|
Name |
Accession |
Description |
Interval |
E-value |
| HECTc |
cd00078 |
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
532-881 |
1.88e-160 |
|
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 472.43 E-value: 1.88e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 532 ILLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGMG-QGVVREWFDILSNEIVNPDYALFTQSADGT-TFQPNSNS 609
Cdd:cd00078 2 KITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDaGGVTREFFTLVSKELFNPSYGLFRYTPDDSgLLYPNPSS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 610 YVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVE 689
Cdd:cd00078 82 FADEDHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELTFTIE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 690 TDV-FGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPE 768
Cdd:cd00078 162 LDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSED 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 769 IDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMggsglQNFTIAAVPYTPNLL 848
Cdd:cd00078 242 IDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLN-----PKFTIRRVGSPDDRL 316
|
330 340 350
....*....|....*....|....*....|...
gi 568965196 849 PTSSTCINMLKLPEYPSKEILKDRLLVALHCGS 881
Cdd:cd00078 317 PTAHTCFNLLKLPPYSSKEILREKLLYAINEGA 349
|
|
| HECTc |
smart00119 |
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ... |
557-880 |
3.33e-133 |
|
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523 Cd Length: 328 Bit Score: 401.23 E-value: 3.33e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 557 KQGIAVRFHGEEGM-GQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQ 634
Cdd:smart00119 4 KRVLEIEFEGEEGLdGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFaNEEHLSYFRFIGRVLGKALYDNR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 635 LVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI-LDNDISDLgLELTFS-VETDVFGAMEEVPLKPGGGSILVTQ 712
Cdd:smart00119 84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEE-LDLTFSiVLTSEFGQVKVVELKPGGSNIPVTE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 713 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQ 792
Cdd:smart00119 163 ENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQTIK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 793 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGgsglqNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDR 872
Cdd:smart00119 243 WFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSP-----KFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317
|
....*...
gi 568965196 873 LLVALHCG 880
Cdd:smart00119 318 LLLAINEG 325
|
|
| HECT |
pfam00632 |
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ... |
581-883 |
2.00e-127 |
|
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880 Cd Length: 304 Bit Score: 385.42 E-value: 2.00e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 581 ILSNEIVNPDYALF-TQSADGTTFQPNSNSYVNPDH--LNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQD 657
Cdd:pfam00632 2 LLSKELFDPNYGLFeYETEDDRTYWFNPSSSESPDLelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 658 VASIDPEYAKNLQWILDNDISDLG-LELTFSVetDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQIN 736
Cdd:pfam00632 82 LESIDPELYKSLKSLLNMDNDDDEdLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 737 AFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGS 816
Cdd:pfam00632 160 AFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGS 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568965196 817 SRVPHGGFANimggsgLQNFTIAAVPYT-PNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL-HCGSYG 883
Cdd:pfam00632 240 SRLPVGGFKS------LPKFTIVRKGGDdDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIeEGEGFG 302
|
|
| HUL4 |
COG5021 |
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; |
533-877 |
8.71e-118 |
|
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain] Cd Length: 872 Bit Score: 379.11 E-value: 8.71e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 533 LLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGM-GQGVVREWFDILSNEIVNPDYALFT-QSADGTTFQPNSNSY 610
Cdd:COG5021 517 IKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIdAGGLTREWLFLLSKEMFNPDYGLFEyITEDLYTLPINPLSS 596
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 611 VNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVET 690
Cdd:COG5021 597 INPEHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDIDETILDLTFTVED 676
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 691 DVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPE-I 769
Cdd:COG5021 677 DSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGIPEdI 756
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 770 DVNDWIKNTEYtSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLP 849
Cdd:COG5021 757 DIDDWKSNTAY-HGYTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDGVRKFTIEKGGTDDDRLP 835
|
330 340
....*....|....*....|....*...
