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Conserved domains on  [gi|568966241|ref|XP_006513082|]
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calcineurin-binding protein cabin-1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MEF2_binding pfam09047
MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the ...
 2123-2157 1.71e-15

MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription.


:

Pssm-ID: 370261 [Multi-domain]  Cd Length: 35  Bit Score: 71.81  E-value: 1.71e-15
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568966241  2123 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2157
Cdd:pfam09047    1 TLLSPKGSISEETKQKLKNAILSAQSAANVKKDSL 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
30-205 8.37e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 67.34  E-value: 8.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   30 EAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEarllreavssgdekeglKHPGLilkYSTYKNLAQLAAQREDLETA 109
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE-----------------LDPDD---AEALYNLGLAYLRLGRYEEA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  110 MEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDC 189
Cdd:COG0457    62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141

                         170
                  ....*....|....*.
gi 568966241  190 RYSKGLVLKEKIFEEQ 205
Cdd:COG0457   142 DDADALYNLGIALEKL 157
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1916-2150 6.86e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 51.11  E-value: 6.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  1916 ATQRQASGDTPTTPKHPKDSRENFFPATVvptvpdPTAPDALQR-PSDSHLKPVLATVITCPPSASASIPdlSTDPGIpr 1994
Cdd:pfam17823   37 AGKQNASGDAVPRADNKSSEQ*NFCAATA------APAPVTLTKgTSAAHLNSTEVTAEHTPHGTDLSEP--ATREGA-- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  1995 phrPETTPSRAPLSPEGEEASGVTEGT----SILPQEPRYSHQIKMAAT-GHLAEQHCWPVEVACQTGAEPTCSQASSTK 2069
Cdd:pfam17823  107 ---ADGAASRALAAAASSSPSSAAQSLpaaiAALPSEAFSAPRAAACRAnASAAPRAAIAAASAPHAASPAPRTAASSTT 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  2070 VPSSgstQTAESHQGKTESSRAKSRLLPNMPKL------VIPSATTKSPPEITVTPPTPTLLSPKGSISEETKQKLKSAI 2143
Cdd:pfam17823  184 AASS---TTAASSAPTTAASSAPATLTPARGIStaatatGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAA 260


                   ....*..
gi 568966241  2144 LSAQSAA 2150
Cdd:pfam17823  261 GTVASAA 267
 
Name Accession Description Interval E-value
MEF2_binding pfam09047
MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the ...
 2123-2157 1.71e-15

MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription.


Pssm-ID: 370261 [Multi-domain]  Cd Length: 35  Bit Score: 71.81  E-value: 1.71e-15
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568966241  2123 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2157
Cdd:pfam09047    1 TLLSPKGSISEETKQKLKNAILSAQSAANVKKDSL 35
MEF2_binding cd13839
Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1; ...
 2123-2157 8.10e-14

Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1; The myocyte enhancer factor-2 (MEF2) binding domain, as found in the calcineurin-binding protein cabin-1, adopts an amphipathic alpha-helical structure, which allows it to bind to a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription. Cabin-1 inhibits calcineurin-mediated signal transduction in T-cell receptor-mediated signalling pathways, by binding to the activated form of calcineurin. Cabin-1 acts as a co-repressor of MEF2, the mycocyte enhancer factor-2, which regulates transcription in a calcium-dependent manner and plays vital roles in T-cell development and function.


Pssm-ID: 260103 [Multi-domain]  Cd Length: 35  Bit Score: 67.02  E-value: 8.10e-14
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568966241 2123 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2157
Cdd:cd13839     1 TLLSPKGSISEETKQKLKNAILSSQSAANVKKDTL 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
30-205 8.37e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 67.34  E-value: 8.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   30 EAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEarllreavssgdekeglKHPGLilkYSTYKNLAQLAAQREDLETA 109
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE-----------------LDPDD---AEALYNLGLAYLRLGRYEEA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  110 MEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDC 189
Cdd:COG0457    62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141

