974
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-----SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    975 ELKLSDSKMEVVQKDVGQEPPYF-------VHQMGNYLVVETDIGLV-LLWDKKTSIFLRLSPEFKGRVCGLCGNFDDNA 1046
Cdd:smart00216   75 EIELKDDNGKVTVNGQQVSLPYKtsdgsiqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*...
gi 568952670   1047 INDFTTRS 1054
Cdd:smart00216  155 EDDFRTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 2707-2875 7.33e-38

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 141.00  E-value: 7.33e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   2707 CCQHYQCQCVCSGWGDPHYITFDGTYYTFLDNCTYVLVQQIvPVFGYFRVLIDNYYCdvGDSVSCPQSIIVEYHQDRVVL 2786
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-SSEPTFSVLLKNVPC--GGGATCLKSVKVELNGDEIEL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   2787 TRRpvsgvmTNQIIFNNKVVS-PGFQQNGIVTSRVGIKMYVTIQEIGV-RVMFSGLI-FSVEVPFnLFANNTEGQCGTCT 2863
Cdd:smart00216   79 KDD------NGKVTVNGQQVSlPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTlLSVQLPS-KYRGKTCGLCGNFD 151

                           170
                    ....*....|..
gi 568952670   2864 NDKKDECRLPGG 2875
Cdd:smart00216  152 GEPEDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 906-1054 1.77e-33

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 127.87  E-value: 1.77e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   906 CAVYGDGHYITFDGQRYSFNGDCEYTLLQDnCGGNgsSQDAFRVITENIPCGTTGTtCSKSIKIFLGNYELKLSDSKMEV 985
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD-CSEE--PDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670   986 V-QKDVgqEPPYF-----VHQMGNY---LVVETDIGLVLLWDKKTSIFLRLSPEFKGRVCGLCGNFDDNAINDFTTRS 1054
Cdd:pfam00094   77 VnGQKV--SLPYKsdggeVEILGSGfvvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 426-590 1.28e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 125.98  E-value: 1.28e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    426 WSCQDIPCAGTCSVMGGSHMSTFDGRQYTVHGDCTYVLSKPCDSN-AFTVLVELRKCGltESETCLKTVTLNLgGGQTEI 504
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEpTFSVLLKNVPCG--GGATCLKSVKVEL-NGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    505 MVKATGEVFVNQIYTQLPVSTANATF-FRPSTFFIVGETNLGLqLEIQLSPIMQTSVRLKPGLRGLTCGLCGNFNSMQAD 583
Cdd:smart00216   78 LKDDNGKVTVNGQQVSLPYKTSDGSIqIRSSGGYLVVITSLGL-IQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 568952670    584 DFQTISG 590
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 437-591 3.77e-32

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 124.02  E-value: 3.77e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   437 CSVMGGSHMSTFDGRQYTVHGDCTYVLSKPCDSN-AFTVLVELRKCGLTESETCLKTVTLNLGGgqTEIMVKATGEVFVN 515
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEpDFSFSVTNKNCNGGASGVCLKSVTVIVGD--LEITLQKGGTVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568952670   516 QIYTQLPVSTANATFFRPSTFFIVGETNLGLQLEIQLSPIMQTSVRLKPGLRGLTCGLCGNFNSMQADDFQTISGV 591
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1610-1696 2.58e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.20  E-value: 2.58e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1610 WTNWLDGSYPgSGRNSGDFDTFVNLRSKGyKFCEKPRNVECRAQFFPNTPLEELGQNVTCSREEGLICLNKNQLPPMCYN 1689
Cdd:pfam13330    1 WTPWFDVDNP-SGSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  1690 YEIRIEC 1696
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2281-2367 2.58e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.20  E-value: 2.58e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2281 WTNWLDGSYPgSGRNSGDFDTFVNLRSKGyKFCEKPRNVECRAQFFPNTPLEELGQNVTCSREEGLICLNKNQLPPMCYN 2360
Cdd:pfam13330    1 WTPWFDVDNP-SGSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  2361 YEIRIEC 2367
Cdd:pfam13330   79 YEVRFLC 85
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 77-230 1.36e-28