gi 568965196 850 TSSTCINMLKLPEYPSKEILKDRLLVAL 877
Cdd:COG5021 836 SAHTCFNRLKLPEYSSKEKLRSKLLTAI 863
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
3-227 |
1.75e-43 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 159.73 E-value: 1.75e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 3 MVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSK 82
Cdd:COG0666 59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 83 LLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVS 162
Cdd:COG0666 139 LLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDND 218
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568965196 163 GATPLYFACRrvclifwtwihsHGQRDTAQILLLRGAK-YLPDKNGVTPLDLCVQGGYGQTCEVLI 227
Cdd:COG0666 219 GKTALDLAAE------------NGNLEIVKLLLEAGADlNAKDKDGLTALLLAAAAGAALIVKLLL 272
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
3-230 |
2.23e-42 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 156.65 E-value: 2.23e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 3 MVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSK 82
Cdd:COG0666 26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 83 LLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVS 162
Cdd:COG0666 106 LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568965196 163 GATPLYFACRrvclifwtwihsHGQRDTAQILLLRGAK-YLPDKNGVTPLDLCVQGGYGQTCEVLIQYH 230
Cdd:COG0666 186 GETPLHLAAE------------NGHLEIVKLLLEAGADvNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
15-229 |
1.43e-31 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 125.07 E-value: 1.43e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 15 LLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICN 94
Cdd:COG0666 5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 95 NEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRrv 174
Cdd:COG0666 85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA-- 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 568965196 175 clifwtwihsHGQRDTAQILLLRGAK-YLPDKNGVTPLDLCVQGGYGQTCEVLIQY 229
Cdd:COG0666 163 ----------NGNLEIVKLLLEAGADvNARDNDGETPLHLAAENGHLEIVKLLLEA 208
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
14-167 |
9.69e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 111.20 E-value: 9.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 14 ELLSNSKFDVNYAfGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNIC 93
Cdd:COG0666 137 KLLLEAGADVNAQ-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568965196 94 NNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPL 167
Cdd:COG0666 216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
35-160 |
1.49e-21 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 89.79 E-value: 1.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 35 LHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYsADVNICNNegltaihwlavngrtellh 114
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN------------------- 60
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 568965196 115 dlvqhvtdvdvedamGQTALHVACQNGHKTTVQCLLDSGADINRPN 160
Cdd:pfam12796 61 ---------------GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1-186 |
4.39e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 93.96 E-value: 4.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 1 MPMVMADQHRSVS--ELLSNSKFDVN-YAFGrvKRSLLHIAANCGSVECLV-----LLLKKGANPNYQDISGCTPLHLAA 72
Cdd:PHA03100 37 LPLYLAKEARNIDvvKILLDNGADINsSTKN--NSTPLHYLSNIKYNLTDVkeivkLLLEYGANVNAPDNNGITPLLYAI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 73 RN--GQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTEL--LHDLVQHVTDVDVE----------------DAMGQT 132
Cdd:PHA03100 115 SKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINAKnrvnyllsygvpinikDVYGFT 194
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 568965196 133 ALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRRVCLIFWTWIHSHG 186
Cdd:PHA03100 195 PLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNG 248
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
47-229 |
1.01e-19 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 90.40 E-value: 1.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 47 LVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVE 126
Cdd:COG0666 4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 127 DAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRrvclifwtwihsHGQRDTAQILLLRGAK-YLPDK 205
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAY------------NGNLEIVKLLLEAGADvNAQDN 151
|
170 180
....*....|....*....|....
gi 568965196 206 NGVTPLDLCVQGGYGQTCEVLIQY 229
Cdd:COG0666 152 DGNTPLHLAAANGNLEIVKLLLEA 175
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
43-167 |
6.47e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 87.77 E-value: 6.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 43 SVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKC---MSKLLEYSADVN---ICnneGLTAIHWLAVNGRTE-LLHD 115
Cdd:PHA03095 26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNapeRC---GFTPLHLYLYNATTLdVIKL 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 568965196 116 LVQHVTDVDVEDAMGQTALHVAC--QNGHKTTVQCLLDSGADINRPNVSGATPL 167
Cdd:PHA03095 103 LIKAGADVNAKDKVGRTPLHVYLsgFNINPKVIRLLLRKGADVNALDLYGMTPL 156
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
18-212 |
3.43e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 81.93 E-value: 3.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 18 NSKFDVNYAFGRVKrSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEG 97
Cdd:PHA02874 112 DCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNG 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 98 LTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQngHKTTVQCLLDSGADINRPNVSGATPLYFACRRVCLI 177
Cdd:PHA02874 191 ESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAINPPCDI 268
|
170 180 190
....*....|....*....|....*....|....*.
