|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
42-482 |
6.28e-137 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 400.46 E-value: 6.28e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 42 AFVTHFCNFTLMAQNSIISITMVAMVNNTDHPPHLNSSTeqlpaglsgdqheASKHLPIKAPVYNWSPQTQGIIFSSVQY 121
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 122 GMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLATRAVQGLMQGTGYGGQFALWQKWAPPNERSR 201
Cdd:cd17318 68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 202 LCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIyddpvshpwisgpereyilsslnqqfsse 281
Cdd:cd17318 148 LTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV----------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 282 eqplpikamlksLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILGGWLADFLLSKN 361
Cdd:cd17318 199 ------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 362 -FRLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPRYASFLMGTSRGLAHSS 440
Cdd:cd17318 267 iLSTTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 568981497 441 AVLVPIVAGFFLSQD-SEFGWRNFFFVVFAVNLLGLIIYLVFG 482
Cdd:cd17318 347 GIISPLIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
27-497 |
1.67e-126 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 376.78 E-value: 1.67e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 27 PALKVPSLCSMRYGIAFVTHFCNFTLMAQNSIISITMVAMVNNTDhpphlnssTEQLPAGLSGDQHEASKHlpikaPVYN 106
Cdd:TIGR00894 6 ASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKEN--------STDLACLSAENELDNIKN-----PNFK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 107 WSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLATRAVQGLMQGTGYGGQ 186
Cdd:TIGR00894 73 WSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPAT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 187 FALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEA-LGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPWISGP 265
Cdd:TIGR00894 153 HKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 266 EREYILSSLNQQFSSEEQPLPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWV 345
Cdd:TIGR00894 233 EKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 346 LGILGGWLADFLLSKN-FRLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPR 424
Cdd:TIGR00894 313 CSIFAGYLADFLKSSKtLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPR 392
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981497 425 YASFLMGTSRGLAHSSAVLVPIVAGFFLSQDSEFGWRNFFFVVFAVNLLGLIIYLVFGKADVQEWARERKLTR 497
Cdd:TIGR00894 393 FLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
41-482 |
2.50e-88 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 276.28 E-value: 2.50e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 41 IAFVTHFCNFTLMAQNSIISITMVAMVNNTDHPPHLNSSTeqlpaglSGDQHEAS--KHLPIKAPVYNWSPQTQGIIFSS 118
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSN-------ACPEHSSSpsVEHNETGKKYDWDAETQGWILGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 119 VQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLATRAVQGLMQGTGYGGQFALWQKWAPPNE 198
Cdd:cd17381 74 FFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 199 RSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIyddpvshpwisgpereyilsslnqqf 278
Cdd:cd17381 154 RSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV-------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 279 sseeqplpikamlksLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILGGWLADFLL 358
Cdd:cd17381 208 ---------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLR 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 359 SK-NFRLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPRYASFLMGTSRGLA 437
Cdd:cd17381 273 EKqNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFA 352
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 568981497 438 HSSAVLVPIVAGFFLSQDSEFGWRNFFFVVFAVNLLGLIIYLVFG 482
Cdd:cd17381 353 TIPGMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
105-482 |
2.34e-67 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 220.50 E-value: 2.34e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 105 YNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLATRAVQGLMQGTGYG 184
Cdd:cd17380 29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 185 GQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIyddpvshpwisg 264
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 265 pereyilsslnqqfsseeqplpikamlksLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFkVNIRDNGFLSSLPFIVAW 344
Cdd:cd17380 177 -----------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 345 VLGILGGWLADFLLSKNFRLITVRKFITLLGNAPPAALVAALPYIqSSYITTIIFLTISCGLCPLSQAGIYINALDIAPR 424
Cdd:cd17380 227 PSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPN 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 568981497 425 YASFLMGTSRGLAHSSAVLVPIVAGFFLSQDSEfgWRNFFFVVFAVNLLGLIIYLVFG 482
Cdd:cd17380 306 YAGIVFGISNTAGTIPGIVGVYLTGYILEATGS--WSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
103-482 |
3.74e-61 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 204.88 E-value: 3.74e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 103 PVYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLATRAVQGLMQGTG 182
Cdd:cd17382 42 AEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVT 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 183 YGGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWfiliyddpvshpwi 262
Cdd:cd17382 122 YPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW-------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 263 sgpereyilsslnqqfsseeqplpikaMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIV 342
Cdd:cd17382 188 ---------------------------MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 343 AWVLGILGGWLADFLLSKNFRLIT-VRKFITLLGNAPPAALVAALPYIqSSYITTIIFLTISCGLCPLSQAGIYINALDI 421
Cdd:cd17382 241 MTIIVPIGGQLADYLRSRGILSTTaVRKIFNCGGFGMEATFLLVVAFS-HSPTVAISFLVLAVGFSGFAISGFNVNHLDI 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981497 422 APRYASFLMGTSRGLAHSSAVLVPIVAGFFLSQDSEFGWRNFFFVVFAVNLLGLIIYLVFG 482
Cdd:cd17382 320 APRYASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
