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Conserved domains on  [gi|568965576|ref|XP_006512882|]
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nephrocan isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-367 9.58e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 9.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  51 SALPANLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLASLQSLMVDGNNIESVVGPLSLPHLKYM 130
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 131 SMENNQLHLIPGNVFTSLQNLQFLSFSGNFLTKIPINLPKsllslkmernqlkvvrfrdmkhLENLSHLYLSENFLSSID 210
Cdd:COG4886   95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAN----------------------LTNLKELDLSNNQLTDLP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 211 GA-QQLTNLTTLEVSQNQLQMLPPRLP--SRLQKLDCSSNFIQRVTAPeFQDLRDLKHLFLDNNVVSLFEAgALQRCSQL 287
Cdd:COG4886  153 EPlGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 288 SNLALEQNLLLSIP-LRLPKTLARLDLKGNAIQDMAerELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNPW 366
Cdd:COG4886  231 ETLDLSNNQLTDLPeLGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308


                 .
gi 568965576 367 N 367
Cdd:COG4886  309 N 309
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-367 9.58e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 9.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  51 SALPANLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLASLQSLMVDGNNIESVVGPLSLPHLKYM 130
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 131 SMENNQLHLIPGNVFTSLQNLQFLSFSGNFLTKIPINLPKsllslkmernqlkvvrfrdmkhLENLSHLYLSENFLSSID 210
Cdd:COG4886   95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAN----------------------LTNLKELDLSNNQLTDLP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 211 GA-QQLTNLTTLEVSQNQLQMLPPRLP--SRLQKLDCSSNFIQRVTAPeFQDLRDLKHLFLDNNVVSLFEAgALQRCSQL 287
Cdd:COG4886  153 EPlGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 288 SNLALEQNLLLSIP-LRLPKTLARLDLKGNAIQDMAerELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNPW 366
Cdd:COG4886  231 ETLDLSNNQLTDLPeLGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308


                 .
gi 568965576 367 N 367
Cdd:COG4886  309 N 309
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
161-364 1.19e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.36  E-value: 1.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 161 LTKIPINLPKSLLSLKMERNQLKVVRfrdmKHLE-NLSHLYLSENFLSSIDGAQQLTnLTTLEVSQNQLQMLPPRLPSRL 239
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLP----ENLQgNIKTLYANSNQLTSIPATLPDT-IQEMELSINRITELPERLPSAL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 240 QKLDCSSNFIQRV--TAPEfqDLRDLKhlFLDNNVVSLFEagalQRCSQLSNLALEQNLLLSIPLRLPKTLARLDLKGNA 317
Cdd:PRK15370 265 QSLDLFHNKISCLpeNLPE--ELRYLS--VYDNSIRTLPA----HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENA 336

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 568965576 318 IQDMAERElrdLKQLQVLNLRNNRISALDfkalEGL-PRLRHLYLDGN 364
Cdd:PRK15370 337 LTSLPASL---PPELQVLDVSKNQITVLP----ETLpPTITTLDVSRN 377
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 193-377 1.99e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 1.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 193 LENLSHLYLSENFLSSIDGAQQLTNLTTLEVSQNQLqmlpprlpSRLQKLDCSS---------NFIQRVtaPEFQDLRDL 263
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKI--------TKIENLEFLTnlthlylqnNQIEKI--ENLENLVNL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 264 KHLFLDNNVVSLFEagALQRCSQLSNLALE-QNLLLSIPLR--------LPKTLARLDLKGNAIQDMAerELRDLKQLQV 334
Cdd:cd21340   71 KKLYLGGNRISVVE--GLENLTNLEELHIEnQRLPPGEKLTfdprslaaLSNSLRVLNISGNNIDSLE--PLAPLRNLEQ 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568965576 335 LNLRNNRISALD--FKALEGLPRLRHLYLDGNPwncTCSLLRARE 377
Cdd:cd21340  147 LDASNNQISDLEelLDLLSSWPSLRELDLTGNP---VCKKPKYRD 188
LRR_8 pfam13855
Leucine rich repeat;
307-365 2.19e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568965576  307 TLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNP 365
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-367 9.58e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 9.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  51 SALPANLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLASLQSLMVDGNNIESVVGPLSLPHLKYM 130
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 131 SMENNQLHLIPGNVFTSLQNLQFLSFSGNFLTKIPINLPKsllslkmernqlkvvrfrdmkhLENLSHLYLSENFLSSID 210
Cdd:COG4886   95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAN----------------------LTNLKELDLSNNQLTDLP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 211 GA-QQLTNLTTLEVSQNQLQMLPPRLP--SRLQKLDCSSNFIQRVTAPeFQDLRDLKHLFLDNNVVSLFEAgALQRCSQL 287
Cdd:COG4886  153 EPlGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 288 SNLALEQNLLLSIP-LRLPKTLARLDLKGNAIQDMAerELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNPW 366
Cdd:COG4886  231 ETLDLSNNQLTDLPeLGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308