gi 568965196 178 fwtwihshgqrDTAQILLLRGAKY-LPDKNGVTPLD 212
Cdd:PHA02874 269 -----------DIIDILLYHKADIsIKDNKGENPID 293
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
101-201 |
4.72e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 71.30 E-value: 4.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 101 IHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSgADINRPNvSGATPLYFACRrvclifwt 180
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAAR-------- 70
|
90 100
....*....|....*....|.
gi 568965196 181 wihsHGQRDTAQILLLRGAKY 201
Cdd:pfam12796 71 ----SGHLEIVKLLLEKGADI 87
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
13-261 |
5.64e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 79.34 E-value: 5.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 13 SELLSNSKFDVNyAFGRVKRSLLHIAANCGSVECLV-LLLKKGANPNYQDISGCTPLHLAARNG---------------- 75
Cdd:PHA02876 256 SLLLYDAGFSVN-SIDDCKNTPLHHASQAPSLSRLVpKLLERGADVNAKNIKGETPLYLMAKNGydtenirtlimlgadv 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 76 -------------------QKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHV 136
Cdd:PHA02876 335 naadrlyitplhqastldrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHF 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 137 A-CQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRRVClifwtwihshgQRDTAQILLLRGAkylpDKNGVTPLD--- 212
Cdd:PHA02876 415 AlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNC-----------KLDVIEMLLDNGA----DVNAINIQNqyp 479
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568965196 213 LCVQGGYGQTCEVLIQYHPRLFQTIVqmtQNEDLRENM--LRQVLQHLSQQ 261
Cdd:PHA02876 480 LLIALEYHGIVNILLHYGAELRDSRV---LHKSLNDNMfsFRYIIAHICIQ 527
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
2-229 |
1.16e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 76.95 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 2 PMVMADQHRSVS--ELLSNSKFDVNYAFGRVkRSLLHIAANCGSVECLVLLLKKGANPN---YQDisGCTPLHLAARNGQ 76
Cdd:PHA02875 38 PIKLAMKFRDSEaiKLLMKHGAIPDVKYPDI-ESELHDAVEEGDVKAVEELLDLGKFADdvfYKD--GMTPLHLATILKK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 77 KKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADI 156
Cdd:PHA02875 115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568965196 157 NrpnvsgatplYFAcRRVCLIFWTWIHSHGQRDTAQILLLRGAkylpDKNGVTpldlCVQGGYGQTCEVLIQY 229
Cdd:PHA02875 195 D----------YFG-KNGCVAALCYAIENNKIDIVRLFIKRGA----DCNIMF----MIEGEECTILDMICNM 248
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
31-231 |
3.57e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 72.39 E-value: 3.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 31 KRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQ-----KKCMSKLLEYSADVNICNNEGLTAIHWLA 105
Cdd:PHA03100 35 PVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 106 VN--GRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGH------------------KTTVQCLLDSGADINRPNVSGAT 165
Cdd:PHA03100 115 SKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidlkilkllidkgvdinaKNRVNYLLSYGVPINIKDVYGFT 194
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568965196 166 PLYFACRRVCLifwtwihshgqrDTAQILLLRGAKY-LPDKNGVTPLDLCVQGGYGQTCEVLIQYHP 231
Cdd:PHA03100 195 PLHYAVYNNNP------------EFVKYLLDLGANPnLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
22-211 |
6.01e-13 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 71.98 E-value: 6.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 22 DVNYAfGRVKRSLLHIAANCGSVEC---LVLLLKKGANPNYQDISGCTPLHLAARNGQK--------------------- 77
Cdd:PHA03095 39 DVNFR-GEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATTldvikllikagadvnakdkvg 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 78 -----KCMSK----------LLEYSADVNICNNEGLTAIHWLAVNGRT--ELLHDLVQHVTDVDVEDAMGQTALHVACQN 140
Cdd:PHA03095 118 rtplhVYLSGfninpkvirlLLRKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLIDAGADVYAVDDRFRSLLHHHLQS 197
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568965196 141 GHKTT--VQCLLDSGADINRPNVSGATPL-----YFACRRVCLIFwtwihshgqrdtaqiLLLRGAKY-LPDKNGVTPL 211
Cdd:PHA03095 198 FKPRAriVRELIRAGCDPAATDMLGNTPLhsmatGSSCKRSLVLP---------------LLIAGISInARNRYGQTPL 261
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
134-229 |
2.02e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.60 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 134 LHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRrvclifwtwihsHGQRDTAQILLLRGAKYLPDkNGVTPLDL 213
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAK------------NGHLEIVKLLLEHADVNLKD-NGRTALHY 67
|
90
....*....|....*.
