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Conserved domains on  [gi|568967465|ref|XP_006513665|]
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cadherin-23 isoform X3 [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 166-264 1.02e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  166 SYQEAVFEDIAVGTVILRVTATDADSGNFALIEYSLVDG--EGKFAINPNTGDISVLSSLDREKKDHYILTALAKDNpgd 243
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|.
gi 568967465  244 vASNRRENSVQVVIRVLDVND 264
Cdd:cd11304    78 -GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-367 4.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  273 QFSTSVYENEPAGTSVITMLATDQDEGSNSQLTYSL-EGPGMEAFSVDMDSGLVTTQRPLQ--SYERFNLTVVATDGGEP 349
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568967465  350 PLWGTTMLLVEVIDVNDN 367
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 61-158 4.70e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   61 YTERVLEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLeDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP 140
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568967465  141 PRAAEIPVYLEIVDINDN 158
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-478 1.44e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  380 LHIKEEIPLRSNVYEVYATDNDEGLNGAVRYSFLkttGNRDWEYFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQP 459
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*....
gi 568967465  460 VPYETMQpLQVALEDIDDN 478
Cdd:cd11304    81 PLSSTAT-VTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 495-601 1.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  495 LTVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGDEDKNFHLQPD-GRLLVLRDLDRETEATFSFIVKASSNRSwtP 573
Cdd:cd11304     4 VSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG--P 80

                          90       100
                  ....*....|....*....|....*...
gi 568967465  574 PRgPSPAldlltdltlqEVRVVLEDIND 601
Cdd:cd11304    81 PL-SSTA----------TVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 610-711 1.42e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  610 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILaihyfralandSEDVGQVFTMGSVDGILRTFDLFMAYSPGYFV 689
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....
gi 568967465  690 VDIVARDLAG--HNDTAIIGIYIL 711
Cdd:cd11304    70 LTVTATDGGGppLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-49 1.23e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.00  E-value: 1.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568967465    2 VKSPLNRELVATYEVTLSVIDNASdlPEHSVSvpnAKLTVNILDVNDN 49
Cdd:cd11304    56 TAKPLDREEQSSYTLTVTATDGGG--PPLSST---ATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 166-264 1.02e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  166 SYQEAVFEDIAVGTVILRVTATDADSGNFALIEYSLVDG--EGKFAINPNTGDISVLSSLDREKKDHYILTALAKDNpgd 243
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|.
gi 568967465  244 vASNRRENSVQVVIRVLDVND 264
Cdd:cd11304    78 -GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-367 4.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  273 QFSTSVYENEPAGTSVITMLATDQDEGSNSQLTYSL-EGPGMEAFSVDMDSGLVTTQRPLQ--SYERFNLTVVATDGGEP 349
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568967465  350 PLWGTTMLLVEVIDVNDN 367
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 61-158 4.70e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   61 YTERVLEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLeDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP 140
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568967465  141 PRAAEIPVYLEIVDINDN 158
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-478 1.44e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  380 LHIKEEIPLRSNVYEVYATDNDEGLNGAVRYSFLkttGNRDWEYFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQP 459
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*....
gi 568967465  460 VPYETMQpLQVALEDIDDN 478
Cdd:cd11304    81 PLSSTAT-VTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 293-369 2.55e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 2.55e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    293 ATDQDEGSNSQLTYSL-EGPGMEAFSVDMDSGLVTTQRPL--QSYERFNLTVVATDGGEPPLWGTTMLLVEVIDVNDNRP 369
Cdd:smart00112    2 ATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLdrEEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 185-267 3.59e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 3.59e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    185 TATDADSGNFALIEYSLVDGE--GKFAINPNTGDISVLSSLDREKKDHYILTALAKDNpgdvASNRRENSVQVVIRVLDV 262
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG----GGPPLSSTATVTITVLDV 76


                    ....*
gi 568967465    263 NDCRP 267
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
274-362 1.10e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 1.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   274 FSTSVYENEPAGTSVITMLATDQDEGSNSQLTYS-LEGPGMEAFSVDMDSGLVTTQRPLQ--SYERFNLTVVATDGGEPP 350
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 568967465   351 LWGTTMLLVEVI 362
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 495-601 1.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  495 LTVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGDEDKNFHLQPD-GRLLVLRDLDRETEATFSFIVKASSNRSwtP 573
Cdd:cd11304     4 VSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG--P 80