                         170
                  ....*....|....*.
gi 568966241  190 RYSKGLVLKEKIFEEQ 205
Cdd:COG0457   142 DDADALYNLGIALEKL 157
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1916-2150 6.86e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 51.11  E-value: 6.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  1916 ATQRQASGDTPTTPKHPKDSRENFFPATVvptvpdPTAPDALQR-PSDSHLKPVLATVITCPPSASASIPdlSTDPGIpr 1994
Cdd:pfam17823   37 AGKQNASGDAVPRADNKSSEQ*NFCAATA------APAPVTLTKgTSAAHLNSTEVTAEHTPHGTDLSEP--ATREGA-- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  1995 phrPETTPSRAPLSPEGEEASGVTEGT----SILPQEPRYSHQIKMAAT-GHLAEQHCWPVEVACQTGAEPTCSQASSTK 2069
Cdd:pfam17823  107 ---ADGAASRALAAAASSSPSSAAQSLpaaiAALPSEAFSAPRAAACRAnASAAPRAAIAAASAPHAASPAPRTAASSTT 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  2070 VPSSgstQTAESHQGKTESSRAKSRLLPNMPKL------VIPSATTKSPPEITVTPPTPTLLSPKGSISEETKQKLKSAI 2143
Cdd:pfam17823  184 AASS---TTAASSAPTTAASSAPATLTPARGIStaatatGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAA 260


                   ....*..
gi 568966241  2144 LSAQSAA 2150
Cdd:pfam17823  261 GTVASAA 267
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1915-2161 1.67e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241 1915 AATQRQASGDTP---TTPKHPKDSRENF------FPATVVPTVPDPTAPDALQRPSDSHLKPVLATvitcPPSASasiPD 1985
Cdd:PHA03247 2581 AVTSRARRPDAPpqsARPRAPVDDRGDPrgpappSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV----PPPER---PR 2653

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241 1986 LSTDPGIPRPHRPETTPSRAPlspegeeasgvteGTSILPQEPR-YSHQIKMAATGHLAEQHcwPVEVACQTGAEPTCSQ 2064
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAA-------------QASSPPQRPRrRAARPTVGSLTSLADPP--PPPPTPEPAPHALVSA 2718

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241 2065 ASSTKVPSSGSTQTAESHQGKTESSRAKSRLLPNMPKLVIPSATTKSPPEIT-----VTPPTPTLLSPKGSISEETKQKL 2139
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPRRLTRPAVASLSESRESL 2798

                         250       260
                  ....*....|....*....|..
gi 568966241 2140 KSAILSAQSAANVRKESLCQPA 2161
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPP 2820
TPR_12 pfam13424
Tetratricopeptide repeat;
36-119 1.97e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.91  E-value: 1.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241    36 AFALYHKALDLQKHDRFEESAKAYHELLEarlLREAVSSGDekeglkHPGLILkysTYKNLAQLAAQREDLETAMEFYLE 115
Cdd:pfam13424    3 ATALNNLAAVLRRLGRYDEALELLEKALE---IARRLLGPD------HPLTAT---TLLNLGRLYLELGRYEEALELLER 70


                   ....
gi 568966241   116 AVML 119
Cdd:pfam13424   71 ALAL 74
 
Name Accession Description Interval E-value
MEF2_binding pfam09047
MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the ...
 2123-2157 1.71e-15

MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription.


Pssm-ID: 370261 [Multi-domain]  Cd Length: 35  Bit Score: 71.81  E-value: 1.71e-15
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568966241  2123 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2157
Cdd:pfam09047    1 TLLSPKGSISEETKQKLKNAILSAQSAANVKKDSL 35
MEF2_binding cd13839
Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1; ...
 2123-2157 8.10e-14

Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1; The myocyte enhancer factor-2 (MEF2) binding domain, as found in the calcineurin-binding protein cabin-1, adopts an amphipathic alpha-helical structure, which allows it to bind to a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription. Cabin-1 inhibits calcineurin-mediated signal transduction in T-cell receptor-mediated signalling pathways, by binding to the activated form of calcineurin. Cabin-1 acts as a co-repressor of MEF2, the mycocyte enhancer factor-2, which regulates transcription in a calcium-dependent manner and plays vital roles in T-cell development and function.


Pssm-ID: 260103 [Multi-domain]  Cd Length: 35  Bit Score: 67.02  E-value: 8.10e-14
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568966241 2123 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2157
Cdd:cd13839     1 TLLSPKGSISEETKQKLKNAILSSQSAANVKKDTL 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
30-205 8.37e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 67.34  E-value: 8.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   30 EAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEarllreavssgdekeglKHPGLilkYSTYKNLAQLAAQREDLETA 109
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE-----------------LDPDD---AEALYNLGLAYLRLGRYEEA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  110 MEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDC 189
Cdd:COG0457    62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141

