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Conserved domains on  [gi|568961720|ref|XP_006511346|]
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WD repeat-containing protein 72 isoform X5 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
413-613 2.13e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  413 GMTATITSSEYIPNLDKLICGCEDGTIFITKalnaakagllegdslLKDSPCHTLLRGHHQSVTSLLY-PhnlasklDQS 491
Cdd:COG2319   202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWD---------------LATGKLLRTLTGHSGSVRSVAFsP-------DGR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  492 WMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPV 571
Cdd:COG2319   260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568961720  572 RMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARI 613
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.06e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720    3 GALQAVALW---------GRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSpelkiSAKEL--LFGHSASVTCLAra 71
Cdd:COG2319    97 SADGTVRLWdlatglllrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA-- 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   72 rdFSkqP---YVVSAAENGEMCMWNVSSGQCVekTSLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLVLDAGTLAVLH 148
Cdd:COG2319   170 --FS--PdgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLR 240

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568961720  149 TFTSLQSPdwmkcmciVHSVRIQEDS--LLVVSITGELKVWDLSS 191
Cdd:COG2319   241 TLTGHSGS--------VRSVAFSPDGrlLASGSADGTVRLWDLAT 277
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
413-613 2.13e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  413 GMTATITSSEYIPNLDKLICGCEDGTIFITKalnaakagllegdslLKDSPCHTLLRGHHQSVTSLLY-PhnlasklDQS 491
Cdd:COG2319   202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWD---------------LATGKLLRTLTGHSGSVRSVAFsP-------DGR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  492 WMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPV 571
Cdd:COG2319   260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568961720  572 RMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARI 613
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-606 2.86e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 2.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  418 ITSSEYIPNLDKLICGCEDGTIFITKalnaakagllegdslLKDSPCHTLLRGHHQSVTSLLYPHnlasklDQSWMVSGD 497
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWD---------------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  498 RGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWH 577
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS 144

                         170       180       190
                  ....*....|....*....|....*....|...
gi 568961720  578 PVENFLIVGCTDDSVYIWEIETG----TLERHE 606
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.06e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720    3 GALQAVALW---------GRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSpelkiSAKEL--LFGHSASVTCLAra 71
Cdd:COG2319    97 SADGTVRLWdlatglllrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA-- 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   72 rdFSkqP---YVVSAAENGEMCMWNVSSGQCVekTSLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLVLDAGTLAVLH 148
Cdd:COG2319   170 --FS--PdgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLR 240

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568961720  149 TFTSLQSPdwmkcmciVHSVRIQEDS--LLVVSITGELKVWDLSS 191
Cdd:COG2319   241 TLTGHSGS--------VRSVAFSPDGrlLASGSADGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-191 2.95e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 2.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   14 KAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELKISAkelLFGHSASVTCLararDFS-KQPYVVSAAENGEMCMW 92
Cdd:cd00200    48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   93 NVSSGQCVekTSLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLVLDAGTLAVLHTFTSLQSPdwmkcmciVHSVRIQ 171
Cdd:cd00200   121 DVETGKCL--TTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGE--------VNSVAFS 186

                         170       180
                  ....*....|....*....|..
gi 568961720  172 ED--SLLVVSITGELKVWDLSS 191
Cdd:cd00200   187 PDgeKLLSSSSDGTIKLWDLST 208
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
413-613 2.13e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  413 GMTATITSSEYIPNLDKLICGCEDGTIFITKalnaakagllegdslLKDSPCHTLLRGHHQSVTSLLY-PhnlasklDQS 491
Cdd:COG2319   202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWD---------------LATGKLLRTLTGHSGSVRSVAFsP-------DGR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  492 WMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPV 571
Cdd:COG2319   260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568961720  572 RMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARI 613
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-606 2.86e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 2.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  418 ITSSEYIPNLDKLICGCEDGTIFITKalnaakagllegdslLKDSPCHTLLRGHHQSVTSLLYPHnlasklDQSWMVSGD 497
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWD---------------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  498 RGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWH 577
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS 144