gi 568965196 214 CVQGGYGQTCEVLIQY 229
Cdd:pfam12796 68 AARSGHLEIVKLLLEK 83
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
9-173 |
2.68e-12 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 70.05 E-value: 2.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 9 HRSVSELLSNSKFDVN--YAFGRVKRSLLHIAANCgSVECLVLLLKKGANPNYQDISGCTPLHLAARN--GQKKCMSKLL 84
Cdd:PHA03095 131 NPKVIRLLLRKGADVNalDLYGMTPLAVLLKSRNA-NVELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELI 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 85 EYSADVNICNNEGLTAIHWLAVNG--RTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVS 162
Cdd:PHA03095 210 RAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSD 289
|
170
....*....|.
gi 568965196 163 GATPLYFACRR 173
Cdd:PHA03095 290 GNTPLSLMVRN 300
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
12-170 |
3.84e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.52 E-value: 3.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 12 VSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVN 91
Cdd:PHA02878 149 ITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 92 ICNNEGLTAIHWLAvnGRT---ELLHDLVQHVTDVDVEDA-MGQTALHVACQNGHKTTVqcLLDSGADINRPNVSGATPL 167
Cdd:PHA02878 229 ARDKCGNTPLHISV--GYCkdyDILKLLLEHGVDVNAKSYiLGLTALHSSIKSERKLKL--LLEYGADINSLNSYKLTPL 304
|
...
gi 568965196 168 YFA 170
Cdd:PHA02878 305 SSA 307
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
4-92 |
3.88e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 62.83 E-value: 3.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 4 VMADQHRSVSELLSN-SKFDVNYAFGRvkrSLLHIAANCGSVECLVLLLKKgANPNYQDiSGCTPLHLAARNGQKKCMSK 82
Cdd:pfam12796 5 AKNGNLELVKLLLENgADANLQDKNGR---TALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79
|
90
....*....|
gi 568965196 83 LLEYSADVNI 92
Cdd:pfam12796 80 LLEKGADINV 89
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
38-160 |
8.00e-12 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 69.13 E-value: 8.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 38 AANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIhWLAV----------- 106
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL-WNAIsakhhkifril 610
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568965196 107 ---------------------NGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPN 160
Cdd:PLN03192 611 yhfasisdphaagdllctaakRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
49-172 |
1.40e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 68.17 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 49 LLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLA-----------VNGRTELLHD-- 115
Cdd:PHA02876 163 MLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVdsknidtikaiIDNRSNINKNdl 242
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568965196 116 -LVQHVTDVDVE---------------DAMGQTALHVACQNGHKTT-VQCLLDSGADINRPNVSGATPLYFACR 172
Cdd:PHA02876 243 sLLKAIRNEDLEtslllydagfsvnsiDDCKNTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAK 316
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
12-216 |
3.84e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 66.14 E-value: 3.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 12 VSELLSNSKFDVNYAFGRVKRSLL---HIAAN-------------------CGSVECLVLLLKKGANPNYQDISGCTPLH 69
Cdd:PHA02874 50 IVELFIKHGADINHINTKIPHPLLtaiKIGAHdiikllidngvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLH 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 70 LAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCL 149
Cdd:PHA02874 130 YAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLL 209
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568965196 150 LDSGADINRPNVSGATPLYFACrrvclifwtwIHShgqRDTAQILLLRGAKYLPDKNGVTPLDLCVQ 216
Cdd:PHA02874 210 IDHGNHIMNKCKNGFTPLHNAI----------IHN---RSAIELLINNASINDQDIDGSTPLHHAIN 263
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
32-84 |
5.81e-11 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 58.44 E-value: 5.81e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 568965196 32 RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLL 84
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
66-199 |
1.76e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 61.57 E-value: 1.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 66 TPLHLAARNGQKKCMSKLLEySADVNICNNEGL--TAIHWLAVNGRTELLHDLVQHVTDVdVEDAM------GQTALHVA 137
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLK-CPSCDLFQRGALgeTALHVAALYDNLEAAVVLMEAAPEL-VNEPMtsdlyqGETALHIA 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568965196 138 CQNGHKTTVQCLLDSGADINRPNVSGatpLYFACRRVCLIFW-----TWIHSHGQRDTAQILLLRGA 199
Cdd:cd22192 97 VVNQNLNLVRELIARGADVVSPRATG---TFFRPGPKNLIYYgehplSFAACVGNEEIVRLLIEHGA 160
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
38-211 |
1.79e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 60.75 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 38 AANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKK------------------CMSK-----LLEYSADVNICN 94
Cdd:PHA02874 42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDiikllidngvdtsilpipCIEKdmiktILDCGIDVNIKD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 95 NEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRrv 174
Cdd:PHA02874 122 AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAE-- 199
|
170 180 190
....*....|....*....|....*....|....*...