                         170
                  ....*....|....*.
gi 568966241  190 RYSKGLVLKEKIFEEQ 205
Cdd:COG0457   142 DDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-199 1.39e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.87  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   34 AEAFALYHKALDLQkhdrfEESAKAYHELleARLLREAvssGDEKEGLKH--------PGLIlkySTYKNLAQLAAQRED 105
Cdd:COG0457    25 EEAIEDYEKALELD-----PDDAEALYNL--GLAYLRL---GRYEEALADyeqaleldPDDA---EALNNLGLALQALGR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  106 LETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKAL 185
Cdd:COG0457    92 YEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLE 171

                         170
                  ....*....|....
gi 568966241  186 EKDCRYSKGLVLKE 199
Cdd:COG0457   172 AAALAALLAAALGE 185
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 27-188 7.83e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 64.24  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   27 QTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEARLLREAvssGDEKEGLKHPGLILK-----YSTYKNLAQLAA 101
Cdd:COG3914    47 LLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQAL---GRYEEALALYRRALAlnpdnAEALFNLGNLLL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  102 QREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFI 181
Cdd:COG3914   124 ALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAY 203


                  ....*..
gi 568966241  182 CKALEKD 188
Cdd:COG3914   204 RRALELD 210
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 30-205 2.87e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 2.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   30 EAQEAEAFALYHKALDLQKHDRFEESAKAYHELLE---------ARLLREAVSSGDEKEGLKHPGLILKYS-----TYKN 95
Cdd:COG2956    70 ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLEldpddaealRLLAEIYEQEGDWEKAIEVLERLLKLGpenahAYCE 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   96 LAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYT 175
Cdd:COG2956   150 LAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPE 229

                         170       180       190
                  ....*....|....*....|....*....|
gi 568966241  176 TCLYFICKALEKDCRYSKGLVLKEKIFEEQ 205
Cdd:COG2956   230 EALELLRKALELDPSDDLLLALADLLERKE 259
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 33-188 2.45e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 2.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   33 EAEAFALYHKALDLQKHDRFEESAKAYHELLEArllreavsSGDEKEGlkhpglilkystYKNLAQLAAQREDLETAMEF 112
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALEL--------DPDNPEA------------FALLGEILLQLGDLDEAIVL 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568966241  113 YLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKD 188
Cdd:COG4783    61 LHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 38-188 4.18e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.88  E-value: 4.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   38 ALYHKALDLQKHDRFEESAKAYHELLEARLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAMEFYLEAV 117
Cdd:COG5010     2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568966241  118 MLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKD 188
Cdd:COG5010    82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
99-188 1.76e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 48.24  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   99 LAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARhAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCL 178
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                          90
                  ....*....|
gi 568966241  179 YFICKALEKD 188
Cdd:COG3063    80 AYLERALELD 89
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
29-174 4.99e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 4.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   29 KEAQEAEAFALYHKALDLQKHDRF-----EESAKAYHELLEARLLREAVSSGDEK--EGLKHPGLIlkySTYKNLAQLAA 101
Cdd:COG4785     8 LLLALALAAAAASKAAILLAALLFaavlaLAIALADLALALAAAALAAAALAAERidRALALPDLA---QLYYERGVAYD 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568966241  102 QREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDY 174
Cdd:COG4785    85 SLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1916-2150 6.86e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 51.11  E-value: 6.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  1916 ATQRQASGDTPTTPKHPKDSRENFFPATVvptvpdPTAPDALQR-PSDSHLKPVLATVITCPPSASASIPdlSTDPGIpr 1994
Cdd:pfam17823   37 AGKQNASGDAVPRADNKSSEQ*NFCAATA------APAPVTLTKgTSAAHLNSTEVTAEHTPHGTDLSEP--ATREGA-- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  1995 phrPETTPSRAPLSPEGEEASGVTEGT----SILPQEPRYSHQIKMAAT-GHLAEQHCWPVEVACQTGAEPTCSQASSTK 2069
Cdd:pfam17823  107 ---ADGAASRALAAAASSSPSSAAQSLpaaiAALPSEAFSAPRAAACRAnASAAPRAAIAAASAPHAASPAPRTAASSTT 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241  2070 VPSSgstQTAESHQGKTESSRAKSRLLPNMPKL------VIPSATTKSPPEITVTPPTPTLLSPKGSISEETKQKLKSAI 2143
Cdd:pfam17823  184 AASS---TTAASSAPTTAASSAPATLTPARGIStaatatGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAA 260