                          90       100
                  ....*....|....*....|....*...
gi 568967465  574 PRgPSPAldlltdltlqEVRVVLEDIND 601
Cdd:cd11304    81 PL-SSTA----------TVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
167-260 2.41e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 2.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   167 YQEAVFEDIAVGTVILRVTATDADSGNFALIEYSLVDGE--GKFAINPNTGDISVLSSLDREKKDHYILTALAKDNpgdv 244
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*.
gi 568967465   245 ASNRRENSVQVVIRVL 260
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 397-480 5.89e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 5.89e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    397 ATDNDEGLNGAVRYSFLkttGNRDWEYFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQpLQVALEDID 476
Cdd:smart00112    2 ATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT-VTITVLDVN 77


                    ....
gi 568967465    477 DNEP 480
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-160 1.79e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 1.79e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465     80 AVDPDKGLNGLITYTLLDLTPPGYVQLEDSSaGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNN 159
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPET-GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 568967465    160 P 160
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
381-466 1.45e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 1.45e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   381 HIKEEIPLRSNVYEVYATDNDEGLNGAVRYSFLKTtGNRDWeyFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPV 460
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ....*.
gi 568967465   461 PYETMQ 466
Cdd:pfam00028   81 LSSTAT 86
Cadherin pfam00028
Cadherin domain;
496-579 7.95e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 7.95e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   496 TVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGDEDKNFHLQPD-GRLLVLRDLDRETEATFSFIVKAsSNRSWTPP 574
Cdd:pfam00028    4 SVPENAPVGTEVLTVT-ATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEA-TDSGGPPL 81


                   ....*
gi 568967465   575 RGPSP 579
Cdd:pfam00028   82 SSTAT 86
Cadherin pfam00028
Cadherin domain;
61-152 9.11e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 9.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    61 YTERVLEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLeDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP 140
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI-DPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 568967465   141 PRAAEIPVYLEI 152
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 513-604 6.33e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 6.33e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    513 AVDADEGPNAIVYYFIAAGDEDKNFHLQPD-GRLLVLRDLDRETEATFSFIVKAsSNRSWTPPRGPSpaldlltdltlqE 591
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEA-TDGGGPPLSSTA------------T 68

                            90
                    ....*....|...
gi 568967465    592 VRVVLEDINDQPP 604
Cdd:smart00112   69 VTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 610-711 1.42e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  610 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILaihyfralandSEDVGQVFTMGSVDGILRTFDLFMAYSPGYFV 689
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....
gi 568967465  690 VDIVARDLAG--HNDTAIIGIYIL 711
Cdd:cd11304    70 LTVTATDGGGppLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-49 1.23e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.00  E-value: 1.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568967465    2 VKSPLNRELVATYEVTLSVIDNASdlPEHSVSvpnAKLTVNILDVNDN 49
Cdd:cd11304    56 TAKPLDREEQSSYTLTVTATDGGG--PPLSST---ATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-51 4.76e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 4.76e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568967465      2 VKSPLNRELVATYEVTLSVIDNASdlPEHSVSVPnakLTVNILDVNDNTP 51
Cdd:smart00112   37 TTKPLDREEQPEYTLTVEATDGGG--PPLSSTAT---VTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
611-711 1.15e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.90  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   611 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILaihyfralandSEDVGQVFTMGSVDGILRTFDLFMAYSPGYFVV 690
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|...
gi 568967465   691 DIVARDLAGHN--DTAIIGIYIL 711
Cdd:pfam00028   70 TVEATDSGGPPlsSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 166-264 1.02e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  166 SYQEAVFEDIAVGTVILRVTATDADSGNFALIEYSLVDG--EGKFAINPNTGDISVLSSLDREKKDHYILTALAKDNpgd 243
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|.
gi 568967465  244 vASNRRENSVQVVIRVLDVND 264
Cdd:cd11304    78 -GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-367 4.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  273 QFSTSVYENEPAGTSVITMLATDQDEGSNSQLTYSL-EGPGMEAFSVDMDSGLVTTQRPLQ--SYERFNLTVVATDGGEP 349
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568967465  350 PLWGTTMLLVEVIDVNDN 367
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 61-158 4.70e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   61 YTERVLEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLeDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP 140
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568967465  141 PRAAEIPVYLEIVDINDN 158
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-478 1.44e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  380 LHIKEEIPLRSNVYEVYATDNDEGLNGAVRYSFLkttGNRDWEYFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQP 459
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*....
gi 568967465  460 VPYETMQpLQVALEDIDDN 478
Cdd:cd11304    81 PLSSTAT-VTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 293-369 2.55e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 2.55e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    293 ATDQDEGSNSQLTYSL-EGPGMEAFSVDMDSGLVTTQRPL--QSYERFNLTVVATDGGEPPLWGTTMLLVEVIDVNDNRP 369
Cdd:smart00112    2 ATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLdrEEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 185-267 3.59e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 3.59e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    185 TATDADSGNFALIEYSLVDGE--GKFAINPNTGDISVLSSLDREKKDHYILTALAKDNpgdvASNRRENSVQVVIRVLDV 262
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG----GGPPLSSTATVTITVLDV 76