106-480 |
3.23e-32 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 126.53 E-value: 3.23e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 106 NWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLMQGTGYGG 185
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--LYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 186 QFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDdpvshpwisgp 265
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 266 ereyilsslnqqfsseeqplpikamlkslpLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWV 345
Cdd:cd17319 181 ------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 346 LGILGGWLADFLLSKNFRLITVrkFITLLGnappaALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPRY 425
Cdd:cd17319 231 GMILGGRLSDRLLRGARRLVII--IGLLLA-----AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGE 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 568981497 426 AsflMGTSRGLAHS----SAVLVPIVAGFFLsqDSEFGWRNFFFVVFAVNLLGLIIYLV 480
Cdd:cd17319 304 A---AATAGGLINSggnlGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
105-483 |
5.09e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 123.06 E-value: 5.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 105 YNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLMQGTGYG 184
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQ--LLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 185 GQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFiliyddpvshpwisg 264
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF--------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 265 pereyilsslnqqfsseeqplpikamlkslplWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAW 344
Cdd:COG2271 183 --------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 345 VLGILGGWLADfllsknfRLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCpLSQAGIYINALDIAP- 423
Cdd:COG2271 231 VGSLLGGWLSD-------RLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG-GAFGLLWALAAELFPk 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 424 RYASFLMGTSRGLAHSSAVLVPIVAGFFLSQdseFGWRNFFFVVFAVNLLGLIIYLVFGK 483
Cdd:COG2271 303 KARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
105-445 |
1.41e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.64 E-value: 1.41e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 105 YNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLMQGTGYG 184
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 185 GQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILiydDPVSHPWISG 264
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP---RPPPESKRPK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 265 PEREYILSSLnqqfsseeqpLPIKAMLKSLPLWSMCLCTMThQWLVNTFIMYTPTYIsSVFKVNIRDNGFLSSLPFIVAW 344
Cdd:pfam07690 182 PAEEARLSLI----------VAWKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 345 VLGILGGWLADFLLSKNfrlitvRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPR 424
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRR------RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
|
330 340
....*....|....*....|.
gi 568981497 425 YASFLMGTSRGLAHSSAVLVP 445
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
104-479 |
5.88e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 97.50 E-value: 5.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 104 VYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLMQGTGY 183
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL--LLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 184 GGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEAL--GWPFVFYSFGGGGVLCSLLWFILIYDDPVSHpw 261
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESA-- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 262 isgpereyilSSLNQQFSSEEQPLPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFI 341
Cdd:cd06174 181 ----------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 342 VAWVLGILGGWLADFLLSKNFRLItvrkfITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIyinALDI 421
Cdd:cd06174 251 AGALGSLLLGLLSDRLIGRKPLLL-----IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI---AELF 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 568981497 422 APRYASFLMGTSRGLAHSSAVLVPIVAGFFLSQDseFGWRNFFFVVFAVNLLGLIIYL 479
Cdd:cd06174 323 PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT--FGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
105-481 |
1.19e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.71 E-value: 1.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 105 YNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLMQGTGYG 184
Cdd:COG2223 35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 185 GQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPWisg 264
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA--- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 265 pereyilsslnqqfSSEEQPLPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAW 344
Cdd:COG2223 190 --------------AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 345 VLGILGGWLADFLLsknfrlitvRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPR 424
Cdd:COG2223 256 LGRPLGGWLSDRIG---------GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPT 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981497 425 Y----ASFLMGTSRGLAhssAVLVPIVAGFFLsqDSEFGWRNFFFVVFAVNLLGLIIYLVF 481
Cdd:COG2223 327 KnagaVYGLVGAAGGLG---GFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
98-355 |
2.63e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 89.26 E-value: 2.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 98 LPIKAPVYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGL 177
Cdd:COG2814 33 LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 178 MQGTGYGGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIyddPV 257
Cdd:COG2814 111 GAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---PE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 258 SHPWISGPEREyilsslnqqfsseeqplPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSS 337
Cdd:COG2814 188 SRPAARARLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250
|
250
....*....|....*...