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 114.42  E-value: 1.36e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670     77 PGHTRRVCSTWGNFHYKTFDGQVFYFPGLCNYVFSAHCGDaYEDFNIQLRRVQESNTTT-LSRVTMKLDGLVVELTKS-- 153
Cdd:smart00216    5 QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS-EPTFSVLLKNVPCGGGATcLKSVKVELNGDEIELKDDng 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    154 SVLVNNHPVQLPFSQSGVLIEL--SNGYLKVVARLGLLFV-WNEDDSLLLELDTKYTNKTCGLCGDFNGSPKsNEFLSNN 230
Cdd:smart00216   84 KVTVNGQQVSLPYKTSDGSIQIrsSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPE-DDFRTPD 162
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 2717-2876 1.92e-27

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 110.54  E-value: 1.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2717 CSGWGDPHYITFDGTYYTFLDNCTYVLVQQIVPVFGyFRVLIDNYYCDVGDSVSCPQSIIVEYHQDRVVLTRRpvsgvmt 2796
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKG------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2797 NQIIFNNKVVSPGFQQNGIVTSRVGIKMYVTIQEIGVRVMFSG---LIFSVEVPFNlFANNTEGQCGTCTNDKKDECRLP 2873
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGdgrGQLFVTLSPS-YQGKTCGLCGNYNGNQEDDFMTP 151


                   ...
gi 568952670  2874 GGS 2876
Cdd:pfam00094  152 DGT 154
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1400-1486 1.97e-27

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 107.81  E-value: 1.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1400 WSPWMDVSRPGrGIDSGDFDTLENLRAHGyPICQVPKAVECRAEASPGVPLPELQQHLECSTTVGLICYNSDQLSGLCDN 1479
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 568952670  1480 YQIKVQC 1486
Cdd:pfam13330   79 YEVRFLC 85
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 627-697 6.45e-27

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 106.27  E-value: 6.45e-27
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952670    627 EKYAQHWCSLLTNASGPFSQCHATVNPSTFFSNCMYDTCNCEKSEDCMCAALSSYVRACAAKGVLLSDWRD 697
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 84-228 6.97e-27

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 109.00  E-value: 6.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    84 CSTWGNFHYKTFDGQVFYFPGLCNYVFSAHCGDAYED-FNIQLRRVQESNTTT-LSRVTMKLDGLVVELTKS-SVLVNNH 160
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFsFSVTNKNCNGGASGVcLKSVTVIVGDLEITLQKGgTVLVNGQ 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952670   161 PVQLPFSQSGVLIELSNGYLKVVAR---LGLLFVWNEDDSLLLELDTKYTNKTCGLCGDFNGSPkSNEFLS 228
Cdd:pfam00094   81 KVSLPYKSDGGEVEILGSGFVVVDLspgVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQ-EDDFMT 150
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1091-1165 1.36e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 99.72  E-value: 1.36e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670   1091 KSWAQKQCSIINSE--TFSACHAHVEPAKYYEACVNDACACdsGGDCECFCTTVAAYAQACHEVGVCVS-WRTPDICP 1165
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2442-2532 1.87e-24

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 99.33  E-value: 1.87e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2442 WTKWFDTDFPVpGPHGGDLETYSNIERSGeRLCHREeiTQLQCRAKNYPEREMEDLGQVVKCDPSVGLVCNNRDQGGDsg 2521
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENP--TDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD-- 74

                           90
                   ....*....|.
gi 568952670  2522 MCLNYEVRLLC 2532
Cdd:pfam13330   75 GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1771-1861 1.87e-24

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 99.33  E-value: 1.87e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1771 WTKWFDTDFPVpGPHGGDLETYSNIERSGeRLCHREeiTQLQCRAKNYPEREMEDLGQVVKCDPSVGLVCNNRDQGGDsg 1850
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENP--TDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD-- 74

                           90
                   ....*....|.
gi 568952670  1851 MCLNYEVRLLC 1861
Cdd:pfam13330   75 GCLDYEVRFLC 85
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 633-696 5.08e-21

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 88.98  E-value: 5.08e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568952670   633 WCSLLTNaSGPFSQCHATVNPSTFFSNCMYDTCNCEKSEDCMCAALSSYVRACAAKGVLLSDWR 696
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWR 63
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1097-1164 9.52e-20

