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Conserved domains on  [gi|568964312|ref|XP_006512411|]
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cAMP-regulated phosphoprotein 21 isoform X10 [Mus musculus]

Protein Classification

NUFIP1 domain-containing protein; PAT1 family protein( domain architecture ID 12927641)

NUFIP1 domain-containing protein; nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) functions in the assembly of the large subunit of the ribosome and in telomere maintenance| PAT1 family protein similar to Schizosaccharomyces pombe DNA topoisomerase 2-associated protein PAT1, an activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 162-223 1.56e-25

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


:

Pssm-ID: 100071  Cd Length: 63  Bit Score: 99.98  E-value: 1.56e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568964312 162 DRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 223
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
 244-298 8.23e-12

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


:

Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 60.80  E-value: 8.23e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568964312  244 ESQKRFILKRDNSSIDKEDNQNRM-HPFRDDRRSKSIEEREEEYQRVRERIFAHDS 298
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSgASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 553-782 5.37e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.03  E-value: 5.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  553 QLSMSRQssgdtpEPPSGTVYPASLLPQTAQPQSYVITSAGQQLS----TG--GFSDSGPPISQQVLQA----PPSPQGF 622
Cdd:pfam09770  99 QVRFNRQ------QPAARAAQSSAQPPASSLPQYQYASQQSQQPSkpvrTGyeKYKEPEPIPDLQVDASlwgvAPKKAAA 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  623 VQQPPPAQMSvyyypsgqyPTSTSQQYRPLASVQY--SAQRSQQIPQTTQQA-------GYQPVLSGQQGFQGMMGVQQS 693
Cdd:pfam09770 173 PAPAPQPAAQ---------PASLPAPSRKMMSLEEveAAMRAQAKKPAQQPApapaqppAAPPAQQAQQQQQFPPQIQQQ 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  694 AHSQGVMSSQQGAPVHGVMVS---YPTMSSYQVPMTQGSQAVPQQTYQPP--IMLPSQAGQ--GSLPATGMPVYCNVTPP 766
Cdd:pfam09770 244 QQPQQQPQQPQQHPGQGHPVTilqRPQSPQPDPAQPSIQPQAQQFHQQPPpvPVQPTQILQnpNRLSAARVGYPQNPQPG 323

                         250
                  ....*....|....*.
gi 568964312  767 NPQNNLRLMGPHCPSS 782
Cdd:pfam09770 324 VQPAPAHQAHRQQGSF 339
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 162-223 1.56e-25

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 99.98  E-value: 1.56e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568964312 162 DRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 223
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
146-223 9.74e-13

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 64.24  E-value: 9.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312   146 IDLHGFLINTLKNNSRDRMILLKMEQEMIDFIAdSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINKT 223
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGpkRRVVISKK 79
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 164-222 6.19e-12

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 61.35  E-value: 6.19e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568964312  164 MILLKMEQEMIDFIADSNNHYKkFPQMSSYQRMLVHRVAAYFGLDHNV--DQTGKSVIINK 222
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
 244-298 8.23e-12

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 60.80  E-value: 8.23e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568964312  244 ESQKRFILKRDNSSIDKEDNQNRM-HPFRDDRRSKSIEEREEEYQRVRERIFAHDS 298
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSgASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 553-782 5.37e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.03  E-value: 5.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  553 QLSMSRQssgdtpEPPSGTVYPASLLPQTAQPQSYVITSAGQQLS----TG--GFSDSGPPISQQVLQA----PPSPQGF 622
Cdd:pfam09770  99 QVRFNRQ------QPAARAAQSSAQPPASSLPQYQYASQQSQQPSkpvrTGyeKYKEPEPIPDLQVDASlwgvAPKKAAA 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  623 VQQPPPAQMSvyyypsgqyPTSTSQQYRPLASVQY--SAQRSQQIPQTTQQA-------GYQPVLSGQQGFQGMMGVQQS 693
Cdd:pfam09770 173 PAPAPQPAAQ---------PASLPAPSRKMMSLEEveAAMRAQAKKPAQQPApapaqppAAPPAQQAQQQQQFPPQIQQQ 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  694 AHSQGVMSSQQGAPVHGVMVS---YPTMSSYQVPMTQGSQAVPQQTYQPP--IMLPSQAGQ--GSLPATGMPVYCNVTPP 766
Cdd:pfam09770 244 QQPQQQPQQPQQHPGQGHPVTilqRPQSPQPDPAQPSIQPQAQQFHQQPPpvPVQPTQILQnpNRLSAARVGYPQNPQPG 323