                 .
gi 568965576 367 N 367
Cdd:COG4886  309 N 309
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-369 2.51e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 2.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  26 ENDTFKTLSTLKTLELWKNKLRQVPSALPA--NLEVLKLNDNAICALrGSEFEGLKNLKVLELKNNlisslspsmlspla 103
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-------------- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 104 slqslmvdgnNIESVVGPLS-LPHLKYMSMENNQLHLIPgNVFTSLQNLQFLSFSGNFLTKIPINLPKsllslkmernql 182
Cdd:COG4886  170 ----------QLTDLPEELGnLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLAN------------ 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 183 kvvrfrdmkhLENLSHLYLSENFLSSIDGAQQLTNLTTLEVSQNQLQMLPPRLP-SRLQKLDCSSNfiqRVTAPEFQDLR 261
Cdd:COG4886  227 ----------LTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNN---QLTDLKLKELE 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 262 DLKHLFLDNNVVSLFEAGALQRCSQLSNLALEQNLLLSIPLRLPKTLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNR 341
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                        330       340
                 ....*....|....*....|....*...
gi 568965576 342 ISALDFKALEGLPRLRHLYLDGNPWNCT 369
Cdd:COG4886  374 LLEATLLTLALLLLTLLLLLLTTTAGVL 401
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
161-364 1.19e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.36  E-value: 1.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 161 LTKIPINLPKSLLSLKMERNQLKVVRfrdmKHLE-NLSHLYLSENFLSSIDGAQQLTnLTTLEVSQNQLQMLPPRLPSRL 239
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLP----ENLQgNIKTLYANSNQLTSIPATLPDT-IQEMELSINRITELPERLPSAL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 240 QKLDCSSNFIQRV--TAPEfqDLRDLKhlFLDNNVVSLFEagalQRCSQLSNLALEQNLLLSIPLRLPKTLARLDLKGNA 317
Cdd:PRK15370 265 QSLDLFHNKISCLpeNLPE--ELRYLS--VYDNSIRTLPA----HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENA 336

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 568965576 318 IQDMAERElrdLKQLQVLNLRNNRISALDfkalEGL-PRLRHLYLDGN 364
Cdd:PRK15370 337 LTSLPASL---PPELQVLDVSKNQITVLP----ETLpPTITTLDVSRN 377
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 193-377 1.99e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 1.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 193 LENLSHLYLSENFLSSIDGAQQLTNLTTLEVSQNQLqmlpprlpSRLQKLDCSS---------NFIQRVtaPEFQDLRDL 263
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKI--------TKIENLEFLTnlthlylqnNQIEKI--ENLENLVNL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 264 KHLFLDNNVVSLFEagALQRCSQLSNLALE-QNLLLSIPLR--------LPKTLARLDLKGNAIQDMAerELRDLKQLQV 334
Cdd:cd21340   71 KKLYLGGNRISVVE--GLENLTNLEELHIEnQRLPPGEKLTfdprslaaLSNSLRVLNISGNNIDSLE--PLAPLRNLEQ 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568965576 335 LNLRNNRISALD--FKALEGLPRLRHLYLDGNPwncTCSLLRARE 377
Cdd:cd21340  147 LDASNNQISDLEelLDLLSSWPSLRELDLTGNP---VCKKPKYRD 188
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
45-332 2.49e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.50  E-value: 2.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  45 KLRQVPSALPANLEVLKLNDNAICALRgsefeglKNLKvlelknnlisslspsmlsplASLQSLMVDGNNIESVvgPLSL 124
Cdd:PRK15370 189 GLTTIPACIPEQITTLILDNNELKSLP-------ENLQ--------------------GNIKTLYANSNQLTSI--PATL 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 125 PH-LKYMSMENNQLHLIPGNVFTSLQNLqflSFSGNFLTKIPINLPKSLLSLKMERNQLKVVRfrdmKHL-ENLSHLYLS 202
Cdd:PRK15370 240 PDtIQEMELSINRITELPERLPSALQSL---DLFHNKISCLPENLPEELRYLSVYDNSIRTLP----AHLpSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 203 ENFLSSIDgAQQLTNLTTLEVSQNQLQMLPPRLPSRLQKLDCSSNFIQ---RVTAPEFQDLrDLKHLFLDNNVVSLFEAg 279
Cdd:PRK15370 313 SNSLTALP-ETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITvlpETLPPTITTL-DVSRNALTNLPENLPAA- 389