gi 568965196 175 clifwtwihsHGQRDTAQILLLRGAKYLPD-KNGVTPL 211
Cdd:PHA02874 200 ----------YGDYACIKLLIDHGNHIMNKcKNGFTPL 227
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
97-150 |
4.30e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 53.05 E-value: 4.30e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568965196 97 GLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLL 150
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
66-227 |
5.65e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 56.13 E-value: 5.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 66 TPLHLAARNGQKKCMSKLLEYSADVNICN----NEGLTAI--------HWLAVNG-----------RTELLHDLVQHVTD 122
Cdd:PHA02874 37 TPLIDAIRSGDAKIVELFIKHGADINHINtkipHPLLTAIkigahdiiKLLIDNGvdtsilpipciEKDMIKTILDCGID 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 123 VDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRrvclifwtwihsHGQRDTAQILLLRGAkYL 202
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIK------------HNFFDIIKLLLEKGA-YA 183
|
170 180
....*....|....*....|....*..
gi 568965196 203 --PDKNGVTPLDLCVQGGYGQTCEVLI 227
Cdd:PHA02874 184 nvKDNNGESPLHNAAEYGDYACIKLLI 210
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
34-119 |
9.74e-08 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 55.67 E-value: 9.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 34 LLHIAANCGSVEcLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELL 113
Cdd:PTZ00322 86 LCQLAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164
|
....*.
gi 568965196 114 HDLVQH 119
Cdd:PTZ00322 165 QLLSRH 170
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
11-125 |
1.19e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 55.06 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 11 SVSELLSNSKFDVNyAFGRVKrsllhiaancgsveclvLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADV 90
Cdd:PHA03100 157 KILKLLIDKGVDIN-AKNRVN-----------------YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANP 218
|
90 100 110
....*....|....*....|....*....|....*
gi 568965196 91 NICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDV 125
Cdd:PHA03100 219 NLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
42-227 |
1.70e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 54.61 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 42 GSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNG---RTELLHDLVQ 118
Cdd:PHA02875 13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGdvkAVEELLDLGK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 119 HVTDVDVEDamGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFAcrrvclifwtwIHSHGQRDTAQILLLRG 198
Cdd:PHA02875 93 FADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLA-----------VMMGDIKGIELLIDHKA 159
|
170 180
....*....|....*....|....*....