                         250
                  ....*....|....*.
gi 568964312  767 NPQNNLRLMGPHCPSS 782
Cdd:pfam09770 324 VQPAPAHQAHRQQGSF 339
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 543-766 1.40e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  543 QREELAAQFSQLSMSR---QSSGDTPEPP--SGTVYPASLLPQTAQPQsyvitsagQQLSTGGFSDSGPPISQQVLQAPP 617
Cdd:PRK10263  660 QQDELARQFAQTQQQRygeQYQHDVPVNAedADAAAEAELARQFAQTQ--------QQRYSGEQPAGANPFSLDDFEFSP 731

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  618 SpQGFVQQPPPAQMsvyyYPSGQYPTSTSQQyRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQQGFQGMMGVQQSAHSQ 697
Cdd:PRK10263  732 M-KALLDDGPHEPL----FTPIVEPVQQPQQ-PVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQ 805

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  698 GVMSSQQGAPvhgvmvsyptmsSYQVPMtqgSQAVPQQTYQPPIMLPSQAGQGSL----------------PATGMPVYC 761
Cdd:PRK10263  806 QPQQPVAPQP------------QYQQPQ---QPVAPQPQYQQPQQPVAPQPQDTLlhpllmrngdsrplhkPTTPLPSLD 870


                  ....*
gi 568964312  762 NVTPP 766
Cdd:PRK10263  871 LLTPP 875
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 543-681 1.14e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  543 QREELAAQFSQLSM-SRQSSGDTPEPPSgtvYPASLLPQTAQPQSYvitsAGQQLstgGFSDSGPPISQQVLQAPPSPQG 621
Cdd:TIGR01628 367 RRAHLQDQFMQLQPrMRQLPMGSPMGGA---MGQPPYYGQGPQQQF----NGQPL---GWPRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  622 FVQQPPPAQMSVYYYPSGQYPTSTSQQYRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQ 681
Cdd:TIGR01628 437 LAPMNAVRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQV 496
SP1-4_arthropods_N cd22553
N-terminal domain of transcription factor Specificity Protein (SP) 1-4 from arthropods; ...
 553-750 3.34e-03

N-terminal domain of transcription factor Specificity Protein (SP) 1-4 from arthropods; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in the chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. One SP is clade SP1-4, which is expressed ubiquitously throughout development. SP1-4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. This model represents the N-terminal domain of SP1-4 from arthropods.


Pssm-ID: 411778 [Multi-domain]  Cd Length: 384  Bit Score: 40.78  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312 553 QLSMSRQSSGDTPEPPSGTVYPASLLPQTAQPQSYVITSAGQ------QLSTGGFSDSGPPISQQVLQAPPSPQgfVQQP 626
Cdd:cd22553  129 NASNVLQNIAQIASGGNAVQLPLNNMTQTIPVQVPVSTANGQtvyqtiQVPIQAIQSGNAGGGNQALQAQVIPQ--LAQA 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312 627 PPAQMSVYYYPSGQ-----YPTSTSQQyRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQQGFQGMMGvqqsahSQGVMS 701
Cdd:cd22553  207 AQLQPQQLAQVSSQgyiqqIPANASQQ-QPQMVQQGPNQSGQIIGQVASASSIQAAAIPLTVYTGALA------GQNGSN 279

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568964312 702 SQQGAPVHGV----MVSYPTMSSYQVPMTQGSQAVPQQTYQPPIMLPSQAGQG 750
Cdd:cd22553  280 QQQVGQIVTSpiqgMTQGLTAPASSSIPTVVQQQAIQGNPLPPGTQIIAAGQQ 332
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 162-223 1.56e-25

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 99.98  E-value: 1.56e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568964312 162 DRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 223
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
146-223 9.74e-13

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 64.24  E-value: 9.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312   146 IDLHGFLINTLKNNSRDRMILLKMEQEMIDFIAdSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINKT 223
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGpkRRVVISKK 79
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 166-222 3.90e-12

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 61.86  E-value: 3.90e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568964312 166 LLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINK 222
Cdd:cd02325    1 REEREEELEAFAKDAAGKSLELPPMNSYERKLIHDLAEYYGLKSESEGEGpnRRVVITK 59
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 164-222 6.19e-12

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 61.35  E-value: 6.19e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568964312  164 MILLKMEQEMIDFIADSNNHYKkFPQMSSYQRMLVHRVAAYFGLDHNV--DQTGKSVIINK 222
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
 244-298 8.23e-12