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568965576 280 alqrcsqLSNLALEQNLLLSIPLRLPKTL------ARLDLKGNAIqdmAERELRDLKQL 332
Cdd:PRK15370 390 -------LQIMQASRNNLVRLPESLPHFRgegpqpTRIIVEYNPF---SERTIQNMQRL 438
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-257 6.74e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 6.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  38 TLELWKNKLRQVPSALPANLEVLKLNDNAICALRGSEFEglkNLKVLELKNNlisSLSPSMLSPLASLQSLMVDGNNIES 117
Cdd:PRK15370 203 TLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPD---TIQEMELSIN---RITELPERLPSALQSLDLFHNKISC 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 118 VvgPLSLPH-LKYMSMENNQLHLIPGNVFTSLQNLQFLSfsgNFLTKIPINLPKSLLSLKMERNQLKVVRFRDMKHLENL 196
Cdd:PRK15370 277 L--PENLPEeLRYLSVYDNSIRTLPAHLPSGITHLNVQS---NSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVL 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568965576 197 ShlyLSENFLSSIDGAQQLTnLTTLEVSQNQLQMLPPRLPSRLQKLDCSSNFIQRV--TAPEF 257
Cdd:PRK15370 352 D---VSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLpeSLPHF 410
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
121-357 2.58e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.04  E-value: 2.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 121 PLSLP-HLKYMSMENNQLHLIPGNVFTslqNLQFLSFSGNFLTKIPINLPKSLLSLKMERNQLKVVRfrdmKHLEN-LSH 198
Cdd:PRK15370 194 PACIPeQITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP----ERLPSaLQS 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 199 LYLSENFLSSIdgAQQLTN-LTTLEVSQNQLQMLPPRLPSRLQKLDCSSNFIQRV--TAPEfqdlrDLKHLFLDNNVVSL 275
Cdd:PRK15370 267 LDLFHNKISCL--PENLPEeLRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALpeTLPP-----GLKTLEAGENALTS 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 276 FEAGAlqrCSQLSNLALEQNLLLSIPLRLPKTLARLDLKGNAIQDMAERELRDLKQLQVlnLRNNRIsaldfKALEGLPR 355
Cdd:PRK15370 340 LPASL---PPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQA--SRNNLV-----RLPESLPH 409


                 ..
gi 568965576 356 LR 357
Cdd:PRK15370 410 FR 411
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
34-182 5.99e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 5.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  34 STLKTLELWKNKLRQVPSALPANLEVLKLNDNAICALRGSEFEGLKNLKVlelKNNLISSLSPSMLSplaSLQSLMVDGN 113
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNV---QSNSLTALPETLPP---GLKTLEAGEN 335

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 114 NIESVvgPLSL-PHLKYMSMENNQLHLIPGNVFTSLQNLQflsFSGNFLTKIPINLPKSLLSLKMERNQL 182
Cdd:PRK15370 336 ALTSL--PASLpPELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTNLPENLPAALQIMQASRNNL 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-364 1.87e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  34 STLKTLELWKNKLR-QVPSALP--ANLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLASLQSLMV 110
Cdd:PLN00113 164 SSLKVLDLGGNVLVgKIPNSLTnlTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 111 DGNN----IESVVGPLSlpHLKYMSMENNQLH-LIPGNVFT-----------------------SLQNLQFLS-FSGNFL 161
Cdd:PLN00113 244 VYNNltgpIPSSLGNLK--NLQYLFLYQNKLSgPIPPSIFSlqklisldlsdnslsgeipelviQLQNLEILHlFSNNFT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 162 TKIPI---NLPKsLLSLKMERNQLKVVRFRDMKHLENLSHLYLSENFLSS--IDGAQQLTNLTTLEVSQNQLQ-MLPPRL 235
Cdd:PLN00113 322 GKIPValtSLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGeiPEGLCSSGNLFKLILFSNSLEgEIPKSL 400