gi 568981497 338 LPFIVAWVLGILGGWLAD 355
Cdd:COG2814 251 LFGLGGVLGALLAGRLAD 268
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
113-464 |
2.73e-18 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 86.66 E-value: 2.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 113 GIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTlcIPLAANLGLVFFLATRAVQGLMQGTGYGGQFALWQK 192
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVN--LFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 193 WAPPNERSRLCTIALSGMTL-GIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVShPWISGPEREYI- 270
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPAEEMPNe 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 271 -LSSLNQQFSSEEQPLPIKA--MLKSLPLWSMCLC---TMTHQWLVNTfimYTPTYISSVFKVNIRDNGFLSSLPFIVAW 344
Cdd:TIGR00881 190 ePDGDAEKKEEELTKKQIFLqyVLLNKVLWYISLGyvfVYVVRTGILD---WSPLYLTQEKGFSKEKASWAFTLYELGGL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 345 VLGILGGWLADFLLSKNFRLITVrKFITLLgnapPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPr 424
Cdd:TIGR00881 267 VGTLLAGWLSDKLFNGRRGPLAV-FFMALI----IVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAP- 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 568981497 425 yaSFLMGTSRGL----AHSSAVLVPIVAGFFLSQdseFGWRNFF 464
Cdd:TIGR00881 341 --KKAAGTAAGFvgffAYLGGILAGLPLGYLADG---FGWAGAF 379
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
113-481 |
1.73e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.08 E-value: 1.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 113 GIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQGLMQGTGYGGQFALWQK 192
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA--RFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 193 WAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPWisgpereyils 272
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 273 slnQQFSSEEQPLPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILGGW 352
Cdd:cd17325 181 ---RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 353 LADFLLSKnfRLITVRKFITLLGnappaalvaALPYIQSSYITTIIFLTISCGLCpLSQAGIYINALdIAPRYASFLMGT 432
Cdd:cd17325 258 LSDRIGRK--PLILIGLLLSAVA---------LLLLPLATSFWLLLLLLALLGLG-LGLVFPATLAL-LADIVPPEGRGT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 568981497 433 SRGLAHSS----AVLVPIVAGFFLSQdseFGWRNFFFVVFAVNLLGLIIYLVF 481
Cdd:cd17325 325 AMGLFNTAfslgMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
108-479 |
5.56e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.19 E-value: 5.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 108 SPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLMQGTGYGGQF 187
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 188 ALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPWISGPER 267
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 268 EYilsslnqqfsseeqplpiKAMLKSLPLWSMCLCTMThqWLVNTFIMYtpTYISSVFKVNIRDNGFLSSLPFIVAWVLG 347
Cdd:cd17324 190 SL------------------LLLLRNPRLRLAYLITFL--LFGGFFALY--TYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 348 ILGGWLADFLLSKNfrlitVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCpLSQAGIYINALDIAPRYAS 427
Cdd:cd17324 248 VVGSPLAGRLADRG-----GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF-AAHSALQTRVLRLAPEARG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 568981497 428 FLMGTSRGLAHSSAVLVPIVAGFFLSQdseFGWRNFFFVVFAVNLLGLIIYL 479
Cdd:cd17324 322 LASSLYLAAYNLGGALGAALGGLVLDH---GGWAGVGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
98-267 |
1.06e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 65.60 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 98 LPIKAPVYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQGL 177
Cdd:COG0477 37 LPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAA--RALQGI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 178 MQGTGYGGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSfgggGVLCSLLWFILIYDDPV 257
Cdd:COG0477 115 GAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI----NAPLGLLALVLRLRLPE 190
|
170
....*....|
gi 568981497 258 SHPWISGPER 267
Cdd:COG0477 191 SRGLLLALLA 200
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
104-252 |
2.91e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 2.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 104 VYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLAtrAVQGLMQGTGY 183
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL--ALLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981497 184 GGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILI 252
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
99-470 |
3.48e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.49 E-value: 3.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 99 PIKAPVYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLG--LVFFLATRAVQG 176
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPvlLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 177 LMQGtgyGGQFALWQkWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLwFILIYDDP 256
Cdd:cd17475 100 SVQP---GGGRAIMR-WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVL-FWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 257 vshpwiSGPEReyilsslnQQFSSEEQPLPIKAMLKSLPLWSMCLCT---MTHQWLVNTFIMytpTYISSVFKVNIRDNG 333
