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Conserved domains on  [gi|568953453|ref|XP_006508924|]
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ceramide synthase 4 isoform X1 [Mus musculus]

Protein Classification

ceramide synthase family protein( domain architecture ID 10053364)

ceramide synthase family protein may catalyze the formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long chains as the acyl donor; contains homeodomain and TLC (TRAM, LAG1 and CLN8) homology domains

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
131-332 2.58e-59

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


:

Pssm-ID: 214789  Cd Length: 205  Bit Score: 191.35  E-value: 2.58e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453   131 KKFCEACWRFVFYLCSFVGGTSILYHESWLWSPSlcwENYPHQTLNLSLYWWYLLELGFYLSLLITLP--FDVKRKDFKE 208
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPK---SLYPIQGMSPLAKFYYLFSLGYFIHDLVALLlfQDLKRKDFKE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453   209 QVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFR--RGCDALFIMFALVFFYTRLIFFPTQVIY 286
Cdd:smart00724  78 MLVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKksLLYDVNFVLFAVVFFVFRLILFPFLILT 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 568953453   287 TSVYDSIKNSG--PFFGYYFFIVLLVMLQILHVYWFCLILRMLYSFLH 332
Cdd:smart00724 158 VTVHYAQAESGlfPPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
83-128 4.18e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.47  E-value: 4.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568953453  83 VLEKYFLRMKQcPEETQMVLLASQCGLTLRQTQRWFRRRRNQDRPS 128
Cdd:cd00086   14 ELEKEFEKNPY-PSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
131-332 2.58e-59

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 191.35  E-value: 2.58e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453   131 KKFCEACWRFVFYLCSFVGGTSILYHESWLWSPSlcwENYPHQTLNLSLYWWYLLELGFYLSLLITLP--FDVKRKDFKE 208
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPK---SLYPIQGMSPLAKFYYLFSLGYFIHDLVALLlfQDLKRKDFKE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453   209 QVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFR--RGCDALFIMFALVFFYTRLIFFPTQVIY 286
Cdd:smart00724  78 MLVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKksLLYDVNFVLFAVVFFVFRLILFPFLILT 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 568953453   287 TSVYDSIKNSG--PFFGYYFFIVLLVMLQILHVYWFCLILRMLYSFLH 332
Cdd:smart00724 158 VTVHYAQAESGlfPPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
TRAM_LAG1_CLN8 pfam03798
TLC domain;
132-325 1.53e-52

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 173.62  E-value: 1.53e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453  132 KFCEACWRFVFYLCSFVGGTSILYHESWLWSPSLCWENYPHQTL---NLSLYWWYLLELGFYLS-LLITLPFDVKRKDFK 207
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLgytSWLVKFYYLIQLGYFIWdLLVLLFYEKRRKDFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453  208 EQVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFRRGCDALFIMFALVFFYTRLIFFPTQVIYT 287
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLFVLFLVSFFVTRLVLGPFWILLS 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568953453  288 SVYDS--IKNSGPFFGYYFFIVLLVMLQILHVYWFCLILR 325
Cdd:pfam03798 161 ILDYAglDVPTGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
LAG1 COG5058
Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, ...
116-353 5.16e-43

Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion];


Pssm-ID: 227391 [Multi-domain]  Cd Length: 395  Bit Score: 154.61  E-value: 5.16e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453 116 RWFRRRRNQDRPSLSKKFCEACWRFVFYLCSFVGGTSILYHES-WLWSPSLCWENYPHQTLNLSLYWWYLLELGFYL--S 192
Cdd:COG5058  140 RPFGLELNVRSEKKIKRFCEQMYAIFYYGVSGPFGLYVMRSSPlWFFNTKALYETYPVFYNPFLFKAFYLIQAAFWAqqA 219
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453 193 LLITLPFDVKRKDFKEQVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFRRgCDALFIMFALVF 272
Cdd:COG5058  220 CILVLQLEKPRKDFKELVFHHIVTLLLIWLSYVFHFTRMGLAIYITMDVSDFFLSLSKTLNYLNSVL-ATFIFGIFVFIW 298
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453 273 FYTRLIFFPTqvIYTSVYDSIKNSGPF-----FGYYFF-------IVLLVMLQILHVYWFCLILRMLYSFLHKGQmTEDI 340
Cdd:COG5058  299 IYSRHYLNLK--ILWSVLTAFRTIGNFvldvaTQQYKCwislpivFILLQALQLVNIYWLFLIVRVAYRVIWEGE-LKDE 375
                        250
                 ....*....|...
gi 568953453 341 RSDVEEPDSSDDE 353
Cdd:COG5058  376 RSDDESEEESDLE 388
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
83-128 4.18e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.47  E-value: 4.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568953453  83 VLEKYFLRMKQcPEETQMVLLASQCGLTLRQTQRWFRRRRNQDRPS 128
Cdd:cd00086   14 ELEKEFEKNPY-PSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
82-126 2.35e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.77  E-value: 2.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568953453    82 PVLEKYFLRmKQCPEETQMVLLASQCGLTLRQTQRWFRRRRNQDR 126
Cdd:smart00389  14 EELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
83-126 2.53e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 35.94  E-value: 2.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568953453   83 VLEKYFLRMKQcPEETQMVLLASQCGLTLRQTQRWFRRRRNQDR 126
Cdd:pfam00046  14 ELEKEFQENPY-PSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
131-332 2.58e-59