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 236 PS-------RLQK-------------------LDCSSNFIQRVTAPEFQDLRDLKHLFLDNNvvSLF-EAGALQRCSQLS 288
Cdd:PLN00113 401 GAcrslrrvRLQDnsfsgelpseftklplvyfLDISNNNLQGRINSRKWDMPSLQMLSLARN--KFFgGLPDSFGSKRLE 478

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568965576 289 NLALEQNLLL-SIPLRLPK--TLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGN 364
Cdd:PLN00113 479 NLDLSRNQFSgAVPRKLGSlsELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
LRR_8 pfam13855
Leucine rich repeat;
307-365 2.19e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568965576  307 TLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNP 365
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
39-350 3.19e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.94  E-value: 3.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  39 LELWKNKLRQVPSALPANLEVLKLNDNAICALRGSEFEglknlkvlelknnlisslspsmlsplasLQSLMVDGNNIESV 118
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPE----------------------------LRTLEVSGNQLTSL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 119 vgPLSLPHLKYMSMENNQLHLIPGnVFTSLQNLQFLsfsGNFLTKIPInLPKSLLSLKMERNQLKVVRFRDmkhlENLSH 198
Cdd:PRK15387 258 --PVLPPGLLELSIFSNPLTHLPA-LPSGLCKLWIF---GNQLTSLPV-LPPGLQELSVSDNQLASLPALP----SELCK 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 199 LYLSENFLSSIDGAQqlTNLTTLEVSQNQLQMLPPrLPSRLQKLDCSSNFIQRVTAPEfqdlRDLKHLFLDNNVVSLFEA 278
Cdd:PRK15387 327 LWAYNNQLTSLPTLP--SGLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPALP----SGLKELIVSGNRLTSLPV 399

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568965576 279 GAlqrcSQLSNLALEQNLLLSIPLrLPKTLARLDLKGNAIQDMAErELRDLKQLQVLNLRNNRISALDFKAL 350
Cdd:PRK15387 400 LP----SELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPE-SLIHLSSETTVNLEGNPLSERTLQAL 465
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 8-343 7.97e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 7.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576   8 GLLALEDFILLASGTESIeNDTFKTLS---TLKTLELWKNklrqVPSALPANLEVLKLNDNAICALRGSEFEGLKNLKVL 84
Cdd:PLN00113  24 SMLHAEELELLLSFKSSI-NDPLKYLSnwnSSADVCLWQG----ITCNNSSRVVSIDLSGKNISGKISSAIFRLPYIQTI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  85 ELKNNLISSLS-PSMLSPLASLQSLMVDGNNIESVVGPLSLPHLKYMSMENNQLHLIPGNVFTSLQNLQFLSFSGNFLT- 162
Cdd:PLN00113  99 NLSNNQLSGPIpDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVg 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 163 KIPINLPK--SLLSLKMERNQLKVVRFRDMKHLENLSHLYLSENFLSSIDGAQ--QLTNLTTLEVSQNQLQMLPPrlpsr 238
Cdd:PLN00113 179 KIPNSLTNltSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEigGLTSLNHLDLVYNNLTGPIP----- 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 239 lqkldcssnfiqrvtaPEFQDLRDLKHLFLDNNVVSLFEAGALQRCSQLSNLALEQNLLL-SIPLRLP--KTLARLDLKG 315
Cdd:PLN00113 254 ----------------SSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIqlQNLEILHLFS 317