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 60.80  E-value: 8.23e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568964312  244 ESQKRFILKRDNSSIDKEDNQNRM-HPFRDDRRSKSIEEREEEYQRVRERIFAHDS 298
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSgASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 553-782 5.37e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.03  E-value: 5.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  553 QLSMSRQssgdtpEPPSGTVYPASLLPQTAQPQSYVITSAGQQLS----TG--GFSDSGPPISQQVLQA----PPSPQGF 622
Cdd:pfam09770  99 QVRFNRQ------QPAARAAQSSAQPPASSLPQYQYASQQSQQPSkpvrTGyeKYKEPEPIPDLQVDASlwgvAPKKAAA 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  623 VQQPPPAQMSvyyypsgqyPTSTSQQYRPLASVQY--SAQRSQQIPQTTQQA-------GYQPVLSGQQGFQGMMGVQQS 693
Cdd:pfam09770 173 PAPAPQPAAQ---------PASLPAPSRKMMSLEEveAAMRAQAKKPAQQPApapaqppAAPPAQQAQQQQQFPPQIQQQ 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  694 AHSQGVMSSQQGAPVHGVMVS---YPTMSSYQVPMTQGSQAVPQQTYQPP--IMLPSQAGQ--GSLPATGMPVYCNVTPP 766
Cdd:pfam09770 244 QQPQQQPQQPQQHPGQGHPVTilqRPQSPQPDPAQPSIQPQAQQFHQQPPpvPVQPTQILQnpNRLSAARVGYPQNPQPG 323

                         250
                  ....*....|....*.
gi 568964312  767 NPQNNLRLMGPHCPSS 782
Cdd:pfam09770 324 VQPAPAHQAHRQQGSF 339
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 543-766 1.40e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  543 QREELAAQFSQLSMSR---QSSGDTPEPP--SGTVYPASLLPQTAQPQsyvitsagQQLSTGGFSDSGPPISQQVLQAPP 617
Cdd:PRK10263  660 QQDELARQFAQTQQQRygeQYQHDVPVNAedADAAAEAELARQFAQTQ--------QQRYSGEQPAGANPFSLDDFEFSP 731

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  618 SpQGFVQQPPPAQMsvyyYPSGQYPTSTSQQyRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQQGFQGMMGVQQSAHSQ 697
Cdd:PRK10263  732 M-KALLDDGPHEPL----FTPIVEPVQQPQQ-PVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQ 805

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  698 GVMSSQQGAPvhgvmvsyptmsSYQVPMtqgSQAVPQQTYQPPIMLPSQAGQGSL----------------PATGMPVYC 761
Cdd:PRK10263  806 QPQQPVAPQP------------QYQQPQ---QPVAPQPQYQQPQQPVAPQPQDTLlhpllmrngdsrplhkPTTPLPSLD 870


                  ....*
gi 568964312  762 NVTPP 766
Cdd:PRK10263  871 LLTPP 875
PRK10927 PRK10927
cell division protein FtsN;
557-708 3.51e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 43.52  E-value: 3.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312 557 SRQSSGDTPEPPSG---TVYPASLLPQTAQPQSYVITSAGQQ---LSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQ 630
Cdd:PRK10927  91 SRQPGVRAPTEPSAggeVKTPEQLTPEQRQLLEQMQADMRQQptqLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAQ 170

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568964312 631 MSVYYYPSGQYPTSTSQQyrplasvQYSAQRSQQIPQTTQQAGYQPVLsgqqgfqgmmgvQQSAHSQGVMSSQQGAPV 708
Cdd:PRK10927 171 QSRTTEQSWQQQTRTSQA-------APVQAQPRQSKPASTQQPYQDLL------------QTPAHTTAQSKPQQAAPV 229
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 543-681 1.14e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  543 QREELAAQFSQLSM-SRQSSGDTPEPPSgtvYPASLLPQTAQPQSYvitsAGQQLstgGFSDSGPPISQQVLQAPPSPQG 621
Cdd:TIGR01628 367 RRAHLQDQFMQLQPrMRQLPMGSPMGGA---MGQPPYYGQGPQQQF----NGQPL---GWPRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  622 FVQQPPPAQMSVYYYPSGQYPTSTSQQYRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQ 681
Cdd:TIGR01628 437 LAPMNAVRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQV 496
PHA03247 PHA03247
large tegument protein UL36; Provisional
 422-733 1.82e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  422 RTHPQSTALTSSVAAGSPGCMAYSENGMGGQVPPSSTSYILLPLESATGIPPGSillnphtgqpfVNPDGTPAIYNPPGS 501
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----------PARPARPPTTAGPPA 2768