gi 568965196 199 AKYLPDKNGVTPLDLCVQGGYGQTCEVLI 227
Cdd:PHA02875 160 CLDIEDCCGCTPLIIAMAKGDIAICKMLL 188
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
66-117 |
2.21e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.42 E-value: 2.21e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568965196 66 TPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLV 117
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
35-226 |
2.62e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 54.12 E-value: 2.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 35 LHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLL----------EYSADVNICNNEGLTAIHWL 104
Cdd:PHA02878 41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIrsinkcsvfyTLVAIKDAFNNRNVEIFKII 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 105 AVNG---------------------RTELLHDLVQHVTDVDVEDA-MGQTALHVACQNGHKTTVQCLLDSGADINRPNVS 162
Cdd:PHA02878 121 LTNRykniqtidlvyidkkskddiiEAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKT 200
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568965196 163 GATPLYFACRrvclifwtwihsHGQRDTAQILLLRGAKY-LPDKNGVTPLDLCVqgGYGQTCEVL 226
Cdd:PHA02878 201 NNSPLHHAVK------------HYNKPIVHILLENGASTdARDKCGNTPLHISV--GYCKDYDIL 251
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
132-173 |
2.76e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.04 E-value: 2.76e-07
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 568965196 132 TALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRR 173
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN 44
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
15-71 |
4.84e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 47.34 E-value: 4.84e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 568965196 15 LLSNSKFDVNYaFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLA 71
Cdd:pfam13857 1 LLEHGPIDLNR-LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
29-228 |
4.90e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 53.48 E-value: 4.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 29 RVKRSLLHIAANCGSVECLVLLLK-KGANPNYQDISGCTPLHLAARNGQKKCMSKLLEysADVNICNN-------EGLTA 100
Cdd:cd22192 15 RISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQGETA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 101 IHWLAVNGRTELLHDLVQHVTDVDVEDAMG------QTAL-----HV----ACQnGHKTTVQCLLDSGADINRPNVSGAT 165
Cdd:cd22192 93 LHIAVVNQNLNLVRELIARGADVVSPRATGtffrpgPKNLiyygeHPlsfaACV-GNEEIVRLLIEHGADIRAQDSLGNT 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568965196 166 PLYFAC-----RRVCLIFwTWIHSHGQRDTAQILLLrgakyLPDKNGVTPLDLCVQGGYGQTCEVLIQ 228
Cdd:cd22192 172 VLHILVlqpnkTFACQMY-DLILSYDKEDDLQPLDL-----VPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
49-102 |
5.83e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 46.96 E-value: 5.83e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568965196 49 LLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIH 102
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
12-173 |
7.03e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 53.14 E-value: 7.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 12 VSELLSNSKFDVNyAFGRVKRSLLHIAANCGSVECLVLLLKKGA---------------------------------NPN 58
Cdd:PHA02876 160 IAEMLLEGGADVN-AKDIYCITPIHYAAERGNAKMVNLLLSYGAdvniialddlsvlecavdsknidtikaiidnrsNIN 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 59 YQDIS-----------------------------GCTPLHLAARNGQ-KKCMSKLLEYSADVNICNNEGLTAIHWLAVNG 108
Cdd:PHA02876 239 KNDLSllkairnedletslllydagfsvnsiddcKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKNG 318
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568965196 109 -RTELLHDLVQHVTDVDVEDAMGQTALHVACQ-NGHKTTVQCLLDSGADINRPNVSGATPLYFACRR 173
Cdd:PHA02876 319 yDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVR 385
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
104-170 |
1.42e-06 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 52.18 E-value: 1.42e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568965196 104 LAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFA 170
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNA 598
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
126-235 |
1.71e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.82 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 126 EDAMGQTALHVA----CQ---NGHKTTVQCLLDSGADINRPNVSGATPLYFACrrvclifwtwihSHGQRDTAQILLLRG 198
Cdd:PTZ00322 71 EEVIDPVVAHMLtvelCQlaaSGDAVGARILLTGGADPNCRDYDGRTPLHIAC------------ANGHVQVVRVLLEFG 138
|
90 100 110
....*....|....*....|....*....|....*...
gi 568965196 199 AK-YLPDKNGVTPLDLCVQGGYGQTCEVLIQYHPRLFQ 235
Cdd:PTZ00322 139 ADpTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
64-95 |
3.48e-06 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 44.20 E-value: 3.48e-06
10 20 30
....*....|....*....|....*....|...
gi 568965196 64 GCTPLHLAA-RNGQKKCMSKLLEYSADVNICNN 95
Cdd:pfam00023 2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
129-157 |
4.62e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 43.73 E-value: 4.62e-06
10 20
....*....|....*....|....*....
gi 568965196 129 MGQTALHVACQNGHKTTVQCLLDSGADIN 157
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
104-195 |
5.67e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 50.28 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 104 LAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRrvclifwtwih 183
Cdd:PTZ00322 89 LAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEE----------- 157
|
90
....*....|..
gi 568965196 184 sHGQRDTAQILL 195
Cdd:PTZ00322 158 -NGFREVVQLLS 168
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
64-92 |
1.44e-05 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 42.57 E-value: 1.44e-05
10 20
....*....|....*....|....*....
gi 568965196 64 GCTPLHLAARNGQKKCMSKLLEYSADVNI 92
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
130-160 |
1.96e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 42.28 E-value: 1.96e-05
10 20 30
....*....|....*....|....*....|..