                         170       180       190
                  ....*....|....*....|....*....|...
gi 568961720  578 PVENFLIVGCTDDSVYIWEIETG----TLERHE 606
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
459-613 3.07e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  459 LKDSPCHTLLRGHHQSVTSLLY-PhnlasklDQSWMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsD 537
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFsP-------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP------D 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568961720  538 GQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARI 613
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 409-606 1.05e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  409 RDEVGMTATITSSEYIPNLDKLICGCEDGTIFITKalnaakagllegdslLKDSPCHTLLRGHHQSVTSLLYpHNlaskl 488
Cdd:cd00200    45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD---------------LETGECVRTLTGHTSYVSSVAF-SP----- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  489 DQSWMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHL 568
Cdd:cd00200   104 DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP------DGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568961720  569 FPVRMIRWHPVENFLIVGCTDDSVYIWEIETG----TLERHE 606
Cdd:cd00200   178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGkclgTLRGHE 219
WD40 COG2319
WD40 repeat [General function prediction only];
430-599 3.66e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 3.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  430 LICGCEDGTIFITKalnaakagllegdslLKDSPCHTLLRGHHQSVTSLLY-PhnlasklDQSWMVSGDRGSYVILWDIF 508
Cdd:COG2319   261 LASGSADGTVRLWD---------------LATGELLRTLTGHSGGVNSVAFsP-------DGKLLASGSDDGTVRLWDLA 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  509 TEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWHPVENFLIVGCT 588
Cdd:COG2319   319 TGKLLRTLTGHTGAVRSVAFSP------DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392

                         170
                  ....*....|.
gi 568961720  589 DDSVYIWEIET 599
Cdd:COG2319   393 DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
458-613 5.83e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 5.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  458 LLKDSPCHTLLRGHHQSVTSLlyphnlASKLDQSWMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsD 537
Cdd:COG2319    64 DAAAGALLATLLGHTAAVLSV------AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP------D 131

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568961720  538 GQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARI 613
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.06e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720    3 GALQAVALW---------GRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSpelkiSAKEL--LFGHSASVTCLAra 71
Cdd:COG2319    97 SADGTVRLWdlatglllrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA-- 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   72 rdFSkqP---YVVSAAENGEMCMWNVSSGQCVekTSLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLVLDAGTLAVLH 148
Cdd:COG2319   170 --FS--PdgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLR 240

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568961720  149 TFTSLQSPdwmkcmciVHSVRIQEDS--LLVVSITGELKVWDLSS 191
Cdd:COG2319   241 TLTGHSGS--------VRSVAFSPDGrlLASGSADGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 412-608 2.67e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 2.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  412 VGMTATITSSEYIPNlDKLICGC-EDGTIFITKalnaakagllegdslLKDSPCHTLLRGHHQSVTSLLYPHNlaskldq 490
Cdd:cd00200    90 TGHTSYVSSVAFSPD-GRILSSSsRDKTIKVWD---------------VETGKCLTTLRGHTDWVNSVAFSPD------- 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  491 SWMV-SGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHLF 569
Cdd:cd00200   147 GTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 568961720  570 PVRMIRWHPVENFLIVGCTDDSVYIWEIETG----TLERHETG 608
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGecvqTLSGHTNS 263
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-191 2.95e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 2.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   14 KAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELKISAkelLFGHSASVTCLararDFS-KQPYVVSAAENGEMCMW 92
Cdd:cd00200    48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   93 NVSSGQCVekTSLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLVLDAGTLAVLHTFTSLQSPdwmkcmciVHSVRIQ 171
Cdd:cd00200   121 DVETGKCL--TTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGE--------VNSVAFS 186

                         170       180
                  ....*....|....*....|..
gi 568961720  172 ED--SLLVVSITGELKVWDLSS 191
Cdd:cd00200   187 PDgeKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
14-191 6.65e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 6.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   14 KAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSpelkiSAKEL--LFGHSASVTCLArardFSKQ-PYVVSAAENGEMC 90
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLrtLTGHSGSVRSVA----FSPDgRLLASGSADGTVR 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   91 MWNVSSGQCVekTSLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLVLDAGTLAVLHTFTSLQSPdwmkcmciVHSVRI 170
Cdd:COG2319   272 LWDLATGELL--RTLTGHSGGV--NSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGA--------VRSVAF 338

