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Conserved domains on  [gi|568980519|ref|XP_006516352|]
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exocyst complex component 3-like protein 4 isoform X1 [Mus musculus]

Protein Classification

exocyst complex component Sec6 family protein( domain architecture ID 10532741)

exocyst complex component Sec6 family protein similar to human exocyst complex component 3, which is part of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 182-708 7.22e-123

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


:

Pssm-ID: 428738  Cd Length: 570  Bit Score: 378.61  E-value: 7.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  182 MDLCLHYDGMAAEIGAIVREALSSEGVDRDALA-ELAQVVHLEEEAHQTSQAEGDFLS----------------TPRHWR 244
Cdd:pfam06046   2 SKVDGLIEKFDKLLWEIIRNLLELVREGNTSLVvRLARIVEREEKEDEKAEALREATKghkdmatrfsinvfrrRPRGYK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  245 MHWEDAVRLSAQERVQQAGAKVIPGAaegssDLAQLLAELGgVVRHDLQKVRLEMQPAYEAtDFPVWETYLRAFHSAVAQ 324
Cdd:pfam06046  82 DKFLEALEESVEERFEECREKFSEDD-----KKLELLYNLD-WVFDDLIVVKDLLAPLFPP-HWKIFKTYANIYHNALHD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  325 RLQELARDARGC-EQLYVLLDWAAnVYGSPDFLGAPDLALPTEPLPPLLEPALWARLESDYTSFLETKITSCFDSILQLE 403
Cdd:pfam06046 155 LLQELVDSEELEaADILAILSWVK-TYYSKMMKGNPELEFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  404 QNRWEAD--EDREVLQGLYHAPLSIDVHMLVAEHVKAAgaiSAELEATTLQICARALCLFVPRFEKAFLA---------- 471
Cdd:pfam06046 234 VKDFTEReePPEEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIElleeelkkym 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  472 ------SKAVSEWYLGAYINACVELR---TSLLARF---------PGTIKELEKPLVAATNSFQKHLLQIVQQDMQPLFK 533
Cdd:pfam06046 311 svnnneSPPGLVEYLIALANDQLKCAdyaESLLQKYeplkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALS 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  534 VLYTKSWLTQDTLRPLMDKVVDFAHHL-EHVTPPLAQETLQEVHRFVVREYLGQVLRPHERFSGQDRLKGSNKMNLDAQA 612
Cdd:pfam06046 391 KLFTKKWYTGEVMEQIVETVEDYLNDYkEYLHPPLFQELLEELLDELVVEYLRALRGKRLKFGAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  613 ISNTFQGLGS-EAKWLDQAILSVA---EILGETYKDDIRRHLETLIRSYPDIRRDHILAILALRR-LGRRRNQNLLQHTQ 687
Cdd:pfam06046 471 LYDFFSKLGSrDAAWLLQALRAIEdllELLELEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGdLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|.
gi 568980519  688 DLLRAAHETRLPsHHVLFEEI 708
Cdd:pfam06046 551 EIKKSYESGVEP-PRTIFSRV 570
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 182-708 7.22e-123