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  502 QQTLRGTVGGQPQQPPQQQPSPQPQQQVQASQPQMAGPLVTQREELAAqfsqlSMSRQSSGDTPEPPSGTVYPASLLPQT 581
Cdd:PHA03247 2769 PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA-----ALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  582 AQPQSYvITSAGQQLSTGGFSDSGPPISQQVLQAPPS--PQGFVQQPPPAQ--MSVYYYPSGQYPTSTSQ-QYRPLASVQ 656
Cdd:PHA03247 2844 GPPPPS-LPLGGSVAPGGDVRRRPPSRSPAAKPAAPArpPVRRLARPAVSRstESFALPPDQPERPPQPQaPPPPQPQPQ 2922

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568964312  657 YSAQRSQQiPQTTQQAGYQPVLSGQQGFQGmmgvqQSAHSQGVMSSQQGAPVHGvmvsyptmsSYQVPMTQGSQAVP 733
Cdd:PHA03247 2923 PPPPPQPQ-PPPPPPPRPQPPLAPTTDPAG-----AGEPSGAVPQPWLGALVPG---------RVAVPRFRVPQPAP 2984
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 572-760 2.48e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  572 VYPASLLPQTAQPQSYVITSAGQQLSTGGFSDSGPPISQQVLQapPSPQGFVQQPPPAQMSVYYYPSGQYPTSTSQQYRP 651
Cdd:PRK10263  332 SWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIA--PAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYA 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312  652 LASVQYSAQrsQQIPQTTQQAGYQPVLSGQqgfqgmmgVQQSAHSQGVMSSQQGaPVHGVMVSYPTMSSYQVPMTQGSQA 731
Cdd:PRK10263  410 PAAEQPAQQ--PYYAPAPEQPAQQPYYAPA--------PEQPVAGNAWQAEEQQ-STFAPQSTYQTEQTYQQPAAQEPLY 478

                         170       180
                  ....*....|....*....|....*....
gi 568964312  732 VPQQTYQPPIMLPSQAGQGSLPATGMPVY 760
Cdd:PRK10263  479 QQPQPVEQQPVVEPEPVVEETKPARPPLY 507
SP1-4_arthropods_N cd22553
N-terminal domain of transcription factor Specificity Protein (SP) 1-4 from arthropods; ...
 553-750 3.34e-03

N-terminal domain of transcription factor Specificity Protein (SP) 1-4 from arthropods; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in the chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. One SP is clade SP1-4, which is expressed ubiquitously throughout development. SP1-4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. This model represents the N-terminal domain of SP1-4 from arthropods.


Pssm-ID: 411778 [Multi-domain]  Cd Length: 384  Bit Score: 40.78  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312 553 QLSMSRQSSGDTPEPPSGTVYPASLLPQTAQPQSYVITSAGQ------QLSTGGFSDSGPPISQQVLQAPPSPQgfVQQP 626
Cdd:cd22553  129 NASNVLQNIAQIASGGNAVQLPLNNMTQTIPVQVPVSTANGQtvyqtiQVPIQAIQSGNAGGGNQALQAQVIPQ--LAQA 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964312 627 PPAQMSVYYYPSGQ-----YPTSTSQQyRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQQGFQGMMGvqqsahSQGVMS 701
Cdd:cd22553  207 AQLQPQQLAQVSSQgyiqqIPANASQQ-QPQMVQQGPNQSGQIIGQVASASSIQAAAIPLTVYTGALA------GQNGSN 279

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568964312 702 SQQGAPVHGV----MVSYPTMSSYQVPMTQGSQAVPQQTYQPPIMLPSQAGQG 750
Cdd:cd22553  280 QQQVGQIVTSpiqgMTQGLTAPASSSIPTVVQQQAIQGNPLPPGTQIIAAGQQ 332
R3H_sperm-antigen cd02636
R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. ...
 168-207 3.54e-03

R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100065  Cd Length: 61  Bit Score: 36.54  E-value: 3.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568964312 168 KMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGL 207
Cdd:cd02636    3 SMEKEVSKFIKDSVRTREKFQPMDKVERSIVHDVAEVAGL 42
R3H_Smubp-2_like cd02641
R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and ...
 176-220 5.67e-03

R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA.


Pssm-ID: 100070  Cd Length: 60  Bit Score: 35.79  E-value: 5.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568964312 176 FIADSNNHYKKFP-QMSSYQRMLVHRVAAYFGLDHNVDQTGKSVII 220
Cdd:cd02641   11 FMKDPKATELEFPpTLSSHDRLLVHELAEELGLRHESTGEGSDRVI 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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