                        330       340
                 ....*....|....*....|....*...
gi 568965576 316 NAIQDMAERELRDLKQLQVLNLRNNRIS 343
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKFS 345
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 25-343 3.92e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 3.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  25 IENDTFKTLSTLKTLELWKNKLR-QVPSALPANLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLA 103
Cdd:PLN00113 109 IPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLT 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 104 SLQSLMVDGNNIESVVgPLSLPHLK-----YMSMEN---------------NQLHLIPGNV-------FTSLQNLQFLSF 156
Cdd:PLN00113 189 SLEFLTLASNQLVGQI-PRELGQMKslkwiYLGYNNlsgeipyeiggltslNHLDLVYNNLtgpipssLGNLKNLQYLFL 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 157 SGNFLT-KIP--INLPKSLLSLKMERNQLKVVRFRDMKHLENLSHLYL-SENFLSSIDGAqqLTNLTTLEVSQNQLQMLP 232
Cdd:PLN00113 268 YQNKLSgPIPpsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLfSNNFTGKIPVA--LTSLPRLQVLQLWSNKFS 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 233 PRLPSRLQK------LDCSSNFIQRVTAPEFQDLRDLKHLFLDNNVVSLFEAGALQRCSQLSNLALEQNlllSIPLRLPK 306
Cdd:PLN00113 346 GEIPKNLGKhnnltvLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN---SFSGELPS 422

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 568965576 307 TLAR------LDLKGNAIQDMAERELRDLKQLQVLNLRNNRIS 343
Cdd:PLN00113 423 EFTKlplvyfLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF 465
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
34-207 3.34e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 46.31  E-value: 3.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  34 STLKTLELWKNKLRQVPsALPANLEVLKLNDNAICALRGSEFEGLKnlkvLELKNNLISSLSPSMlsplASLQSLMVDGN 113
Cdd:PRK15387 282 SGLCKLWIFGNQLTSLP-VLPPGLQELSVSDNQLASLPALPSELCK----LWAYNNQLTSLPTLP----SGLQELSVSDN 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 114 NIESVvgPLSLPHLKYMSMENNQLHLIP------------GNVFTSL----QNLQFLSFSGNFLTKIPInLPKSLLSLKM 177
Cdd:PRK15387 353 QLASL--PTLPSELYKLWAYNNRLTSLPalpsglkelivsGNRLTSLpvlpSELKELMVSGNRLTSLPM-LPSGLLSLSV 429

                        170       180       190
                 ....*....|....*....|....*....|
gi 568965576 178 ERNQLKVVRfRDMKHLENLSHLYLSENFLS 207
Cdd:PRK15387 430 YRNQLTRLP-ESLIHLSSETTVNLEGNPLS 458
LRR_8 pfam13855
Leucine rich repeat;
237-297 1.44e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568965576  237 SRLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDNNVVSLFEAGALQRCSQLSNLALEQNLL 297
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-226 2.97e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  56 NLEVLKLNDNAICALRGseFEGLKNLKVLELKNnlisslspsmlsplaslqslmvdgNNIESVVGPLSLPHLKYMSMENN 135
Cdd:cd21340   25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQN------------------------NQIEKIENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 136 QLHLIPGnvFTSLQNLQFL------SFSGNFLTKIP---INLPKSLLSLKMERNQLKVVrfRDMKHLENLSHLYLSENFL 206
Cdd:cd21340   79 RISVVEG--LENLTNLEELhienqrLPPGEKLTFDPrslAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154

                        170       180
                 ....*....|....*....|....
gi 568965576 207 SSIDGAQQL----TNLTTLEVSQN 226
Cdd:cd21340  155 SDLEELLDLlsswPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
7-377 5.57e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 5.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576   7 TGLLALEDFILLASGTESIENDTFKTLSTL----KTLELWKNKLRQVPsALPANLEVLKLNDNAicalrgsefegLKNLK 82
Cdd:PRK15387 211 SGLTTLPDCLPAHITTLVIPDNNLTSLPALppelRTLEVSGNQLTSLP-VLPPGLLELSIFSNP-----------LTHLP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  83 VLElknnlisslspsmlsplASLQSLMVDGNNIESVvgPLSLPHLKYMSMENNQLHLIPGnvftSLQNLQFLSFSGNFLT 162
Cdd:PRK15387 279 ALP-----------------SGLCKLWIFGNQLTSL--PVLPPGLQELSVSDNQLASLPA----LPSELCKLWAYNNQLT 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 163 KIPiNLPKSLLSLKMERNQLKVVRFRDmkhlENLSHLYLSENFLSSIDGAQqlTNLTTLEVSQNQLQMLPPrLPSRLQKL 242
Cdd:PRK15387 336 SLP-TLPSGLQELSVSDNQLASLPTLP----SELYKLWAYNNRLTSLPALP--SGLKELIVSGNRLTSLPV-LPSELKEL 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 243 DCSSNfiqRVTApefqdlrdlkhlfldnnvVSLFEAGALqrcsqlsNLALEQNLLlsipLRLPKTLARL------DLKGN 316
Cdd:PRK15387 408 MVSGN---RLTS------------------LPMLPSGLL-------SLSVYRNQL----TRLPESLIHLssettvNLEGN 455