Cdd:cd17475 175 ------PAASA--------ATESASTLLRSLKEVLRNRDVWLIAIAGallVAPQFALLTFLL---LFLHDHLGLSVVAAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 334 FLSSLPFIVAWVLGILGGWLADFLLSKNFRLITVrkFITLLGNAPPAALVAALPYIQSSYITTIIFLTiscGLCPLSQAG 413
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLV--ITAAIAAAALLVLSLLSPGTPLWLLVLLLILL---GLFAIGWNG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 568981497 414 IYINAL-DIAP-RYASFLMGTSRGLAHSSAVLVPIVAGFFLSQDSEFGWRNFFFVVFAV 470
Cdd:cd17475 313 LYLTLVaESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLV 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
104-252 |
1.86e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.03 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 104 VYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIG--TKKVVGIALLGSSLLTLCIPLAANLGLVFFLAtrAVQGLMQGT 181
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALL--FLAGFGLGG 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981497 182 GYGGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILI 252
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
105-250 |
3.11e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 55.83 E-value: 3.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 105 YNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLglVFFLATRAVQGLMQGTGYG 184
Cdd:TIGR00895 47 WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--TQLLILRFLAGLGLGGLMP 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568981497 185 GQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSfgGGGVLCSLLWFI 250
Cdd:TIGR00895 125 NLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV--GGIAPLLLLLLL 188
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
104-251 |
1.04e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 104 VYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLAtrAVQGLMQGTGY 183
Cdd:cd06173 238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAAL--FLLGLAGGLFN 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568981497 184 GGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFIL 251
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
131-481 |
5.29e-07 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 51.91 E-value: 5.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 131 GYLAGKIGTKKVVGIALL---GSSLLTLCIPLAANLGL---VFFLATRAVQGLMQGTGYGGQFALWQKWAPPNERSRLCT 204
Cdd:cd17367 61 GRLADRIGRRAALTLSVSlmaAGSLVIAVTPTYATIGIwapIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 205 I----ALSGMTLGIFTVLLVGGIISE----ALGW--PFVFysfgggGVLCSLLWFILIYDDPVShpwisgpereyiLSSL 274
Cdd:cd17367 141 FqyvtLIGGQLLALGVLLVLQHTLGEdqmaAWGWriPFLL------GGVLAVVVLWLRRGLEET------------ESFE 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 275 NQQFSSEEQPLPIKAMLKS-LPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILGGWL 353
Cdd:cd17367 203 AIAESNEASAGTLRELRRHpRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 354 ADfllsknfrLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSqAGIYINALDIAPRYASFLMGTS 433
Cdd:cd17367 283 SD--------RIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLS-GYTSINAVVKAELFPTHVRALG 353
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 568981497 434 RGLAHSSAVLV-----PIVAGFFLSQDSEFGwrnFFFVVFAVNLLGLIIYLVF 481
Cdd:cd17367 354 VGLPYALAVAIfggtaPYVALWLKSIGHEWV---FFWYVAGLIAISLVVYLRM 403
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
108-247 |
9.22e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.05 E-value: 9.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 108 SPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLmqgtGYGGQF 187
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGL----GLGAAM 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981497 188 ----ALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLL 247
Cdd:cd17365 106 pnaiTLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
104-214 |
1.07e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.74 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 104 VYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLAtrAVQGLMQGTGY 183
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL--FLLGFGFGLLF 314
|
90 100 110
....*....|....*....|....*....|.
gi 568981497 184 GGQFALWQKWAPPNERSRLCTIALSGMTLGI 214
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
122-357 |
1.38e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 50.33 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 122 GMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGlvFFLATRAVQGLMQGTGYGGQFALWQKWAPPNERSR 201
Cdd:cd17327 53 GYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFG--GLIALRFFLGLFESGVFPGFILYLGMWYKREEQAK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 202 ----------LCTIALSGMTLGIFTVLLVGGIiseaLGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPWISGPEREYIL 271
Cdd:cd17327 131 riaffyaaagLGSIFGGLLAYGVFKILGVGGL----AGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAV 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 272 SSL--NQQFSSEEQPLP--IKAMLKSLPLWSMCLCTMThQWLVNTFIM-YTPTYISSVFKVNIRDNgFLSSLPFIVAWVL 346
Cdd:cd17327 207 ERLraNQTGKGDQKFKWkqIKEAFKDPRTWLLFLFFFC-SQITNNGISnFLPLILKSLGFYSLQTN-LLSVPIGALGAVS 284
|
250
....*....|.