gi 568965196 130 GQTALHVAC-QNGHKTTVQCLLDSGADINRPN 160
Cdd:pfam00023 2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
43-160 |
4.83e-05 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 46.75 E-value: 4.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 43 SVECLVLLLKKGANPNYQDISGCTPLHLAARNGQK-----KCMSKLLEYSADVNICNNEGLTAIHWLAVNG---RTELLH 114
Cdd:PHA02798 50 STDIVKLFINLGANVNGLDNEYSTPLCTILSNIKDykhmlDIVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILL 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 568965196 115 DLVQHVTDVDVEDAMGQTALHVACQNGHKT---TVQCLLDSGADINRPN 160
Cdd:PHA02798 130 FMIENGADTTLLDKDGFTMLQVYLQSNHHIdieIIKLLLEKGVDINTHN 178
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
50-173 |
5.68e-05 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 46.59 E-value: 5.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 50 LLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGR--TELLHDLVQHVTDVD--- 124
Cdd:PHA02946 58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINnsv 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 125 ------------------------------VEDAMGQTAL--HVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACR 172
Cdd:PHA02946 138 deegcgpllactdpservfkkimsigfearIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCS 217
|
.
gi 568965196 173 R 173
Cdd:PHA02946 218 K 218
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
130-157 |
6.87e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 40.70 E-value: 6.87e-05
10 20
....*....|....*....|....*...
gi 568965196 130 GQTALHVACQNGHKTTVQCLLDSGADIN 157
Cdd:pfam13606 2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
32-87 |
1.48e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.66 E-value: 1.48e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568965196 32 RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYS 87
Cdd:PTZ00322 116 RTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHS 171
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
64-92 |
2.41e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 39.16 E-value: 2.41e-04
10 20
....*....|....*....|....*....
gi 568965196 64 GCTPLHLAARNGQKKCMSKLLEYSADVNI 92
Cdd:pfam13606 2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
116-170 |
2.52e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.64 E-value: 2.52e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568965196 116 LVQHVT-DVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFA 170
Cdd:pfam13857 1 LLEHGPiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
32-61 |
3.34e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 38.81 E-value: 3.34e-04
10 20 30
....*....|....*....|....*....|.
gi 568965196 32 RSLLHIAA-NCGSVECLVLLLKKGANPNYQD 61
Cdd:pfam00023 3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
|
|
| PHA02884 |
PHA02884 |
ankyrin repeat protein; Provisional |
30-101 |
5.90e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165212 [Multi-domain] Cd Length: 300 Bit Score: 43.05 E-value: 5.90e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568965196 30 VKRSLLHIAANCGSVECLVLLLKKGANPN-YQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAI 101
Cdd:PHA02884 69 SKTNPLIYAIDCDNDDAAKLLIRYGADVNrYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPI 141
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
32-59 |
1.10e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.18 E-value: 1.10e-03
10 20
....*....|....*....|....*...
gi 568965196 32 RSLLHIAANCGSVECLVLLLKKGANPNY 59
Cdd:smart00248 3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
22-211 |
3.19e-03 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 41.05 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 22 DVNYAFGRVKRSLLHiaANCGS----VECLVLLLKKGANPNYQDISGCTPLHLAARNGQ--KKCMSKLLEYSADVNI--C 93
Cdd:PHA02716 168 NLNYVCKKTGYGILH--AYLGNmyvdIDILEWLCNNGVNVNLQNNHLITPLHTYLITGNvcASVIKKIIELGGDMDMkcV 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965196 94 N---------------NEGLTAIHWLAVNGRT-----ELLHDLVQHVTDVDV---------------EDAMGQTALH--V 136
Cdd:PHA02716 246 NgmspimtyiinidniNPEITNIYIESLDGNKvknipMILHSYITLARNIDIsvvysflqpgvklhyKDSAGRTCLHqyI 325
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568965196 137 ACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACRRVCL--IFWTWIHSHGQRDTAQILLLRGAKYLPDKN-GVTPL 211
Cdd:PHA02716 326 LRHNISTDIIKLLHEYGNDLNEPDNIGNTVLHTYLSMLSVvnILDPETDNDIRLDVIQCLISLGADITAVNClGYTPL 403
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
83-137 |
6.44e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 35.79 E-value: 6.44e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568965196 83 LLEY-SADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVA 137
Cdd:pfam13857 1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| |