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 378.61  E-value: 7.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  182 MDLCLHYDGMAAEIGAIVREALSSEGVDRDALA-ELAQVVHLEEEAHQTSQAEGDFLS----------------TPRHWR 244
Cdd:pfam06046   2 SKVDGLIEKFDKLLWEIIRNLLELVREGNTSLVvRLARIVEREEKEDEKAEALREATKghkdmatrfsinvfrrRPRGYK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  245 MHWEDAVRLSAQERVQQAGAKVIPGAaegssDLAQLLAELGgVVRHDLQKVRLEMQPAYEAtDFPVWETYLRAFHSAVAQ 324
Cdd:pfam06046  82 DKFLEALEESVEERFEECREKFSEDD-----KKLELLYNLD-WVFDDLIVVKDLLAPLFPP-HWKIFKTYANIYHNALHD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  325 RLQELARDARGC-EQLYVLLDWAAnVYGSPDFLGAPDLALPTEPLPPLLEPALWARLESDYTSFLETKITSCFDSILQLE 403
Cdd:pfam06046 155 LLQELVDSEELEaADILAILSWVK-TYYSKMMKGNPELEFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  404 QNRWEAD--EDREVLQGLYHAPLSIDVHMLVAEHVKAAgaiSAELEATTLQICARALCLFVPRFEKAFLA---------- 471
Cdd:pfam06046 234 VKDFTEReePPEEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIElleeelkkym 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  472 ------SKAVSEWYLGAYINACVELR---TSLLARF---------PGTIKELEKPLVAATNSFQKHLLQIVQQDMQPLFK 533
Cdd:pfam06046 311 svnnneSPPGLVEYLIALANDQLKCAdyaESLLQKYeplkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALS 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  534 VLYTKSWLTQDTLRPLMDKVVDFAHHL-EHVTPPLAQETLQEVHRFVVREYLGQVLRPHERFSGQDRLKGSNKMNLDAQA 612
Cdd:pfam06046 391 KLFTKKWYTGEVMEQIVETVEDYLNDYkEYLHPPLFQELLEELLDELVVEYLRALRGKRLKFGAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  613 ISNTFQGLGS-EAKWLDQAILSVA---EILGETYKDDIRRHLETLIRSYPDIRRDHILAILALRR-LGRRRNQNLLQHTQ 687
Cdd:pfam06046 471 LYDFFSKLGSrDAAWLLQALRAIEdllELLELEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGdLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|.
gi 568980519  688 DLLRAAHETRLPsHHVLFEEI 708
Cdd:pfam06046 551 EIKKSYESGVEP-PRTIFSRV 570
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 182-708 7.22e-123

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 378.61  E-value: 7.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  182 MDLCLHYDGMAAEIGAIVREALSSEGVDRDALA-ELAQVVHLEEEAHQTSQAEGDFLS----------------TPRHWR 244
Cdd:pfam06046   2 SKVDGLIEKFDKLLWEIIRNLLELVREGNTSLVvRLARIVEREEKEDEKAEALREATKghkdmatrfsinvfrrRPRGYK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  245 MHWEDAVRLSAQERVQQAGAKVIPGAaegssDLAQLLAELGgVVRHDLQKVRLEMQPAYEAtDFPVWETYLRAFHSAVAQ 324
Cdd:pfam06046  82 DKFLEALEESVEERFEECREKFSEDD-----KKLELLYNLD-WVFDDLIVVKDLLAPLFPP-HWKIFKTYANIYHNALHD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  325 RLQELARDARGC-EQLYVLLDWAAnVYGSPDFLGAPDLALPTEPLPPLLEPALWARLESDYTSFLETKITSCFDSILQLE 403
Cdd:pfam06046 155 LLQELVDSEELEaADILAILSWVK-TYYSKMMKGNPELEFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  404 QNRWEAD--EDREVLQGLYHAPLSIDVHMLVAEHVKAAgaiSAELEATTLQICARALCLFVPRFEKAFLA---------- 471
Cdd:pfam06046 234 VKDFTEReePPEEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIElleeelkkym 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  472 ------SKAVSEWYLGAYINACVELR---TSLLARF---------PGTIKELEKPLVAATNSFQKHLLQIVQQDMQPLFK 533
Cdd:pfam06046 311 svnnneSPPGLVEYLIALANDQLKCAdyaESLLQKYeplkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALS 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  534 VLYTKSWLTQDTLRPLMDKVVDFAHHL-EHVTPPLAQETLQEVHRFVVREYLGQVLRPHERFSGQDRLKGSNKMNLDAQA 612
Cdd:pfam06046 391 KLFTKKWYTGEVMEQIVETVEDYLNDYkEYLHPPLFQELLEELLDELVVEYLRALRGKRLKFGAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980519  613 ISNTFQGLGS-EAKWLDQAILSVA---EILGETYKDDIRRHLETLIRSYPDIRRDHILAILALRR-LGRRRNQNLLQHTQ 687
Cdd:pfam06046 471 LYDFFSKLGSrDAAWLLQALRAIEdllELLELEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGdLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|.
gi 568980519  688 DLLRAAHETRLPsHHVLFEEI 708
Cdd:pfam06046 551 EIKKSYESGVEP-PRTIFSRV 570
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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