gi 568981497 347 GILGGWLADFL 357
Cdd:cd17327 285 LLIAALLSDRF 295
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
113-484 |
1.80e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 50.03 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 113 GIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTlcIPLAANLGLVFFLATRAVQGLMQGTGYGGQFALWQK 192
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTT--VAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 193 WAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVShpwiSGPEREYILS 272
Cdd:cd17343 119 WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSD----VGLNNIEEEE 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 273 SLNQQFSSEEQPLPIKAMLKSLPLWSMCLCTMThQWLVNT--------FIM---YTPTYISSVFKVNIRDNGFLSSlpfi 341
Cdd:cd17343 195 SKGKKKKSPRGESTLKELLLSPFLWLLSLGYLV-VFGVKTavtdwgqlFLIqdkGQSALTGSSFMSSLEVGGFVGS---- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 342 vawvlgILGGWLADFLLSK-------NFRLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGI 414
Cdd:cd17343 270 ------IAAGYLSDWAVAKhgsssrgNPRMPLALVFMAGLTVSLHLFRVHITSDSSELFILLLGFLIGFSLYGPIAIFGV 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981497 415 YinALDIAPryaSFLMGTSRGLAHSSAVLVPIVAGFFLSQ-DSEFGWRNFFFVVFAVNLLGLIIYLVFGKA 484
Cdd:cd17343 344 I--ANESAP---SHLCGTSHAIVALAANVGGVLAGLPFSYiAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
105-480 |
3.38e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 49.16 E-value: 3.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 105 YNWSPQTQGIIFS--SVQYGmiLMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIP--LAANLGLVFFLATRAVQGLMQG 180
Cdd:cd17345 33 YGLSKTEIGLIGSalSIAYG--LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGfvPSATSSVGLMFILLFLNGWFQG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 181 TGYGGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLC---SLLWFILIYDDPV 257
Cdd:cd17345 111 MGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAiivAVIVLFLGKDTPE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 258 S------HPWISGPEREYILSSLNQQFSSEEqpLPIKAMLKSLPLWSMClctmthqwLVNTFIM--------YTPTYISS 323
Cdd:cd17345 191 SeglppiEEYKGDYPEEADGEEEEQELSAWE--IFVKYVLKNKLLWYIA--------IANVFVYlvrygildWAPTYLSE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 324 VFKVNIRDNGFLSSLPFIVAWVLGILGGWLADfLLSKNFRLITVRKFITLLgnappaaLVAALPYIQSSYITTIIFLTIS 403
Cdd:cd17345 261 VKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSD-KLFKGRRAPTGIIFMILV-------IVALIVYWLAPNVLVDLIALIA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 404 CG-LCPLSQAGIYINALDIAPRYASflmGTSRGL---------AHSSAVLVPIVAGFflsqdseFGWRNFFFVVFAVNLL 473
Cdd:cd17345 333 LGfLIYGPVMLIGLQALELVPKKAA---GTAAGLtglfgylggSVLATALIGIIVDH-------FGWNGGFIVLLASCIL 402
|
....*..
gi 568981497 474 GLIIYLV 480
Cdd:cd17345 403 AIIFLAL 409
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
113-456 |
5.92e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.47 E-value: 5.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 113 GIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLATRA--VQGLMQGTGYGGQFALW 190
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAglGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 191 QKwappNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYddpvshpwisgPEREyi 270
Cdd:cd17333 114 EE----SSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLF-----------PELP-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 271 lSSLNQQFSSEEQPLPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILG 350
Cdd:cd17333 177 -SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 351 GWLADFLLSKNFRLITVrkFITLLGnappaalvaalpYIQSSYITTIIFLTISCGLCPLSQAGIYINAL----DIAPRYA 426
Cdd:cd17333 256 GPISRRIKPHTLLVLSG--SGALLG------------LLILLLAPTLVVGLVATALLGLFMAALFPTILslgiSNLPYAK 321
|
330 340 350
....*....|....*....|....*....|
gi 568981497 427 SFLMGTSRGLAHSSAVLVPIVAGFFLSQDS 456
Cdd:cd17333 322 GKGTSVLLAAGSIGGAIIPFIMGFIAEAVG 351
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
105-488 |
6.03e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.33 E-value: 6.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 105 YNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLMQGTGYG 184
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVAL--LLAGTALIGAGIAVGNV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 185 GQFALWQKWAPpNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPwisg 264
Cdd:COG2807 126 LLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA---- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 265 pereyilsslnqqfsSEEQPLPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYissvfkvnIRDNGF-------LSS 337
Cdd:COG2807 201 ---------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPI--------LRDAGLsaataglLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 338 LPFIVAWVLGILGGWLADfllsknfRLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCpLSQAGIYIN 417
Cdd:COG2807 258 LFQLAGIPGSLLVPLLAD-------RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGL-FPLALTLIG 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981497 418 ALDIAPRYASFLMGTSRGLAHSSAVLVPIVAGFFLSQDSefGWRNFFFVVFAVNLLGLIIYLVFGKADVQE 488
Cdd:COG2807 330 LRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG--SWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
131-481 |
7.15e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.04 E-value: 7.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 131 GYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLglVFFLATRAVQGLMQGTGYGGQFALWQKWAPPNERSRLCTIALSGM 210
Cdd:cd17312 59 GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSL--WFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSH 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 211 TLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPvshpwisgpereyilsslnqqfsseeqPLpikam 290
Cdd:cd17312 137 NFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP---------------------------PY----- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 291 lkslpLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILGGWLADFLLSKNFRLITVrkf 370
Cdd:cd17312 185 -----VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAV--- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 371 ITLLGNAPPAALVAALPyiqSSYITTIIFLTISCGLCPLSQAGIYINALDIAPRyaSFLMGTSRGLAHSSAVLVPIVAGF 450
Cdd:cd17312 257 IYMLLMTLSLALFWFFP---HNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGR--KEAAGTATGFVGLFGYLGASLAGL 331
|
330 340 350
....*....|....*....|....*....|..