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 191.35  E-value: 2.58e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453   131 KKFCEACWRFVFYLCSFVGGTSILYHESWLWSPSlcwENYPHQTLNLSLYWWYLLELGFYLSLLITLP--FDVKRKDFKE 208
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPK---SLYPIQGMSPLAKFYYLFSLGYFIHDLVALLlfQDLKRKDFKE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453   209 QVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFR--RGCDALFIMFALVFFYTRLIFFPTQVIY 286
Cdd:smart00724  78 MLVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKksLLYDVNFVLFAVVFFVFRLILFPFLILT 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 568953453   287 TSVYDSIKNSG--PFFGYYFFIVLLVMLQILHVYWFCLILRMLYSFLH 332
Cdd:smart00724 158 VTVHYAQAESGlfPPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
TRAM_LAG1_CLN8 pfam03798
TLC domain;
132-325 1.53e-52

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 173.62  E-value: 1.53e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453  132 KFCEACWRFVFYLCSFVGGTSILYHESWLWSPSLCWENYPHQTL---NLSLYWWYLLELGFYLS-LLITLPFDVKRKDFK 207
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLgytSWLVKFYYLIQLGYFIWdLLVLLFYEKRRKDFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453  208 EQVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFRRGCDALFIMFALVFFYTRLIFFPTQVIYT 287
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLFVLFLVSFFVTRLVLGPFWILLS 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568953453  288 SVYDS--IKNSGPFFGYYFFIVLLVMLQILHVYWFCLILR 325
Cdd:pfam03798 161 ILDYAglDVPTGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
LAG1 COG5058
Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, ...
116-353 5.16e-43

Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion];


Pssm-ID: 227391 [Multi-domain]  Cd Length: 395  Bit Score: 154.61  E-value: 5.16e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453 116 RWFRRRRNQDRPSLSKKFCEACWRFVFYLCSFVGGTSILYHES-WLWSPSLCWENYPHQTLNLSLYWWYLLELGFYL--S 192
Cdd:COG5058  140 RPFGLELNVRSEKKIKRFCEQMYAIFYYGVSGPFGLYVMRSSPlWFFNTKALYETYPVFYNPFLFKAFYLIQAAFWAqqA 219
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453 193 LLITLPFDVKRKDFKEQVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFRRgCDALFIMFALVF 272
Cdd:COG5058  220 CILVLQLEKPRKDFKELVFHHIVTLLLIWLSYVFHFTRMGLAIYITMDVSDFFLSLSKTLNYLNSVL-ATFIFGIFVFIW 298
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953453 273 FYTRLIFFPTqvIYTSVYDSIKNSGPF-----FGYYFF-------IVLLVMLQILHVYWFCLILRMLYSFLHKGQmTEDI 340
Cdd:COG5058  299 IYSRHYLNLK--ILWSVLTAFRTIGNFvldvaTQQYKCwislpivFILLQALQLVNIYWLFLIVRVAYRVIWEGE-LKDE 375
                        250
                 ....*....|...
gi 568953453 341 RSDVEEPDSSDDE 353
Cdd:COG5058  376 RSDDESEEESDLE 388
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
83-128 4.18e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.47  E-value: 4.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568953453  83 VLEKYFLRMKQcPEETQMVLLASQCGLTLRQTQRWFRRRRNQDRPS 128
Cdd:cd00086   14 ELEKEFEKNPY-PSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
82-126 2.35e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.77  E-value: 2.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568953453    82 PVLEKYFLRmKQCPEETQMVLLASQCGLTLRQTQRWFRRRRNQDR 126
Cdd:smart00389  14 EELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
83-126 2.53e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 35.94  E-value: 2.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568953453   83 VLEKYFLRMKQcPEETQMVLLASQCGLTLRQTQRWFRRRRNQDR 126
Cdd:pfam00046  14 ELEKEFQENPY-PSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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