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568965576 317 AiqdMAERELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNPWnctcsLLRARE 377
Cdd:PRK15387 456 P---LSERTLQALREITSAPGYSGPIIRFDMAGASAPRETRALHLAAADW-----LVPARE 508
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-239 7.73e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 7.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  28 DTFKTLSTLKTLELWKNKLRQVPSALPA--NLEVLKLNDNAICALrgSEFEGLKNLKVLELKNNLISSLSPSMLSplASL 105
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLANL--TNL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 106 QSLMVDGNNIESVVGPLSLPHLKYMSMENNQLHLIPGNVFTSLQNLQFLSFSGNFLTKIPINLPKSLLSLKMERNQLKVV 185
Cdd:COG4886  275 KTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568965576 186 RFRDMKHLENLSHLYLSENFLSSIDGAQQLTNLTTLEVSQNQLQMLPPRLPSRL 239
Cdd:COG4886  355 LLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 149-364 8.18e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 8.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 149 QNLQFLSFSGNFLTKIPINLpKSLLSLKMERNQLKVVRFRDMKHLENLSHLYlsENFLSSidGAQQLTNLTTLEVSQNQL 228
Cdd:cd00116   51 PSLKELCLSLNETGRIPRGL-QSLLQGLTKGCGLQELDLSDNALGPDGCGVL--ESLLRS--SSLQELKLNNNGLGDRGL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 229 QML---PPRLPSRLQKLDCSSNFIQ----RVTAPEFQDLRDLKHLFLDNNVV------SLFEAGALQrcSQLSNLALEQN 295
Cdd:cd00116  126 RLLakgLKDLPPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGIgdagirALAEGLKAN--CNLEVLDLNNN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 296 LL-------LSIPLRLPKTLARLDLKGNAIQDMAERELRD-----LKQLQVLNLRNNRISALDFKAL-EGL---PRLRHL 359
Cdd:cd00116  204 GLtdegasaLAETLASLKSLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDITDDGAKDLaEVLaekESLLEL 283


                 ....*
gi 568965576 360 YLDGN 364
Cdd:cd00116  284 DLRGN 288
LRR_8 pfam13855
Leucine rich repeat;
285-342 8.20e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 8.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568965576  285 SQLSNLALEQNLLLSIPLRLPKTLARL---DLKGNAIQDMAERELRDLKQLQVLNLRNNRI 342
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLkvlDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
104-159 8.28e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 8.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568965576  104 SLQSLMVDGNNIESV--VGPLSLPHLKYMSMENNQLHLIPGNVFTSLQNLQFLSFSGN 159
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
56-115 1.60e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576   56 NLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLASLQSLMVDGNNI 115
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
216-271 2.09e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568965576  216 TNLTTLEVSQNQLQMLPPRL---PSRLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDNN 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 330-365 2.71e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 2.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568965576  330 KQLQVLNLRNNRISALDFkaLEGLPRLRHLYLDGNP 365
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNN 34
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 23-165 4.09e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576  23 ESIENdtFKTLSTLKTLELWKNKLRQVP--SALPaNLEVLKLNDNAICALRGseFEGLKNLKVLELKNNLISSLS----- 95
Cdd:cd21340   37 TKIEN--LEFLTNLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEkltfd 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568965576  96 -PSMLSPLASLQSLMVDGNNIESVVGPLSLPHLKYMSMENNQLHLIP--GNVFTSLQNLQFLSFSGNFLTKIP 165
Cdd:cd21340  112 pRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 234-344 8.81e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.11  E-value: 8.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568965576 234 RLPSRLQKLDCSSNFIQ----RVTAPEFQDLRDLKHLFLDNNVV----SLFEAGALQRCSQLSNLALEQNL--------L 297
Cdd:cd00116  162 RANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNltdagaaaL 241

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568965576 298 LSIPLRLPKTLARLDLKGNAIQD----MAERELRDLKQLQVLNLRNNRISA 344
Cdd:cd00116  242 ASALLSPNISLLTLSLSCNDITDdgakDLAEVLAEKESLLELDLRGNKFGE 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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