gi 568981497 451 FLSQ-DSEFGWRNFFFVVFAVNLLGLIIYLVF 481
Cdd:cd17312 332 PLGYiIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
98-479 |
7.54e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 7.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 98 LPIKAPVYNW--SPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQ 175
Cdd:cd17316 22 APVLAAEFSLglSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL--RFLQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 176 GLMQGTGYGGQFALWQKWAPPNERSRLCTIALSGMTLGIftvllvggiisealgwpfvfysfggggVLCSLLWFILIYDD 255
Cdd:cd17316 100 GIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGA---------------------------LLAALVASLLIPLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 256 PVSHPWISGpereYILSSLnqqfsseeqPLPIKAMLKSLPLWSMCLCTMTHQWlVNTFIMYTPTYISSVFKVNIRDNGFL 335
Cdd:cd17316 153 SGDWGWRIL----FLIGAL---------PALLALLLRRRTLLLILLWFFISFG-YYGLTTFLPTYLQTVLGLSPATSSLY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 336 SSLPFIVAWVLGILGGWLADFLlsknFRLITVrkFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIY 415
Cdd:cd17316 219 LLLISLGALVGALIAGLLSDRI----GRKKTL--VIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAY 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981497 416 INALdIAPRYASFLMGTSRGLAHSSAVLVPIVAGFFLSqdSEFGWRNFFFVVFAVNLLGLIIYL 479
Cdd:cd17316 293 LAEL-FPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA--STGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
98-374 |
8.80e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.07 E-value: 8.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 98 LPIKAPVYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQGL 177
Cdd:cd17371 22 LPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL--RALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 178 mqgtGYGGQFA----LWQKWAPPNERSRLCTIALSGMTLG-IFTVLLVGGIISEAL---GWPFVFYSfgggGVLCSLL-W 248
Cdd:cd17371 100 ----GFGGEWAagaaLMAEYVPARHRGKALGYVQSGWAVGwLLATLLAALLFPLLPpeiAWRVLFLL----GALPALLvL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 249 FIliyddpvsHPWISGPEREYILSSLNQQFSSEEQPLPI--KAMLKSLPLWS-MCLCTMTHQWLVNTFImytPTYISSVF 325
Cdd:cd17371 172 FI--------RRFVKEPPQWQAARAARRHFADRPSLRELfsPPLLRTTLLASlLATGALGGYYGITTWL---PSYLTGER 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 568981497 326 KVNIRDNGFLSSLPFIVAWVLGILGGWLADFLLSK-NFRLITVRKFITLL 374
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRnNFALFALGSAISIL 290
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
104-251 |
2.90e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.03 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 104 VYNWSPQTQGIIFSSVQYGMILMQGP-GGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLAtrAVQGLMQGTG 182
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAA--AILAFGTGIV 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981497 183 YGGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGwPFVFYSFGGGGVLCSLLWFIL 251
Cdd:cd17330 282 FPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG-PGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
107-260 |
1.09e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 107 WSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLgLVFFLATRAVQGLMQGTGYGGQ 186
Cdd:cd17355 35 WSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSL-WQLYLLWGLLGGGGAGTLAAVA 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981497 187 FALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHP 260
Cdd:cd17355 114 FATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLA 187
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
299-498 |
1.62e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 299 MCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILGGWLADFLlsknfrlitVRKFITLLGNAP 378
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 379 PAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPRYASFLMGTSRGLAHSSAVLVPIVAGFFLSQdseF 458
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL---F 148
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 568981497 459 GWRNFFFVVFAVNLLGLIIYLVFGKADVQEWARERKLTRL 498
Cdd:pfam07690 149 GWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
131-235 |
2.76e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 131 GYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLG-LVFFlatRAVQGLmqGTGYG---GQFALWQKwAPPNERSRLCTIA 206
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAsLIIF---RILQGF--GGGVLiplAQTILLRI-YPPEKRGAAMGLV 125
|
90 100
....*....|....*....|....*....