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 85.51  E-value: 9.52e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1097 QCSIIN-SETFSACHAHVEPAKYYEACVNDACACdsGGDCECFCTTVAAYAQACHEVGVCV-SWRTPDIC 1164
Cdd:pfam08742    1 KCGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSC--GGDDECLCAALAAYARACQAAGVCIgDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 268-337 3.73e-16

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 75.11  E-value: 3.73e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670   268 ICEMILKGELFSGCAALVDISSYVEACRQDVCLCEslDPSDCICHTLAEYSRQCAHAGGQPQDWRGPNLC 337
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCG--GDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 3312-3384 3.25e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 70.12  E-value: 3.25e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568952670   3312 NCSSEGpVSISYCQGNCGDSismYSLEANKVEHTCECCQELQTSQRNVTLRCDDGSSQTFSYTQVEKCGCLGQ 3384
Cdd:smart00041   12 GCTSVT-VKNAFCEGKCGSA---SSYSIQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 341-397 6.77e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 6.77e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568952670  341 CPLNMQHQECGSPCVDTCSNPQHSQVCEDHCIAGCFCPEGMVLDDINQmgCVPVSQC 397
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGK--CVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 341-397 7.76e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 68.18  E-value: 7.76e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568952670   341 CPLNMQHQECGSPCVDTCSNPQHSQVCEDHCIAGCFCPEGMVLDDINQmgCVPVSQC 397
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNSGGK--CVPPSDC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2920-2983 2.36e-11

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 61.63  E-value: 2.36e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568952670  2920 LCELILSNT-FKLCHDVIPPLQFYQGCLFDYCHM-LDLEVVCSGLELYASLCAAQGVCI-PWRSQTN 2983
Cdd:pfam08742    1 KCGLLSDSGpFAPCHSVVDPEPYFEACVYDMCSCgGDDECLCAALAAYARACQAAGVCIgDWRTPTF 67
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 278-337 1.30e-10

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 59.66  E-value: 1.30e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    278 FSGCAALVDISSYVEACRQDVCLCESLdpSDCICHTLAEYSRQCAHAGGQPQDWRGPNLC 337
Cdd:smart00832   18 FAACHSVVDPEPFFENCVYDTCACGGD--CECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2921-2982 2.07e-09

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 56.58  E-value: 2.07e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568952670   2921 CELILSN--TFKLCHDVIPPLQFYQGCLFDYC-HMLDLEVVCSGLELYASLCAAQGVCI-PWRSQT 2982
Cdd:smart00832    8 CGILLSPrgPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCIsPWRTPT 73
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
399-467 1.62e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 45.25  E-value: 1.62e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670    399 CLYNGTLYAPGTNYSTDCTKCTCSGGQWSCQDIPCAGT-CSVMGGSHMSTFDGRQYTVHGDCtyvLSKPC 467
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCGPKpCLLHNLSGECPLGQGCVPSLSDC---LSSPC 67
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 805-866 2.68e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 44.23  E-value: 2.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568952670  805 CDAPMIYFDChnatpgdtGAGCQKSCHTLD--MTCySSECVPGCVCPNGLVADGNGGCVVTEDC 866
Cdd:cd19941     1 CPPNEVYSEC--------GSACPPTCANPNapPPC-TKQCVEGCFCPEGYVRNSGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 707-764 1.63e-04

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 41.92  E-value: 1.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670  707 CPKSMTYQYHISTCQPTCRALNEkDVTCHVSFIPvdGCTCPKGTFLDDLGKCVQATSC 764
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNA-PPPCTKQCVE--GCFCPEGYVRNSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 805-866 3.04e-04

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 41.22  E-value: 3.04e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568952670   805 CDAPMIYFDCHNAtpgdtgagCQKSCHTL--DMTCySSECVPGCVCPNGLVADGNGGCVVTEDC 866
Cdd:pfam01826    1 CPANEVYSECGSA--------CPPTCANLspPDVC-PEPCVEGCVCPPGFVRNSGGKCVPPSDC 55
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1869-2227 3.53e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 3.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1869 SMTTHVTLLSSTSEIVTSS---------TPGTT-----SMHVASSTSMPQTSSPNTgktstiSTTQTSSPNTGKTSTTST 1934
Cdd:pfam05109  413 TTTTHKVIFSKAPESTTTSptlnttgfaAPNTTtglpsSTHVPTNLTAPASTGPTV------STADVTSPTPAGTTSGAS 486

