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Conserved domains on  [gi|568954130|ref|XP_006509200|]
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probable tRNA methyltransferase 9B isoform X3 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1904022)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Penicillium polonicum methyltransferase verB

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE super family cl43651
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 19-52 8.49e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


The actual alignment was detected with superfamily member COG2226:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 8.49e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 568954130  19 VIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 52
Cdd:COG2226   96 VLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 19-52 8.49e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 8.49e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 568954130  19 VIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 52
Cdd:COG2226   96 VLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 19-44 1.38e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.24  E-value: 1.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 568954130   19 VIHHFSTKERRiRAIKEMARVLAPGG 44
Cdd:pfam13649  72 VLHHLPDPDLE-AALREIARVLKPGG 96
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 19-52 8.49e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 8.49e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 568954130  19 VIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 52
Cdd:COG2226   96 VLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 19-44 1.38e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.24  E-value: 1.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 568954130   19 VIHHFSTKERRiRAIKEMARVLAPGG 44
Cdd:pfam13649  72 VLHHLPDPDLE-AALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 19-48 4.30e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.80  E-value: 4.30e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 568954130   19 VIHHFstkERRIRAIKEMARVLAPGGQLMI 48
Cdd:pfam08241  68 VLHHV---EDPERALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 19-61 2.61e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 38.74  E-value: 2.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568954130  19 VIHHFStKERRIRAIKEMARVLAPGGQLMIYVWAMEQKNRRFE 61
Cdd:COG0500  103 VLHHLP-PEEREALLRELARALKPGGVLLLSASDAAAALSLAR 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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