                   ....*..
gi 568966241  2144 LSAQSAA 2150
Cdd:pfam17823  261 GTVASAA 267
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 95-174 1.00e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   95 NLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDY 174
Cdd:COG4235    22 LLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDY 101
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1-155 1.35e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 47.26  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241    1 MIRIAALNASSTIEDDHEGSFKSHKIQTKEAQEAEAFALYHKALDLQKhdRFEESAKAYHELLEArllreavssgdekeg 80
Cdd:COG5010    21 RTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLG--DFEESLALLEQALQL--------------- 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568966241   81 lkHPGlilKYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNP 155
Cdd:COG5010    84 --DPN---NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1915-2161 1.67e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241 1915 AATQRQASGDTP---TTPKHPKDSRENF------FPATVVPTVPDPTAPDALQRPSDSHLKPVLATvitcPPSASasiPD 1985
Cdd:PHA03247 2581 AVTSRARRPDAPpqsARPRAPVDDRGDPrgpappSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV----PPPER---PR 2653

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241 1986 LSTDPGIPRPHRPETTPSRAPlspegeeasgvteGTSILPQEPR-YSHQIKMAATGHLAEQHcwPVEVACQTGAEPTCSQ 2064
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAA-------------QASSPPQRPRrRAARPTVGSLTSLADPP--PPPPTPEPAPHALVSA 2718

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241 2065 ASSTKVPSSGSTQTAESHQGKTESSRAKSRLLPNMPKLVIPSATTKSPPEIT-----VTPPTPTLLSPKGSISEETKQKL 2139
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPRRLTRPAVASLSESRESL 2798

                         250       260
                  ....*....|....*....|..
gi 568966241 2140 KSAILSAQSAANVRKESLCQPA 2161
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPP 2820
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
92-158 3.71e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.69  E-value: 3.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568966241   92 TYKNLAQLAAQREDLETAMEFyLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHW 158
Cdd:COG3063    28 ALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPSAL 93
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 34-174 6.38e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 6.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241   34 AEAFALYHKALDLQKHDRFEESAKAYHELLEarllreavssgdekeglKHPGLIlkySTYKNLAQLAAQREDLETAMEFY 113
Cdd:COG2956     6 AAALGWYFKGLNYLLNGQPDKAIDLLEEALE-----------------LDPETV---EAHLALGNLYRRRGEYDRAIRIH 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568966241  114 LEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDY 174
Cdd:COG2956    66 QKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126
TPR_12 pfam13424
Tetratricopeptide repeat;
36-119 1.97e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.91  E-value: 1.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241    36 AFALYHKALDLQKHDRFEESAKAYHELLEarlLREAVSSGDekeglkHPGLILkysTYKNLAQLAAQREDLETAMEFYLE 115
Cdd:pfam13424    3 ATALNNLAAVLRRLGRYDEALELLEKALE---IARRLLGPD------HPLTAT---TLLNLGRLYLELGRYEEALELLER 70


                   ....
gi 568966241   116 AVML 119
Cdd:pfam13424   71 ALAL 74
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1921-2127 2.00e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241 1921 ASGDTPTTPKHPKDSRENFFPATVVPTVPDPTAPDALQRPSDSHLKPVLATVITCPPSASASIPDLSTDPGIPRPHR-PE 1999
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAaPA 2776

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241 2000 TTPSRAPLSPEGEEASGVTEGTSiLPQEPRYSHQIKMAATGHLaeqhcwPVEVACQTGAEPTCSQASSTKVPSSGSTQTA 2079
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLP-SPWDPADPPAAVLAPAAAL------PPAASPAGPLPPPTSAQPTAPPPPPGPPPPS 2849

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568966241 2080 ESHQGKTESSRAKSRLLPNMPKLVIPSATTKSP----PEITVTPPTPTLLSP 2127
Cdd:PHA03247 2850 LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvrrlARPAVSRSTESFALP 2901
TPR_21 pfam09976
Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.
 48-151 4.03e-03

Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.


Pssm-ID: 430959 [Multi-domain]  Cd Length: 194  Bit Score: 40.65  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966241    48 KHDRFEESAKAYHELLEArllreaVSSGDEKEGL--------KHPGlilkySTYKNLAQL-----AAQREDLETAMEfYL 114
Cdd:pfam09976   32 QRSQAEEASALYQQLLEA------VAAGDAAKAQaaaaqlkdEYGG-----TGYAALAALllakaAVEAGDLAAAKA-QL 99

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 568966241   115 EAVMLDSTDVNLwykiGHVA-LRLIRLPLARHAFEEGL 151
Cdd:pfam09976  100 EWVADNAKDEAL----KALArLRLARVLLAQGKYDEAL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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