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1935 TQTSSPNTGKTSTISTTQTSSPNTGKASTPsTPHTSSPNTGktstistTQTSSPNTgktsttsttqtSSPNTGKTSTIST 2014
Cdd:pfam05109  487 PVTPSPSPRDNGTESKAPDMTSPTSAVTTP-TPNATSPTPA-------VTTPTPNA-----------TSPTLGKTSPTSA 547

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2015 TQTSSPNTGK---ASTPSTPHTSSPNTGKTSTisttqtsspnTGKASTPsTPQTSSPNTGKTSTISTTQtsspNTGKGST 2091
Cdd:pfam05109  548 VTTPTPNATSptpAVTTPTPNATIPTLGKTSP----------TSAVTTP-TPNATSPTVGETSPQANTT----NHTLGGT 612

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2092 PSTPQTSSPNTGKTSTIsttqtsspNTGKTSTTSTTQtsspNTGKTSTISTTQTSSPNTGKASTPSTPHTSS--PNTGKT 2169
Cdd:pfam05109  613 SSTPVVTSPPKNATSAV--------TTGQHNITSSST----SSMSLRPSSISETLSPSTSDNSTSHMPLLTSahPTGGEN 680

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568952670  2170 STISTTQTSSPNTGKASTPST-PQTSSPNTGKTSTISTTQTSSPNTGKGSTP---STPQTSS 2227
Cdd:pfam05109  681 ITQVTPASTSTHHVSTSSPAPrPGTTSQASGPGNSSTSTKPGEVNVTKGTPPknaTSPQAPS 742
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 2980-3130 4.16e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 45.24  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670 2980 SQTNNTCSFTCPDNQVYQPCGPSNPhycyrDDSISP--SLTLQEAGPKTEgcfcpdsTTLFSTNDSICVPSCQWCLGPRG 3057
Cdd:PHA02682   19 ADTSSSLFTKCPQATIPAPAAPCPP-----DADVDPldKYSVKEAGRYYQ-------SRLKANSACMQRPSGQSPLAPSP 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568952670 3058 EPVEPGHTISIDCQDCICKEATLTCQKKACP---QPTCPEPGFVPVPVAleagqccPQFSCACNSSHCP--PPLHCPK 3130
Cdd:PHA02682   87 ACAAPAPACPACAPAAPAPAVTCPAPAPACPpatAPTCPPPAVCPAPAR-------PAPACPPSTRQCPpaPPLPTPK 157
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1877-2196 1.57e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.52  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1877 LSSTSEIVTSSTPGTTSMHVASSTSMPQTSSPNTGKTSTISTTQTSSPNTGKTS---TTSTTQTSSPNTGKTSTISTTQT 1953
Cdd:pfam05109  506 MTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTpavTTPTPNATIPTLGKTSPTSAVTT 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  1954 SSPNtgkASTPSTPHTS-SPNT-----GKTSTISTTQTSSPNTGKTSTTSTTQTSSPNTGKTS--TISTTQTSSPNTGKA 2025
Cdd:pfam05109  586 PTPN---ATSPTVGETSpQANTtnhtlGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSlrPSSISETLSPSTSDN 662

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2026 STPSTPHTSS--PNTGKTSTISTTQTSSPNTGKASTPST-PQTSSPNTGKTSTISTTQTSSPNTGKGSTPSTPQTSSPNT 2102
Cdd:pfam05109  663 STSHMPLLTSahPTGGENITQVTPASTSTHHVSTSSPAPrPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPS 742

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952670  2103 GKtstisttQTSSPNTGKTSTTSTTQTSSPNTGKTSTISTTQTSSPNTGKASTPSTPHTSS----PNTGKTSTISTTQTS 2178
Cdd:pfam05109  743 GQ-------KTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRTRYNATtylpPSTSSKLRPRWTFTS 815

                          330
                   ....*....|....*...
gi 568952670  2179 SPNTGKASTPSTPQTSSP 2196
Cdd:pfam05109  816 PPVTTAQATVPVPPTSQP 833
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 707-764 2.19e-03

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 38.52  E-value: 2.19e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952670   707 CPKSMTYQYHISTCQPTCRALNEKDV---TChvsfipVDGCTCPKGTFLDDLGKCVQATSC 764
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVcpePC------VEGCVCPPGFVRNSGGKCVPPSDC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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