                    ....*
gi 568967465    263 NDCRP 267
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
274-362 1.10e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 1.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   274 FSTSVYENEPAGTSVITMLATDQDEGSNSQLTYS-LEGPGMEAFSVDMDSGLVTTQRPLQ--SYERFNLTVVATDGGEPP 350
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 568967465   351 LWGTTMLLVEVI 362
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 495-601 1.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  495 LTVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGDEDKNFHLQPD-GRLLVLRDLDRETEATFSFIVKASSNRSwtP 573
Cdd:cd11304     4 VSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG--P 80

                          90       100
                  ....*....|....*....|....*...
gi 568967465  574 PRgPSPAldlltdltlqEVRVVLEDIND 601
Cdd:cd11304    81 PL-SSTA----------TVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
167-260 2.41e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 2.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   167 YQEAVFEDIAVGTVILRVTATDADSGNFALIEYSLVDGE--GKFAINPNTGDISVLSSLDREKKDHYILTALAKDNpgdv 244
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*.
gi 568967465   245 ASNRRENSVQVVIRVL 260
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 397-480 5.89e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 5.89e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    397 ATDNDEGLNGAVRYSFLkttGNRDWEYFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQpLQVALEDID 476
Cdd:smart00112    2 ATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT-VTITVLDVN 77


                    ....
gi 568967465    477 DNEP 480
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-160 1.79e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 1.79e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465     80 AVDPDKGLNGLITYTLLDLTPPGYVQLEDSSaGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNN 159
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPET-GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 568967465    160 P 160
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
381-466 1.45e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 1.45e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   381 HIKEEIPLRSNVYEVYATDNDEGLNGAVRYSFLKTtGNRDWeyFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPV 460
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ....*.
gi 568967465   461 PYETMQ 466
Cdd:pfam00028   81 LSSTAT 86
Cadherin pfam00028
Cadherin domain;
496-579 7.95e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 7.95e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   496 TVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGDEDKNFHLQPD-GRLLVLRDLDRETEATFSFIVKAsSNRSWTPP 574
Cdd:pfam00028    4 SVPENAPVGTEVLTVT-ATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEA-TDSGGPPL 81


                   ....*
gi 568967465   575 RGPSP 579
Cdd:pfam00028   82 SSTAT 86
Cadherin pfam00028
Cadherin domain;
61-152 9.11e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 9.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    61 YTERVLEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLeDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP 140
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI-DPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 568967465   141 PRAAEIPVYLEI 152
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 513-604 6.33e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 6.33e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465    513 AVDADEGPNAIVYYFIAAGDEDKNFHLQPD-GRLLVLRDLDRETEATFSFIVKAsSNRSWTPPRGPSpaldlltdltlqE 591
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEA-TDGGGPPLSSTA------------T 68

                            90
                    ....*....|...
gi 568967465    592 VRVVLEDINDQPP 604
Cdd:smart00112   69 VTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 610-711 1.42e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465  610 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILaihyfralandSEDVGQVFTMGSVDGILRTFDLFMAYSPGYFV 689
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....
gi 568967465  690 VDIVARDLAG--HNDTAIIGIYIL 711
Cdd:cd11304    70 LTVTATDGGGppLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-49 1.23e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.00  E-value: 1.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568967465    2 VKSPLNRELVATYEVTLSVIDNASdlPEHSVSvpnAKLTVNILDVNDN 49
Cdd:cd11304    56 TAKPLDREEQSSYTLTVTATDGGG--PPLSST---ATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-51 4.76e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 4.76e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568967465      2 VKSPLNRELVATYEVTLSVIDNASdlPEHSVSVPnakLTVNILDVNDNTP 51
Cdd:smart00112   37 TTKPLDREEQPEYTLTVEATDGGG--PPLSSTAT---VTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
611-711 1.15e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.90  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967465   611 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILaihyfralandSEDVGQVFTMGSVDGILRTFDLFMAYSPGYFVV 690
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|...
gi 568967465   691 DIVARDLAGHN--DTAIIGIYIL 711
Cdd:pfam00028   70 TVEATDSGGPPlsSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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