gi 568981497 207 LSGMTLGIFTVLLVGGIISEALGWPFVFY 235
Cdd:cd17503 126 GLVILLAPAIGPTLGGWLTDNLSWRWIFY 154
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
123-252 |
3.11e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.98 E-value: 3.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 123 MILMQGPGGYLAG-----KIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQGLMQGTGYGGQFALWQKWAPPN 197
Cdd:cd17490 239 YLLPNALASLLSGtlfykKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLL--QALNGFGTGILFPLLMSLSIEGVPAE 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 568981497 198 ERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILI 252
Cdd:cd17490 317 QRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
102-243 |
3.40e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.03 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 102 APVYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKV--VGIALLGssLLTLCIPLAANLGLVffLATRavqgLMQ 179
Cdd:PRK11551 42 AQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRIliVSVALFG--LFSLATAQAWDFPSL--LVAR----LLT 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568981497 180 GTGYGGQF----ALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYsFGGGGVL 243
Cdd:PRK11551 114 GVGLGGALpnliALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFY-VGGVGPL 180
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
131-259 |
5.04e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 42.37 E-value: 5.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 131 GYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQGLMQGTGYGGQFALWQKWAPPNERSRLCTIALSGM 210
Cdd:TIGR00711 58 GWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIF--RVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTV 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 568981497 211 TLGIFTVLLVGGIISEALGWPFVFY-SFGGGGVLCSLLWFILIYDDPVSH 259
Cdd:TIGR00711 136 LVAPALGPTLGGWIIENYHWRWIFLiNVPIGIIVVVVAFFILPRDKPAAS 185
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
196-355 |
7.85e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 7.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 196 PNERSRLCTIALSGMTLGIFTVLLVGGII------SEALGWPFVFYSFGGGGVLCSLLWFILIyddpvshpwisgPEREY 269
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGT------------KERPV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 270 ilsslnqqfsSEEQPLPIKAMLKSL----PLWSMC---LCTMTHQWLVNTFIMYtptYISSVFKVNIRDNGFLSSLPFIV 342
Cdd:COG2211 210 ----------PEEEKVSLKESLKALlknrPFLLLLlayLLFFLALALVAALLLY---YFKYVLGLSAALVGLLLALYFLA 276
|
170
....*....|...
gi 568981497 343 AWVLGILGGWLAD 355
Cdd:COG2211 277 ALLGAPLWPRLAK 289
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
122-481 |
8.46e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.79 E-value: 8.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 122 GMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLvfFLATRAVQGLMQGTGYGGQFALWQKWAPPNERSR 201
Cdd:cd17320 46 GFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--LLIARFLQGLGAAAGSVVARAIVRDLYSGAELAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 202 LctIALSGMTLGIFTVL--LVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIyddpvshpwisgPEreyILSSLNQQFS 279
Cdd:cd17320 124 I--FSLLMMILAIAPALapLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFL------------PE---TLPEEKRKPL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 280 SEEQPLPIKAMLKSLPLWSMCLCtmthQWLVNTFIMytpTYISSVFKVNIRDNGFLS---SLPFIVAWVLGILGGWLADF 356
Cdd:cd17320 187 LSSLLRAYKRVLKNRRFLGYALA----LGLSFAGLF---AYLAAAPFIYIEQLGLSPaqfGLLFALNAIALILGSLLNGR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 357 LLSKnFRLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPRYAsflmGTSRGL 436
Cdd:cd17320 260 LVRR-FGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA----GTASAL 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 568981497 437 AHSSAVLVPIVAGFFLSQDSEFGWRNFFFVVFAVNLLGLIIYLVF 481
Cdd:cd17320 335 LGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
108-253 |
1.06e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 108 SPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQGLmqgtGYGGQF 187
Cdd:cd17477 29 STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLL--RFVMGI----GLAGLF 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568981497 188 ALWQKW----APPNERSRLctIALSGMTLGIFTVL--LVGGIISEALGWPFVFysfgggGVLCSLLWFILIY 253
Cdd:cd17477 103 VVSESWlnalATNENRGRV--LGLYSTVLGLGFALgpLLLALVGTAGALPFLI------AAVLLLLALVPLL 166
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
107-267 |
1.12e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.14 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 107 WSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQGLMQGTGYGGQ 186
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLAL--RFLAGAASAFVFVFG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 187 FALWQKWAPPNERSRLCTIALSGMTLGIF-TVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPWISGP 265
Cdd:cd06180 109 SNLVLHHATAAGRGHLIGLLFAGVGLGIAlSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAA 188
|
..