                         170       180
                  ....*....|....*....|...
gi 568961720  171 QEDS--LLVVSITGELKVWDLSS 191
Cdd:COG2319   339 SPDGktLASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
458-613 1.35e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  458 LLKDSPCHTLLRGHHQSVTSLlyphnlASKLDQSWMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsD 537
Cdd:COG2319    22 AAALGALLLLLLGLAAAVASL------AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP------D 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568961720  538 GQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARI 613
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165
WD40 COG2319
WD40 repeat [General function prediction only];
4-191 1.15e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720    4 ALQAVALWGRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELkisAKELLFGHSASVTCLARARDfskQPYVVSA 83
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPD---GKTLASG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   84 AENGEMCMWNVSSGQCVekTSLPyRHTAICYyhcSFRMTGEG-WLLCCGEYQDVLVLDAGTLAVLHTFTSLQSPdwmkcm 162
Cdd:COG2319   139 SADGTVRLWDLATGKLL--RTLT-GHSGAVT---SVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGA------ 206

                         170       180       190
                  ....*....|....*....|....*....|.
gi 568961720  163 ciVHSVRIQEDS--LLVVSITGELKVWDLSS 191
Cdd:COG2319   207 --VRSVAFSPDGklLASGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-299 1.94e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   17 PHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELKISAKEllfGHSASVTCLARardFSKQPYVVSAAENGEMCMWNVSS 96
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK---GHTGPVRDVAA---SADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   97 GQCVEKtslpYR-HTAICyYHCSFrMTGEGWLLCCGEYQDVLVLDAGTLAVLHTFTSLQSPdwmkcmciVHSVRIQEDSL 175
Cdd:cd00200    83 GECVRT----LTgHTSYV-SSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW--------VNSVAFSPDGT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  176 LVVSIT--GELKVWDLSS------------SINSIQekqdVHEKESKFLDSFNCQTIrfcpyteRLLLVVFSKCWKIYDY 241
Cdd:cd00200   149 FVASSSqdGTIKLWDLRTgkcvatltghtgEVNSVA----FSPDGEKLLSSSSDGTI-------KLWDLSTGKCLGTLRG 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568961720  242 CDFSLLWTEVSRDGQFFAGGevlaahrilvwTEDGHSYIYQLLNrwaqmGATLRTFSG 299
Cdd:cd00200   218 HENGVNSVAFSPDGYLLASG-----------SEDGTIRVWDLRT-----GECVQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 415-596 8.27e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 8.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  415 TATITSSEYIPNLDKLICGCEDGTIFITkalnaakagllegdSLLKDSPCHTLlRGHHQSVTSL-LYPhnlasklDQSWM 493
Cdd:cd00200   135 TDWVNSVAFSPDGTFVASSSQDGTIKLW--------------DLRTGKCVATL-TGHTGEVNSVaFSP-------DGEKL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720  494 VSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPenlkrsDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRM 573
Cdd:cd00200   193 LSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP------DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTS 266

                         170       180
                  ....*....|....*....|...
gi 568961720  574 IRWHPVENFLIVGCTDDSVYIWE 596
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
14-100 2.08e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   14 KAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSpelkiSAKEL--LFGHSASVTCLARARDfskQPYVVSAAENGEMCM 91
Cdd:COG2319   285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLLrtLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRL 356


                  ....*....
gi 568961720   92 WNVSSGQCV 100
Cdd:COG2319   357 WDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-191 3.02e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   58 LFGHSASVTCLArardFS-KQPYVVSAAENGEMCMWNVSSGQCVEKTSLpyrHTaICYYHCSFRMTGEgWLLCCGEYQDV 136
Cdd:cd00200     5 LKGHTGGVTCVA----FSpDGKLLATGSGDGTIKVWDLETGELLRTLKG---HT-GPVRDVAASADGT-YLASGSSDKTI 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568961720  137 LVLDAGTLAVLHTFTSLQSPdwmkcmciVHSVRIQEDSLLVVSIT--GELKVWDLSS 191
Cdd:cd00200    76 RLWDLETGECVRTLTGHTSY--------VSSVAFSPDGRILSSSSrdKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
10-96 1.98e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961720   10 LWGRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELKISAkelLFGHSASVTCLARARDfskQPYVVSAAENGEM 89
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---LTGHTGAVTSVAFSPD---GRTLASGSADGTV 396


                  ....*..
gi 568961720   90 CMWNVSS 96
Cdd:COG2319   397 RLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 567-608 6.36e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 6.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568961720  567 HLFPVRMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETG 608
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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