gi 568981497 266 ER 267
Cdd:cd06180 189 ES 190
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
113-236 |
1.72e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.71 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 113 GIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAAN---LGLVFFLATRAVQGLMQGTGyggqfAL 189
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTpwqLGILRFLLGLATGGLLPAIN-----SL 317
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 568981497 190 WQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYS 236
Cdd:cd17391 318 LAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
104-252 |
2.04e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.63 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 104 VYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAAnLGLVFFLATRAVQGLMQGTGY 183
Cdd:COG2223 235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL-GSLWLFLVLFLLLGLALGGGN 313
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 184 GGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALG-WPFVFYSFGGGGVLCSLLWFILI 252
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
129-235 |
2.41e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 129 PGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGlvFFLATRAVQGLMQGTGYGGQFALWQKWAPPNERSRLctIALS 208
Cdd:cd17321 50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA--FLIAARALQGIGAAAIMPASLALIAATFPGERRGRA--LGLW 125
|
90 100
....*....|....*....|....*....
gi 568981497 209 GMTLGIFTVL--LVGGIISEALGWPFVFY 235
Cdd:cd17321 126 GAVVGIGAALgpLLGGLLLELFGWRWIFL 154
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
113-260 |
2.79e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 2.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 113 GIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGLVFFLatRAVQGLMQGTGYGGQFALWQK 192
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVL--RLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 193 WAPPNERSRlcTIALSGMTLGIFTVL--LVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHP 260
Cdd:cd17489 112 IIPPSRRGE--GIGYYGLATTLAMALgpALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAE 179
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
97-215 |
2.98e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 97 HLPIKAPVYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLG-LVFFLATRAVQ 175
Cdd:pfam07690 222 YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLsSLWLLLALLLL 301
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 568981497 176 GLMQGTGYGGQFALWQKWAPPNERSRLCTIALSGMTLGIF 215
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
104-484 |
3.89e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 104 VYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANLGlvFFLATRAVQGLMQGTGY 183
Cdd:COG0738 37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--LLLLALFLLGLGLGLLD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 184 GGQFALWQKWAPPNERSRLcTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIyddPVSHPWIS 263
Cdd:COG0738 115 VAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL---RSKLPEIE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 264 GPEREyilsslnqqfsSEEQPLPIKAMLKSLPLWSMCLCTMTH---QWLVNTFImytPTYISSVFKVNIRdngfLSSLPF 340
Cdd:COG0738 191 EEEEE-----------AAGSAASLKSLLKNPRLLLGGLAIFLYvgaEGAIGDWL---PLYLKDVLGLSEA----TAALGL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 341 IVAWVLGILGGWLADFLLSKnFRLITVRKFITLLGnappAALVAALPYIQSSYITTIIFLTISCGLCPLsQAGIYINALD 420
Cdd:COG0738 253 SLFWGGMTIGRFLGGFLLKR-FGPVRLLRLSALLA----AVGLLLALLAPGPWLALIGLALVGLGLSLM-FPTIFSLALD 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981497 421 IAPRYASFLMGTSRGLAHSSAVLVPIVAGFFLSQdseFGWRNFFFVVFAVNLLGLIIYLVFGKA 484
Cdd:COG0738 327 GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA---FGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
113-479 |
8.11e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 8.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 113 GIIFSSVQYGMILMQGPGGYLAGKIGTKKVVGIALLGSSLLTLCIPLAANlgLVFFLATRAVQGLMQGTGYGGQFALWQK 192
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS--FALLLAGRALQGIGAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 193 WAPPNERSRLctIALSGMTLGIFTVL--LVGGIISeALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPWISGPEReyi 270
Cdd:cd17474 115 LFEGGERAKA--MGLYEAALGLGIAVgpLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKL--- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 271 lsslnqqfsseeqpLPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFiVAWVLG--I 348
Cdd:cd17474 189 --------------RDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWS-VLLALGslF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981497 349 LGGWLADFLLSKNfrlitvrkfITLLGNAPPAALVAALPYIQSSY--ITTIIFLTISCGLCPLSQAGIYINALDIAPRya 426
Cdd:cd17474 254 VGRLLKKRFGARR---------ILVIGLLLYALSLLLLGFVPSLAllLIAIVLFGLGLGLNLPLLTTLVTELAPEEER-- 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 568981497 427 SFLMGTSRGLAHSSAVLVPIVAGFFLsqdSEFGWRNFFFVVFAVNLLGLIIYL 479
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| |
